CA 15-3 - bundu zvechinguvana kuti kenza yemazamu

In mushonga, CA15-3 (bundu zvechinguvana) rinoshandiswa murabhoritari zvokuongorora kenza yemazamu, anowedzera iri serum inoratidza kuvapo chirwere, kunyanya mune yepamusoro chirwere uye kuvapo metastases pamuviri. zvechinguvana Uyu chinokosha zvikuru, ine yakakwirira specificity, ndikarangarira tsvakurudzo kuona kunaka kurapwa, uye dzokororo kana metastasis dropouts. Zvinoshanda ongororo CA 15-3 uye rokuongorora muedzo zamu chirwere chakadai zvakadai carcinoma, membranes nazvo chaizvo mune serum.

Chii bundu zvechinguvana

Bundu zvezvinangwa muri zvinhu akasiyana hunhu, zvinogona kuve mvura nhau (kazhinji weti kana ropa) mune imwe pfungwa vanogona kuratidza pamberi kenza. Ari kurwara nacho muitiro zvezvinangwa kuvimba specificity uye aikanganiswa pakati bundu. Specificity ndiyo chikamu kunaka mugumisiro bundu zvezvinangwa vari kuongorora hwakanaka munhu. Utetsa ndiyo chikamu yakanaka vakawana pavarwere vane kenza zvokurwara. Nhasi haisati kuwanikwa chero dzakananga antigen, izvo zvaizoita zvakananga uye ane mukana rimwe zana muzana aigona kubatsira kuisa Cancer zvawanikwa. Bundu inogona wakawedzera, uye anogumbura zvirwere zvakasiyana siyana hunhu, uye ndichaita kunowedzerawo uye benign kwacho.

Kazhinji, kenza zvezvinangwa anobudiswa masero chete embryo. Recently vanachiremba vakatanga kuwana zvezvinangwa nekenza vechiduku uye kunyange vana. Izvi zvinoitika nokuda mumwe kuparara kwezvakatipoteredza ezvinhu, kuvapo tsika dzakaipa, kana comorbidity.

sei zvakanakisisa

Kuona yakanaka bundu zvechinguvana ari rinomutsa, zvino ane mukuru chirwere ukoshi pane imwe chete-nguva Diagnostics. The zvazvingava panguva iyo kuwedzera chakarurama chinoratidza bundu kukura zvazvingava, uye kuvapo metastases. Kunyange pashure kenza kurapwa antigen CA 15-3 munguva kubva nhanhatu mwedzi mipfumbamwe mwedzi kuwana mberi kukura kunotoda mufananidzo. About 80% yevakadzi vane kenza yemazamu metastatic, kuuya chiremba pamwe kunowedzerwa, 20% vari kenza kwacho rokutanga kana kuti rechipiri danho zvechinguvana kunowedzerawo.

kana mupei

Mashoko chidzidzo ndiro ropa, iro CA 15-3 zvechinguvana kupfuure nokuda zvachose uye nenguva zvichiongororwa, ari kuonekwa wokukurumidza chirwere dzokororo, metastasis, uye kubudirira kurapwa. Uyewo ichangobva wakatora uye differential chirwere kuti malignancy uye mastitis.

Chii CA 15-3 (mota zvechinguvana)

Izvi yakakwirira samolecular uremu mucin-mhando glycoprotein uye ane samolecular kurema 300 kilodaltons. In kwomuzvarirwo chiratidzo dziri secreting muchitokisi Kamudzira pemvura. It rinogona kuona zamu carcinoma, asiwo pamberi chinoratidza ichi dai rabhoritari uye carcinoma pamusoro zvemapapu, ovarian, uye gastro-intestinal turakiti, uye rwatata.

Kunze kuti CA15-3 (bundu zvechinguvana) aigona vabereke bundu rinenge rinogona upgraded mune dzimwe pathological inoti umo yakawedzera muchitokisi turnover. Izvi nezvimwe glycoproteins kubva mumuviri, kunyanya kubva muropa, goho kubudikidza chiropa uye kuti ayo zvokurwara, kunyanya cirrhosis, anogona kuva chimwezve chinhu nechirwere.

The kukosha chokuongorora

kenza yemazamu rakanyatsojeka achinyengera chirwere, riri tanga nechirwere iri havaratidzi. Rizowedzerwa ropa kuongorora CA15-3 munokosha uyewo nechinangwa muzvidzivirire, saka hapana mukana Oncology panguva mangwanani chaizvo pavaipfuura kwacho. Uyezve, achaita nenguva chirwere kuti chiropa zvokurwara. Pfungwa kunofanira kubhadharwa-ngozi vari varwere vave vachionekwa, kana vakadzi kubereka. Uyezve, zvinoita here kuziva benign kana nekusiyana, zvinoda kurapwa pakarepo uye kupindira nyanzvi.

Zvirwere kuti zvinoda ongororo

Chokutanga, izvo zvinofanira kutora CA15-3 ongororo - ndiko, Sezvambotaurwa, kenza yemazamu, carcinoma, uye metastatic muitiro. Sezvo mapuroteni ichi, uye nzvimbo huru yaro muviri - chiropa nezvinetso izvi zvinogona kupiwa chaizvo. Chokutanga, muchiitiko ichi zvakafanira kufunga cirrhosis, muchiitiko ichi, vakawedzera CA 15-3, ndozvakajairwa hazvisi akaenzana 50 inokwana zviyero muzana Rine mamiririta. Uyewo kuteerera dzimwe nzira kuzviongorora chiropa, kunyanya Ultrasound uye histology. It histologist anogona kuisa wokupedzisira pfungwa nechirwere. Nekuti kenza angatanga kwete chete nechityu, uyewo mudumbu, rwatata, ovaries uye mapapu uye metastasize kuna zvomukati ava kunyanya kukosha zvechinguvana CA 15-3 unowana nevarume. Dynamics ongororo kuchaita kuongorora apedza kurapwa uye ayo unhu.

Kazhinji chiratidzo uye kunowedzera benign muitiro, zviri kutanga ose ataurwa pamusoro zvirwere mammary mumasero. Autoimmune zvirwere vangapa akawedzera CA 15-3. Bundu zvezvinangwa anogona ngazviwedzerwe kunyange zvakadaro vasiri mamiriro nhengo vakadzi, sezvo pamuviri, kunyanya panguva yechitatu trimester, kuti chinoratidza muchiitiko ichi akaenzana 50 U / Rine mamiririta.

Chii? Where? Apo?

Imi chete vanofanira kutora ropa kubva tsinga, iyo achatora mukoti vari kurapwa mukamuri. Just tichiyeuka kuti unofanira kutora usina chawadya CA15-3 pachisara decoding nayo iyi yaizova yakawanda yakarurama. Kuongororwa serum, umo vakatsunga parameter Cancer mapuroteni. Kuita kuongorora nguva kwemaawa matatu - uye mugumisiro zvagadzirirwa. Gadzai ongororo anogona oncologist mammolog kana gayinakorojisiti. Kudzidza ropa serum kunoitika pamwe immunohemilyuminestsentnogo pachisara uye hafu yeawa pamberi chokuendesa ari kuongorora haafaniri kusvuta.

Sezvo rokupedzisira kudya anofanira kuva maawa anopfuura 8 uye kwete kupfuura 14. The ropa zvakare zvakaitika mushonga risati, uye kwete kwokutanga pane 1-2 mavhiki pashure discontinuation chourongwa yavo. Kana mushonga zvisingaiti kusiya, nenzira inofanira kutaurwa chaizvo izvo zvinodhaka munhu anotora, uye chii dose. Zuva pamberi kubatwa ari kuongorora vanofanira kungorara kurovedza muviri, uyewo kuramba mafuta uye zvakakangwa zvokudya.

The Zvabuda vakawana

The bhuku ukoshi pakutsvaga indekisi zvishoma pane 31.3 inokwana zviyero por milliliter. Sezvo kuwedzera CA 15-3 anogona kutonga padariro acho, uye zvikuru maperembudzi vakatanga, makuru bundu iri zamu tishu. Metastatic kenza, kunyanya mu pfupa uye / kana chiropa, sezvo anogona anoratidzawo ongororo. Usakanganwa kuti mukutanga nzendo muitiro CA 15-3 (bundu zvechinguvana) anogona haapfuuri vasingambooni chakaipa nazvo. Maererano nenhamba, kuti chikamu varwere izvi ndizvo 25 kusvika 30, kenza rinenge chete hakuiti ino chaiyo mapuroteni. Kana zvachose Zvakawanikwa wevasungwa pamusoro pakanyorwa kunokwanisa zvakachengeteka kufunga nokushayiwa ake kubudirira kana nekusiyana, chirongwa wava kusvutazve.

Mugumisiro inogona kukanganiswa

Comorbidities kungaita Kuongorora zviratidzo, uye ichi rakundwa nezvarwo. Pane rose mazita zvirwere, vari pamusoro pakanyorwa kukura kenza kwacho kunogona kukanganisa mugumisiro uye regai chiremba zvakaipa njanji. For zvirwere zvakadai zvinosanganisira autoimmune urongwa, tibhii, sarcoidosis. With ichi Zvingaguma zvokurwara lozhnopolozhitelen.

The chirwere kuongorora CA15-3 kenza yemazamu yaizova yakawanda inokosha kana panguva imwecheteyo kuona carcinoembryonic antigen. Uye kuita bvunzo pacharo nani muvhiki shomanana pashure kutanga kurapwa.

nemimwe miedzo

Rokuongorora zvinogoneka kwete chete kupfuura ropa zvinhu kunogonawo kuva pleural fluid ascitic (kunyanya mu cirrhosis), cerebrospinal, cystic (cysts biopsy kuti zamu kana ovarian) mvura. Kuti atonge chirwere, kunofanira kutungamirirwa nomudzimu nechokwadi nemitemo. Mune imwe nhengo utano, bundu zvechinguvana hakurevi kusapfuudza mwero 0 kusvika 22 Iu chete milliliter, muganhu ezvinhu dzinofanira kuzokurukurwa kubva 22 kusvika 30 Iu chete milliliter, mumwe zvokurwara vaiona pachisara unoratidza 30 Iu paminiti milliliter kana kupfuura.

Prophylaxis ane ukoshi

Bundu zvezvinangwa havasivo chete tsvakurudzo nzira kuti unobvumira vanachiremba kuti zvakarurama zvawanikwa. In pamberi kenza zvezvinangwa kuchaita kuongorora kubudirira mushonga kana kuziva chirwere achiri padanho kwayo kukura. Tora zvakafanira kuongorora kanenge kamwe pagore, kunyanya pashure 35-40 makore.

Pamwe tsanangudzo kenza zvezvinangwa asina precluded pakuongorora murwere nokushandiswa paku nzira uyewo nzwisisika kunotoda kuongorora. Apo mukuru mwero CA15-3 uye kusavapo kuchinjwa mumakore kuongorora mumasero mammary regai dzikama Cancer muitiro unogona kuvanda dzimwe nhengo dzakadai ura, chiropa, ovary, kana dumbu. Kuvapo antigen iyi varume hunoratidza nezvinetso chiropa kana nemudumbu, kudzivisa kuona CA 15-3 uye vanoda navo.

Kuti abatsire kududzira ongororo chete rubatsiro nyanzvi, sezvo yakazvimirira dudziro kungaita kuti mafungiro zvinetso kana kunetseka, kunyange zvazvo kuwedzera zvezvinangwa kunogonawo kuonekwa benign kwacho. Gadzai ongororo kunogona chete kuva nyanzvi, pashure basa chiremba kuongororwa izere uye pashure kungwarira anamnesis. Kenza zvezvinangwa kubvumira nyanzvi rokuongorora mangwanani chirwere kwacho, asi chete misoro nzira inogona kutongwa hwokupedzisira mugumisiro.