Bundu Necrosis Factor: kugadzirira

Bundu necrosis chinhu (TNF) - boka cytokines chaizvo mapuroteni - kemikari-zvakadai zvinokuvadza neve zvirwere. Chinokonzera yakawanda kufarira mushonga nokuda kwayo ehupfumi - kukwanisa kufurira sero rufu (necrosis) intratumoral tishu. Ichi budiriro chaicho mushonga, achibvumira kuti kushandisa zvinhu pamwe TNF kuti kurapwa kenza.

History yakawanikwa

By pakutanga XX remakore ari okurapa yava dzakaonekwa muenzaniso: mune vamwe varwere paiva kuderera uye / kunyangarika kana bundu inotungamirwa pashure kutapurirana chirwere chipi. Zvadaro nyanzvi American William Coley akatanga nemaune dzakabatwa nekenza zvinodhaka ane chirwere musha (utachiona uye dzavo zvinokachidza). Nzira haana kuwanikwa kuti tibudirire, sezvo ane simba hunokachidza zvainoita murwere. Asi zvakanga kutanga nhamba kutsvakurudza inotisvitsa kuwanikwa munhu puroteni, inonzi bundu necrosis chikonzero. Found fuma kukonzera nokukurumidza rufu kenza akaisa pasi ganda experimental mbeva. Papera chinguva, zvakanzi dzoga TNF yakaisvonaka, iyo akabvumira kuti kurishandisa yokutsvakurudza zvinangwa.

Izvi zvakawanikwa vakabatsira kuti budiriro iri kenza mishonga. Kare, uchishandisa mapuroteni cytokines anokwanisa zvinobudirira kubata kenza vari shomanana Education - melanoma kenza ganda, kenza itsvo. Zvisinei, zvinokosha mberi munda uyu akabvumira kudzidza zvivako akadzadzwa bundu necrosis chikonzero. Kugadzirira anoritsanangura vanobatanidzwa mune mishonga nzira.

mashandiro chiito

bundu necrosis chikonzero anoita pamusoro sero chaiwo - chipfuro. Kune nzira dzakawanda kuita:

• Kuburikidza chinokosha TNF receptors paanounza multi-Danho mashandiro - chiite sero rufu (apoptosis). Izvi zvinonzi cytotoxic. Panguva iyoyowo kucherechedza imwe Kutsakatika rakakwana namamota, kana kuderedza saizi yayo.
• Kuburikidza pakaputsika kana kumisa muchitokisi kutenderera. Kenza Sero anova asingakwanisi zviparadzanise uye bundu kukura anomiswa. Izvi zvinonzi cytostatic. Yemanyorero kuzvimba sezvamakaropafadzwa kana akarega kuwedzera, kana kudzikira ukuru.
• By ichivharira paumbwe gadziriro neovascularization kuti bundu rinenge uye kukuvadza kwerubwinyo rwakagara rwuripo huripo capillaries. Bundu anobviswa zvokudya, necrotic, kunodzikira uye haarambi.

Pane mamiriro ezvinhu apo kenza masero vari basa jekiseni mushonga nokuda kunotouraya. Ipapo pamusoro zvigadziriswe regai simuka.

The kushandiswa mushonga

Bundu necrosis chikonzero rinoshandiswa dzinonzi Cytokine kurapa - kurapwa kwemapurotini chaizvo kuti kunotangira ropa masero anokonzera kutapata. Procedure zvinogoneka chero pavaipfuura bundu kwacho uye kwete contraindicated vanhu vane comorbidities - zvemwoyo, renal, hepatic. Kuderedza toxicity rakaiswa njodzi recombination bundu necrosis chikonzero.

Treatment pamwe cytokines - itsva uye zvishoma nezvishoma kuva munda oncology. Kushandiswa TNF anonzi inonyatsobudirira. Sezvo fuma iyi zvikuru chepfu, rinoshandiswa anonzi remunharaunda perfusion. The nzira ine iri yokuti utachiona bundu nhengo kana muviri chikamu achibatsirwa chaiyo michina anonunurwa kubva zvavo vakawanda. Zvadaro artificially kukonzera ropa kuparadzirwa ne jekiseni TNF.

migumisiro ngozi

In kurapwa tsika, bundu necrosis chinhu yaishandiswa nokungwaririra. A nhamba yezvidzidzo kwakaratidza kuti TNF - huru pakuderedza kukura sepsis, chepfu kuvhunduka. Kuvapo mapuroteni ichi zvakawedzera pathogenicity kwemabhakitiriya uye kutapukirwa noutachiona, riri kunyanya ngozi pamberi HIV mune murwere. Rakaratidza kuti TNF zvinobatanidzwa kukonzera autoimmune zvirwere (semuenzaniso, dzinonzi rheumatoid arthritis) umo zvirwere zvisiri anogamuchira munyama uye mumasero nhengo yemiviri vatorwa uye kukuvadza navo.

Kurerutsa yakakwirira hunokachidza mugumisiro kucherechedza zvinotevera matanho:

• kushandisa chete munharaunda panguva nzvimbo mota inotungamirwa;
• sangana nevamwe zvinodhaka;
• Vanoshandira nezvishoma chepfu mutant TNF mapuroteni;
• raitongwa neutralizing antibodies.

ezvinhu aya kumanikidzira dzisina kushandisa bundu necrosis chikonzero. Treatment vanofanira kuva rakanyatsorongwa.

chirwere chakarurama

A bvunzo ropa asingagari kuona TNF ari kumuviri. Asi ayo mwero kunowedzera zvinoshamisa zvirwere apo ropa kunobva utachiona hwakakura muchetura. Ipapo chinogona kuvapo weti. Bundu necrosis chinokonzera synovial mvura okuremadzwa chearthritis inoti.

Kunowedzerawo kuti chokukomborerwa ichi anotaura neutachiona, zvirwere kenza uye chiratidzo kuramba wakasimwa anyatsoronga nhengo. Pane uchapupu hwokuti kuwedzera chinoratidza ichi zvingaratidza kuti non-pezvirwere zvinopomerwana zvakadai mwoyo kukundikana, Árbol asima.

In immunodeficiency siyana (kusanganisira AIDS) uye zvakakomba zvinokonzerwa nemavhairasi zvirwere kuitika uyewo kukuvara uye anopisira, mamiriro ezvinhu zvinosikwa izvo kuderedza bundu necrosis chinhu. A mushonga rine immunosuppressive zvazviri, ipai ndozvinoitawo.

gadziriro

kwakavakirwa TNF zvinodhaka anonzi zvakanangwa - kukwanisa kuita aiming yazvakaitikira mamorekuru masero kenza, kukonzera rufu yokupedzisira. Sei dzimwe nhengo iri shoma, izvo zvinoderedza toxicity, izvo ane bundu necrosis chinhu. zvinodhaka inobva anoshandiswa senzira TNF oga (monotherapy) uye kubatanidza nevamwe vamiririri.

Nhasi, pane zvinhu zvakawanda nemhaka TNF, anoti:

• NGR-TNF - yokumwe chigadzirwa, zvinoshingaira chirungiso rinobva pakati TNF. Zviri anogona kukuvadza ropa nhumbi bundu, nokunyima izvozvo simba rayo.
• "Alnorin" - Russian kukura. Zviri zvikuru inobudirira akabatana mainterferon.

"Refnot" - reRussia mushonga ane bundu necrosis chinhu uye thymosin Alpha 1. toxicity Its yakaderera chaizvo, asi kushanda akaenzana yepanyama TNF, uye kunyange kukasapfuura nayo nevanhu immunostimulatory chiito. The mushonga akasikwa 1990. It yakabudirira akapfuura nemiedzo ose anodiwa kurapwa uye chete muna 2009 hwakanyorwa, zvaakapiwa yepamutemo mvumo kubata kenza dzavo.

Self-kwokubatsira zvinodhaka zvose nokuda bundu necrosis chinokonzera zvachose wairambidza. kurapwa kenza - zvikuru yakarongwa muitiro kuti zvinotora nzvimbo bedzi pasi pokudzora nyanzvi.