Exchange bilirubin
Respiratoria basa rinopa zvose ropa nyama dzomuviri zvakakodzera okisijeni kutakurwa zvikuru kushandiswa conveyor - Chizenga - marongerwo masero matsvuku eropa. Zvisinei, masero aya vane zvishoma upenyu hupfupi, avhareji mazuva 100-120. Next vapinda kroverazrusheniya zvomukati, apo vakasunungura hemoglobin. It anosunga haptoglobin uye pakarepo zvifambiswe kuti masero ari reticuloendothelial marongedzero humwe kutendeutsa munhu asiri hunokachidza ruvara (zvakananga bilirubin) uye nevamwe kuti bile. In macrophages uye histiocytes Chizenga pakutanga uchiora kuti biliverdin, inova ina pyrrole zvindori zvakabatana methane bridged. Uyezve, pane rutapudzo wayo vakasununguka bilirubin, iyo akabatwa mapuroteni conveyors uye zvifambiswe kuti chiropa. In kwayo parenchyma raro kushanduka kupinda zvakananga bilirubin, kureva tichisunga glucuronate nokuda kwayo inoraswa.
Basa mabhakitiriya
Chinokosha pakuita zvimwe chinja pamusoro hurumende ichiisa bile pigments anoita chakaipa intestinal microflora. Bilirubin ari Achinanga kubva chiropa iri riri Zvinoumba bile ari vesica fellea, uye kana kuvhura faterova munyatso anopinda duodenum, uye zvakare, muna ari ura duku, apo vasunungurwa glucuronic asidhi uye dzikwanise sterkobilinogena outputting ari faeces. Part izvozvo kana achipfuura mugaranhoko wefodya unopinda hemorrhoidal mutsinga kupinda muropa, pavaigona kutora chikepe chaienda chiropa, uye yabudiswa kuburikidza itsvo dziri weti. Saka, ropa nguva padzakacherechedza sevakasununguka, uye yakananga bilirubin. inoenzanirana rokupedzisira anenge 5.1 mol / L, uye vanosvika - 15.
Chirwere zvirwere chiropa
Maererano vibration uye nhamba zviratidzo izvi zvinogona kutongwa pamusoro kushanda chiropa. Saka, kana parenchyma muviri ane chirwere kana chepfu kukuvadzwa, vakawanda vakasununguka ruvara uye anoramba vasina kusungwa, uye wevasungwa muropa kwose ruvara rwacho inowedzera zvinoshamisa. Direct bilirubin muropa riri kuona ari kunzi saka obstructive jaundice, panguva iyo pane zvipingamupinyi chaiko chokubuda bile, uye saka bile regurgitation rikaitika muropa. Chikonzero ichi kunogona kuva compression bile mutsinga dzinofamba nemukaka mapundu ose rwatata musoro, ibwe, zvichingodaro obliteration. Pane suprarenal uye jaundice, mhosva iyo kunosimudzirwa kuora kuti Chizenga iri muropa. Izvi zvinogona kukanganisa hemolytic muchetura uye microbial muchetura, vamwe vasiri ezvinhu. Zvisinei, nezvirwere zvose izvi nehepatitis bilirubin anovaka munyama. Vasina kusungwa chete nokuda kwayo lipophilicity, panoparadzana mwoyo nyore muzvitokisi, kusanganisira kuburikidza neropa-pfungwa mhinganidzo, uye anotsaura Erekitironi chokufambisa cheni ari mitochondria, nokudaro zvichivhiringidza simba muviri. Safer Panyaya iyi, yakananga bilirubin, ane ndeyokuva dzisiri chepfu, sezvo insoluble Morekuru.