The mushonga "Ursodez" - mirayiridzo kushandiswa. Mahwendefa "Ursodez": analogs uye wongororo

Drug "Ursodez" - hepatoprotective zvinodhaka. Chine choleretic medicament, hypolipidemic, holeliticheskoe chiito, ane hypocholesterolemic uye immunomodulating mugumisiro kunyora nezvavo. Active fuma - ursodeoxycholic acid. The mushonga haana chipimo chemushonga chimiro "mapiritsi". "Ursodez" anogadzirwa muchimiro capsules.

basa mashandiro

The rinoita chinodhaka fuma anokwanisa kuti rapinzwa Kamudzira pamusoro hepatocytes, pakudzikamisa mamiriro ayo. Somugumisiro, masero vanodzivirirwa anokangaidza zvinhu, basa bile asidhi munyu. Saka The kuchirapa mugumisiro zvinodhaka richiratidzwa richikwidibira munhu cytotoxic maturo. Tikafunga cholestasis zvaanopa simba Ca2 + nemataundi runovharidzira mamwe Alpha-dzinovhurika exocytosis. Rinoreva "Ursodez" (User chikumbiro kunoratidza izvozvo) kunoderedza zvikuru hunokachidza bile acids (deoxycholic, lithocholic, chenodeoxycholic nevamwe) panguva yakakwirira kuwanda mu varwere hepatic pathologies mune chirwere kosi.

Kana kugamuchira mushonga akacherekedza kuderera remafuta akawandisa usage uye secretion, chinovhiringidza kuti Absorção de Água yaro ura. Nokuda kwaizvozvo, izvozvo zvinoderedza ari saturation kuti bile pamwe akakura ichi. Kugadzirira anokwanisa competitively kuderera absorbability pamusoro lipophilic acids vari ura, kuwedzera zvavo fractional turnover ivhu enterohepatic kutenderera. Mishonga zvinoita excretion chepfu acids, vakawedzera ndima.

The mashandiro kuita zvinodhaka kuripowo kwakavakirwa achivhara nonpolar bile acids. Nemhaka iyi chepfu vakavhengana micelles. Zvinoreva Kunowedzera ari biliary ino, kuti solubility pamusoro remafuta akawandisa, pakudzikamisa kugadzirwa uye secretion kuti bile. The mushonga kunoderedza lithogenicity kwayo, anowedzera wevasungwa pamusoro acids, nokudaro afunge kuwedzera basa pancreatic uye gastric secretion.

Kana muchigamuchira capsules zvakakwana kana zvisina kukwana pokufa namabwe. Akaroromesawo bile remafuta akawandisa saturation kunowedzera kuunganidza yematombo. Immunomodulatory basa iri hwakaratidza nokuda rokuchinja nhengo maitiro pedyo chiropa. The mushonga akazoita kutaura zvinoverengeka histocompatibility maantigen. The medicament ane zvainoita huwandu T-lymphocytes, kwakaderedza nhamba eosinophils.

Pharmacokinetics zvinoreva

Absorção de Água zvinodhaka "Ursodez" (mirayiridzo Chinyorwa kunoratidza ichi) ari ura duku kuitwa inofanira pusa diffusion. Zvikaramba pamwe vanenge 90% yezviri zvinoriumba. Munguva ileum nefuma wefodya nokuda tichishingaira senga. The soro zviri vanoshingaira zvinoriumba rinosvika ingangoita awa. Mukomboni ine mukuru chikamu nokusungwa mapuroteni - 99%. Ursodeoxycholic asidhi anokwanisa zvinopfuura placenta.

The kuchirapa efficacy zvinodhaka kunoenderana wevasungwa kuti basa chinoita ari bile. Nguva enderana kugamuchirwa ichi bile asidhi inova huru serum. ursodeoxycholic iine acid wevasungwa anenge 48%.

Mukomboni rinoita, nepano chiropa masero. Somugumisiro, yakaumbwa glycine uye taurine verlauf. The kuora zvigadzirwa vari secreted kupinda bile. About 50-70% vakagamuchira mushonga iri yabudiswa muna mutsvina yadzo. A shoma zvinodhaka riri zvifambiswe kupinda muura. Ikoko zviri yakatsemuka chiito utachiona (7-dehydroxylation).

Lithocholic acid, izvo inoumbwa iyi, ari pasi zvishomanana Absorção de Água huru ura, asi inopfuura sulfation ari chiropa uye yabudiswa sezvo sulfolitoholiltaurinovogo kana sulfolitoholilglitsinovogo Conjugate.

umboo

Medicine "Ursodez" ndaizoitwa munhu symptomatic kurapa nokuda chikuru biliary cirrhosis pasina zviratidzo decompensation. Kuratidza nzira wokuparadza svikiro nezviduku remafuta akawandisa mabwe, pamwe basa gallbladder. Prescribers vane biliary reflux gastritis.

Contraindications

Rinoreva "Ursodez" mirayiridzo iri kushanda haabvumiri kuti kuenda kana murwere rentgenpolozhitelnyh (yakakwirira Kuwanda Ca2 +) matombo omunduru kusashivirirana medicament zvinoriumba. Contraindications zvinosanganisira cirrhosis tichifambirana decompensation vakaratidza kusagadzikana rwatata, itsvo. Recommended mushonga vanhu nevasiri kutoitwa nduru dundira, chenjera anogumbura pathologies pamusoro pezvawakaita, uyewo bowel chirwere uye bile mutsinga dzinofamba nemukaka. Regai mishonga kuti mimba uye ukoti. Rinoreva contraindicated nokuti vakuru nevana haaremi pane 34 makirogiramu.

nemishonga

Mune zvimwe zviitiko, kuva pasingadiwi migumisiro apo kutora zvinodhaka, "Ursodez". Mirayiridzo yokushandisa kuyambira mukana kuda kurutsa, manyoka, kurutsa. Muvhu kunokwanisa kuumba calcified matombo omunduru. Amplification chiropa transaminase basa, abdominal marwadzo, neutachiona (kusanganisira urticaria) zvakare varwadziwe ingestion "Ursodez".

Testimonials vanoratidza tolerability zvakanaka. Subject kuti chiremba wacho nachiremba nemishonga kashoma. Mune zvimwe zviitiko, panguva Mabatirwo biliary cirrhosis vakachengeta vavanongogara decompensation. Kazhinji, chiitiko ichi oga anoramba pashure discontinuation zvinodhaka.

Drug "Ursodez". Price. kurayira

Zvinoreva achitora manheru. The chipimo chemushonga zuva nezuva Kuparadzwa matombo - avhareji 10 MG / makirogiramu. Nokuti vanhu yairema kusvika 60 makirogiramu yakafanana 2nd capsules pazuva kusvika 81 kg- 3-m, 100 makirogiramu - 4 mamwe 100 - 5. Duration - kubva mwedzi mitanhatu mwedzi 12. Mushure Kuparadzwa mabwe kudzivisa nokuumbwa Recommended yaunodya mutsva mumwe mwedzi inoverengeka.

Treatment biliary cirrhosis kuitwa panguva dose 250 MG / zuva. Duration kosi - 10-14 mazuva. kusvika mwedzi mitanhatu. Mune zvimwe zviitiko, ya ARV yawedzera makore maviri. Somunhu symptomatic kurapwa medicament raitongwa 10-15 MG / zuva. Apo mukanyiwa kusvikira 34 makirogiramu Recommended rinoreva akarembedzwa chimiro. Mari mushonga mu Kamudzira muchimiro - kubva zana rubles.

It anozviita rinoreva "Ursodez" dzomuzana?

Zvinodhaka kuti ane chete rinoita fuma, yakabereka chaizvo chaizvo. Pakati pavo zvakakodzera kutaura zvinoreva akadai "Ursodoksa", "Ursol". Chimwe chezvinhu dzakakurumbira ndiye chinodhaka "Ursosan". Zvairatidza kuti kushandiswa kwezvinodhaka iri zvishoma yakakura. Zvikurukuru, izvozvo chinotarisirwa mu cystic fibrosis chiropa skleroziluyuschem cholangitis chisingaperi mhando.

Varwere vakawanda vanofarira vachigadzirira chii nani "Ursodez" kana "Ursosan". Zvinofanira akati kuti chiremba anosarudza mumwe kana kuti dzimwe nzira maererano hunhu, nzira zvokurwara uye murwere akashivirira zvinodhaka. In zvirwere chiropa, gallbladder haasi zvikuru inokurudzirwa kuzvidzora. Usati kutora mushonga upi unofanira kuongorora uye zano nyanzvi.

Monitoring kubudirira kurapwa yaifanira ose 6 mwedzi. Panyaya iyi zvinonzi basa nguva Ultrasound uye X-ray kuongororwa mugore kurapwa rokutanga. Kana mwedzi mitanhatu pokufa matombo havana kuitika wokutanga, zvingangoita kuenderera kosi dzisingashandi nokuda inefficiency.

mamwe mashoko

Kuti vave nechokwadi anobudirira pokufa mabwe zvakafanira kuti matombo zvaiva chete remafuta akawandisa, asi kukura kwavo hakurevi pfuura 15 kana 20 millimeters. Panguva iyoyowo vakazadzwa nduru dundira inofanira kuva kupfuura hafu, uye biliary turakiti vanofanira kuramba ayo basa zvachose.

Kana kuenda mazhinji kurapwa, kupfuura mwedzi, zvinokosha kuita nokukanganisika munhu akaidza kuti dzinoongorora nebasa transaminases vari chiropa. Uyezve, tinofanira kudzora wevasungwa pamusoro bilirubin nezvimwe yeimwe. kurega kutora "Ursodez" zvinoreva apo kuramba vaine unongotaura. Zvisinei, Reviews nyanzvi dzakawanda, achivaka pamusoro kubudirira chezvinodhaka.

mhedziso

Kana pasina mugumisiro anogona kupiwa imwe medicament kana kurapwa zano anodzokororwa zvachose. Asati kushandisa chigadzirwa anofanira kuziva Musumo.