PTH akawedzera - sezvinoratidzwa ongororo?

Parathyroid kemikari (zvimwe kunzi parathyroid kemikari, parathyrin) - hormone neve parathyroid zvinyama (parathyroid) omumuviri, izvo iri anterolateral divi mumutsipa. Vari seri thyroid shwanu, riri chakada yakabatana rwemberi pamusoro waro ezasi chikamu zvose mugove wayo. Parathyroid kemikari dzavo makemikari hunhu chinhu chisinganzwisisiki mapuroteni fuma - polypeptide amino asidhi nomukaka.

chikuru basa racho chinhano uye mutemo calcium phosphorus muviri mumuviri. The kugutsikana calcium muropa uye secretion zviri parathyroid kemikari anotomirira zvakananga kubva mumwe. Kemikari anogona kuwedzera karusiyamu wevasungwa uchiita pfupa rinenge itsvo nemudumbu. Pfupa parathyrin kunowedzera logoff Kuparadzwa zvicherwa chikamu nokuita kuti masero kwetunhu dzakananga makemikari zviri kukonzera yokuparara repfupa zvokunyama. Bone rinenge riri pasi pasi pokudzora PTH resorption uye calcium yakawanda ions dziri muropa. Pamwe chete karusiyamu Exchange paratgormot kunobatsira waidzora padanho phosphate pamuviri. Kuderedza kusimba wokutanga zvipenyu muitiro, izvozvo anotowedzera kumukomborera kuerera wechipiri. Uyezve, kemikari rinobatanidzwa dzekugonesa kwetunhu calcitriol ari ura, kubatsira karusiyamu reabsorption. Parathyroid kemikari anotora isina kunanga chikamu murau mabasa ose karusiyamu-nemataundi makemikari katalirizuemye kwavo kuita. Under ake simba uyewo anopiwa ropa coagulation hurongwa.

Kana PTH rakakwirira, ipapo kuumbwa zvikuru kwemakemikari anobudiswa zvirwere chokuita mapfupa kuvimbika kutyora - hyperparathyroidism, uye osteoporosis. Mugumisiro kuremadza vasiri kwakadaro zvikuru zvinoderedza muropa karusiyamu yomuropa, iyo inotungamirira vawedzere neuromuscular excitability. Comorbidities muchiitiko ichi inogona kushanda dzakakwirira alkali kugutsikana mumuviri uye kukura renal kukundikana. Akaroromesawo kugutsikana calcium mu gogorosi meso cataract kunoitika.

Kwevari kemikari of parathyroid mumasero muropa riri pasi rimwe Ritmos mutinhimira. The basal pamwero yakaiswa pa anenge 8 am, apo ari maawa 14-16 zuva, kana munhu ari nhamba kwebasa, parathyroid kemikari vakawedzera. bvunzo ropa riri kuitwa nokuwanda parathyrin immunohemilyuminestsentsii. Zvinofanira kuita chinhu dumbu, ane zuva kana maviri asati ropa zvakabudiswa kubvisa doro yaunodya uye rinorema muviri kwemaawa anoverengeka pamberi muitiro, regai kuputa.

On kuongorora parathyroid kemikari iri ushandiswe chete kana murwere vanofungidzirwa kuvapo kwezvirwere zvakadai hyper- uye gipokaltsimiya, urolithiasis uye neurofibromatosis. Uyewo zvairatidza kuti ongororo chinangwa zvingasanganisira: osteoporosis psevdoperelomy mapfupa refu, chero vasiri anochinja pfupa osteosclerosis kana vertebral miviri uye vanofungidzirwa vakawanda kwemakemikari anobudiswa neoplasia mhando 1 uye mhando 2 (VARUME 1.2). On parathormone zvazvingava munhu mukuru anonzi 9,5-75 pg / Rine mamiririta. Izvi zvinoshanda varume nevakadzi kubata pamuviri zera. Kana kuona kuti PTH rakakwirira, pane chikonzero chose kufunga kuti murwere ane chikuru, chesekondari, tertiary hyperparathyroidism, pseudohypoparathyreosis kana Zollinger-Ellison syndrome.

Pasi zvikabatanidzwa chikuru hyperparathyroidism hyperplasia isiri yekenza pamusoro parathyroid shwanu, kenza kweprostate rinenge uye kwemakemikari anobudiswa neoplasia mhando mbiri. Co. hyperparathyroidism yechipiri inosanganisira chisingaperi renal insufficiency, hypervitaminosis D, maronda colitis, kusimba, Crohn chirwere. Kana PTH rakakwirira, ipapo kuongorora kunowanzoitwa pavanoparidza tsanangudzo chechetere calcium muropa uye mune ramangwana fananidzo zviratidzo zviviri uye kuziva dependencies.