"Pentoxifylline": analogues, mirayiridzo kushandiswa, mitengo chaiwo

The mushonga inogona kutsiviwa ne "Pentoxifylline?" An analogue zvinodhaka zvichakurukurwa munyaya zvinhu. Mariri uchadzidza zvinorehwa akati medicament siyana umo inotengeswa, sei inofanira kushandiswa, uye zvichingodaro.

The sezvamunoita, chimiro, kavha

In chii chimiro chakatengeswa zvinodhaka "Pentoxifylline?" Mirayiridzo yokushandisa (analogues zvinodhaka ichi chinogona kuwanika chero chezvinodhaka) kunoratidza kuti mushonga inowanika zvakasiyana siyana, zvinoti:

• In mahwendefa (400 uye 100 MG) vari zvemapuranga pingi. Mune imwe atorwa ingasanganisira 60 kana 20 zvidimbu.
• The pellets (400 uye 100 MG). The Audio remidzanga makadhibhokisi kungava 60 kana 20 zvidimbu.
• In pamahwendefa, asi kwenguva refu chiito (600 uye 400 MG) vari zvemapuranga uye enteric-zvemapuranga vane mutsetse kuti kupesana. Kazhinji kavha atorwa ine zvidimbu 50.
• The ndiro pamwe kuitwa jekiseni. The Zvinoumba Pfungwa iyi zvinosanganisira pentoxifylline uye yavaibvisa chloride uye mvura.

pharmacological zvinhu

Chii ehupfumi anoita zvinodhaka "Pentoxifylline?" Analogue nzira iyi ine unhu sezvo akati medicament oga. Nderake mutsva pharmacological boka hemorheological mari. Anokwanisa kudzosa plasticity masero matsvuku eropa uye kuderedza deformation yavo. Izvi Kunowedzera permeability rwengarava ropa, vane rakamanikana lumen.

ehupfumi izvi zvinodhaka kunotungamirira kwakavandudzwa microcirculation, kunobatsirawo tishu hypoxia.

anoita sei "Pentoxifylline?" Analogues pakati imupota uye Russian zvakafanana kuchirapa mugumisiro sezvo kuti mari pachayo. Pashure kushandiswa kwezvinodhaka, izvozvo zvinoderedza aggregation pamusoro erythrocytes izvo zvinowedzera ropa riyerere kune mapazi vakazoroorwa nyore uye kupinda munzvimbo extravascular negwara.

Hatigoni kutaura kuti vaiona chinodhaka kunoderedza ropa viscosity, saka kunosimudzira platelet disaggregation. Somugumisiro migumisiro zvinodhaka vowanda miniti uye ronda vhoriyamu, asi haina kuchinja kwemwoyo nemifananidzo.

Saka, bapu nokuwedzera mudziyo anovandudza O ₂ zviri ropa, uye kuwedzera kwebasa coronary arteries kuwedzera O ₂ hurukuro kuti myocardium.

Viewed Pfungwa inokwanisa kuwedzera mataurire kufema tsandanyama uye diaphragm. Under nawo kunowedzera uwandu ropa inoyerera kuburikidza collaterals, uyewo kunowedzera ropa riyerere mavari.

Ndezvipi zvimwe zvinhu zvinodhaka ane "Pentoxifylline?" Analogue zvinodhaka ichi uye zvinodhaka pacharo kuwedzera wevasungwa pamusoro ATP muuropi uyewo kuvandudza ropa wedzerai ukama kumatunhu (semuenzaniso, mu ischemic sitiroko).

Zvinofanira kucherechedzwa kuti akati zvinodhaka ine pesvedzero inobatsira nechepakati tsinga uye huchishanda. In maronda ose peripheral arteries vachishandisa izvi zvinoreva zvinoisa dzichiwedzera kufamba madaro, kusanganisira nezvirwere zvakadai obliterative endarteritis.

pharmacokinetic parameters

zvinodhaka "Pentoxifylline" wakavhomorwa rinhiko? Mirayiridzo yokushandisa (analogues Mushonga uyu akanyorwa pazasi) anotiudza kuti mushonga uyu ane zvakaisvonaka rakapinza simba, kusanganisira kuburikidza neropa-uropi nokuidzivirira.

The hafu-upenyu zvinodhaka kana raitongwa nomutsinga iri maminitsi 30. Kana muchigamuchira mushonga mukati maro wefodya kubva nemudumbu zvachose.

Medicament kushandurwa muna chiropa, apo anoumba metabolites theobromine. The kunonyanyisa ropa wevasungwa zvinodhaka kunoitwa mukati 4 maawa pashure kushanda. Zvisinei, zvazvinosarira panguva kuchirapa mumatunhu kwerinenge zuva.

Akaratidza medicament mu itsvo (vanenge 95%). ura kuburikidza mishonga kubva zvishoma.

Panguva naka pabonde uyo breastfeed, mushonga anogona kusunungurwa pamwe mukaka. Zvinofanira kucherechedzwa kuti kuchaitwa zvinodhaka kufambira vari varwere zvikuru cheitsvo, chiropa uye vakwegura.

Zvairatidza yokushandisa

Nokuti kwezvinangwa chii murwere anogona kupiwa mishonga "Pentoxifylline?" Analogs uye zvinodhaka Sevamiririri vane zviratidzo.

Pari, zvakadai anobudirira zvinodhaka inoshandiswa kurapa zvirwere zvakawanda. Pano vari ikozvino:

• cerebrovascular kushaikwa;
• urolithiasis;
• arteriosclerotic encephalopathy;
• ischemic Kurohwa;
• shuga nefroangiopatiya;
• neBP;
• obstructive bronchitis;
• Árbol asima;
• peripheral kweropa zvirwere ;
• encephalopathy;
• algomenorrhea;
• sepsis;
• cholecystitis;
• intestinal dyskinesia ;
• pilorospazm;
• kwakanaka tsandanyama spasm;
• post-trombophlebitic urwere;
• dysmenorrhea;
• angioneyropatii (Raynaud chirwere) ;
• kweropa zvirwere ziso;
• trophic tishu zvirwere;
• trophic maronda;
• kutyisidzira kusvodza;
• dzichipfekeka kusagadzikana pakati uye yomukati nzeve;
• vascular kusabetsera;
• chinonzi dystrophy;
• neronda rinonyenga, frostbite.

Contraindications

Ndezvipi zvirwere hazvibvumidzwe kubva kushandisa zvinodhaka "Pentoxifylline?" An analogue zvinodhaka uye mushonga pachayo haigoni kubatwa vanhu vane kusashivirirana kune huru zvinoriumba, uyewo mamwe vamiririri xanthine boka.

Uyewo, vaiona zvinodhaka contraindicated Varwere vachangobva akatambura sitiroko Hemorrhagic kana chakasimba myocardial infarction uyewo chirwere chakakomba atherosclerosis mwoyo uye pfungwa arteries, porphyria.

Intravenous zvinodhaka chinorambidzwa nokuda arrhythmia, ropa, pasi BP, hemorrhages ari the retina. Uyewo, kuti mushonga wacho contraindicated panguva lactation uye gestation, vana makore 18.

Nokungwarira akakosha basa zvinoreva vakavhiyiwa vanhu (kuitira kudzivirira ropa pamusoro mucous membranes uye nhengo dzomukati), uye varwere zvikuru itsvo uye chiropa, ura urikanwi chirwere, gastritis uye mwoyo nokukundikana.

Nzira Use

Sei kushandisa zvinodhaka "Pentoxifylline?" Mirayiridzo yokushandisa, chaicho (analogues kuti chokushandisa ichi vangava dosages yakasiyana) ruzivo vanachiremba vanoti mushonga uyu akatorwa nomuromo uye parenterally (zvichienderana kwokuomerwa chirwere).

Oral kwokubatsira mushonga kutanga dose pakati 200 MG (i.e., 2 mahwendefa katatu pazuva, pashure zvokudya). Mushure kusvika yakanatsa kuwanda kuchirapa kushanda ipfupi nehafu. Yawapiwa mapiritsi vanofanira kugara hapana kupfuura mwedzi.

In zvakakomba uye rikwanise zvirwere zvomukati mushonga wakawanda mu capsules. Pane 2 nzira zvinodhaka kuunganidza: intravenous uye intraarterial. Wokutanga nzira unoitiswa dropper. Nokuti chinangwa ichi, 1 chinu 250 Rine mamiririta shuga mhinduro kana yavaibvisa chloride. Akati chipimo chemushonga chinotarisirwa mukati 2 maawa.

Kana intraarterial kutarisira izvozvo chinotarisirwa ari dose pamusoro 0.1 g pa 50 ml yavaibvisa chloride mhinduro.

nemishonga

Pakati inonyanya nemishonga ndedzinotevera:

• dzungu, kufunganya, hope zvirwere, nezvipusha, kuchinja, kutemwa;
• cholecystitis exacerbation, yakakwirira chiropa transaminases, budiriro cholestatic kuzvimba chiropa;
• kurutsa, kunzwa pakuzara mudumbu, kuda kurutsa, manyoka, kurasikirwa havi;
• mikoko, anaphylactic kuvhunduka, kuvaviwa, angioneurotic edema, akatsvuka ganda;
• panowanikwa arrhythmias, marwadzo mwoyo, kudukupiswa BP, stenokardicheskie kurwadziwa;
• thrombocytopenia, leukopenia;
• pekugara, avhiringidzwa zvakaratidzwa;
• exacerbation kuti asima, bronchospasm, kufema insufficiency;
• ropa dzakasiyana etiology.

Drug "Pentoxifylline": analogues, mutengo

Analogs vanoonekwa mishonga zvinodhaka zvinotevera:

• dragees "Agapurin" (100 MG) uye mhinduro jekiseni mu ampoules (100 MG);
• Mahwendefa "Pot", zvemapuranga Mahwendefa (600 MG);
• dragees, mapiritsi uye injectable mhinduro "Trental".

Zvinofanira kucherechedzwa kuti "Trental" inomiririra yepakutanga zvinodhaka. Ari basa varwere encephalopathy dzakasiyana mavambo.

Kana mutengo, ipapo kugadzirira izvi zvose zvakasiyana. Analogue "Trental" "Pentoxifylline" inogona kutengwa nokuda 120 rubles yepakutanga medicament - nokuti 520 rubles "Agapurin" - 300 rubles, ukuwo "Pot" - 400 rubles.

Reviews

Reviews pamusoro kwezvinodhaka iyi kunyanya akanaka. Mushonga vanobudirira vascular zvirwere zvakawanda nadzo uye hurongwa. Wongororo Most pakushandisa "Pentoxifylline" yakasiyiwa nevarume vari kutambura kubva vatsvaire endarteritis pamwe inoratidza claudication. medicament Uyu kwavari nzira № 1, sezvo chirwere ichi uderedze mberi.