"Mesipol": mirayiridzo kushandiswa, dzomuzana chaiwo

Chii chinodhaka "Mesipol"? pamusoro pokushandisa chokushandisa richitungamirira, ayo contra-zvairatidza uye ichakurukurwa munyaya ino. Uyewo, uchadzidza kana kwete ichi mishonga nemishonga kuti zvaizova zviri chiitiko ane ovhadhozi, chimiro umo zviri kutengeswa uye chii nefuma rine.

Chimiro zvinodhaka uye ayo sezvamunoita

Kugadzirira "Mesipol" iri kutengeswa muna mbiri dzakasiyana siyana: mahwendefa uye mhinduro kuti intramuscular jekiseni. Dzavo uchishandisa musimboti ndiyo chete. Kana hazvibviri nemumuromo Kutarisirwa kwezvinhu, jekiseni inoshandiswa.

Kugadzirisa "Mesipol" ane chinoshingaira maatomu akafanana zvakadai meloxicam. Kunosanganisirawo zvinotevera ebetsero zvokubikisa: glycofurol, meglumine, yavaibvisa chloride, Poloxamer 188, yavaibvisa hydroxide, glycine, uye mvura kuti jekiseni.

The Kugadzirisa ane yeyero kana greenish-yellow. Hazvina segirazi. Uyewo ine maitiro zvakanaka. Atorwa ndiyo 3 ampoules (1.5 Rine mamiririta).

Sezvineiwo, kuwedzera kune mapiritsi kana negadziriso intramuscular majekiseni, makambani anogadzira akatanga kubudisa makenduru "Mesipol" uye suspensions dzaizopiwa nomumukanwa yaitonga.

The pharmacological zvechadenga zvinodhaka

"Mesipol" mushonga chinhu nonsteroidal Anti-anogumbura mumiririri. The mushonga anokwanisa richiva unonyaradza marwadzo uye antipyretic kushanda. The antiinflammatory mugumisiro nzira kusonganirana tava kuderera pamusoro enzymatic webasa cyclooxygenase-2, iyo rinobatanidzwa biosynthesis pakati prostaglandins ari zvomoto munharaunda.

Muduku rinoita meloxicam chaikosha anoita cyclooxygenase-1, icho avepo prostaglandin usage, izvo dzivirira mucous Kamudzira pamusoro ura obva murau ropa riyerere ari itsvo.

Pharmacokinetics zvinodhaka

Drug "Mesipol" (majekiseni uye mahwendefa) wefodya chose. The bioavailability zvinodhaka riri 100%. Pashure intramuscular jekiseni (anenge 15 MG meloxicam), kufadza Absorção de Água zvasvika pashure maminitsi 65.

tiri kufunga mushonga anosunga kuti mapuroteni eplasma, kusanganisira sealbumin (99%). It nyore ichipfuura ropa-zvinyama zvipingamupinyi, asiwo chinopinda munzvimbo synovial mvura. Wevasungwa mairi 50% of zvinodhaka wevasungwa munguva plasma.

The vanoshingaira zvacho medicament rinoita zvinenge zvachose chiropa. Izvi unoumba zvina pharmacological akaneta metabolite.

Pashure pokushandisa medicament zvakafanana akaratidza ura uye itsvo (a metabolite). Paavhareji hafu-upenyu yezviri fuma iri maawa 20.

Zvairatidza kuti kushandisa mishonga

Mune zvimwe zviitiko, taurira "Mesipol"? Mirayiridzo Dzokushandisa rinoti kazhinji kutokurudzira kushandiswa NSAIDs ari symptomatic kurapwa kwezvirwere zvakadai:

• chemajoini;
• dzinonzi rheumatoid arthritis;
• Ankylosing spondylitis (kana ankylosing spondylitis).

Mukuwedzera, zvinodhaka "Mesipol" (majekiseni uye mahwendefa) rinowanzoshandiswa nachiremba dzimwe chinopedza uye anogumbura zvirwere mapfundo, ayo achiperekedzwa kurwadziwa.

Contraindications pakushandisa asiri steroidal vamiririri

Mune zvimwe zviitiko, mishonga haagoni kushandiswa "Mesipol"? Mirayiridzo dzokushandisa ine guru mazita contraindications. Izvi zvinosanganisira zvinotevera:

• Hypersensitivity kuti basa vanzwe zvinodhaka kana zvayo ebetsero zvinoriumba;
• Mienzaniso kana zvakakwana mubatanidzwa asima, kusada acetylsalicylic acid, polyposis (idzokororo) paranasal sinus uye nasal mhango, uye dzimwe NSAIDs, kusanganisira anamnesis;
• chevana zera (makore 16-18);

• maronda kana erosive maronda ari mucous Kamudzira 12 tiperstnoj ura kana dumbu;
• achiyamwa;
• cerebrovascular ropa kana zvimwe ropa mavambo;
• kushingaira ropa iri dumbu kana mudumbu;
• panguva gestation (nhumbu);
• anogumbura bowel chirwere (semuenzaniso Crohn nehosha kana maronda colitis);
• mberi renal chirwere, kusanganisira hyperkalemia (yasimbiswa);
• nguva pashure coronary tsinga ndavhiyiwa;
• renal kukundikana (akaratidza) vanhu vasina pasi dialysis (CC asingasviki 30 Rine mamiririta / Nha);
• decompensated mwoyo kutadza;
• vanoshingaira kuchiita chiropa chirwere kana chiropa kutadza (kwazvo).

Shandisa nokungwarira zvikuru!

Zvino kuti unoziva umo nguva unogona kushandisa zvinodhaka "Mesipol" (Mahwendefa, majekiseni), uye umo iri contraindicated. Zvisinei, pane mamiriro ezvinhu apo zvatakurukura zvinodhaka anofanira kuzviita nokungwarira zvikuru. Funga pamazita Muzviitiko zvakadaro:

• akwegura (Makore 60);
• nechirwere chemwoyo;
• chisingaperi mwoyo kutadza;
• cerebrovascular zvirwere;
• chirwere cheshuga;
• dyslipidemia kana hyperlipidemia;
• peripheral tsinga chirwere;
• creatinine Clearance asingasviki 60 ML / Maminitsi;
• kusvuta;
• maronda maronda of zvomudumbu ino munhau;
• kushandiswa kwenguva refu vasiri steroidal zvinodhaka, uyewo avo kusingadzoreki kushandiswa guru mishonga;
• hutachiwana rinozivikanwa Helicobacter pylori;
• dzose kunwa doro (kunyange ane pasi zviri doro);
• Kushandisa chimwe-nguva nomumukanwa corticosteroids, kusanganisira "Prednisolone" chinodhaka;
• zvakakomba somatic abnormalities;
• concomitant kushandiswa anticoagulants (semuenzaniso, zvinodhaka "Warfarin"), antiplatelet vamiririri (semuenzaniso, acetylsalicylic asidhi uye medicament 'Clopidogrel') uyewo FIs (zvokusarudza) kweserotonin reuptake (kusanganisira zvinodhaka "Tsitmedialopram", "Fluoxetine", "paroxetine" uye "sertraline").

Nonsteroidal Anti-anogumbura zvinodhaka "Mesipol": mirayiridzo kushandiswa

Intramuscular kwokubatsira ari medicament pamberi pedu kuratidzwa chete nokuda 3 mazuva kurapwa okutanga. Mune ramangwana, rambai kurapa vane mukanwa siyana mishonga, kureva mahwendefa.

The yakarumbidza chipimo chemushonga ari mumiririri iri 7.5 MG kana 15 MG kamwe pazuva. A chitsama achapiwa zvinodhaka kunoenderana zvikuru kurwadziwa, uyewo kwokuomerwa kushoma. The medicament chinotarisirwa nevanhu zvakadzama intramuscular jekiseni.

Zvinoita chokubatanidza nevamwe zvinodhaka zvinodhaka "Mesipol" (kwepfuti)? Instruction zvinodhaka rinoti zviri ndiro chero zvazvingava haagoni kusanganiswa chete sirinji nedzimwe mhinduro. Izvi imhaka yokuti pane mukuru ndingangokuvara kusapindirana yezviri nhumbi meloxicam nevamwe vanachiremba zvinoriumba.

Zvinofanira kucherechedzwa kuti varwere vane mikana yakawanda nenjodzi, uyewo itsvo kukundikana (akaratidza) pamusoro hemodialysis, mumwe nonsteroidal zvinodhaka chipimo chemushonga hakufaniri kupfuura 7.5 MG pazuva.

Zvinokoshawo kuyeuka kuti zvinodhaka "Mesipol", analogues izvo tichaita funga zvimwe, chero zvazvingava havafaniri kupiwa nomutsinga.

Kufadza daily dose kuti meloxicam vanoshingaira maatomu akafanana inofanira kuva 15 MG. Zvakafanana medicament kuteverwa uye kushandisa akabatana pamahwendefa, suspensions, nokuti nemumuromo kutarisira suppositories, uye intramuscular jekiseni.

zviitiko ovhadhozi

Pane zviitiko ovhadhozi kubva pakushandisa "Mesipol" chinodhaka? Majekiseni (wongororo pamusoro pavo zvichakurukurwa panopera nyaya), mapiritsi, suppositories uye suspensions zvingakonzera murombo munhu kana akashandiswa zvisingadzorwi uye bhuku guru.

Zviratidzo ovhadhozi zvingasanganisira zvinotevera ezvinhu: svoto, havachanyatsogoni kuziva, epigastric marwadzo, chenjera renal kukundikana, kurutsa, ropa mudumbu kana ura, chiropa kukundikana, asystole, uye kufema kusungwa.

Zvokuita nyaya ovhadhozi? Nyanzvi vanokurudzira gastric lavage, uyewo symptomatic kurapa.

Panzira, mukufamba kurapwa netsvakurudzo kuti cholestyramine anobatsira mhanyisa kubviswa meloxicam. Hemodialysis ovhadhozi riri basa, sezvo pane mukuru riine ropa mapurotini.

nemishonga

Kunogona kukonzera marwadzo zvinodhaka "Mesipol" (kwepfuti)? pakushandisa asiri steroidal yomuchipatara Guide rinoti rinogona kukonzera vakawanda migumisiro yakaipa. Ngationgororei navo zvakadzama:

• Zvomudumbu turakiti: dyspepsia, manyoka, kuda kurutsa, perforation pamusoro zvomudumbu turakiti, abdominal marwadzo, kurutsa, flatulence, kupatira, zvinopfuura kuwedzera transaminases (chiropa), burp, hyperbilirubinemia, maronda kana erosive maronda ari zvomudumbu ezvinhu, esophagitis, stomatitis, yakajeka kana chakavigwa svota kubva zvomudumbu turakiti, colitis, gastritis uye kuzvimba chiropa.
• Skin: mapundu, pruritus, bullous mapundu, ganda mapundu, photosensitivity, Stevens-Johnson urwere, erythema multiforme, epidermal necrolysis muchetura.
• hemopoietic hurongwa: kupererwa, thrombocytopenia, kuchinja Counts ropa uye leukopenia.
• Chisimbwa: angioedema , uye anaphylaxis.
• Huta System: vertigo, dzungu, kuvhiringidzika, nomusoro, mupfungwa lability, tinnitus, nekuvhiri- ngika uye hope.
• Respiratoria maitiro: bronchospasm.
• Kumwoyo: nhokwe ropa ganda, peripheral edema, palpitations uye cheBP.
• Nhengo wokuratidzwa; avhiringidzwa kana vakadhakwa chiono, conjunctivitis.
• Urinary maitiro: chenjera renal kukundikana, hypercreatininemia kana kuwedzera urea ropa, interstitial nephritis, hematuria uye albuminuria.
• Local siyana: marwadzo uye nokupisa pa nzvimbo intramuscular jekiseni.

Kudyidzana nevamwe zvinodhaka

• Apo mumwe-nguva kushandisa zvimwe zvinodhaka nonsteroidal uye acetylsalicylic asidhi kunowedzera njodzi urikanwi uye erosive maronda ari zvomudumbu turakiti, uyewo ropa mavari.
• Tiine mawa kushandiswa zvinodhaka antihypertensives chinowanzoitika kuderedza kubudirira yokupedzisira.
• Mawa kurapwa nemishonga "Mesipol" pamwe lithium kurapa inosimudzira kuunganidza yokupedzisira uye kuwedzera ayo chepfu nemigumisiro.
• Apo mumwe-nguva kushanda "Methotrexate" kunoreva kuwedzera ayo nemishonga iri hematopoietic hurongwa.
• Mawa kushandiswa zvinodhaka "Mesipol" pamwe diuretics ndiyo mukana renal kukundikana.
• Imwe-nguva Kushandiswa cyclosporine kunowedzera nephrotoxic migumisiro yezviri fuma meloxicam.
• Pamwe mawa kushandiswa ne intrauterine nhumbu zvinoderedza kubudirira yokupedzisira.
• Apo mumwe-nguva kushandisa imwe anticoagulant uye thrombolytic vamiririri kunowedzera mukana ropa.
• Mawa Kushandisa asiri steroidal zvinodhaka "Mesipol" pamwe kolestiraminom kunonatsiridza excretion kwayo vachishandisa gastrointestinal zvomukati. Izvi kunoitika pamusana nokusungwa meloxicam.
• Disposable mishonga pamwe FIs ose (zvokusarudza) kweserotonin reuptake yekudyidzana kunowedzera ngozi yokubatwa ropa kubva nemudumbu.
• zvinodhaka Myelotoxic kuwedzera okuti gematotoksichnosti kushingaira fuma meloxicam.

nhungamiro chaiwo pakushandisa zvinodhaka

• Drug "Mesipol" vanofanira kuva nokungwarira kunyanyisa mune varwere peptic urikanwi mudumbu uye ura, uyewo vanhu vari anticoagulant mishonga.
• Panguva kurapwa pamwe mishonga iyi inodiwa kudzora parameters ose renal basa, kunyanya mune vakwegura uye varwere chirwere chemwoyo.
• Varwere panguva kugamuchira diuretics uye rinoreva "Mesipol", vanofanira tikanwa zvinwiwa zvakawanda.
• Kana nzira yokurapa, murwere kwakaonekwa Kurwara, ari dose kurapwa kunofanira vakarega.

Analogues zvinodhaka mutengo

How zvikuru redu vaitirei mushonga? Chemishonga injectable chimiro zvinodhaka inogona kutengwa nokuda 400 rubles Russian. Kana pamahwendefa, suspensions uye suppositories, mutengo wavo akaderera zvishoma.

Zvakadini kana iwe kugona kutenga zvinodhaka "Mesipol"? Analogs of mari dziri kutengeswa zvinenge zvose drugstores. Pakati pavo pane zvinotevera zvinodhaka: "Amelotex", "Eksen-Sanovel", "Artrozan", "killing", "M-Cam," "liberum", "Medsikam", "Melbek", "Melox", "ambodzidza Xico "," Meloxicam "," Melox "," Meloflam "," Miksol-Aude "," Mirloks "," Movalis "," Movasin "," Moviks "," lem "," Oksikamoks "uye zvichingodaro.

"Mesipol": wongororo kuti medicament

Zvino munoziva kuti chinhu chinodhaka tiri kufunga. Ndiyo nguva yokuti uzive chii varwere vanoti pamusoro "Mesipol" gadziriro. Reviews iyi nonsteroidal Anti-anogumbura zvakawanda nzira. Kudivi rimwe, varwere vachitiwo zvakanaka Unotsigira marwadzo syndromes kuti vari kuri mumashoko osteoarthritis, dzinonzi rheumatoid arthritis, ankylosing spondylitis nezvimwe chinopedza uye anogumbura zvirwere mapfundo. Ukuwo, varwere kazhinji vanotsutsumwa kuti mushonga akadyisa kumbonyanya yokuwanda nemishonga, somugumisiro iyo vakamanikidzwa kurega kuushandisa.

Kazhinji, mushonga pamberi pedu 'Mesipol "chose kuzvigona kwayo basa.