Hypothalamic kusunungura mahormone

Anosunungura mahormone vari neurohormone kwevanhu kuti synthesized hypothalamic neerekitironi. Ivo tunodzivisa (statins) kana kukurudzira (liberiny) kugadzirwa tropic pituitary mahormone. Zvaanopa simba kuti kwemakemikari anobudiswa omumuviri, uye pane mutemo nokubudiswa mahormone. The epamusoro zvikamu nechepakati tsinga uye kwemakemikari anobudiswa mamiriro zvine chokuita nokuda kwokusunungura mahormone.

hypothalamic basa

Chimwe chinokosha zvinoumba ari kwemakemikari anobudiswa gadziriro anokonzera pagadzirwe mahormone - the hypothalamus. Zvinoberekwa hypothalamus zvinhu vari mahormone munyaya metabolic pezvakaitwa muviri.

Munguva hypothalamus pane masero etsinga kuti tibu- kugadzirwa zvakafanira zvinhu muviri inoda kuti kwomuzvarirwo inoshanda. Masero aya anonzi neurosecretory. basa ravo - kugamuchira pulses kuti vanzwisise dzakasiyana zvikamu tsinga. Kusurukirwa zvinhu kunoitika kuburikidza aksovazalnye synapses.

Yakabudiswa neZvapupu hypothalamic muchisunungura mahormone, kana sezvo dzinonzi zvakasiyana, statins uye liberiny, zvinokosha dzose kushanda pituitary shwanu. By zvavo nemakemikari hunhu, ndivo peptides. Nokuda makemikari uye tsinga nomunhu ndiko kwetunhu yavo, vari zvifambiswe muropa parutivi pituitary hypothalamic-pituitary hurongwa.

kupatsanura pakati mahormone

Funga inozivikanwa zvikuru kusunungura mahormone:

• Zvichivhiringidza ari secretion kuti pituitary basa - iri somatostatin melanostatin, prolaktostatine.
• Rinodhaka - tiri kutaura pamusoro melanoliberine, prolaktoliberine, folliberine, lyuliberine, somatoliberin, thyrotropin-kusunungura kemikari, gonadotropin-kusunungurwa kemikari uye corticotropin.

Izvi zvinhu, kana pane vamwe vavo, zvinogona nehasha zvinoberekwa dzimwe miviri, kwete chete hypothalamus (semuenzaniso, rwatata).

Statins uye liberiny

Kushanda pituitary shwanu iri zvakananga hunotsigirwa pavo. ivowo kunyatsobatsira kushanda peripheral kwemakemikari anobudiswa mumasero:

• thyroid;
• ovaries muvasikana;
• testes vari vanhurume.

Statins uye liberiny izvo zvakanakisisa kuzivikanwa vari:

• dopamine;
• GnRH (lyuliberin, folliberin);
• melonostatin;
• somatostatin;
• tireoliberin.

The secretion pamusoro luteinizing kemikari uye follicle-unokurudzira mahormone ari pituitary GnRH anopa.

On basa androgen nevanhu uyewo kukanganisa GnRH, pave kuwedzera dzisingaoneki basa uye padanho libido.

Uye vakadzi neurohormone anokonzera kuenda kumwedzi, uwandu mahormone kunosiyana-siyana pamwe chokutambudzika kutenderera izvozvo.

Kushomeka kugadzirwa yokusunungura mahormone kunowanzokonzera kushaya mbereko uye kusabetsera.

Zvinoitwa mahormone

Corticotropin kemikari anokonzera Kufunganya, zvinoberekwa hypothalamus. Ichi chimwe chinokosha muchisunungura chinhu, kuita pavanoparidza pituitary hormone migumisiro dzavo pamusoro adrenal mumasero. Vanhu nokusava kemikari ichi vanowanzotambura kubva BP, uye adrenal insufficiency.

GnRH - hormone runogonesa kugadzirwa gonadotropins - uyewo inogadzirwa hypothalamus. It Anonziwo gonadotropin-kusunungura kemikari.

The chakaipa nokushanda kwenhengo dzokubereka nadzo haagoni kuita pasina GnRH. Hazvina kemikari iri anokonzera dzinongoitika nzira kumwedzi vakadzi. With ake Kupinda inoitika chirongwa kuibvisa uye kusunungurwa zai. kemikari Izvi anokonzera libido (bonde tikachirega). Kana paine kukwana kugadzirwa kemikari parutivi hypothalamus vakadzi kazhinji kutanga kushaya mbereko. Ndezvipi zvimwe zviri kwokusunungura mahormone?

somatoliberin

Most nokukurumidza asunungurwa kupinda uduku uye kuyaruka. Its chikuru chepfungwa ndiwo muitiro womunhu normalization kuti nhengo kukura uye muviri hurongwa. Kubva ayo kugadzirwa kunobva pahunhu uye paumbwe mwana. Kushomeka Kugadzirwa kemikari kubva hypothalamus kungaita kuti dwarfism (dwarfism).

Prolaktoliberin

Ake kupfuura rinoita kukura kunoitika munguva gestation uye rose zvokudya nguva mai vomwana. Izvi kusunungura chikonzero normalizes kugadzirwa prolactin, achiumba ducts ari mammary mumasero.

Prolaktostatin

Prolaktostatin anoreva subclass pamusoro statins zvinoberekwa hypothalamus, ndiye anokonzera chinovhiringidza kuti prolactin.

By prolaktostatinam dzinosanganisira:

· Dopamine;

· Somatostatin;

· Melanostatin.

Zvavakaita chikuru nechinangwa kudzivisa tropic mahormone ari pituitary uye hypothalamus.

Melanotropin-kusunungura kemikari

In nedanho rwe-melanin ruvara uye kupatsanurwa masero kunokanganisa melanoliberin. Iyewo anoita pamusoro pezvokuvamba DWP pituitary.

Kunechekuita neurophysiological maitiro. Rinoshandiswa chokubvisa pakurapa kuora inoti uye parkinsonism.

Thyrotropin-kusunungura kemikari (TRH)

By thyrotropin-ichibudisa mahormone ari hypothalamus rinoshandawo thyroliberine. Zvinokurudzira kugadzirwa mahormone ari Anterior pituitary thyritropic.

Muduku pamwero unochinja chirongwa prolactin. Thyroliberine runogonesa wevasungwa kuti thyroxine muropa.

CNS ine simba zvikuru dzinotsanagura pagadzirwe mahormone. Nokuti Kugadzirwa neurohormones ndivo neurosecretory sero pamutemo hurongwa.

Basic mabasa liberinov

hypothalamic ichi kusunungura mahormone. Kuita pamutemo mabasa. GnRH normalize nokushanda kwenhengo dzokubereka nadzo nevakadzi.

Ndivo mhosva kubereka vana follicle-anotokonya kemikari uye kukanganisa mashandiro ari testes uye ovaries.

chinoumba akadai lyuliberin, inoshandura oga zvazvinoita ovulation, achiumba mukana fetus pamuviri.

Vakadzi hava- revanoshamwaridzana upenyu, uye lyuliberin folliberin kugadzirwa kukwana akawanda.

Kunewo kwokusunungura zvinokonzera chokuita avhareji mugove hypothalamus, asi kubatana hwavo pituitary Anterior pituitary masero uye vasina kudzidza.

Agonists kusunungura kemikari: zvinodhaka

Sezvatotaurwa, mahormone izvi zvinoberekwa hypothalamus. Kana aida inotokonya ovaries, somuenzaniso pamberi IVF nzira, kushandiswa agonists kana corticotropin kusunungura kemikari analogs. Kureva, vane muviri zvimwechetezvo sezvo vayo kemikari.

Asi mikana nenjodzi kudivi munhukadzi muviri. Izvi zvinoitika nokuda yakaderera inonzi estrogen nhanho. Rakajairika Migumisiro dzinosanganisira:

• kurwadziwa nemusoro;
• kunyanya vangadikitira;
• kupiswa;
• kusangana nekutsi kwemukadzi kuoma;
• Zvinyamusi;
• kuora mwoyo.

Drugs anoshandiswa sezvinotevera:

• "Diferelin" ane hazvizivi decapeptide analogue zvakasikwa kemikari anosunungura.
• "Dekapeptil" sezvo chikamu triptorelin, rakagadzirwa nevanhu analogue pamusoro GnRH. The hafu-upenyu hwakareba. Inowanzoshandiswa nokuda chakagadzirwa insemination.
• "Lyukrin dhepoti" - leuprorelin. Rine Anti estrogen, Anti-androgenic zvazviri, anorapa endometriosis, kemikari-nemataundi mapundu - kenza kweprostate, uterine fibroids. "Lyukrin dhepoti" akazoita wevasungwa pakati testosterone nevanhu, estradiol vakadzi, mukuwedzera, kuchititadzisa pituitary incretia FSH, LH.
• Zvazvakaita zvinodhaka zvishoma nezvishoma anodzoreredza vasiri secretion pakati mahormone.
• 'Zoladex' - chakaita zvokugadzirwa analogue dzinongoitika kemikari-kusunungura kemikari (LH). Rinowanzoshandiswa IVF. Akazoita wevasungwa kuti estradiol muropa, ichi chinoitika nemhaka kudzvinyirira pamusoro LH secretion ose Anterior pituitary.
  

Takakurukura gadziriro agonists kusunungura kemikari.

mhandu

Sezvo kana kugamuchira kusunungura kemikari agonists rwunokura zvikurusa estradiol zvingaitika chimbichimbi kusunungurwa luteinizing kemikari. Izvi zvinotungamirira vakurumidze ovulation uye kuparadzwa mazai. Kuti izvi zvisaitike, asi mhandu kusunungura kemikari kushandiswa. Somugumisiro zviito zvavo zvinogona inotokonya pituitary shwanu zvakare. Ovarian hyperstimulation chirwere hakuiti unooneka, asi ndizvo zvinowanzoitika nokuda kushandiswa kwenguva yakareba GnRH agonists. Vari kutarisirwa mumazuva mashanu kubvira pakutanga kushandiswa follicle nekurukurirano kemikari.

Mushonga uri kubudirira, zvose-chinangwa kugadzirira vanofanira chete kuva nyanzvi.