Chii "Lyrics" piritsi? Kushandisa mari

Medicine "mashoko" (Mahwendefa), mutengo unobva 700 kusvika 4000 rubles, -. Zvakakwana rinozivikanwa zvinodhaka. Active fuma - pregabalin - analog kuti wegamma-aminobutyric (neGhebha) asidhi (neGhebha). Gare gare munyaya achapiwa Musumo kune mishonga. Ngationei kuti mapiritsi "Lyrics" vachishandisa varwere.

mashandiro chiito

Pregabalin rinoratidza efficacy yayo pakurapa chirwere cheshuga neuropathy uye postherpetic neuralgia, uhwo mapiritsi "mashoko" ushandiswe mwero kusvikira vhiki 13 ne zuva yaunodya zvazvingava 2 nguva uye kusvika 8 mavhiki, 3 kanomwe pazuva. Tikafunga kukura nzira yakaratidza chete nemishonga. Chokuita fibromyalgia zvakajeka kuoneka zvinoderedza marwadzo zviratidzo Point apo kutora zvinodhaka mishonga ine 300-600 MG pazuva. Daily chipimo chemushonga kuti 450 MG uye 600 MG ungafananidzwa kuti kunyatsoshanda, asi vapedzisira iri shoma zvakanaka kuregerera. The mushonga akazoita kwokuomerwa zvipusha nezvipusha, izvo mapiritsi "mashoko" vanokurudzira mararamiro kwemavhiki 12, 2 kana 3 nguva pazuva. Panguva kugamuchirwa kunoitika mumuitiro nemishonga uye kubudirira mushonga pa dose ichi. nepfari maitikiro anotanga kutapudzwa kare mumavhiki kurapwa rokutanga. Symptomatology pamusoro generalized mwoyo rebipolar inoratidza katsika kutapudzwa mumazuva manomwe kurapwa rokutanga. Pashure kwemavhiki masere 52% of zvinodhaka varwere kugamuchira pregabalin uye 38% wevarwere kugamuchira kurapa kunonyaradza pfungwa, vakaratidza 50 muzana zvinoderedza zviratidzo zvechirwere Hamilton pakafunuka (HAM-A).

Pharmacokinetics

The medicament "mashoko" (Hwendefa) - User inosimbisa izvi - iri yakarumbidza mishonga zuva nezuva divi pharmacokinetic inozivikanwa linearity, pasi (<20%) interindividual variability. Akadzokorora pokushandisa pharmacokinetics zvinodhaka zvinogona akafanotaura maererano munhu chairema chipimo chemushonga Data. Naizvozvo nguva kuongorora wevasungwa yezviri chirungiso hakusi zvakakodzera. Pharmacokinetic parameters zvinodhaka "Lyrics" iri vakazvipira utano, varwere nepfari vanogamuchira antiepileptic kurapa, uyewo kupiwa mushonga nokuda kudzvanyirira marwadzo syndromes akafanana.

Absorção de Água uye kubviswa

Apinza usina chawadya pregabalin wefodya nokukurumidza chaizvo. awa rimwe gare gare, plasma Cmax kubudirira sezvo apo kushandisa kokutanga, uye zvichimurova. On pakanyorwa pregabalin nomumukanwa bioavailability yava ≥90% uye pasina dose. Zvakanyatsoenzana kunokwanisika kana achitora kudzokororwa munguva maawa 24-48. Kana mushonga rinoshandisirwa pashure zvokudya, asi Cmax anogona kuderedzwa 25-30% uye kuwedzera kwayo nguva chingati kune maawa 2,5. Zvisinei, hapana akaora zvinokosha zvainoita Absorção de Água zvinodhaka vasina zvokudya. Chaizvoizvo chinodhaka yabudiswa kubudikidza itsvo kuchinja. T1 / 2 avhareji yemaawa 6.3.

Pharmacokinetics chaihwo zviitiko

Kana iwe wogadzirisa renal basa, zvakakodzera kufungawo peculiarity pamusoro pregabalin Clearance, zviri Proportional kuti zvakananga creatinine Clearance. Chaizvoizvo chinodhaka yabudiswa parutivi itsvo, saka zvinokosha kana kutyora mabasa avo kuderedza dose. Kunze netsvo, kuti medicament inogona zvakabvisa kubva plasma kubudikidza hemodialysis (4-awa hemodialysis chechikamu anopa 50% vasanyanye zvinodhaka wevasungwa munguva yeplasma) uye zvadaro vanodiwa nokugadzwa zvinodhaka dose. Kudzidza pharmacokinetics ose nevamiririri "Lyrics" iri varwere havachanyatsogoni chiropa basa rinokosha havana inoitwa.

Pregabalin rinoita zvinenge kwete pachena, rwunoratidzwa pamwechete weti iri kuchinja chimiro Zvisinei vasingadzoreki chiropa basa hazvirevi yekudyidzana kukanganisa wevasungwa zvinodhaka zviri plasma. Kana mushonga kunopiwa varwere makore 65 okuberekwa, unofanira kuyeuka kuti nezera Pregabalin Clearance ruchigona kutapudzwa. Kana munhu akwegura ungaderedza renal basa, zvakakodzera zvinoderedza mishonga waakaudzwa dose.

chipimo chemushonga

The daily chitsama rekugadzirira chinorondedzerwa muna 150-600 MG pazuva. Rubvumo rinoitwa kaviri kana katatu, pasinei kudya. The medicament "mashoko" (Mahwendefa) kudzidziswa Chinyorwa anokurudzira akatora neuropathic marwadzo pane MG 150 pazuva. Kana yakawana kushanda uye tolerability akanaka vhiki imwe zuva dose anogona ngazviwedzerwe 300 MG (kunan'anura "mashoko 300" Mahwendefa). Kana zvakakodzera, kufadza dose kuti MG 600 pazuva anogona kupiwa vhiki imwe gare gare. Saizvozvowo dzaona dose panguva nokurapa netsviyo. Sezvataurwa pamusoro apa, yakarumbidza zvinodhaka kuti kurapa fibromyalgia, izvo mapiritsi "mashoko" chinotarisirwa ari dose pamusoro 75 MG pazuva iri mishonga maviri. On kuwedzera dose kusvika 300 MG kunokubatsira kubudirira kushanda uye tolerability. Kana pasina zvakwakanakira, kuwedzera dose kusvika 450 MG, uye kana zvichidiwa - vhiki rimwe MG 600. Itirawo generalized mwoyo chirwere kutanga dose kuti 150 MG. Uyewo pavhiki, nokuchengeta kubudirira zvazviri uye tolerability, nezuva dose yakawedzera kusvika 450 MG, uye shure kwamazuva 7 - kuti 600 MG (kana zvakakodzera).

nokubviswa zvinodhaka

Kana zvakakodzera, kurapwa discontinuation inokurudzirwa kuzviita kwenguva vhiki zvishoma nezvishoma zvinoderedza dose. Varwere vanenge vakadhakwa itsvo basa, kunze nomumwe vakasarudzwa mishonga. In zvinoitirwawo nemigumisiro Varwere kugamuchira zvinoreva "Lyrics" piritsi-neShanduro anosarudza nyanzvi. Pakati rakajairika rinoreva zvakafanana mugumisiro anogona kutaurwa zvinodhaka "Mydocalm" "Apizartron" "Sedavit" "Ambene".

umboo

Mishonga pachii kuchaitwa neuropathic marwadzo, sezvo adjunctive kurapa nokuda haasaruri pfari kubva nepfari, kuti pamwe kana kwete achiperekedzwa zvavo yechipiri. Zvinoreva akaratidza kuti mwoyo chirwere generalized zvisikwa, uyewo fibromyalgia.

Contraindications

Hapana mashoko ari kushandiswa kwezvinodhaka muvana uye kuyaruka makore anosvika 17 zvichibatanidzwa. Maererano mishonga iyi basa chete vakuru. Contraindications zvinosanganisira nhaka zvirwere sezvo galactose kusashivirira, lactase kushaikwa, uyewo malabsorption kuti shuga / galactose. The turusi hakuratidzwi kuti hypersensitivity. Kuti tirambe nokungwarira kushandiswa kwezvinodhaka vari varwere renal uye mwoyo nokukundikana.

nemishonga

Maererano noruzivo kunotoda kurapwa pokushandisa medicament, mune nemuumbi hope uye dzungu sezvo varwadziwe. Izvi zviitiko vanowanzotevedzera kuitika mune mwero kana vanyoro dhigirii. Pakati mhiri migumisiro kwakaguma discontinuation kurapwa zvinodhaka, zvinofanira kucherechedzwa asthenia, kuvhiringidzika, madzerere, incoordination, ataxia, peripheral edema. Pakati Migumisiro akacherechedza nemusoro, kurasikirwa pfungwa, pfari, kuzvimba rurimi, manyoka, kuda kurutsa, keratitis. Kashoma vane itchy ganda uye angioneurotic kuita. Kune Urinary chengetedzo, pulmonary edema uye gynecomastia. Pakati mhiri migumisiro anonzi kuneta.