Bone metastases.

Chimwe chikuru matambudziko kenza zvose - zvisingadzivisiki kutanga wokupedzisira Danho - padariro metastasis. Metastasis foci ndiko nyanyisa neoplasms kuti nokuyerera node kana ropa zvinonyorwa kure nadzo uye munyama, sezvamakaropafadzwa kachitanga neoplastic muitiro.

Kenza zvinenge nhengo zvose uye nyama vanogona metastasize kuti pfupa. maronda kwakadaro kunogona kuwanikwa chero mapfupa zvivako. Inonyanyoshandiswa - metastases ari nomuzongoza, dzinenge dziri pakati chiuno, mbabvu uye maoko nemakumbo.

Chii mapundu metastasize kune pfupa?

Kakawanda, izvi zvinoitika apo ari thyroid kenza shwanu, prostate uye mammary mumasero.

Kune mhando mbiri inokosha pathological kwacho pfupa - osteoblastic uye osteolytic metatstazirovanie. Nokuti chekutanga fomu chisimbiso ndizvo pfupa rinenge zvikurukuru ayo chikamu chicherwa. The chimiro chechipiri anobatsira "kugeza kunze" zvicherwa, izvo kunotozongoita rinobatanidza rive dete uye mitswe.

The pathogenesis chirwere ichi ndicho zvinosimudzira bundu masero. Kana metastasis kenza hunosanganisira osteoblasts pakuitika - kukura osteoblastic fomu. Kana bundu rokutanga munzira dzavo asangana pfupa resorbing masero (osteoclasts) - iri paumbwe metastases osteolysis.

Kazhinji, chimiro metastases mu pfupa kunokonzera marwadzo rokupedzisira. Marwadzo chirwere kunokonzerwa kukuvara tsinga harinzwi bundu growths, kumanikidza kuwedzera mukati pfupa, uye nemhaka kutsamwa harinzwi tsinga fibers dzinounzwa metastasis zvinhu. Mukuwedzera, marwadzo kunoitika apo pfupa mitswe zvinokonzerwa rive dete wekupedzisira (hunhu osteolytic siyana). Kuumba osteoblastic unhu akaratidza hypercalcemia (BP karusiyamu).

Nengozi mitswe yakakwirira mukana yematambudziko - pulmonary embolism, rakadzika tsinga thromboembolism (pakupedzisira, izvi zvinotungamirira kurasikirwa dzichipfekeka vachizvitakudza nhengo kana mutezo uye chinhanho).

Bone metastases vari panoonekwa kushandisa X-ray. Nokuti chinangwa ichi, kushandisa pachena radiography ari multiplicity pamusoro metastatic maronda, uyewo osteolytic chimiro. Kana osteoblastic vakatakura radionuclide Scans. Mumwe nzira zvitupa, iyo inogona kuonekwa kwete chete pfupa metastases, asiwo dzimwe nhengo uye nyama - PET 18P-deoxyglucose.

Kuvhiya Mabatirwo pfupa metastases kunoratidzwa pakupedzisira zvichibvira kutsemuka. Wemabhonzo akaita kuvhiyiwa kusimbisa pfupa kuburikidza kuisa nembambo uye kutsiva ne mapfupa simende bundu.

Radiation mushonga ari dose anenge gumi nemashanu - maviri nezvishanu Gy (pamusana kuti zvikamu zviduku mana), hafu varwere ndiyo kunyangarika marwadzo. The dose makumi matatu - mana namashanu-Gy kunokonzera chinokosha nani ezvinhu omurwere, zvikurukuru kuvandudzika yakadaro yakatanga pamusoro inotevera kuona kuti vaviri - nhatu.

The waivako rechipiri pashure nemwaranzi kurapa, ndiye kushandiswa radioactive strontium. Iye zvino zvikuru kushandiswa bisphosphonate kurapwa. acids ichi chinokosha kuti tunodzivisa webasa osteoclasts. Uyezve, zvinodhaka izvi zinyekenyeke kwokuomerwa marwadzo ari mitswe mapfupa, uyewo kugadzirwa kwepurogiramu anomera.

Nokudaro, fungidziro yokuti metastasis kuti pfupa angava akasiyana, zvichienderana localization kuti osteblastnoy kana osteolytic mhando uye nzira kurapwa.