Alkaline phosphatase - imwe enzayemu zvechinguvana

In tsika, vanachiremba kazhinji nematambudziko pakarepo kuwedzera alkaline phosphatase basa. Uchishandisa multi-Muedzo Kits nokuda nokukanganisika zvidzidzo ine mukana kudzora basa enzayemu. Maererano padanho webasa akati enzayemu anogona kuziva zvirwere zviri hepatobiliary ino uye mafupa tishu.

Alkaline phosphatase - imwe enzayemu rinopiwa mukirasi hydrolases, wakanamatira rimwe phosphate boka akasiyana biopolymers (mapuroteni, nucleic acids, alkaloids). The soro enzayemu basa yaiitwa munzvimbo alkaline ezvinhu. The enzayemu riri mumasero chokuita plasma membranes wenyika, saka zvinoreva kuti Kamudzira-akasungwa makemikari. Alkaline phosphatase (ALP) rinoumbwa isozymes akasiyana kuti inoiswa mumba epithelium zhelchnovyvodnyh ducts plasmatic membranes ose hepatocytes uye Tutsinga tunofambisa mashoko utwu, mapfupa, ura, placenta, itsvo.

Sarudza Basa isoenzymes achishandisa electrophoresis. Zvisinei, ALP isozymes havana yakajeka nhengo specificity, uye electrophoretic nzira rakaoma chaizvo. Naizvozvo, kuti ndirarame yokutsvakurudza uchishandisa nzira iyo inobva siyana isoenzymes aikanganiswa kuchipisa. Intestinal alkaline phosphatase chokuita thermostable chikamu uye isozymes kuti chiropa uye mapfupa - munhu thermolabile. Most nzwisisa kuti vakuchidzire ndiyo pfupa phosphatase.

Serum alkaline phosphatase musanganiswa pfupa uye chiropa isoenzymes. Kusunungurwa enzayemu kubva ropa nyama siyana zvinoenderana vasiri mamiriro uye makore nhengo (pamuviri, parturition, lactation umbirimi). Yakakwirira basa alkaline phosphatase muropa nevechiduku nokuda kwakanyanya nokushanda osteoblasts mu mapfupa rinenge izvo anokonzerwa dzinotsanagura basa ikure muviri. Panguva iyi, enzayemu basa muropa kunowedzera yakafanira kune pfupa isoenzyme. In yechipiri yezana nepamuviri uye pakusununguka nokushingaira kuwedzera uye kuparadzwa placenta kukonzera nokuwedzera wevasungwa pakati placental isoenzyme.

Kuwedzera wevasungwa pakati alkaline phosphatase muropa kazhinji rinonyoreswa zviri zvokurwara chiropa uye mapfupa. kukuvara Parenchymal chiropa kunokonzera zvishomanana yakawedzera enzayemu basa muropa serum, sezvo alkaline phosphatase chokuita muchitokisi membranes. In kurapwa hepatology chiropa isoenzyme unodoma kuti chirwere kuti cholestasis. Izvi imhaka vawedzere kwetunhu bile mutsinga dzinofamba nemukaka masero AP uye enzayemu voga kutyora mu bile. Hyperenzymemia kunonyanya yakakwirira panguva pave pathologic kwacho uye bile stasis mu chiropa bile ducts. Ipapo enzymatic basa alkaline phosphatase muropa serum ichiwedzerwa zvakapetwa kagumi. Kana zvaparadzwa intrahepatic biliary enzayemu basa muropa inowedzerawo 2-3 chete nguva. alkaline phosphatase wokuyera kuti vakuru kusvika makore 31 vanoumba 39,0-92,0 Iu / L pashure pemakore 31 - 39,0-117,0 Iu / L. Alkaline phosphatase mwero vana pasi pemakore 10 - 106,0-213,0 Iu / L 3 makore - 71,0-213,0 Iu / L, uye nokuda vachangoberekwa - 35,0-106,0 Iu / L.

Mune zvokurwara remafupa, kana pane ichiwedzerwa nezvebasa osteoclasts, panguva kukura kusimba, osteodistorofii, hyperparathyroidism muropa kunowedzera basa mapfupa alkaline phosphatase. Panyaya iyi, yose alkaline phosphatase basa muropa yakawedzera 3-10 nguva. Nokuti mangwanani chirwere kusimba uye osteodystrophy chinhu wakananga kuwedzera phosphatase basa iri synovial mvura. The kuwedzera alkaline phosphatase basa iri cerebrospinal mvura chiratidzo pokukundwa neuronal membranes, umo vemunyika.