"Alendronic asidhi": mirayiridzo kushandiswa, analogs, wongororo

Ndezvipi zvinoda "Alendronic asidhi"? Mhinduro nyaya iyi yokurapa, uchadzidza kubva zvinhu ino. Uyezve, isu achakuudza sei kutora mushonga, umo nguva hazvisi chinodiwa kushandisa, uye kana vane chero nemishonga. Uchadzidzawo pamusoro fomu tiri kufunga iri kuwanikwa nzira, kana ane dzomuzana kuti varwere nezvazvo.

The Kuronga zvinodhaka uye ayo vasunungurwe chimiro uye kavha

"Asidhi Alendronic", kana kuti vanonzi zvinodhaka "Alendronate", iri kutengeswa muchimiro chena kumativi pamahwendefa. The kushingaira wemafuta zvinodhaka riri alendronate yavaibvisa trihydrate, kana alendronic acid.

Kana mamwe okunze, zvinoshingaira zvinodhaka unotora zvinotevera: monohydrate, povidone, microcrystalline cellulose, croscarmellose yavaibvisa uye magnesium stearate.

In Pharmacies "Alendronic asidhi" rinogona kuwanikwa Maronda akasiyana 4 mahwendefa nerimwe.

The pharmacological ehupfumi zvinodhaka

Chii chinonzi "Alendronic asidhi"? gadziriro Guide inopa kuti chokushandisa chiri inhibitor repfupa resorption. The mashandiro chiito zvinodhaka iri chokuita vasanyanye nezvebasa osteoclasts. Iye zvishoma inowedzera arambe achirema (chicherwa) mapfupa rinenge uyewo mari yayo inotungamirwa.

The pharmacokinetics zvinodhaka

Sei takabatikana "Alendronic asidhi"? Mirayiridzo yokushandisa zvinodhaka ichi chine ruzivo kuti kana achiita usina chawadya (nokuti 2 maawa asati adya), panguva imwe chipimo chemushonga 70 MG bioavailability yezviri chinhu ari naka pabonde anenge 0,65%, uye akasimba paburiro - anenge 0,6%.

Kana mushonga kwehafu yeawa kana awa pamberi kudya, yekudyidzana izvozvo zvinoderedza ari bioavailability (kusvika 0.45% uye 0,4%, ukuwo).

Kugamuchira mushonga mukati 2 maawa pashure zvokudya hazvina chokuita bioavailability. Zvisinei, pashure kudyiwa kofi uye orenji muto kuderedzwa bioavailability ne vanenge 60%.

Nokusungwa yezviri wemafuta mushonga neropa mapuroteni riri anenge 78%.

Pashure pokugamuchira medicament yekutanga dzakagoverwa pamusoro zvinyoronyoro munyama, mapfupa uye ipapo, apo, chokwadi, zviri Kuda kutamba kwayo, itsvo uye vakasara.

Wevasungwa zvinodhaka muropa kunoreva paakaudzwa kuchirapa dose riri pazasi nokuyerwa muganhu (asingasviki 5 kumar / Rine mamiririta).

The medicament ndiyo biotransformation. Ari yabudiswa kubva muviri kuchinja. Kugadzirira kunoratidzwa akurumidze kuderera muropa wevasungwa, uye zvishoma chaizvo kusunungurwa mapfupa tishu.

Zvairatidza kuti kushandiswa mahwendefa

Zvino munoziva kuti "Alendronic asidhi". Nei tichifanira chokushandisa ichi? Maererano zvakabatanidzwa mirayiridzo, mushonga une zvinotevera zvairatidza:

• osteoporosis ari naka vasikana postmenopausal vakadzi (somunhu kudzivirira pfupa mitswe, kusanganisira musana uye hudyu);
• osteoporosis ari kusimba pabonde;
• Osteoporosis, iyo kunokonzerwa nokushandisa kwenguva yakareba glucocorticoid vamiririri;
• chirwere Paget vake.

"Alendronic asidhi": contraindications pakushandisa

Kana tiri kufunga mushonga haagoni kushandiswa? Mirayiridzo kushandiswa kwezvinodhaka rinoti zvinodhaka ichi ane zvinotevera contraindications:

• hypocalcemia;
• Inosimudzira murwere medicament aikanganiswa zvinhu;
• nekusagona murwere ari akarurama nzvimbo (akagara twasu kana kumira) kwehafu yeawa;
• kwazvo zvirwere zviri chicherwa muviri;
• zvakakomba renal kukundikana;
• hypoparathyroidism rinorema;
• esophageal stricture kana achalasia uyewo mamwe mamiriro zvinozoguma mhingaidzo pakati yegurokuro zvokudya;
• shuga-galactose malabsorption, lactase kukanganisika kana lactose kusashivirirana ;
• lactation;
• Karusiyamu malabsorption;
• pamuviri;
• chevana zera.

Vakangwarira paakatora mishonga

Mune zvimwe zviitiko, "Alendronic asidhi" riri basa nokungwaririra? Under kuzviomesera zvokurapa cherechedzo inofanira kuti chikamu wevarwere, ndiro chinhu kutsaudzira ari zvomudumbu turakiti (semuenzaniso, zvirwere zvakadai esophagitis, dysphagia, duodenitis, gastritis, peptic urikanwi chirwere 12 duodenal urikanwi uye dumbu). Mukuwedzera, mushonga zvinofanira nokungwarira kunyanyisa mune varwere kushayikwa vhitamini D.

"Alendronic asidhi": mirayiridzo kushandiswa kwezvinodhaka

Medicament "Alendronate" vanofanira chete kubatwa nomuromo mune imwe mari 1 piritsi. Kana mishonga iyi haisi varumbidzwa kutsenga, kana kuiparadza. zvinokubatai ake achitsanya 2 kwemaawa asati adya (kanenge hafu yeawa pamberi dose kwezvokudya, mvura, kana zvimwe navanachiremba mano vokutanga).

The mushonga unofanira kunwa mvura pachena. Izvi imhaka yokuti zvimwe zvinodhaka (semuenzaniso, chicherwa mvura, tii, kofi, orenji muto) chaizvo kuderedza Absorção de Água yezviri fuma.

The yakarumbidza chipimo chemushonga of medicament 1 piritsi (kana 10 MG) pazuva kamwe mukati. Mune zvimwe zviitiko, vanachiremba mumwe dose raitongwa murwere, riri sezvinotevera: 1 piritsi (kana 70 MG), 1 nguva pavhiki.

Nokuti kurapa osteoporosis mune varume nevakadzi (vakadzi postmenopausal), uyewo osteoporosis, izvo zviri kukonzerwa kushandiswa kwenguva yakareba glucocorticoid vamiririri, mushonga anotorwa 10 MG daily kana 70 MG kamwe pavhiki.

With chirwere ichi sezvo Paget nechirwere, runoonekwa kwatiri mushonga wakawanda ari chipimo chemushonga 40 MG pazuva. Ya yokurapa iri 6 mwedzi.

Kana iwe netsaona kurovha gadziriro muoti 1 pavhiki, hwendefa zvinofanira kutorwa mangwanani zuva rakatevera. It hakubvumidzwi kushandisa mishonga iri uwandu mahwendefa maviri kamwe pazuva.

Ovhadhozi zvinodhaka

Chii chinoitika kana murwere rinova zvisingadzorwi kutora nzira dzakadai se "Alendronic asidhi"? Kugadzirira iyi mhando vane zviratidzo ane ovhadhozi sezvo hypophosphatemia, chirungurira, hypocalcemia, erosive uye maronda maronda ari nemudumbu, esophagitis, manyoka.

Kana murwere akapa zvaitika zvinofanira kupiwa mukaka rose kana karusiyamu tubhokisi antacids. Zvakafanira kuti kunyorerana zvinodhaka. Tichifunga mukuru pangozi yokuita esophageal mucosa akashatirwa hakusi varumbidzwa kufurira kurutsa. Kana ovhadhozi murwere unofanira kuva akarurama chinzvimbo.

Nemigumisiro yomuka pashure pakugamuchira medicament

Anogona kukonzera "Alendronic asidhi" kunaka chaiyo? Reviews wevarwere uye vanachiremba vanoti mushonga ane hwakanyatsorwisa vazhinji nemishonga. Chii chaizvo, tinotarisira zvishoma mberi.

• Zvomudumbu hurongwa: esophagitis, manyoka, dysphagia, dyspepsia, abdominal marwadzo, bloating, kupatira, uye chirungurira. Quite kashoma pashure dosing Varwere vane kurutsa, melena, kuda kurutsa, esophageal stricture, gastritis, esophageal urikanwi, urikanwi pharynx uye kunanzvana mhango mucous membranes, esophageal urikanwi perforation pamwe veMubatanidzwa ropa.
• Tsinga: nomusoro.
• Zvetsandanyama nemapfupa maitiro: kurwadziwa tsandanyama, mapfupa uye mapfundo.
• Nhengo wokuratidzwa; scleritis uye uveitis.
• Chisimbwa: edema angioedema, mapundu, Stevens-Johnson chirwere uye hunokachidza epidermal necrolysis (mu zvisingawanzoitiki zviitiko).
• Other nemishonga: erythema, mapundu, photodermatosis, kuvaviwa uye symptomatic hypocalcemia. Panewo nyaya osteonecrosis repasi uye yokumusoro rushaya pavarwere vane kenza avo vanosangana anticancer kurapa kuti kunosanganisira kushandisa bisphosphonates. Saka, panowanikwa osteonecrosis pangozi zvinhu zvinosanganisira: mishonga, kenza, kurapwa pamwe corticosteroids, nemwaranzi kurapa, murombo nemumuromo utsanana, zvomunharaunda noutachiona kana kuzvimba, kusanganisira osteomyelitis.
• Laboratory miedzo: zvinopfuura uye zvishomanana vasanyanye wevasungwa calcium phosphate.

Hatigoni kutaura kuti mifananidzo zviratidzo pakutanga zvinodhaka mishonga vari zvinotevera: zvakawanda zvive, myalgia, uye fivha.

Kudyidzana nevamwe zvinodhaka

Pamwe chete chero zvinodhaka varwere haana basa "Alendronic asidhi", ayo anoreva zvakafanana?

Maererano murayiridzo, hazvina yakakodzera mawa negashiro chishandiso pamwe mishonga ane karusiyamu mu marongerwo uye antacids (nokuda kuti zvinobvira kuderera Absorção de Água yezviri zvinodhaka fuma).

The penguva pakati kwokubatsira mushonga "Alendronate" uye kushandisa dzimwe mishonga anofanira kuva asina kutapudza pahafu yeawa.

Nonsteroidal vamiririri, uyewo acetylsalicylic asidhi anogona yekudyidzana kuwedzera divi zvinokonzerwa zvinodhaka riri nemudumbu nhengo.

Combined kugamuchira "alendronate" (asi kwete zvose) pamwe inonzi estrogen haisi achiperekedzwa vachinje mabasa avo uye kukura chero nemishonga.

Negashiro ane mushonga zvakadaro, sezvo munhu "prednisolone", haasi pamwe zvinokosha kuchinja bioavailability acid.

Mirayiridzo Special pakugamuchira kuchipatara mudziyo

Zvaunofanira kuziva usati watanga kugamuchira chombo akadai "Alendronic asidhi"? Analogs, uye akaona mushonga anogona kukanganisa mashoko gastrointestinal zvomukati. Naizvozvo, kuti kuderedza irritant mugumisiro mishonga inokurudzirwa kutora mangwanani usina chawadya girazi remvura.

Pashure pokugamuchira mishonga zvakafanira kuti hafu yeawa mu akarurama chinzvimbo. Uchishandisa chinjikira nechinzvimbo kana panguva yokurara kunowedzera ngozi Kutsauka akadai esophagitis.

Murwere inofanira kuziviswa mashoko discontinuation zvinodhaka kana chirungurira kunoitika, pakuonekwa marwadzo ari mubhokisi uye kumedza, uyewo kugadzirwa kwepurogiramu dysphagia.

Kana hypocalcemia vanofanira kutsiura kwayo pamberi kutanga kurapwa. Zvinonzi Dzakamukurudzirawo kubvisa vachivavhiringidza pamusoro chicherwa muviri kuti kukonzera kutsauka ichi.

Panguva kushandiswa bisphosphonates murwere vanofanira nechokwadi yaunodya pokugara yakawanda vhitamini D uye calcium yakawanda.

Panguva kurapa nokuda zvinobatsira asidhi repfupa chicherwa arambe achirema mune murwere vanogona zvishomanana vasanyanye wevasungwa pakati phosphate uye calcium yakawanda muropa.

Asati kurapwa pamwe bisphosphonates vari varwere concomitant zvinokonzera njodzi (nekenza achirapwa mishonga, nemwaranzi kurapa, etc.). Iva nechokwadi zvakaitika mazino kuongorora.

Price uye analogues zvinodhaka

Zvino munoziva kuti chinodhaka ichi zvinofanira kutorwa se "Alendronic asidhi". Ko mushonga uyu chairayirwa chiremba, isuwo kuwanikwa. Zvisinei, vakawanda varwere vakanga ushandiswe mushonga uyu, nguva dzose ainetseka pamusoro mubvunzo iwoyo, zvakawanda sei kunzanga?

Nhasi "Alendronic asidhi" inogona kutengwa nokuda 350 rubles (4 mahwendefa). Tichifunga dosing purogiramu (kamwe pavhiki), mutengo haasi mukuru chaizvo.

Kana pamberi pedu mishonga asingadi kukunakira upi chikonzero, rinogona kutsiviwa nezviri. Izvi zvinosanganisira mishonga yakadai se "Tevanat", "Ostalon", "Alendronate", "Strongos", "Alendrokern", "Ostealen", "Lindron", "Alental", "Foroza", "Osterepar ',' FOSAMAX "zvichingodaro.

Reviews wevarwere uye vanachiremba pamusoro mushonga

Chii Varwere uye vanachiremba pamusoro chivako ichi se "Alendronic asidhi"? Maererano mhinduro dzavo, mushonga kuzvigona basa. Zvakanaka kunosimbisa Pfupa rinenge anobata osteoporosis uye Paget chirwere.

Zvisinei, zvakaoma haana kuziva kuti chinodhaka ichi ane hwakanyatsorwisa vazhinji nemishonga. Saka, mushonga zvinofanira kutorwa chete pamusoro kugadzwa nyanzvi. The yokupedzisira vanofanira nguva dzose zvapinda murwere pamusoro contraindications.

Nhamba huru kunaka wongororo vari kero "alendronic asidhi" rinobva varwere vane matambudziko pamwechete zvomudumbu turakiti. Izvi imhaka yokuti chinodhaka ichi kunogona kukanganisa mudumbu, yegurokuro uye ura.