ACE FIs - vanobudirira zvinodhaka zviri cardiology ano

FIs kana ACE angiotensin rokutendeutsa chinhu rinonzi simba vasodilators akashandiswa cardiology nokuda nokurapa neBP. Kuitwa boka iri zvinodhaka kuripo ichivharira adrenal kemikari angiotensin II - pressor chikuru chinoita kukanganisa BP ukoshi. ACE FIs kutadzisa kuparara bradykinin, izvo hunobata mamiriro midziyo, uye saka mumhu kweropa. zvinodhaka izvi kubatsira kuwedzera kwevari vasodilator prostaglandins ropa kuderedza chirwere chemwoyo, kunowanzokonzerwa kuchengetwa varwere zvinokosha neBP. Panguva iyoyowo, ACE FIs, kusafanana nedzimwe zvinodhaka kuti kudzikisa BP hazvina zvazvinoita shuga uye lipid muviri, kuderedza Urinary itsvo mapuroteni.

ACE FIs anoshandiswa kwemakore anopfuura 40. Rokutanga boka iri zvinodhaka muna 1975 akanga synthesized captopril, kushandiswa nhasi. Makore mashomanana gare gare akanga vakawana enalapril uye lisinopril. Vakatsiviwa zvakawanda ano ACE FIs chizvarwa chitsva.

In cardiology ano ACE FIs zvinoshandiswa sezvo huru zvinodhaka nokuda pakurapa chirwere cheBP chirwere, ischemic mwoyo chirwere, chirwere chemwoyo.

ACE FIs kupatsanura

Kune classifications vanoverengeka ACE FIs, iyo inotorwa nzira kubviswa zvinodhaka mumuviri, zvichienderana makemikari boka iri Morekuru kuwadzana ACE muzinda basa matanho. Vakawanda kupatsanura pakati pharmacological chiito.

Maererano pharmacological zviito angiotensin rokutendeutsa FIs zvinhu zvose vanokamurwa muzvikwata zvitatu.

Boka rokutanga ndiro captopril kana Hood, izvo zvakananga kuchititadzisa, i.e. kuchititadzisa ari angiotensin I unoponesa basa kemikari ari unozotevera danho - angiotensin II. Kuti tirambe captopril kana kapoten zvakajairika BP atora nguva nhatu vana pazuva.

Wechipiri boka ndezvaJehovha enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril uye zvimwe zvinodhaka kuti mudzoke mumuviri kupinda basa yeimwe vane vasodilatory maturo. mishonga ava zvakakwana kutora kamwe chete pazuva.

Pakupedzisira, boka rechitatu chinosanganisira lisinopril Zestril, prinivil, prestarium kana perindopril. ACE FIs ndivo wechitatu boka inokurudzirwa kutora kamwe kana kaviri pazuva.

Side migumisiro ACE FIs

Kana ukapiwa boka iri zvinodhaka vanofanira kungwarira inobvira kukura nemigumisiro. Mune zvimwe zviitiko, achitora ACE FIs kuonekwe yakaoma chikosoro, yakawedzera potassium yomuropa muropa, dzungu, sema ganda mapundu, angioedema. yematambudziko izvi zvinopedzwa zvachose pashure zvinodhaka kurega. Dry chikosoro rinowanikwa yechitatu rechishanu zuva kurapwa. chitarisiko Its imhaka kuunganidza mumapapu ose bradykinin. Chikosoro nokupera zvachose pashure discontinuation pamusoro FIs. Vamwe varwere vanogona kuderera kushumba uye vachanetseka kuravira maonero.

Chimwe chikuru contraindications pakushandisa ACE FIs ndiyo bilateral renal tsinga constriction. Panyaya iyi, kweropa ichiwedzerwa nokumutsa padanho renin muropa kuti zvinodhaka izvi havana maturo.

Special hanya zvinofanira kupiwa ACE FIs mune chirwere chiropa uye itsvo nezvirwere kukudziri- zviratidzo hepatic uye renal insufficiency.