Tiotriazolin: mirayiridzo yekushandiswa

Unoziva here chirwere "Tiotriazolin"? Mirayiridzo yekushandiswa kwemishonga iyi icharondedzerwa zvakadzama munyaya yakataurwa. Mukuwedzera, tichakuudza nezvemaitiro ayo mushonga uri kutengeswa, chii chinoratidza, migumisiro uye zvinopesana.

Kuumbwa, kugovera uye chimiro chekugadzirira

Ndeipi mhando yemishonga "Tiotriazolin"? Mirayiridzo inozivisa kuti ine maitiro akasiyana-siyana. Inonyanya kuzivikanwa ndeyotevera:

• Mhinduro inogadziriswa mujoyi yegumbo uye intravenous. 1 ml yemugovera uyu ane 0.025 g ye thiotriazoline. Uyewo, mishonga inewo zvinyorwa zvinoshandiswa mumadziro emvura. Mushonga wacho unogona kutengwa mumaboules 4 ml (akaiswa mumakadhibhodhi pakurongwa).
• Donhwe reziso "Tiotriazolin". Mirayiridzo yekushandiswa kwechirongwa ichi inotaura kuti 5 ml yemudhiyo ine 50 mg ye thiotriazoline, pamwe nezvimwe zvinhu. Mushonga unoenderera mberi uchitengeswa mu polyethylene mabhodhoro-droppers, akaiswa mubhodhibhokisi bhokisi.
• Mapiritsi "Tiotriazolin." Iyo mirayiridzo yeiyo maitiro emushonga inotaura kuti mune imwe yepepuru yakaipoteredza piritsi ine nzvimbo yakadzika ine 100 mg ye morpholinium methyltriazolylthioacetate, kana inonzi thiotriazoline. Sezvimwe zvikamu zvezvinodhaka izvi mbatata starch, microcrystalline cellulose, pasi maserosiyo mashoma povidone, calcium stearate uye sucrose. Kazhinji, mune kadhibhodhi bhokisi mune mahwendefa makumi mashanu.

Pharmacodynamics

Chii chinogadzirisa saTiotriazolin? Mirayiridzo yekushandisa inotaura kuti iyi inonzi antioxidant drug. Kubudirira kwayo kwakanyanya kunokonzerwa ne antioxidant, anti-ischemic, immunomodulating uye membrane-stabilizing properties.

Mushonga uyu unodzivirira kufa kwehepatocytes, kunokurudzira kupora, kunoderedza kuwanda kwemafuta ekuputika, kunotungamirira mukusimudzira kweprotheni, kakinhydrate, lipid uye pigment metabolism, uye kunoderedzawo mikana ye centrolobular necrosis yomuviri yakadai sechiropa. Mukuwedzera, ichi chinodhaka chinowedzera kusiyanisa uye kushandiswa kwebi, zvinowanzogadzirwa (chimiro).

Zvigadzirwa zvemishonga

Ndezvipi zvimwe zvinhu zvinogadzirirwa "Tiotriazolin"? Mirayiridzo yekushandisa mushonga uyu inofanirwa kuverengwa. Mushure mezvose, kubva chete iyo unogona kuona kuti mushonga uri mubvunzo unoderedza kuvhara kwehutachiona hunoitika muKrebs cycle, kuchengetedza intracellular ATP fund, uye kunowedzera kushandiswa (kubhadhara) kwevanaerobic glycolysis.

Inofanirawo kutariswa kuti mushure mekutora mishonga, iyo inoshandiswa inoshanda inotanga kushandisa antioxidant system, kudzivisa hutachiona hwehutano hwemafuta muzvikamu zvesimba zvemuviri. Mukuwedzera, ichi chinodhaka chinowedzera nzvimbo (rheological) yeropa kuburikidza nekushandura fibrinolytic system.

Antioxidant yemiti yemishonga inoratidzwa nekuda kwekuti pane sulfuri ions muurongwa hwei tiotrazoline molecule, iyo inoratidzirwa nehujijidhi uye kuderedza zvinhu, pamwe neyitrogen yepamusoro, iyo inosunganidza yakawandisa yehydrogen ions.

Inofanira kuonekwa zvakare kuti inoshandiswa chikamu chechirwere ichi inokwanisa kugadzirisa zvinodhaka zvinopisa uye maitiro anoshandiswa emojeni. Izvi zvinokonzerwa nekuderedza kuderedza zvinhu zveboka iri. Mukuwedzera, mishonga inodzivisa kuumbwa kwemaitiro anoshandiswa ejinijeni, kushandiswa kwemaantikiki akadai anonzi catalase, glutathione peroxidase uye superoxide dismutase.

Pharmacokinetics

Imwe mishonga "Tiotriazolin" inobatwa here? Iyo mirayiridzo inotaura kuti nguva yekumisa-miviri yemishonga maminitsi makumi matatu, uye bioavailability 65.5%.

Iyo yakanyanya kukanganiswa kwemishonga iri muropa inosvika 1.4 maawa mushure mokunge vapinda. Kubatana neprotein hakupfuuri 10%.

Mune zvakawanda, mushonga unounganidza mumatumbu eropa, mwoyo, rectum, spleen uye itsvo, uye zviduku - mumukati muduku nemapapu. Tiotriazolin yakanyanyiswa kunyanya neitsvo.

Zviratidzo

Pamberi pezvimwe zvipupuriro, mahwendefa, majekiseni uye madonhwe eziso "Tiotriazolin" inogona kunyorwa? Mirayiridzo yekushandiswa kwemafomu aya ane zvirevo zvinotevera:

• Kurwisa kwechiropa;
• Chiropa kukuvadza zvakashata, zvinodhakwa, utachiona uye mishonga (semuenzaniso, mushure mekutora mishonga inorwisa mabhakitiriya, mishonga yemishonga inorwisa mishonga, antituberculosis uye antitumor agents, zvirongwa zvekudzivirira pamuviri uye tricyclic vanodzvinyirira);
• Hepatitis viral chronic;
• Kunwa doro rehepatitis kusinganzwisisiki uye zvishoma;
• Chiropa chiropa dystrophy.

Zviratidzo zvekushandiswa kwemadonhwe:

• Zvirwere zvekornea;
• Kupisa kana kushungurudzwa kweziso;
• Viral conjunctivitis.

Sei uchishandisa chirwere che ophthalmologic "Tiotriazolin"? Dzidziso (madonhi anokwanisa kutengwa mune imwe yemishonga yemishonga) inozivisa kuti mishonga iyi inowanzogadzirirwa kuitira kudzivirira maziso akaoma, asthenopia nedzimwe zvirwere zvinoputira zvezvioni zvinoonekwa.

Nhamba yemapiritsi

Ndingashandisa sei mahwendefa eTiotriazolin? Iyo mirayiridzo ine ruzivo rwekugadzirira kwakapiwa kunofanira kutorwa chete mukati. Sezvo mutemo, tiotriazolin inorayirwa 1 kana 2 mapiritsi kane kana pazuva kwemazuva 25-30.

Nguva yekurapa nemudzvinyiriri uyu inofanira kuongororwa chete nachiremba mumwe nomumwe (zvichienderana nemamiriro ekudzidzira uye kuoma kwezvirwere zviripo).

Mishonga yekurapa "Tiotriazolin": mirayiridzo yekushandiswa

Injections ye "Tiotriazolin" yakaitwa intramuscularly kana intravenously. Nhamba yavo inotsanangurwa nachiremba (inobva pane chirwere). Ne myocardial infarction uye hepatitis, mishonga inojowa zvishoma nezvishoma mukati 2 ml 2-3 kazuva. Apo mishonga ye-cirrhosis inopiwa intramuscularly (2 maminitsi 2-3 kazuva). Nzira yekurapa mazuva makumi matanhatu.

Donhwe reziso "Tiotriazolin": mirayiridzo yekushandiswa

Matsipa kumeso "Tiotriazolin" anoiswa mu conjunctival sac. Kazhinji, muyero wevanhu vakuru 2 inodonha kusvika 4 kana pazuva. Kana vari vana, muwandu wemishonga inongororwa chete nevanachiremba. Nguva yekurapa nemadonhwe eziso inofanirawo kusimbiswa chete nechiremba anoenda.

Kazhinji, nguva yekurapa nemishonga iyi haisi mavhiki maviri. Asi kana kuvandudzwa kusati kwaonekwa, dzidzo inogona kuwedzerwa kusvika mwedzi.

Muchiitiko apo zvipembenene zvezvioni zvinoonekwa zvakakura uye zvakakomba, zvino majekesiti kumadonzvo eziso anowanzonyorerwa (mamwe magadzirira).

Kuchengetedza kuomeswa kunze kwezvigamba zveziso (pavanenge vachishanda pamakombiyuta), zvinokosha kushandisa mushonga wemadonhwe maviri mukati mezuva neine nguva yeawa 2.

Migumisiro Yechiri

Ndeipi migumisiro yechirwere ingakonzerwa nemishonga "Tiotriazolin" (injections) inokonzera? Iyo mirayiridzo yechechi iyi inotaura kuti mushonga unopiwa unoshandiswa zvakanaka. Zvisinei, pamwe nemishonga iri mubvunzo, kuchinja kusingadi kunogona kuitika.

• Central nervous system: dutu, dambudziko guru, tinnitus.
• Nzira yekudya: yakaoma muromo, kushungurudzika, kuputika.
• Zvikepe nemoyo: kuwedzerwa ropa, tachycardia, arrhythmia, kurwadziwa mumoyo.
• Kufuridzira hurongwa hwekudzivirira: asthma kurwisa uye kupera kwekufema.
• Kurwisana: fever, hypersensitivity reaction, angioedema.
• Kugadziriswa kwemunharaunda: kubwinya uye kumira panzvimbo yejojo.
• Dermatological reaction: ganda remaperembudzi, kunhuwa, mikoko.

Kana ari madonhwe eziso, pakanga pasina migumisiro yega pavari.

Kubatana Kwemishonga

Maererano nenyanzvi, mushonga we "Tiotriazolin" unogona kushandiswa mukubatana nemishonga inotarisirwa kuitirwa chirwere chemwoyo. Izvi zvinokonzerwa nekuti izvo zvinonzi mishonga inhengo yehupenyu.

Inofanirawo kuonekwa kuti mishonga iyi inobvumirwa kushandiswa panguva imwe chete nemishonga inorayirwa kurapwa kwehepatitis ye etiology inofanana.

Donhwe reziso "Tiotriazolin" inogona kupiwa kuvakadzi vane pamuviri, pamwe chete panguva yeakisi. Uye zvakare inofanira kutaurwa kuti iyo inotaurwa nezvechirwere inobvumirwa kushandiswa panguva imwe chete nedzimwe mishonga yezvechiremba.

Doro nemishonga "Tiatriazolin" inosimbisa chiito cheumwe. Panyaya iyi, mvumo yavo yekufanana yakarambidzwa.

Special instructions

Mahwendefa ari pasi pekufungidzira anosanganisira sucrose (muwandu we 2.8 mg mune imwe piritsi). Nokudaro, mwero wemazuva ose wechirwere unogona kunge uri ne 22.4 mg yezvinhu. Zvakakosha kuziva pamusoro peizvi muvarwere vane chirwere cheshuga mellitus.

Nzira uye nguva dzekuchengetedza

Zvechokwadi mhando dzose yemishonga "Tiatriazolin" inofanira kuchengetwa munzvimbo inodzivirirwa kubva pachiedza uye isingakwaniswi nevana pamusana wekushisa kwe14 kusvika 26 degrees. Sirifu upenyu hwemishonga ndeye makore matatu.