Chii Anti-TB zvinodhaka riri kushandiswa nokuda kwokurapa?

Undiagnosed pulmonary tiibhii inogona kurapika mukati munguva 10 months pakarenda makore 1.5. Rinhiko kuda kurapwa kunoenderana kwokuomerwa hosha kwacho uye kugadzwa kupfuura yakakodzera zvakakukodzera zvinodhaka.

Tiibhii munguva yedu - munhu isingarapiki chirwere

Mazuva tiibhii mushonga kurapa ndiye anozviita kuti wemishonga kurapwa. Izvi imhaka yokuti kana munhu-nguva kutambira zvinodhaka siyana zviri zvikuru nomumugwagwa kwaitora nguva kukura mycobacteria kuramba zvinodhaka. The murwere itungamirirwe kosi pakarepo Hour 2 kana 3 zvinodhaka. Sezvineiwo, yaaizova zvokurapa nhasi vari yakakura. Izvi zvinogona chete kuva nhamba 1 TB zvinodhaka kana mubatanidzwa Formulations zvabatanidzwa I uye II dzakatevedzana.

Kupatsanura pakati Anti-TB nevasori akavaka nokuda mwero kubudirira kwavo. Zviya, akavonga vazhinji vedu Research Institute for nokugadzirwa mishonga yakadai se "INH". Uyu ndiwo mumwe chikuru Anti-tiibhii madhiragi, ine mukana pamatunhu chaizvo bacteriostatic basa. Muchiitiko chino, zviri kunyanya kubudirira unyanzvi pavarwere uchangorimwa chirwere.

Next pachikwata

Wechipiri-Kushanda kwokurapa pashure "Isoniazid" - iri "Rifampicin". Too yakanaka uye nzira inobudirira. Active gadziriro hunotevedzana inogona dzinounzwa inotevera urongwa: "streptomycin yakawanikwa", "Kanamycin", mberi "Pyrazinamide" "Ethionamide" akateverwa "Prothionamide" "Ethambutol", uye 3 zvakawanda 'florimitsina "" Pask, "TB "Thioacetazone" chinodhaka.

mishonga All vozdeystuyuschie kuna Mycobacterium uye kubatsira kugadzirisa zvekuchipatara zvinetso varwere zvaiswa pasi boka Anti-TB zvinodhaka:

1. Antibacterial zvikuru Anti-TB madhiragi 1 dzino
2. kuchengeterwa zvinodhaka II dzakatevedzana.

The siyana gadziriro 1 ne2 misara

Napamusara wokutanga ndivo vanonyanya mishonga anoti chepamusorosoro kunyatsoshanda pamusoro chemotherapeutic yomuchipatara vavo nomukaka. Kuva usingashandi toxicity.

Antituberculosis zvinodhaka 2 yamahwindo, kusanganisira negadziriro yeparutivi zvinodhaka, havana mugumisiro wakanaka kudaro kurwisa Koch seinä, pamwe zvikuru muchetura. Vari raitongwa varwere zvakadyiwa kana muviri Eriya aitombotyawo mishonga nhamba 1 kana kusada zvinodhaka izvi zviri kuchengetwa.

Sad nhamba inoratidza kuti chero nguva mishonga ndivo muropa nemuviri, i.e. ari kushanda zvakanaka ipfupi kwazvo. Uyewo, huru Anti-TB madhiragi pashure imwe nguva, nokuvagarisa pachavo uye muropa nekuti mycobacteria kuva zvadzinoitwa kwavari. Somuenzaniso, kana ari zindoga kubvuma chimwe chete chaiyo zvinodhaka, ipapo nemishonga kwairi mycobacteria kuchengetwa mukati 2-4 mwedzi.

TB zvinodhaka: kushandisa simba nezvainoita

Unorema zvinodhaka TB kurwiswa bacteriostatic kwakabatsira mycobacteria, kureva, ivo kuderedza virulence yavo kwava mukana kuwanda. Saizvozvowo, "INH" uye "Rifampicin" iri kuramba mishonga vachikwanisa kuita bactericidal. Kuti vawane kugadzikana zvokurapa zvazviri, uyewo kuti anyevere uye kufuratira zvichiita dzokororo ine Anti-TB mishonga inofanira mberi kwenguva yakareba.

With zvose izvi kusarudzwa uye kugadzwa yakanakisisa mubatanidzwa zvinodhaka, uyewo ya chikumbiro yavo zvakananga novimba Rwako murwere panguva iyoyo siyana tibhii, achishandisa chii kunze rapfuura kurapwa (kana), sezvo kuzoregwa murwere vamwe mishonga kubva sezvo Mycobacterium tiibhii vari inonyatsoziva akasarudzwa zvinodhaka.

yakanakisisa kugarisana

Tikafunga Anti-TB zvinodhaka yakarongwa pamusoro kubvuma kuti chirongwa mishonga anofanira kuva mumwe kana vaviri vokutanga-mutsetse zvinodhaka. Chokwadi, kana ivo vasina contraindications kana kuratidza kuti hachichinji. At dose ichi kugadzirira zvose zvabatanidzwa kazhinji haana ipfupi.

Kana hurukuro (dzemari ftiziologa) inofanira kufungwa nezvake kuti Anti-TB zvinodhaka zvakadai, sezvo streptomycin yakawanikwa uye nomukaka ayo hazvigoni pamwe florimitsina, kanamycin nemamwe mishonga kuti vane nephrotoxic uye ototoxic nemigumisiro.

Imhandoi kugadzirira "Pas"

"Pas" - TB mushonga bacteriostatic migumisiro. Hongu kwemazuva masayendisiti pharmacologists akahusika. Chaizvo pamusoro TB bacilli. Nyanzvi pakurapa-siyana uye localizations siyana tibhii. Rinopa zvazviri kunyange nani kana pamwe kugadzwa zvimwe zvinodhaka TB chiito.

The mushonga ane Latin zita "PASK-AKRI" yacho. Available kana muhomwe of 4 d kana 100 g kubhengi ari mishonga bhegi "Pas" mabhati 3.2 aminosalicylate yavaibvisa, sapamazuva rimwe piritsi - 1 g yavaibvisa ya-aminosalicylate. Mahwendefa akafuka goko inodzivirira dumbu uye pakutengeswa dzinoiswa nokuda 50/100/500/1000 zvidimbu. ari pasuru.

Chii nani chokubatanidza

TB zvinodhaka "Pas" maererano basa tuberkulostaticheskoy muduku mishonga yakadai isoniazid uye streptomycin, uye nokuti zvinofanira kushandiswa pachiimbwa ine zvakawanda zvinoshingaira nevamiririri. Combination kurapa DZEMUNHU DZINODZORA kukura kurapika uye runogonesa migumisiro concomitant mishonga.

Pharmacokinetics "Pas"

The mushonga ane mukuru (90%) kubva Absorção de Água. It rinoita mune chiropa. Akakwanisa kupinda ropa-zvinyama Miganhu nyore uye vakagovera munyama. The soro zvazvingava zvinodhaka wevasungwa kwakacherechedzwa mumapapu, itsvo uye chiropa. More zvine mwero "Pas" (antituberculosis mushonga) chinopinda kupinda cerebrospinal mvura. Asi nyaya kuzvimba ari cerebrospinal mvura anoshongwa aminosalicylic iine acid wevasungwa uri 10-50% of wevasungwa muropa plasma. Most (80%) zvinodhaka yabudiswa kunyanya weti.

Kugadzirira II dzino

2 Anti-TB zvinodhaka ari nhamba vavo kusarudza uye kugadzwa nenguva vane rakaisvonaka kuchirapa mugumisiro tichitarisa detoxification, pamwe uyewo chinokosha regression kuti anogumbura zvachinja zvemapapu rinenge uye kunyange mukurapa tiibhii pamusoro principales.

Maererano zvokurapa tsvakurudzo munguva pakurapa vana uye vakuru vane kwakatooma, chirwere uye inoparadza siyana panowanikwa tibhii pamwe anofambidzana siyana zvinodhaka anoverengeka II, vakapiwa varwere navanachiremba nemishonga, uye nemishonga okuva utachiona kuti zvinodhaka Ini series, muna 65 muzana kacho akagamuchirwa, izvo zvinofadza chaizvo , mamwe yezvokurapwa mugumisiro.

TB zvinodhaka: nemishonga

Uye, chokwadi, kufarira vaya zvinodhaka zvinotsanangurwa munyaya, zvaangadaro nemishonga. Kunyanya nemhaka wapinda achangopfuura makore muitiro mishonga Anti-TB zvinodhaka zvakakodzerwa nezvawo. Izvi imhaka yokuti chirwere ichi achakurumidza akayambuka denda vomukova, pasinei zvaikosha pashure peHondo Yenyika II kuderedza hwevanhu vanorwara pamwero. Uyewo chinokosha ndechokuti ari Mabatirwo tibhii, sezvataurwa pamusoro apa, zvichiitika rebei, uye inokanganisa mishonga chete kwakaratidzwa pacharo, kana ane ovhadhozi kana panguva mazhinji mabiko ake.

vamwe nhamba

Kana TB kurapa kuziviswa zvinyorwa vavatorwa mudzimba vamiririri mushonga divi migumisiro zvinodhaka uye avo kakawanda chiitiko saka sezvo dzaisiyana sezvo yezvakaita chirwere. Somuenzaniso, kubva 3148 varwere vari kurapwa norunyerekupe vamiririri vanoshingaira pamusoro mycobacteria, nenjodzi vakanga kuchengetwa 12,2 chete% vanhu, pamwechete voruzhinji vavo yakanga kuratidzwa sema hunhu, uye chete varwere 74 pakava muchetura chepfu.

Kubva musi rakabudiswa data, tinogona kugumisa kuti akaona divi Migumisiro Anti-TB mishonga yakasiyana maitikiro mhinduro. nokufamba Large zvinotsanangurwa avo vasiri-dzakafanana mabatiro ezvinhu zvinokosha mishonga kwete chete kushandiswa, asi nzira tibhii, uyewo nemakore varwere, kunyange mhando zvokurapa zvivako (chipatara, pachipatara pacho, kiriniki, tsika).

tsvakurudzo mberi

Mishonga dzinokanganisa Koch kuti bacillus, anosanganisira zvinoverengeka dzinongoitika uye Semi-chakaita zvokugadzirwa yeimwe iyo pane chimwe chinhu chakafanana - ndiko basa kwavo, kureva Mycobacterium tibhii (M.tuberculosis). TB madhiragi, mumwe kupatsanura iyo, sezvo ambotaurwa munyaya ino, rinokamukana zvinodhaka mu 2 dzinoti (zvepuraimari uye negadziriro yeparutivi), muri zvikuru masayendisiti.

Cherechedzai ndiko kukura kurwisa zviri TB bacilli. All kuferefeta rabhoritari yaitwa, uye panyaya iyi migumisiro akaratidza kuti vakawanda varwere ukuru kurapika panguva kurapwa dzingasiyana, zvichikwira uye pasi, richisvika dzimwe nguva kuti kudzorerwa nehanya kutopedza.

Rutapudzo kuti nenjodzi

Kana yaivhuvhuta zvinoitika munguva kurapwa, iyo dose kurapwa rokutanga kuderedzwa kana kuti kutsiva dzimwe gadziriro. In zvikuru nyaya divi maitiro antituberculous zvinodhaka kwenguva rambidza womuchato unozotevera pakutsiva nerimwe. Kuitira kudzivirira uye kubvisa zviratidzo nechirwere chemwoyo murwere basa zvichienderana uchapupu chero dzinoverengeka zvinodhaka antispasmodics, yakadai se: "Eufillin", "papaverine", "Teofedrin" anosiya "Zelenin," nezvimwewo ...

Zvinoitwa nekuomarara yaivhuvhuta zviitiko panguva TB kurapwa vari zvikuru siyana. Antituberculosis zvinodhaka, kupatsanura apo zvakananga zvinoratidza chete namakemikari chikabviswa, dzikarongwa pamwe kuti zviite tsvakurudzo.

TB kurapwa

In pakurapa tuberculous chirwere munguva yedu zviri inokoshesa basa kudzivirira kupararira chirwere. Kutyisidzirwa rinobva varwere pulmonary tiibhii munzvimbo isina chimiro. ndichibvunza kurapwa kwavo kuchabatsira kuti kuderedza nhamba kutapukirwa, uyewo kudzivisa itsva kacho chirwere ichi hachifadzi.

Sezvo kurapwa nguva yakareba, murwere anotora yakawanda murefu uye samodistsiplinirovannost. Zvechokwadi, tiibhii ndiyo nezvakwakaipira kwete chete akarova nokuda muviri, asi yose seboka. nguva zvikuru kutanga inorwisa utachiona kurapa, apo kosi ndiyo atirari simba vakawanda, estosnovnye TB zvinodhaka. Nemhaka kwavari, asi zvinoita kugumiswa bacilli mukuvamba mumatanho, izvo achabatsirawo kuti kudzorerwa njodzi nhengo zvishomanana kana pasina kukuvara yose muviri.

Nzwisisika kurapwa chinofanira kutarisirwa kufungisisa zera uye akaratidza nzira chirwere, zvinosanganisira migumisiro pamusoro pathological dzinotsanagura ane hosha nhengo, kuderedza concomitant zviratidzo (marwadzo, chikosoro) ne zvakasiyana inhalations uye mumuviri kurapa unyanzvi.

Kubvuma yakasarudzwa boka mishonga vanofanira hazvo kuva nguva sezvo pfuti kutaura kunogona kukonzera kukura nemishonga kwavari. Treatment zvinofanira kuitwa muchipatara pasi pokudzora chiremba. Pashure kokuyerera phthisiatrician nokungwarira kuongororwa.

Serious kusvika uye Implementation zvokurapa nachiremba uye zvinangwa ndiyo kiyi kupedzisa apore. Mazuva ano TB haasi mutongo.