"Quinidine ': mirayiridzo kushandiswa, akafanana, tsananguro uye wongororo

Nei tichifanira kuva chishandiso akadai "quinidine" sei? Mirayiridzo yokushandisa, mutengo, uye wongororo kugadzwa zvinodhaka dzinoturwa pazasi. Uchadzidzawo zvakaitwa pharmacological ehupfumi chakanangana zvinodhaka, kana zviri kuitwa kurutivi hunhu uye kana ane mitemo yokushandisa.

The sezvamunoita, chimiro, tsananguro

In ipi nemakambani anogadzira mishonga kuti zvinodhaka "quinidine"? Mirayiridzo Use, kuda nzira iyi, ndiko kuti anogona kutengwa muchimiro sandarara uye kumativi mahwendefa. Vane kwenguva refu kushanda uye film-Coated.

The chikuru wemafuta mushonga uyu quinidine sulfate. Instructions, chigadzirwa Rondedzero havapi ruzivo pamusoro dzokuwedzera zvinhu.

Pharmaceuticals Pharmaceutical Products

Ndezvipi mapiritsi "quinidine"? Mirayiridzo yokushandisa, description, wongororo akashuma kuti mushonga Kirasi IA arrhythmia. It anogona kuderedza chokufambisa pakati ions kuburikidza Na migero zvakasimba sero masvingo cardiomyocytes uye kuderedza sipidhi inodiwa depolarization uye kuwedzera ya nezvezvakaitwa kwaniso uye refractory (inobudirira) rebei.

Womuchato ane medicament attenuates myocardial excitability, DZEMUNHU DZINODZORA automaticity uye AV-conduction ari nodes, chiputu bazi nechigumbuso, atrial nedzimwe nhengo. Also vaiona zvinoreva ane vagolytic mugumisiro kunoratidza M-anticholinergic zvazviri, kunoderedza basa (contractility) mwoyo tsandanyama uye rinoita rutapudzo BP.

ehupfumi zvinodhaka

Chii chinoshamisa chiri mushonga se "quinidine"? Mirayiridzo dzokushandisa anoti kuti kunogona inotropic kushanda. Izvi kunoitika pamusana deceleration of womukati simba kutendeuka kwacho mitochondria. Panyaya antiarrhythmic ehupfumi zvinodhaka, izvo chokuita pamberi mapoka amide ari morekuru maumbirwo yezviri fuma.

Maererano nenyanzvi, ari kudya kuti medicament iyi yekudyidzana akaderedza excitation uye kupararira velocity, iyo chokuita nokufumura yezviri zvinoriumba zvinodhaka nedanho depolarization.

Kudzvanyirira M-cholinergic receptors, vaiona zvinodhaka zvinosimudzira AV-conduction. At kuchirapa mishonga kwayo rinoratidza hypotensive ehupfumi chokuita kudzikira inzwi peripheral tsinga uye tsinga, uyewo zvakaipa inotropic kushanda.

Hatigoni kutaura kuti zvinodhaka izvi unogona kuratidza vemo kunovhiringidza kushanda. Rinewo unonyaradza marwadzo uye antipyretic zvivako zviri chokuita ine mwoyo chaizvo uropi.

The pharmacokinetic zvechadenga

Kunyura kana akadaro chinoshingaira wemafuta zvinodhaka sezvo quinidine sulfate? Mirayiridzo dzokushandisa anoudza kuti womuchato ane nomumukanwa mumiririri kunoita wevasungwa wayo mukuru muropa mushure maminitsi 95.

Maitiro medicament pamwe mapuroteni vanenge 77-80%. biotransformation Its rikaitika chiropa. Saka vamwe vakaumba nomukaka cardiotonic chiito.

The hafu-upenyu chokushandisa uyu maawa anenge 7. Zvakange anobviswa mu neitsvo. By acidification kuti weti excretion medicament kunowedzera uye kana ayo alkalization - hwakaipa.

Kubva zvaanoda?

Ndezvipi zviratidzo yokushandisa zvinodhaka ane "quinidine"? Mirayiridzo Dzokushandisa rinoti kuti chinangwa zvinodhaka anoruramiswa chete zvinotevera nyaya:

• panguva atrial tachycardia, AV-tachycardias, extrasystoles ventricular uye supraventricular, yokurwiswa atrial fibrillation uye flutter;
• kudzivirira yokurwiswa tachycardia (supraventricular uye ventricular), uye ventricular fibrillation;
• mushure cardioversion kuramba sinus mutinhimira.

Kurambidzwa kushandiswa

Ndezvipi ezvinhu omurwere kurambidza kushandiswa mishonga "quinidine"? Mirayiridzo yokushandisa (mutengo mishonga dziri pazasi) rinoshuma contraindications hwemabasa zvinodhaka, zvakadai:

• cardiogenic kugwinha;
• AV-chigumbuso (wechipiri kana wechitatu dhigirii);
• thrombocytopenic purpura, iyo yakatanga pashure achitora zvinodhaka;
• nyonganyonga (zvakakomba) intraventricular conduction;
• tutira bazi misa;
• Digitalis kudhaka, icho pamwe conduction abnormalities;
• chinhu sema pavakanzwa zvinodhaka;
• myasthenia gravis.

Medicament "quinidine": mirayiridzo kushandiswa

Bvuma chishandiso inofanira kuva mukati maminitsi 60 vasati kana pashure maminitsi 125 pashure kudya pamwe zvakazara girazi remvura. Kana uchida kuderedza irritant mugumisiro zvinodhaka riri mucous Kamudzira ari zvomudumbu turakiti, zvakakodzera kutsiva mvura nomukaka.

Refu mushonga hauna varumbidzwa kutsenga kana apwanye.

Standard chipimo chemushonga pasi kufunga 200-300 MG mahwendefa nguva mana daily. Kana supraventricular tachycardia (pamwe paroxysms) mari iyi yawedzera kusvika 400-600 MG maawa ose 3 pamberi Mufananidzo paroxysm zvakakwana. In atrial fibrillation, medicament kugamuchira 200 MG ose 2 chasa (5-8 nguva zuva). Pakazoti kwerunyararo dose ndiyo 200-300 MG kanokwana rimwe zuva.

Alternative regimens: 400 MG (kana pasina nezvokubvuta akanga stoped, ari 200 MG) ose maminitsi 60 kusvikira zvakakwana kumira kurwiswa kana kuti vabudirire zvachose chipimo chemushonga pakati 1 g

Pasina divi anokonzerwa pashure yokutanga dose iri zvakazosunungurwa negashiro uwandu medicament kuti ngazviwedzerwe MG 600. Kutora mushonga zvinopfuura 4 magiramu pazuva hakubvumidzwi.

Dosing vana

Mune dose kurapwa ushandiswe vana "quinidine Dyuruls"? Mirayiridzo yokushandisa, pediatricians ratings vanoti mureza chipimo chemushonga kuti mumiririri uyu vacheche 6 MG / KG 5 nguva pazuva. Prescribers vanofanira kuva chiremba chete ane ruzivo, zvikurukuru kupupura.

Zviito ne-hunhu

Migumisiro ipi akaipa anogona kuitika mushure kushandiswa mishonga "quinidine Durules"? Mirayiridzo yokushandisa, tsananguro zvinodhaka uku kunoratidza zvinotevera nenjodzi:

• asthenia, vakawedzera pakureba QRS, myasthenia gravis;
• ectopic ventricular vakurumidze anorova, kunzwa kurasikirwa;
• kurasikirwa kudya, ventricular fibrillation, arterial thrombosis, nechepazasi BP;
• ziso vachivavhiringidza, ventricular tachycardia, paroxysmal, tinnitus,
• asystole;
• kuda kurutsa, sinus bradycardia, hepatitis, abdominal marwadzo, kuvhiringidzika;
• gastralgia, nomusoro, kurutsa, thrombocytopenia, manyoka, dzungu, haemolytic kupererwa neropa;
• nefivha, lupus-kufanana chirwere ganda nekumhanyirira.

zviitiko ovhadhozi

Ndezvipi zviratidzo ovhadhozi anogona kukonzera mishonga "quinidine Dyuruls"? Instructions, mhinduro kubva nyanzvi nezvazvo kuratidzwa akadai tinnitus, kuora mwoyo pamusoro cardiac basa, donhwe BP, dzungu, atrial flutter, diplopia, quinidine kuvhunduka, kunzwa kurasikirwa.

Kubvisa inoti zvakadaro sei ushandiswe gastric lavage, okisijeni wedzerai, vane chirwere cheBP vamiririri, pacing, hemodialysis uye ventilator.

zvinodhaka kwavatori

Sei kubata mushonga interacts pamwe fuma sezvo Quinine? Mirayiridzo yokushandisa (mutengo wongororo kuti medicament zvichakurukurwa panopera nyaya) akashuma kuti mubatanidzwa uyu kunowedzera toxicity zvose.

Uyewo, "quinidine" mapiritsi anosangana anotevera mishonga:

• zvinodhaka Antiarrhythmic kuvandudza cardiodepressive chiito.
• Anticholinesterase zvinodhaka uye mishonga hunowedzera zvinokonzerwa kalisodergaszczye "Quinidine".
• zvinodhaka Anticonvulsant kuderedza ropa kwevari "Quinidine" uye kubudirira kwayo nokuda kweiyi ayo muviri.
• Laxatives kuderedza kubudirira uye mumisasa zvinodhaka muropa pasi pakudzokorora.
• Mishonga alkalising kuti weti, kunowedzera ngozi chepfu siyana.
• Zvinodhaka "amiloride" uye "Amiodarone" kuderedza kubudirira "Quinidine" uye urebese ayo penguva QT, ukuwo.
• Acetylsalicylic asidhi kunosvika ropa, petechiae uye anotsigirwa ropa kubva zvomudumbu hurongwa.
• Medicaments "Warfarin" uye "Verapamil" - kunowedzera anticoagulant mugumisiro wokutanga uye chechipiri kuderedzwa mwero excretion.
• Drug "Haloperidol" - anowedzera kugutsikana kwayo muropa uye anowedzera mukana nenjodzi.
• Zvinodhaka "Hydroxyzine" uye "dextromethorphan" - vakawedzera ndingangokuvara zvakakomba arrhythmia pamabiko rokutanga uye rechipiri muropa.

chaicho mashoko

Nokungwarira chaiyo anorondedzerwa mishonga pachii chisingaperi mwoyo nokukundikana rwakazara 2-3, tachyarrhythmia (ventricular) ane elongation penguva QT, sinus raiva pedyo nebundu, AV-blockade 1st dhigirii, asima, hyperthyroidism, hypotension, chenjera zvirwere emphysema , angled-kuvhara yemaziso, hypokalemia, chiropa kukundikana, thrombocytopenia, prostate hyperplasia isiri yekenza, chisingaperi renal kukundikana, lactation, nepamuviri uye psoriasis.

Vanhu vane myocarditis nezvimwe zvirwere myocardial apo kugamuchira "Quinidine" Kugara kudzora zvokurapa kunodiwa. Asati kurapwa, murwere anofanira nokururamiswa zviratidzo hypokalemia uye kukundikana mwoyo.

The kurapa kunodiwa kuti kuramba kuongorora ECG Data ari peripheral ropa uye hemodynamics.

Similar zvinoreva, mutengo

Drug analogues nezvazvo kakawanda. Nyanzvi vanoti kwavari zvinotevera zvinoreva: "Kinidin Durules", "Bretilat", "procainamide", "Etatsizin" "Lidocaine", "Amiokordin", "Propanorm", "Amiodarone" "Verapamil", "Propranolol", "Ritmonorm ".

Kana mutengo mishonga yakadai "quinidine" uye "quinidine Durules" pamusoro, vagari venyika yedu, havambozivikanwi nokuti kuti zvinodhaka izvi havachasungirwi inotengeswa Russia. Zvisinei, vanogona kutenga muUkraine. Mari zvinodhaka munyika anenge 540 uye 670-679 Hryvnia ukuwo, izvo zvakaenzana 1380 uye 1760-1780 rubles.

Reviews

Vanoti chii pamusoro medicament chipo vanachiremba uye dzimwe nyanzvi? Maererano navo, chokushandisa ichi chinoratidza kuti kubudirira chaizvo antiarrhythmic kwezvinodhaka, chakanaka uye zvakasimba zvokuti kubata zvirwere zvakadai ventricular uye supraventricular tachycardia. Zvisinei, zvinofanira kucherechedzwa kuti kutsvaka "quinidine" piritsi iri Pharmacies Russian hazvibviri. Nokuti kuti mishonga akanga risingabatanidzwi vakasununguka kuparadzirwa, uye haasisina kushandiswa muzvipatara. Doctors tsanangura ichi mamiriro ezvinhu kuti kune ngozi uye hubudirire uyewo inokwanisika dzomuzana iri mishonga kumusika, uko ari kushingaira kushandiswa chete zviratidzo. Muchiitiko chino, vanamazvikokota vanoti quinidine sulfate kuramba kushandiswa senzira constituent pamusoro multicomponent zvinhu zvakawanda Anti-arrhythmic zvinodhaka.