Lactulose: mirayiridzo yekushandisa

Lactulose is stereoisomic artificially synthesized of lactose - sugar sugar. Kungofanana nayo, lactulose molecule inosanganisira zvakasara zvemakemikari e fructose uye galactose, asi mumasikirwo aya chinhu hachiitiki.

Lactulose, iyo yakasanganiswa yakawanda yepuruvara, yakatanga kuwanikwa kubva ku lactose muna 1929, asi mishonga yayo yemishonga yakawanikwa kare gare gare. Migumisiro yekushandiswa kwayo yakatanga kurondedzerwa mushure memakore makumi matatu. Parizvino, zvinodhaka zvakabva pane izvi ndezvimwe zvezvinonyanya kushandiswa uye zvakakurumbira .

Lactulose, murayiridzo wekushandisa kwayo inotsanangura zvakadzama zvairi, ndeyekirasi yeiyo inonzi prebiotics - zvinhu zvinopinda mumuviri pamwe chete nezvokudya, asi zvisingaiti uye hazvisi pasi pekudya. Kukosha kwavo kunowanikwa mukuti ivo vanokurudzira kukura kwe microflora inobatsira mumatumbo, iyo inobatanidzwa mukudya. Munyaya iyi-musiyano mukuru pakati peiyo prebiotics uye yakawanda yemarara, iyo inokonzerwa nemigumisiro inokonzerwa nekukanganiswa pamusana unotapira wemukumbo. Kuwedzerwa kwepachiviri peristalsis ye lactulose (murayiridzo wekushandisa kwemishonga inotsanangura chiito chayo) inokonzerwa nekuwedzera kwomuviri wayo wevasmotic. Chigaro chinobva pamusangano uyu chinowedzera kuwanda uye mvura, uye semugumisiro, kune kuderedza.

Mukuwedzera pane zvinokonzera kukora, lactulose inowedzerawo kuvhara kwebi, inosimudzira chiropa basa uye inoderedza zviratidzo zvekunyanyisa kunokonzera. Mushure mekushandisa kwayo, kuwanda kwezvinhu zvakasviba muropa , kunyanya, ammonia, zvakanyanya kuderedzwa. Munharaunda ivo vanoita kuti vasave nehupombwe nemasero emuropa - hepatocytes. Zvisinei, kune varwere vane chirwere chisina kukwana, icho chinoitika, somuenzaniso, muropa rechirwere, zvinokonzera metabolites zvinoputirwa kubva mumutsipa uye zvine uroyi hunoita huropi. Somugumisiro, murwere anoumba chinyorwa chisinganzwisisiki systemic encephalopathy (PSE) - chirwere chakakomba chinonzi neuropsychic syndrome. Iyo inoratidzirwa neururumuscular disorders, kukanganiswa kwekuita uye kuziva. Lactulose (murayiridzo pamusoro pekushandiswa kwemishonga inoratidza izvi) ndiyo inonyanya kushandisa mishonga inoita kuti zvikwanise kuderedza mamiriro ezvinhu emuurwere muSES: inopa kubviswa nokukurumidza kweammonia kubva mumuviri uye kunodzivirira kubata kwayo muropa.

Izvozvo zvinokonzerwa nelactulose pamubumbo microflora zvakafanana neyezvokudya zvefibre, zvakashandiswa pakurapa kuvimba. Zvidzidzo zvakaratidza kuti semugumisiro wekushandiswa kwayo mumatumbo, kuwanda kwelactobacilli inobatanidzwa mukudya kwezvokudya kunowedzera kuwedzera. Mukuwedzera, iyo inoshandiswa pamhando dzakasiyana-siyana dzepachivi zvirwere: kuderera kwehuwandu hwebhakitiriya hwepathogenic mudumbu ndeimwe yemigumisiro yekutora Lactulose. Mirayiridzo yekushandiswa kwemishonga inoti inoti inoderedza kubereka kweSalmonella uye ma causative maitiro emaronda - Shigella. Nemhaka yezvinhu izvi, lactulose inoshandiswa pakurapa dysbacteriosis.

Kusvika iye zvino, makumi emakumi maviri ekugadzirira anobva ku lactulose anobudiswa munyika: Dufalac, Normaze, Livolak, Lactofiltrum, Laktusan nevamwe. Lactulose, iyo mirayiridzo iyo inotsanangura zvakajeka kuti zvinogona kuitika migumisiro yezvinodhaka, ndeyeiyo yakakosha yevana vaduku, vakwegura, vane pamuviri uye vanodhakwa vakadzi. Inobata zvinyoro uye zvinyoro, zvichiita pasina kuisa pfungwa dzisina kufadza. Pakati pemigumisiro yemigumisiro - marwadzo emimba uye flatulence. Dzimwe nguva pane kushungurudza uye kurutsa, kazhinji kunobatanidza nemumwe munhu kusagadzikana kwemishonga. Munyaya iyi, kugamuchirwa kwayo kunofanira kumira.

Nzira yekurapa ne lactulose, inowanikwa, inenge mwedzi miviri. Kurapa kwekudzivirirwa kwe lactulose (murayiridzo unonyatsoratidzira maitiro anodiwa emushonga) anotanga kushandiswa kune 15-45 meri pazuva (chido chinogadziriswa pachavo). Mushure memazuva mashomanana, vanoenda kune imwe chirongwa chekuchengetedza - zvichave zvishoma. Vana syrup lactulose (murayiridzo unoratidza izvi) inokurudzirwa kuti inotorwa mumwero we 5 ml pazuva. Apo PSE pakutanga kwechirwere, inoputika mumvura uye inorasirwa rectally 3-4 pazuva. Pashure pokusimbiswa kwemamiriro ekurwara, mushonga wacho unotorwa nemuromo pane imwe chirongwa chakataurwa nachiremba.