"Avastin" kugadzirira: mhinduro dzevarwere, mirayiridzo yekushandiswa, migumisiro

Mushonga we "Avastin" unofungidzirwa kuti an antitumor agent, iyo inoreva maitiro anonzi monoclonal antibodies. Panguva yekushandiswa kwechirwere, kune kuyerwa kwemaitiro ekugadzirisa kwehutachiona uye hutachiona hwehutachiona hwehutachiona hwehutachiona hwakasiyana siyana, kunyanya izvo zvine chokuita nechero pakati pevakadzi, colon, uye pancreas uye prostate gland.

Maitiro ekugadzirira

Chirwere ichi "Avastin" chinobudiswa nenzira yekufungisisa, iyo inogadzirirwa kugadzirisa mhinduro yekudzivirira, inogona kuva isina kujeka kana neine tinge isina kuchena.

Chinhu chikuru chechirwere ndeye bevacizumab. Ichi chigadzirwa chinowanikwa mumapakiti e 100 mg, pane 4 ml yezvisikwa zvinoshanda, uye 400 mg / 16 ml.

Pharmacological action

"Avastin" chirwere chinopesana nemamota, chinotadzisa kuumbwa kwemidziyo mitsva inopa michina uye oksijeni kune zvinyuchi zveeoplasm, uye zvino inobvumira kuendesa chirwere chinouraya kubva pachigamba chinotyisa kusvika kune chisingagumi. "Avastin" (kuongororwa kwevarwere uye vanachiremba - ichocho chisimbiso) chiri kuita zvakanyanya pamasitasisiti emakumbo akasiyana-siyana akaipa.

Nokuda kwemugadziro uyu, unhu hunopararira mumasukisi mune zvishoma, kunze kweizvi, unobviswa mumuviri kwenguva yakareba, iyo inobvumira kuchengetedza huwandu hunokosha hwechikamu chikuru chechirwere, uchichiisa zvakakwana maererano nemirairo - kamwe chete mazuva gumi nemashanu. Zvinodhaka hazvibvi kuburikidza nechiropa kana zviputi, asi kuburikidza nemasero ose emuviri kwemazuva gumi nemasere varume, uye nevakadzi - 20.

Asi "Avastin" yakanaka here? Mafungiro evarwere anotaura kuti ichi chirwere chinoshanda zvikuru kana chakabatanidzwa nemakemikirini emhando dzakasiyana dzekenza. Ichi chinodhaka chinowedzera kuponeswa kwemazuva ose mumapoka evarwere, uye kuwedzera kwechirwere hakuiti.

Avastin: zviratidzo zvekushandiswa

Ichi chinodhaka chinowanzoshandiswa mukurapa kwekenza. Vanachiremba vanomugadza:

1. Nechirwere chemastatic colorectal cancer. Mishonga inokurudzirwa kuti ishandiswe pamwe chete nemakemikrasi zvichienderana ne "Fluoropyrimidine".
2. Nekenza yemasasa yepfupa. Inoshandiswa seyokutanga yerapa nePaclitaxel.
3. Kana isingagoni kushandiswa, pamwe chete nekuvapo kwemazana akawanda emasitema kana kuti kwete-planar, isina kamudiki kenza yemapapu emapapu - seyokutanga yekurapa pamwe chete nekemotherapy inobva pamishonga yeplatinum.
4. Nekufambira mberi kana mastraseti yemukenza inobata mafungiro emagetsi - senzira yekurapa kwepamweya pamwe ne "Interferon alfa-2a."
5. Ne glioblastoma, pamwe chete ne radiotherapy uye "Temozolomide" kune varwere vanongobva vaongororwa, mune monotherapy kana pamwe chete ne "Irinotecan" mune varwere vanezve kudarika glioblastoma kana nekupfuurira kwekenza.
6. Varwere vakaonekwa kuti vane "kuipa kwakagadzirirwa nhengo dzepabonde dzevakadzi," uye nepisitoni yepisitoneal. Muchiitiko ichi, zvinokurudzirwa kuudza Avastin sechirwere chekutanga chekurapa pamwe chete naCarboplatinum uye Paclitaxel.

Mukuwedzera, mushonga unorayirirwa pamwe chete ne "Carboplatinum" uye "Gemcitabine" nechirwere chinoramba chichiwedzera kana chinokonzerwa nemishonga yeplatinum-based nevakadzi vane chirwere chepabonde kana peritoneal vasina kumbobatwa nechirwere ichi kana rumwe rudzi rweVEGF inhibitor.

Zvakanaka sei kupinda "Avastin"?

"Avastin" (kuongororwa kwevarwere uye vanachiremba vanosimbisa izvi) - mishonga yakanaka, asi inofanira kunyatsogadziriswa, uye iri pasi pekutarisirwa kwechiremba. Inorambidzwa zvachose kupinda jet - chete intravenously, uye zvishoma nezvishoma sezvinobvira. Iko kuverenga 5 mg pa1 kg yehutano hwemuviri kamwe chete kwevhiki mbiri.

Chiyero chinodiwa chekufungisisa chinoderedzwa mu 100 ml ye 0,9% sodium chloride. Nhamba yekutanga inokurudzirwa kuti inotarisirwa kweawa imwe nehafu mushure memakemikari, ipapo chirongwa che "Avastin" chinoitwa mushure mekunge kana mushure mekuita. Kana murwere asingatambudziki chero dambudziko mumutambo wekutanga wezvinodhaka, zvino inogona kuendeswa mberi mukati meawa, uye majekiseni ose anotevera - kwehafu yenguva, asi chete kana yechipiri pfuti ichiendeswa kumurwere zvakanaka.

Chirwere chechirwere ichi, kunyange pakuvapo kwemigumisiro isina kunaka, hazvikurudzirwi kuderedzwa, kana zvichidiwa, ipapo kurapwa kunomiswa kana kuregererwa.

Kana murwere ane chirwere chinokonzera chirwere chepakati, chirwere chekutanga chinotenderwa 5 mg pa kg yehutano hwemuviri kamwe kwemazuva gumi nemaviri kana 7.5 mg / kg, asi mazuva ose maviri. Kana rutivi rwechipiri rwerapi, chirwere chacho chakawedzerwa kaviri.

Kana mukadzi akaonekwa kuti ane kenza yemazamu, munyaya iyi, sejisi rekutanga, zvinokurudzirwa kuverenga mishonga pa 10 mg / kg uye kuvhara kwevhiki mbiri. Kana vatatu, asi munyaya ino, 15 mg nekg ye uremu hwenyama inotorwa.

Kana pane zviratidzo zvokufambira mberi kwehutachiona, kurapwa kunomira.

Nechinhu chisingawanzogoni kushandiswa, mastastrase kana kuti inogara isingaiti kanzira kana kuti isina-duku-kenza kanzera mumapapu, kurapwa kunoitwa pamwe chete nekemotherapy pamwe nePt zvinodhaka (kwete kupfuura maitiro matanhatu), uye zvino mushonga unoshandiswa se monotherapy.

Kana zviratidzo zvekuwedzera kwekenza zvichioneka, Avastin inofanira kuregwa. Mirayiridzo yekushandisa inoti: kana pasina kuwedzera, kuverenga kuri 7.5 mg / kg kwemazuva gumi nemaviri kana kuti chirwere chacho chakavirirwa uye inorowa vhiki nhatu dzose kunze kwe "Cisplatinum" kana "Carboplatinum."

Nekenza yemusero wesero, chiremu hachifaniri kudarika 10 mg / kg kamwe kamwe mazuva gumi nemashanu. Kana pane zviratidzo zvokufambira mberi kwechirwere, ipapo kurapwa kunomira.

Hazvisi izvo kuti vakwegura vashandure muroti.

Avastin: overdose

Kuwedzeredza kwechirwere kunowanzoitika kakawanda kana murwere akapiwa chirwere chakakura che 20 mg pa kg yehutatu hwemuviri kamwe chete mazuva gumi nemaviri.

Muchiitiko ichi, migraine kurwiswa kunogona kuonekwa mune imwe nzira yakaoma, mukuwedzera, pane kuwedzera kwemigumisiro isina kunaka inotsanangurwa pasi apa. Ikoko hakuna mushonga unokosha, chete chirwere chinoshandiswa chinoshandiswa.

Avastin: madhara

Avastin imishonga yakanaka kwazvo, inowanzobatsira kubatsira kuderedza kufambira mberi kwechirwere chakakomba, asi kazhinji zvisingaoneki zvinoratidzwa zvinowanikwa mune varwere. Muzviitiko zvisingawanzoitiki, zvinogona kunge zvakakomba zvikuru:

1. Kupera kwemuviri nemukumbo.
2. Internal bleeding.
3. Arterial thromboembolism.
4. Dambudziko reRopa rinobuda uye proteinuria inokura. Zvingangodaro, izvi ndezvikonzero zvekutendesa kwechiremba.

Mukuwedzera, varwere vakanyorerwa Avastin, migumisiro yakaipa inoratidzwa uye zvimwe zviratidzo:

• Iyo yakadzika inopisa, kufanana kwakakosha kwemoyo kusakatika, supraventricular tachycardia, kubuda ropa;
• Leukopenia, neutropenia, pasi hemoglobin, thrombocytopenia;
• Kusagadzikana mu peritoneum, indigestion, ropa mumadziya, kupisa kwepachirwere mumuromo, kubuda ropa, kuvhara mumimba;
• Kubvambura kubva mumhino, kusava kwe oksijeni, mapurmaria thromboembolism;
• Danda rakasviba, dermatitis, kuchinja kwerudzi rwetema;
• Kurasikirwa kwevira, kupera kwakakosha mumuviri, syncope, migraine, kurohwa, kunzwa kwehope;
• Kuona kuora mwoyo;
• Pain inzvimbo iyo mushonga unorayirwa;
• Kubvisa kubva muchibereko, kutapukirwa kwemuguta wemuguta, kunzwa kwekurumidza kuneta, kupera mvura.

Contraindications for use

Ndi "Avastin" yakakodzera munhu wose here? Kuongororwa kwevarwere kunotaura kuti ichi chinhu chinoshamisa chemishonga, asi zvakadaro iyo inopesana nechokuita, uye isati yatanga kurapwa, chiremba anofanira kutaura pamusoro pavo. Iyo mishonga haigone kurongedzwa mumatambudziko anotevera:

• Kana paine kusagadzikana kwakanyanya kwezvinhu zvakasimba zvinoshanda;
• Kune zvirwere zvinotapukira zvemaziso uye periocular region;
• Intraocular inflammatory processes occur;
• Age kusvika makore 18;
• Kubata uye lactation.

Uyezve, kana murwere ane mukana wekuita chirwere, chirwere cheAvastin chinopiwa chete mushure mekunge murwere aongororwa uye achisvika pakugumisa kuti mishonga ichave yakabatsirwa.

Special instructions

Mushonga unofanirwa kutarisirwa chete nechiremba ane ruzivo rwekuita majekiseni epraocular.

Mushure mekunge chigadzirwa chacho chave chakatumirwa, hachina kukurudzirwa kwechinguva kuti upinde seri kwegumbo yemotokari uye kuita basa rinoenderana nemichina, uye zvose nokuti nguva dzisingatarisirwi maziso zvinogona kukura.

"Avastin" (mugadziri anoratidza izvi mumirayiridzo) inofanira kuchengetwa chete mufiriji, uye hapana kana iyo inogona kunge yakaoma. Inongowanikwa chete pamutemo.

Avastin anobata sei nemamwe madhiragi?

Mushonga we "Avastin" hauna kufanana nemhinduro dze dextrose. Uyezve, mishonga inogona kuwedzera mungozi yekuva nemagumisiro akaipa kana akabatwa pamwe chete nemishonga yakadaro:

• "Sunitinib malate" - kukura kwe microangiopathic hemolytic anemia inogona kuitika;
• Platinum uye mitoro - zvinokonzera kukura kwezvinetso zvehutachiona hunopararira, neutropenia yakakomba, dambudziko rekufa rinowedzera;
• "Panitumumab" uye "Cetuximab" - inowedzera kutyisa kwezvinodhaka uye inotungamirira kurufu.

"Avastin" mune ophthalmology

Munguva pfupi yapfuura, pepanhau rakashuma kuti mushonga we "Avastin" unoshandiswa ne ophthalmologists kuti uite zvirwere zvemaziso uye unopa zvibereko zvakanaka kwazvo. Asi ndizvo zvakadaro? Chii chinogadzirwa nemuiti pamusoro peizvi? Izvi zvinogona here kugadzirisa kwete kukura kwechirwere, asi zvakare kurapa zvirwere zveziso?

Hungu, chaizvoizvo pane ruzivo rwekuti vamwe varwere, mushure mekunge vanzwa nezvekubatsira kwechirwere chemaziso, vakasarudza uye vakatema "Avastin" mumavreous, asi mhinduro dzakashata. Mushonga wacho hauna kuunza chero mushonga, pane zvinopesana, wakatungamirira kukuti vanhu vakangopofumadzwa chete. Kambani "Rosh" yakasimbisa kakawanda kuti "Avastin" mune ophthalmology haigoni kushandiswa, chinangwa chayo chakasiyana.

Mishonga iyi yakagadzirirwa kuderedza kusimba kwekukura kwemidyo yeropa iyo inopa neoplasm yakaipa, nokudaro kuderedza kushanda kwekukura kwemuviri. Ndicho chikonzero usati watanga kurapa uye uchiteerera kusingabatsirwe mazano, zviri nani kuti uone chiremba.

Avastin: analogues

Kana zviripo kune vatsigiri vangave vane chinhu chimwe chete chakakosha mukugadzirwa kwavo, saka havana Avastin. Nhaurirano pamusoro pemichina yekuita ndeye, uye inopawo zvibereko zvakanaka mukuderedza kukura kwemidziyo yeropa uye nekugadzirwa kwemakumbo ekenza. Kwavari zvinokwanisika kutakura:

• "Arzerra".
• "Campas".
• "Rituximab."
• "MabThera" nevamwe.

Asi inofanira kuyeukwa kuti chiremba anofanira kusarudza analogo.

"Avastin": kuongorora kwevarwere uye vanachiremba

"Avastin" (mirayiridzo yekushandura inosimbisa izvi) ndiyo chete mishonga inosanganisira bevacizumab, inobatsira kuderedza kukura kwemitsipa yeropa inopa chirwere ichi uye zvinotadzisa kufambira mberi kwechirwere. Vazhinji vechiremba avo vakaona kusimba kwechirwere mumurwere, taura kuti mushure mokunge majekiseni maviri, kune kuwedzera kunokonzerwa nekukura kwechirwere, chinhu chikuru ndechokutora mishonga yacho zvakanaka uye kwete kuisunganidza nemishonga iyo pamwe chete inogona kukuvadza zvakanyanya murwere.

Kupfupisa, munhu anogona kutaura zvakasimba kuti Avastin (muvambi - F. Hoffmann-La Roche) akanaka, iyo inobatsira kupedzera hupenyu hwevarwere vane tumaronda yekenza. Asi kungoishandisa chete kunokosha pasi pekudzivirira kwakasimba kwachiremba, zvisinei kuti migumisiro inogona kuregererwa uye kuguma kusuruvara.