Inorwisa mabhakitiriya "Linezolid": mirayiridzo kushandiswa, mutengo dzomuzana, kusunungurwa chimiro uye wongororo

Vakawanda anozivikanwa mushonga kwemabhakitiriya kana kutapukirwa noutachiona amenable kurapwa pachishandiswa kwakajairika zvinodhaka. Zvisinei, pane utachiona kuti dzakashandisa anonzi nosocomial ezvinhu. Pakurwisa wavo rakaoma chaizvo, nekuti mishonga zhinji vakanga havambokwanisi kushanda. Inorwisa mabhakitiriya "linezolid" rinoreva avo zvinodhaka izvo zvinogona kugadziriswa kunzi saka zvirwere nosocomial kana zvimwe husingakwanisi mamwe marudzi zvinodhaka. Ndizvo nezvazvo uye ichakurukurwa munyaya ino.

tsananguro

Drug "Linezolid" mirayiridzo inoshanda inorwisa utachiona yakafara-chakarondedzera. Maererano zvayo zvinokosha zvivako uye unhu ndeye kukirasi oxazolidinone kuti simba uye kuwanda Varwisei tusingaoneki muzvinhu zvakawanda zvikuru kune zvinodhaka "Vancomycin" nezvimwewo ane zvakafanana sezvamunoita.

Nhasi, kune marudzi anoverengeka inorwisa utachiona mumiririri "linezolid". Product chimiro, kunowanzoitwa kushandiswa kurapa, - mumwe Kamudzira goko mahwendefa ane 400 kana 600 MG kuti basa fuma. Uyezve, mune zvokurapa tsika aizomupa mhinduro inowanzoshandiswa, izvo neimwe milliliter rine 2 MG pakati vanoshingaira fuma uye upfu (granules) kugadzirira kuturika, wevasungwa yezviri chirungiso inova 100 MG pa 5 ml chokupedzisira chigadzirwa.

zvairatidza

Sezvambotaurwa munyaya ino, mushonga "Linezolid" mirayiridzo Chinyorwa anokurudzira kuti ukashandisa kuvapo zvirwere zvinokonzerwa nemabhakitiriya husingakwanisi dzimwe nemishonga. Izvi zvinosanganisira zvose giremu-akanaka uye giremu negative tusingaoneki kungova anaerobic kana Kurovedza marudzi kuti taumba nemishonga (kugadzikana) kuti methicillin, gikopeptidnym yeimwe, kuti penicillin nezvimwe inorwisa mabhakitiriya.

The pamazita zvirwere izvo "linezolid" medicament kurairirwa zvinosanganisira:

• chipatara kana munharaunda vawana nemabayo;
• ganda noutachiona;
• nyoro tishu noutachiona;
• Other Zvirwere zvinokonzerwa asingaurayiwi nemishonga Enterococcus.

Kazhinji, asati kushandisa zvinodhaka tsvakurudzo iyi kuziva nemishonga kuti utachiona kune zvimwe zvinodhaka. Kana hapana akawanikwa, kurapwa rinoitwa achibatsirwa nedzimwe zvinodhaka inorwisa utachiona.

Contraindications

Huru uye kukosha contraindication pakushandisa mushonga 'Linezolid' mirayiridzo kushandiswa zvinoreva hypersensitivity kwairi. Zvinonzi zvakare haana yakarumbidza kushandisa mushonga kunorapwa dzevarwere vari kutora zvimwe zvinodhaka kubva boka kuti Mao FIs. Mukuwedzera, hazvina pachii mumiririri uyu pamwe tricyclic antidepressants uye zvinhu anokwanisa kumutsa BP (epinephrine, dopamine, uye dzimwe triptan).

Kugadzirira "linezolid" (Mahwendefa, aizomupa mhinduro uye slurry) iri contraindicated mu zvirwere zvakadai neBP, hyperthyroidism, kana seratoninovy carcinoid chirwere, feohromotsitoz. Kuvapo contraindications izvi zvinofanira kuonekwa pamberi kutanga kurapwa kushandisa zvinodhaka.

Mashandiro chiito zvinodhaka mumuviri

Action "Linezolid" mushonga nokuda kukwanisa kwayo chaivharidzira rokushandura muitiro mapuroteni hurongwa huri mumasero kwemabhakitiriya. Nokuda kuwanda zvigare anomiswa uye pane rufu rwavo. Kupikiswa kuti mushonga ari ruzhinji mabhakitiriya anogadzirwa zvishoma nezvishoma.

Pashure ingestion zvinodhaka vanoshingaira chirungiso anoumba metabolite hydroxyethyl glycine. The mwero nokuwadzana raro mapuroteni eplasma inowana ane 31% unongotaura. Murabhoritari zvidzidzo vakawana kuti mukomboni chinopinda kunyika nyama yose uye nhengo. Rinewo anokwanisa apfuure placenta kupinda mudumbu uye mukaka (pfuma iyi mushonga kunooneka kunenge kutora mushonga nevakadzi vane pamuviri uye lactating).

The hafu-upenyu rinoita nenhumbi dzaro metabolite yabudiswa ndiyo maawa 4.5-5. Excretion iri vachishandisa nezvezvimwe zvinetso zvedundira (50% sechinhu metabolite uye 35% sanganisika), uye kuburikidza zvomudumbu turakiti (kwete asingasviki 9%). Complete excretion kunoitika mumaawa 8-12 pashure pakugamuchira medicament.

Sei kutora "Linezolid"

Nyanzvi dzinotaura kuti kakawanda murwere anogona vakazvimiririra kuita chisarudzo pamusoro nzira kugamuchirwa "Linezolid" chinodhaka. Note, mapiritsi, mhinduro uye emulsions zvisina sechinhu yoga kugadzirira, uye sezvo nzira zvinodhaka, ine panguva iyi zvizere mashoko. Pazasi pane pfungwa dzinokosha pamusoro chipimo chemushonga uye nguva yokurapa.

Medicine "Linezolid" mirayiridzo Chinyorwa zvinoratidza kushandisa zvinotevera mazano:

1. A mhinduro aizomupa chinotarisirwa nomutsinga 2 kanomwe pazuva. A chete dose pamusoro 400-600 MG vanoshingaira fuma. Ya kurapwa kunoenderana kwokuomerwa chirwere chacho localization. Kazhinji, zvirwere vakawanda kunoda nguva vanenge 10 uye hapana mazuva anopfuura 14, uye chete zvirwere zvinokonzerwa enterococci, kurapwa kunotora 2 kusvika 4 mavhiki.
2. Kugadzirira "linezolid" (Mahwendefa) rinotorwa sezvo 2 kanomwe pazuva iri mari 400 kana 600 MG por mabiko. Varwere vane makore 5 kusvika 14 makore, kuti chipimo chemushonga rinowanikwa pahwaro uremu muviri uye kwakanga 10 MG pa 1 kg kurema muviri, 2 kanomwe pazuva. The kunonyanyisa dose paminiti ingestion (p.o.) hazvifaniri kupfuudza MG 600. Ya ARV pakutsvaga chete parameters izvo vaionekwa kumusoro.
3. Granules, vakaitwa chinhu emulsion, rakaiswa parutivi apa zano. chipimo chemushonga kukarukureta kana zvakakodzera kuti tiite maererano chete nhungamiro.

Sezvo mushonga "Linezolid" riri basa chete nokuda mushonga uye ari kungoshandisa muchipatara, imwe ovhadhozi kuti chivako ichi uye chitarisiko raidudzwa nemishonga dzinenge chapedzwa. Doctors mu nhoroondo dzavo anotaurwa zviitiko zvakawandisa kuunganidza mumuviri yezviri zvinodhaka fuma yaro metabolites nokuda zvinetso zviri Urinary nadzo uye chiropa. Migumisiro wakawandisa dzakadaro kazhinji nokukurumidza akabvisa, sezvo murwere ari kurapwa pasi kuramba pokudzora unyanzvi.

zvinodhaka kwavatori

Sezvo mumwe chipimo chemushonga siyana mushonga "linezolid" inhoroondo ya intravenous kutarisira zvakakosha kuti mushonga inowirirana chose pamwe dzinokosha mhinduro inoshandiswa panguva kurapwa (5% shuga mhinduro, 0,9% mhinduro kubva yavaibvisa chloride uye Ringer anogadzirisa).

Cherechedzai inofanira kubhadharwa kuti mamiriro varwere, uyo kuwedzera "Linezolid" zvinodhaka adrenergic. Kana kuramba yokupedzisira kwakakwana hazvibviri, vanachiremba vanofanira kuongorora chipimo chemushonga yavo.

Medicine "Linezolid '(zvakafanana sezvamunoita kunogonawo kuenzaniswa nawo) inowirirana zvakazara ne mishonga" Chlorpromazine "," Cotrimoxazole "" Diazepam "uye" Phenytoin ". Kana murwere pamberi pokushandisa mushonga akatora akati kunoreva zvinokosha kuraramisa penguva 3 mazuva asati kurapwa "linezolid" gadziriro.

Zvokungwarira

Sezvo mamwe mazano pamusoro kushandiswa kwemishonga inorwisa mabhakitiriya 'Linezolid' Kurayiridza Chinyorwa rine mashoko chokuita pamuviri vakadzi uye vanhu vane huripo comorbidities. Uyezve, rinotaura mukana nemishonga. Asi zvinhu zvokutanga pakutanga.

Kana mabiko "Linezolid" chinodhaka wongororo vanachiremba kutaura chinokosha yambiro kana raitongwa vakadzi vane pamuviri uye lactating. Izvi imhaka yokuti kubata zvinodhaka riri kukura mudumbu kana achangoberekwa mwana yave insufficiently kudzidza. Kazhinji, kurapwa ane kushandiswa kwayo chete here kana ngozi kuti mudumbu yekudyidzana pazasi zvinotarisirwa kubatsira kuna mai.

A zvakaoma renal uye hepatic kukundikana, dzinodawo nokungwarira pokushandisa zvinodhaka, nekuti metabolites vari yabudiswa kunyanya nhengo idzi, uye kuunganidza zvinhu izvi mavari zvingakonzera Kushatiswa murwere.

nemishonga

Pachishandiswa migumisiro kurapwa zvaanorumbidza, zvisingadiwi zvinoitwa siyana nadzo uye hurongwa pamabiko mushonga "linezolid" kazhinji zvinokanganisa huta uye zvomudumbu nehurongwa. About 10% wevarwere panguva kurapwa vakanga vakachengeta svoto uye nomusoro. A zvishoma zvishoma kunetseka manyoka zvavo, dzungu, uye candidiasis mune nemumuromo mucosa.

Uyezve, nyanzvi yakati pasingadiwi Migumisiro mushonga sezvo peripheral neuropathy, nezvipusha, zvakadai kutadza kuona zvakanaka (kukwira kwayo zvachose kurasikirwa), thrombocytopenia, kweserotonin chirwere, angioedema uye anaphylactic kuvhunduka. Nokuti kuti mushonga wacho chete kushandiswa muchipatara ezvinhu, kazhinji migumisiro dzinodziviswa.

Treatment akaonekwa zvisingadiwi chinja kwevanhu symptomatic uye hurongwa. Nokubviswa zvinodhaka zvinoita chete kana kwokuomerwa nemishonga idambudziko guru kupfuura chirwere aibatwa vaiona asingaurayiwi.

Drug analogues "Linezolid"

Vaverengi kunge vane mubvunzo pamusoro kana "Linezolid" analogues zvinodhaka ikoko. Chokwadi, mishonga musika kana asina kuzara, ine zvinodhaka shoma kuti akafanana izvi inorwisa utachiona sezvamunoita. zvinodhaka izvi anorondedzera dzokuSerbia asingaurayiwi "Zeniks" Norwegian "zyvox" uye Israeli "Linezolid din email". The Zvinoumba zvose zvinodhaka izvi sezvo huru vanoshingaira fuma zvaisanganisira linezolid.

Pane Misiyano pakati nzira uye kugadzirira "Linezolid" pamusoro apa? Mutengo zvinodhaka - ndicho musiyano mukuru. Chokwadi ndechokuti muchiva nziyo, zvinodhaka izvi vanoita womunhu nomuviri zvakangofanana: kunetseka chete tupukanana tusingaoneki, kukonzera chete nemigumisiro zvakafanana contraindications. Hapana zvakawanda mazwi uye nzira kurapwa uye uwandu husingakuvadzi.

Kazhinji, zvikuru anodhura kupinza analogues "Linezolid" mushonga rinoshandiswa chiitiko kuti ichi chaiyo zvinodhaka haamo mune drugstores. Izvi zvinoitika kakawanda, nokuti nemashandisiro ayo akasiyana-siyana varwere kwakaoma zvisingaiti nokuda mishonga inonyorwa uye overdo pamusoro echiShinto haangavi kugadziriswa hapana chemishonga cheni. Kubva ichi chiduku bato bookings saka zvinodhaka uye, mukana pane imwe nguva kutengesa wemari yake yose.

Mari zvinodhaka

The medicaments of oxazolidinone boka kuva kudhura nokuda kunzwisisa multistep kwetunhu fuma iri mishonga mumarabhoritari. Chii "Linezolid" chinodhaka mutengo? Mahwendefa (kugutsikana huru vanoshingaira fuma 600 MG, remidzanga 10 zvidimbu) mu chemishonga ngetani zvinenge 18 zviuru. The kunonyanyisa Kukosha ichi chipimo chemushonga muchimiro zviuru 20 rubles muzana mahwendefa 10. Zvishoma isingadhuri ndiwo mushonga ari dose 400 MG. mutengo wayo vanenge zviuru 17-18 rubles kuti mahwendefa 10.

Kuitwa aizomupa "Linezolid" unogona kutenga zvishoma isingadhuri: remidzanga 10 omumasherufu ose 100 ml achaita mari 7.5-9 zviuru rubles, 10 packs it 300 Rine mamiririta nerimwe - muna 15,3-16,2 zviuru rubles.

The gadziriro chete zita, zviri isingadhuri zvikuru, vanowanzoenda kuva chitsotsi uye, panguva yakanakisisa, hazvina zvazvinoita muviri murwere. Kunyange zvakadaro, kunonoka kurapa chirwere, iyo inobatsira kubvisa mushonga 'Linezolid' pachayo ngozi chaizvo. Ndokusaka nyanzvi dzinokurudzira kuti mushonga chete Pharmacies vane mukurumbira wakanaka.

Comments pamusoro inorwisa mabhakitiriya "Linezolid"

mabhuku akasiyana kunogona kashoma kuwana wongororo pamusoro mushonga mukirasi iyi. Izvi zvinoshandawo zvikurukuru mashoko pamusoro kubvuma kwake, varwere zvatsanangurwa. Izvi imhaka yokuti vazhinji varwere panguva kurapwa vari chakakomba zvikuru ezvinhu, mugorangarira kutakura-mberi nokusurukirwa wavo zvakaoma.

Unyanzvi, zvinozoita sei mishonga "Linezolid" chaizvo zvakanaka. Maererano navo, mushonga anokwanisa kurarama kunyange utachiona husingaurayiwi nemishonga. Naivowo vanoti njodzi yematambudziko nokuda nemishonga kana ovhadhozi zvachose haazovipo. Izvi imhaka yokuti mushonga unorwisa iri chete kushandiswa muchipatara muzviruva. At chiratidzo sema kana nenjodzi kuti mushonga wekutanga vakatakudzwa kubva ose anodiwa kurapwa kuvabvisa.

Saka, isu akatarira zvose zvinodhaka "linezolid". Mirayiridzo kushandiswa, mutengo uye zvinoita zvinodhaka siyana vakarondedzerwa pepa rino zvakadzama. Zvinofanira kucherechedzwa kuti, pasinei kwemitengo zvinodhaka, kushandiswa kwayo vanonzi dzose nyaya. Kuti kusarudza pakurapa varwere zvinodhaka izvi unogona chiremba chete.