Hyperandrogenism vakadzi: hunokonzera, zviratidzo, kurapwa. The hyperandrogenism ngozi vakadzi

Mukurapa, rimwe dambudziko inozivikanwa hyperandrogenism vakadzi. Zvinokonzera, zviratidzo, kurapwa pamwe chirwere chakadai zvinoda kunyatsoongorora uye kutora chikamu vanachiremba vaikodzera. Kunyange zvazvo chirwere ichi Zvakaoma chaizvo kukunda zvachose, vhura vanachiremba nani pasina kunonoka.

Musimboti chirwere

Kana totaura chirwere ichi sezvo hyperandrogenism vakadzi, anoita zviratidzo, kurapwa uye matanho tinongogara chokuita dambudziko rakadai, sezvo matambudziko ari muviri adrogenov. Izvi zvinotungamirira chimiro hadzi chimiro rume miitiro, uye vamwe kuchinja kudaro unofadza. Muudzame, tiri kutaura pamusoro kuratidzwa akadai chitarisiko chiso bvudzi uye muviri bvudzi, inzwi yakadzika, uye anochinja vamwe zvinhu nhamba.

Zvinokosha kucherechedza kuti hadzi kwemakemikari anobudiswa hurongwa zvokurwara kwakakurumbira, uye haigoni kunongokonzera kusingafadzi zvokunze kuchinja, asi anokonzerawo kushaya mbereko. Naizvozvo, kana zviratidzo hyperandrogenism wokutanga, hwobva kuronga kushanyira chiremba.

Sei kuva zvokurwara

The Musoro "hyperandrogenism vakadzi: kunokonzera zviratidzo, kurapwa» Zvakakosha zvikuru kuti naka pabonde, nokuti dambudziko iri kunoratidzwa anenge 20% wevarwere. Saka zvine musoro kuti ateerere zvinhu uye pezvakaitwa kuti kutungamirira kukudziri- chirwere ichi.

Chikonzero chikuru chinogona tsunga AGS - adrenogenital syndrome. Chinonyanya kukosha ndechokuti adrenal mumasero vanokwanisa kugadzira mamwe mahormone akawanda, mukuwedzera adrogenov, zvakadai glucocorticoids. Ekupedzisira kuoneka pasi pokudzora imwe enzayemu. The hwaro chiitiko yavo akaunganidza androgens. Dzimwe nguva vakadzi vari vatovapo pakuzvarwa kuremara yacho enzayemu, zvichiguma munhurume mahormone asina kutendeuka uye dzakaunganidza nguva dzose, kuva mhaka zvisingafadzi kuchinja munhukadzi muviri.

Pane imwe chichiitwa, izvo anovandudza nokuda hyperandrogenism pamusoro adrenal mavambo. Tiri kutaura pamusoro namamota ari adrenal mumasero. Vari akaumba zvakare pamusoro pakanyorwa kuwedzera kuwanda androgens.

Ngozi chirwere yambotaurwa iri nyaya kana pane kugadzirwa munhurume mahormone ari mukadzi ovaries. Uyezve, masero kuti pave Adrogué anogona kukonzera bundu inotungamirwa ari ovaries.

hyperandrogenism chirwere dzimwe nguva nemhaka yokuwana kwemakemikari anobudiswa pathologies dzimwe nhengo, dzakadai pituitary shwanu.

Zviratidzo androgen zvakawandisa

Kana isu kutaura pamusoro zvekuchipatara zviratidzo yakakwirira kuwanda gono kemikari, vanogona kunzi sezvinotevera:

• mburwa;
• pahuma bvudzi kurasikirwa uye pamhazha makwapa (alopecia adrogennaya);

• mumasero sebaceous vanotanga kubudisa yakawandisa secretion, zvichizoita jikichira ganda kunowandawo;
• barifoniya kuti kunoreva kudzamisa inzwi;
• pamusoro dumbu rake uye muchipfuva bvudzi kuoneka.

Zvinokosha kucherechedza kuti hirsutism - kunyanya kukura chinouraya bvudzi riri hadzi muviri, ane chirwere muna 80% varwere dambudziko iri sezvo hyperandrogenism syndrome.

Ane chirwere chakadaro dzimwe naka pabonde zvinobvira Kuvhiringidza kumwedzi, pasina kumwedzi zvakakwana, uyewo myocardial hypertrophy, kufutisa, kushaya mbereko, uye BP.

Kuwanda varume mahormone kunogona kukonzera amplification munhukadzi muviri susceptibility zvirwere zviri siyana. Zvinogonekawo kuneta uye katsika mwoyo.

Acne uye sebaceous mumasero

Kuti kunyatsonzwisisa chokuita zvakadai dambudziko sezvo hyperandrogenism vakadzi, hunokonzera, zviratidzo, kurapwa, uye chirwere vanofanira kufunga kwazvo. Sezvo zvinhu kuparira kukura chirwere, zvataurwa pamusoro apa, zvine musoro kuti kudzidza hunhu zviratidzo.

Kana mukabata dambudziko iri sezvo mburwa, zvinokosha kuziva kuti ndivo mugumisiro keratinization pamusoro follicle rusvingo dzikawedzera sebum kugadzirwa, izvo zvinosimudzira androgen kuwanda, kusanganisira plasma. Kana Kazhinji zviratidzo zvakadai Nachiremba COCs kana antiandrogens, iyo ambotirega yekudyidzana kuvandudza murwere ezvinhu.

Uyewo pasi pokudzora varume mahormone mu androgenozavisimyh dzinodengenyeka kuonekwa pigmented, mukobvu, zvinonyadzisa bvudzi panzvimbo vellus. Izvi zvinowanzoda unowanikwa pakuyaruka. Panyaya iyi, matambudziko androgen pamusoro pemaziso, eyelashes, zvenyama occipital zvikamu zviri zvishoma.

adrenal hyperandrogenism

Zvinokosha kuyeuka kuti adrenal shwanu - vari vaviri mumasero kwemakemikari anobudiswa kuti dziri chete pamusoro itsvo pachavo.

Ndivo panobva 95% zvinoberekwa androgen (Dhea-sulfate). Kuoma kunzwisisa hyperandrogenism chokuita mumasero izvi, mamota pasi ndechokuti zvokurwara iri vachiberekwa zvakasikwa uye anoita pachayo akanzwa pakanyorwa androgenitalnogo syndrome. It zvinotisvitsa vasanyanye dzinonetsa pamwero ari munhukadzi makemikari zvakafanira kuti kubereka mahormone muviri zvakadai glucocorticoids.

Hyperandrogenism pamusoro adrenal mavambo oubslovlena zviri kushaikwa ichi, iyo inosvitsa nokuwedzera kuwanda mamwe mahormone -. pregnenolone, progesterone, etc. kuchinja kwakadaro akapera rakawedzera kugadzirwa androgen ari munhukadzi muviri.

Dzimwe nguva chirwere zvokurwara, iyo kunokonzerwa namamota pamusoro adrenal mumasero kuti pave mukono kemikari. Maererano nenhamba, chimiro ichi chirwere sezvo adrenal hyperandrogenism ndee muna 30-50% yevakadzi vane dambudziko androgen.

Impact pamusoro ovaries

Mukuru wevasungwa kwevarume mahormone zvinogona kukanganisa kushanda ovaries. Kazhinji, dambudziko iri zvinoita pacharo bata kaviri: gipertekoz uye polycystic. Zvakakosha kuti kuteerera ndechokuti pangozi yokuita chirwere ichi mu vakadzi kunowedzera nguva muviri simba zvemitambo.

Ovarian hyperandrogenism iri migumisiro kuderera kukura follicles pasi pokudzora androgens. Nokuda izvi uye umbwa ovaries, mugumisiro pezvakaitwa akadaro anova imperforate kare. Zita yezvokurapa dambudziko ichi - follicular Surgery.

Asi hazvisi zvose matambudziko pematanho ovarian hyperandrogenism Genesisi. Chinonyanya kukosha ndechokuti mukono kemikari anoita somunhu chinhu pamusoro iyo anovandudza zvemamiriro inotungamirwa fibrous connective zvinyama, iyo inosvitsa polycystic. Pakadaro, mashoko akanaka ndechokuti yakafanana dambudziko nezvakaonekwa 5 chete% yevakadzi.

Uyewo kucherechedza kuti chimiro ichi hyperandrogenism, ari naka pabonde ndiko kunokonzera kukundikana nezvebasa mutemo androgen siyana. Izvi zvinoitika panguva yakati sandara iri hypothalamus uye pituitary. Somugumisiro kuchinja kwemakemikari omuviri yekudyidzana.

Signs kuti unofanira kuteerera

Kune nezviratidzo zvinoverengeka inotaridza panowanikwa dambudziko pamusoro apa. Chokwadi kuti tinofanira kuva dzakadai zvokurwara pamusoro ovarian hyperandrogenism mavambo, anogona kuwanika zvinotevera zvinoratidza:

• osteoporosis;
• seborrhea;
• kumeso, kuwedzera mburwa, pane peeling uye kuzvimba, izvo zvakaoma neutralize vanongogara nzira cosmetology;
• tsandanyama atrophy;
• kufutisa;
• kuchinja kukura munhukadzi muviri - masculinization;
• kudzamisa nenzwi (barifoniya);
• kukura bvudzi zvose pamusoro muviri, kunyange mukutarisana;
• paumbwe pamhazha makwapa akasvibirika mumusoro.

Uyezve, pane zvakawanda yechipiri zviratidzo, zvakadai yakawedzera ropa shuga yomuropa, chirwere cheBP, akaderedza kutapata, uye vamwe.

yokufutisa

Kufutisa vakadzi vanogona kukonzera ovarian hyperandrogenism inorondedzerwa pamusoro. In chimiro ichi zvirwere rinowanzoshandiswa ndee nokumutsa estradiol.

Medical kudzidza chaiitirwa, maererano iyo asimbise mashoko anotevera: sei kwevari gono kemikari mukuru, uye pasi yayo kufurirwa estrogens vane zvakananga kukanganisa kukura kufutisa, kuti unoenderana mukono mhando.

pezvakaitwa ava kukonzera jekiseni-zvaanoda amplification kwaizotevera yevasungwa kuwedzera kemikari mumuviri yevakadzi mukono kutambura kubva zvinetso inorondedzerwa kumusoro. Mune zvimwe zviitiko, androgens sei vakadzi kwete underweight kuburikidza epfungwa.

yakavhenganiswa chimiro

Doctors dzimwe nguva kugadzirisa wandei siyana nokuratidzwa hyperandrogenism. Izvi zvinotsanangurwa nokuti panguva iyoyo kune kukanganisa pamusoro adrenal uye ovarian mabasa.

Mukana yematambudziko akadaro kunokosha kuti funga kudzidza chii hyperandrogenism ngozi vakadzi. Kutaura zvazviri, izvi zvinoitika: adrenal androgens, vonyanya ari adrenal omumuviri, saka kuwedzera huwandu varume mahormone vari ovaries. Izvi rinowanikwa muropa, iyo inotungamirira vawedzere kugadzirwa luteinizing kemikari. The yokupedzisira, uyewo, chinokurwadzai nechitarisiko hyperandrogenism syndrome.

Chinowanikwazve hwakakanyiwa siyana zvokurwara zvinogona kunzi zvikuru kunotevera, kudhaka uropi kana pituitary bundu.

Diagnostics

Pakutanga, chiremba anofanira kuparadzaniswa nedzimwe hosha hyperandrogenic pamusoro izvo zvinoita (acromegaly, Cushing kuti urwere, chiropa zvirwere uye nevamwe.). Chinotevera ndechokuti kuziva mahomoni. nzira iyi yaifanira usina chawadya mangwanani. Ongororo kwakadaro kunofanira kuita katatu sezvo mahormone dzakakwirira androgen wevasungwa ari dzichichinja.

Nezvemabasa unokweverwa kuna padanho dehydroepiandrosterone, mukuru zviri izvo zvichava uchapupu adrenal hyperandrogenism. Zvinokoshawo uye mwero ketosteroids mu weti. Kana zviri kunze ndozvakajairwa, zvine musoro kufungidzira kukura zvokurwara.

kurapwa

Hyperandrogenism - ichi chakakomba zvikuru nyaya kusateerera rubatsiro kuvarapi vaikodzera. Uye kana isu kuongorora yose yawapiwa, zvinganzi vakagumisa kuti nechinangwa kuwana ina dzinokosha zvinangwa:

• Removals ganda kuratidzwa;
• normalization kumwedzi;
• Mabatirwo mwana, yakanga kunokonzerwa anovulation;
• kubviswa uye kudzivirira metabolic zvirwere chokuita zvikuru zvawanikwa.

Diet nokuti hyperandrogenism vakadzi anogadzwa nyaya inokosha uremu kuwedzera. Muchiitiko chino, zvakakosha chaizvo kutevera mazano ose chiremba, chete pasi ichi, unogona kuwana zvakanaka mugumisiro.

varwere vaya kuenda nomwana, kazhinji, akarayira kemikari kurapa anogona zvizere ovulation.

Vakadzi vasiri kuronga pamuviri, vanosangana kurapwa, kusanganisira nemumuromo pamuviri, uye mune zvimwe zviitiko, ovarian resection achikanganisa.

Kugadzirira kurapa hyperandrogenism vakadzi iri kushingaira kushandiswa, kana muviri haakwanisi neutralize yakakwirira kwevari androgen oga. Tiri kutaura munowanika "metipred" "Dexamethasone", uye vamwe. Surgery zvaangatarirwa ari chiitiko kuti akaparirwa bundu zvokurwara.

zvabuda

Mukuru wevasungwa kwevarume mahormone ari munhukadzi muviri - zviri kupfuura nechinetso chakakomba kuti kazhinji anova pamusoro pakanyorwa zvirwere hapana zvishoma ngozi. Naizvozvo, kana vokutanga zviratidzo zvokuongorora uye kurapwa yaifanira pasina kukundikana.