DNA methylation: muchidimbu

Methylation ndiye kubatana mumwe kabhoni uye zvitatu rehydrogen maatomu mumwe Morekuru. Fani iyi kuonekwa shoko rokupedzisira zveutano. Ari anoteverwa Implementation kusvika zvose mabasa muviri.

mabasa

Mapoka Methyl (kabhoni uye rehydrogen maatomu) vanobatanidzwa mune:

1. The muviri apindura zvinokangaidza.
2. Development uye kubudiswa glutathione. It anoita somunhu anokosha antioxidant mumuviri.
3. Detoxification mahormone, inorema nesimbi uye makemikari.
4. Kudzora anogumbura kwendangariro.
5. Rokugadzirisa masero.
6. Immune Mhinduro uye murau pamusoro nemavhairasi uye zvirwere, zvichiita kuti kudzorwa T-masero.

. Zvakafanana rinokosha chirongwa DNA methylation. Ngationgororei izvozvo zvizere.

Epigenetic kudzora

способствует передаче паттернов следующему поколению клеток при митозе. DNA methylation mapatani hwezvekukurukurirana kuchinjwa runotevera masero ari mitosis. Tichishandisa ichangopfuura, zvave kuwanikwa kuti muitiro kubatana mapoka kwemaatomu ari airwara-kusiyaniswa zvivako ane zvimwe chokuita paumbwe ndangariro uye synaptic plasticity. K. Miller uye D. Sweet nezvokumwe DNA methylation. Kudzidza Chiitiko wakavatungamirira kuti kugumisa kuti basa methyltransferase dezoksiribonukleinovokislotnoy yekudyidzana yakawedzera mhuka panguva nomusoro mashoko matsva. Izvi zvinobatsira kuderedza kutaura majini izvo vasaziva ndangariro kwendangariro. Mukuwedzera, hachishandi dzinotaura chimwe chinhu. Vaongorori dzinoshuma kuti puroteni reelin Gene activation, kusimudzira shanduko uye synaptic kwokubatana munyaya pathological mukufamba schizophrenia kunokanganisa ndangariro inotungamirwa. Kana chinhu ichi vakaumbwa demitalazy-makemikari kupa DNA demethylation (kusunungurwa kubva mumapoka methyl). Chiripo mashoko kunotungamirira kuti mhedziso inokosha. , а также обратное ему явление, играют существенную роль при хранении информации и запоминании. DNA methylation somumwe epigenetic zvenhengo uyewo Ivan Kuchin Fani, kuridza chinokosha basa mashoko chekuchengeta uye ndangariro. Pfungwa iyi hwakasimbiswa kubudikidza migumisiro boka pakudzidza E. Costa. It Vakawana kuti demitilirovanie reelin uye glutamate decarboxylase majini zvinogona vakaumbwa makonzo duku mamorekuru kuti kuvhiringidza chirimwa DNA iri musimboti. Zvidzidzo izvi kunoratidza kwete chete zvinoita kuchinja huripo pfungwa pamusoro paumbwe ndangariro. является динамическим. Ivo vanotaurawo kuti chokwadi kuti kare akafunga zvachose DNA methylation rine simba. Uyezve, unogona kushandiswa mushonga.

Features

имеют определенную связь, нельзя назвать новой. Pfungwa yokuti kuyeuka uye DNA methylation vane imwe ukama, haagoni kunzi itsva. It hwakatogadzwa conditionality synaptic hutachiwana histone acetylation. Vanoumba marangwanda iro DNA iri muchikuvadza. Acetylation akazoita sungano yacho histone kuti nucleic acids. Izvi anovhura kuwana DNA uye dzimwe mapuroteni chokuita, Inter Alia, pamwe activation majini. Kutaura zvazviri, histone basa atsetilotransferaznaya CREBBP (tichisunga mapuroteni), kuita sechinhu chinokosha transcription chinhu Tutsinga tunofambisa mashoko utwu akanga chokuita mugumisiro mapuroteni ichi pamusoro nomusoro. Uyezve, kwakaratidzwa amplification rakasimba hunhu ndangariro panguva kushandiswa histone deacetylase FIs. Zvakaita kuti kumhanyisa kuti histone acetylation.

hypotheses

Sweet uye Miller akabvunza mibvunzo inotevera panyaya histone-kubatsirwa kudzvinyirira kutaura avaiita. ? Kana unogona nezvaanoita yokudzora ndangariro, kuchatungamirira zvimwechetezvo kana DNA methylation? Fani iyi wakaonekwa zvikurukuru senzira kuramba mumwaka mitosis uye ezvirevo zvichiumba nehurongwa. Zvisinei, muna mammalian muuropi akakura kuchengetwa kuchinyanya methylases, pasinei nokuti vakawanda masero ari nondividing. Nokuti kuti vaiona Fani hunoita kuti kudzvinyirira kuti Gene okuti, vaongorori vakatadza kuramba kutaurirana mukana methylase uye pamutemo pezvakaitwa mu Tutsinga tunofambisa mashoko utwu.

vachiongorora zvekungofungira

этого явления в формировании памяти, обрабатывали срезы гиппокампа ингибиторами дезоксирибонуклеинокислотных метилтрансфераз. Sweet uye vamwe vake nokuongorora methylation DNA, zvinorehwa Fani iyi pakugadzirwa ndangariro, hippocampal zvidimbu kubatwa FIs dezoksiribonukleinokislotnyh methyltransferases. Vakawana kuti rinovatadzisa kutanga kwenguva refu potentiation - nokusimbaradza synaptic vavanozivana mukupindura neuronal basa. Izvi chinokonzera mugumisiro rekudzidza ndangariro zvigadziriswe. Masayendisiti vakaonawo kuti FIs ungaderedza pamwero methylation mu DNA reelin. It akanongedza ayo reversibility.

kuedza

Kusarudza kuenda mberi muzvidzidzo zvavo, Sweet uye Miller akatanga kuongorora kuchinja methylation muenzaniso makonzo mune muenzaniso umo mhuka kudzidza kusonganirana imwe nzvimbo ine zvisingafadzi kuitika, kunyanya simba ukapisa murwi. Maitiro experimental kugamuchira FIs, anotaura mukana wokudzidza kuoma. Vanozviwana vari mumamiriro ezvinhu apo vaifanira kuva kutya, ivo ndakadaro yekudyidzana isingasviki kudzora mhuka.

zvakawanikwa

Sei methylation kungakanganisa ndangariro mbeva? Masayendisiti akatsanangura ichi sezvinotevera. The DNA aripo zvakawanda migove izvo zvinogona kukanganisa kubatana mapoka sehydrogen kabhoni maatomu. Panyaya iyi, vatsvakurudzi vakasarudza kushandisa kune zvinotevera chinonakidza. Vaka zvikurukuru methylation majini vane basa paumbwe ndangariro kare yakaiswa. Akanga chokutanga kukwidzwa imwe nharaunda iri iyo puroteni phosphatase ndangariro pezvakaitwa vari woutsinye. ungaderedza mashoko aigona kuti vanetsane. Zvechokwadi, awa rimwe kutonhodza chechinyorwa kutya methylation pamwero kwakawedzera zvinopfuura zana. Panyaya iyi, iyo mRNA nhanho munzvimbo hippocampal CA1 mudunhu pasi simba, asi statistically chinokosha rutapudzo. Izvi inowanikwa mune pfungwa mhuka pamwe mubatanidzwa ukapisa murwi duku wamativi uye mashoko akapoteredza utsva. Oga, incentives izvi regai kupa zvainoita methylation. Nokudaro, va- mapoka rinoitwa chete pamwe nedzidziso chipo.

DNA methylation uye zvokukwegura

Nematambudziko okukwegura uye chitarisiko kenza ndechimwe chezvinhu nyaya. Makore akawanda tsvakurudzo, masayendisiti pfungwa dzakasiyana-siyana nedzidziso uye yokutevedzera. Zvisinei, kana pfungwa panguva akasaita zvakazara mibvunzo yose. Zvichakadai, mubereko mukuru kutsvaka zvinogadzirisa kudzidza vakwegura kuchinja Gene basa. Zvikurukuru, ayo mafungiro panyaya akataura Purofesa Anisimov. Iye anotaura kuti pakuoneka (okuti) majini kunobva pakuti, pakati pezvimwe zvinhu, nokuda methylation, izvo zvinogona kukanganisa mwero kukwegura. Kusvikira 5% kubva cytosine residues ose deoxyribonucleic asidhi akanga akabatana mapoka kabhoni uye rehydrogen maatomu yokuumba 5mTs (5-methylcytosine). garo iri kuonekwa chete chenguva muDNA dzakakwirira zvipenyu. Ndakabatana mapoka zvinoitika panguva zvose tambo symmetrically. Marangwanda 5mTs nguva dzose kuvanda kuseri guanine residues. In mamiriro ichi vaine mabasa. Zvisinei, zvinokosha kuziva kuti methylation rinobatanidzwa mutemo Gene basa. Kuchinja mararamiro yokuzova mapoka kunokonzerwa Kukundikana padanho transcription.

zvikonzero

Age-demethylation yakatanga kurondedzerwa muna 1973. musiyano uyu dzakaonekwa mwero kupatsanurwa mapoka gonzo munyama. Muuropi, demethylation akaenda zvakawanda vachishingaira pane ari chiropa. Zvakanga dzakwidzwa kwatemwa 5mTs kuderera nezera mumapapu, uyewo fibroblast ganda idzodzo. Vaongorori akataura kuti nemakore-demethylation predispose masero kuti akaipa kushanduka. Fani iyi kungaratidzwa zviri nyore sezvinotevera. An akaneta Gene akanga machira kuti boka methyl. Pasi pokudzora kwomudzimu nemakemikari mberi kwayo disconnection. Nokudaro, jini kusashanda. Group anoita mabasa kwemaatomu fiyuzi. The duku nhamba, ari kusiyaniswa zvikuru masero uye nokudaro ekare kupfuura zvavo zvakawanda - saka zviri muduku. A muenzaniso chaiwo zvinowanzodavirwa kushandiswa mumabhuku, zvinogona kuguma kukura kwezvimwe Sarimoni. A Chiitiko zvavo zvikuru nokukurumidza rufu pakarepo pashure zviri kukonzera. Nezuro vachiri vaduku nevanhu dzokubereka zera vanofa mukati pfupi. Muurongwa zvipenyu, chiitiko ichi nokukurumidza kukwegura, izvo pamwe pamwero mukuru DNA demethylation.

How kubatsira muviri?

Pane nzira dzakasiyana-siyana iyo kuvandudza chokuziva DNA methylation. Pakati zvikuru nevanhu anofanira kunzi:

1. Kudya yakachena hanyanisi. vachiwaridza miriwo vari kunyanya inokurudzirwa. Vanoita seinokonzera folic asidhi zvinodiwa kuitira methylation zvakakodzera.
2. Mavhitaminzi B12 uye B6, riboflavin. Zvinyorwa zvavo vari mazai, hove, omuamanda, fruit, asiparagasi uye zvichingodaro.
3. Kugamuchira zvakakwana yakawanda zingi uye magnesium. Vanopa rechengetedzo methylation.
4. Rubvumo probiotics. Ivo inobatsira kuti kugadzirira uye Absorção de Água mavhitamini B boka uye folic kuti-imi.

Zvinokoshawo kuti kuderedza kushushikana, regedza tsika dzakaipa (doro, kusvuta). Care zvinofanira kutorwa kuitira kuti muviri haana kuwana muchetura fuma. yeimwe izvi tora mapoka methyl akatakudza chiropa.