CheAlzheimer: chinokonzera uye kurapwa, musimboti, kwokutanga zviratidzo, budiriro, mufananidzo cheAlzheimer

CheAlzheimer - chirwere iyo inotungamirira kurufu masero uropi. Achiperekedzwa chakakomba mupfungwa uye dzichipfekeka zvirwere. Mumwe nechepakati zvirwere tsinga, kuti zvigadziriswe iyo hadzisi aizvinzwisisa.

nzira nechirwere

Mukuru chishandiso tsvakurudzo pamusoro pokumuka dementia ndiyo neuroimaging. Nokuti chinangwa ichi, CT, MRI, PET uropi. Chiremba anoongorora ukuru kuparadzwa woga migove, uyewo anoyera zvichibvira zvinokonzera uye concomitant chirwere.

Uchishandisa eeg nzira kunotibvumira kuchengeta pfungwa basa uye mwero vanotaura kuti Neural kubatana. Laboratory inoongorora kusimbisa chirwere cheAlzheimer, vanoratidza zvinoshamisa kuderera α-β-42 uye mawa zvibereko rokuti tau mapuroteni.

Zvinokonzera Disease yeAlzheimer

Musimboti cheAlzheimer harisati zvakazarurirwa masayendisiti kuburikidza. Nhasi, kune vashoma dzidziso pamusoro zvinokonzera kuti chidzoke uye kukura chirwere, asi hapana ane asi kugamuchira Kuzivikanwa dzakawanda. Aitungamirira nzvimbo pakati aronga tsvakurudzo anotora majini chinhu.

Pakati pezvimwe zvinhu, musiyano mapoka 3 ngozi chirwere:

• nekorrigiruemye;
• aoma correctable;
• correctable.

chirwere cheAlzheimer, zvinokonzera uye kurapwa chirwere ichi - zvose mibvunzo iyi panguva nekorrigiruemyh zvikonzero chaizvo kunzwisisa uye zvisingagadziriswi kwechinguva chiduku.

The majini chinhu kukura

Nhaka zvokurwara Zviri 10% vose rakashuma zviitiko. Kukura cheAlzheimer uri majini mashandiro rinotanga asati makore 65 ekuberekwa. Gene chinopfuudzwa munzvimbo autosomal hune fashoni: kunyange kana mubereki wechipiri haasi mutakuri, chakasvitswa kwavari Gene utano chakatsiva pathological. mwana hutachiwana ndingangokuvara kazhinji inozadziswa hafu mhosva.

Pasinei nekusimba kuvabereki chinhu, masayendisiti anobvuma kuti kukura chirwere zvinoita kuti mhando dzakasiyana okutodza. Most ichangopfuura, mukufamba pakutsvakurudza Gene kuremara sezvayakawanikwa nokuda rechi14 chromosome, izvo 70% nyaya kunotungamirira kukura chirwere.

Kutyorwa chromosome 21 kuti anokonzera chirwere cheDown syndrome, muna 5% nyaya kukonzera mangwanani kutanga cheAlzheimer. Chinonyanya isingawanzowanikwi zvokurwara - Gene urema pamusoro chromosome 1 - ane yakaderera ndingangokuvara "mhuri" zvirwere.

zvinhu zvakakwirira ngozi

Nekorrigiruemye zvikonzero zviri vachiberekwa kana vakatodzidza anatomical kana vasiri abnormalities, izvo kare haagoni kugadzira kana kushandurwa. Zvinhu izvi zvinosanganisira:

• kukwegura (anopfuura 80 years);
• kuva mukadzi;
• cranial kunotevera;
• chakakomba mwoyo uye kunetseka mupfungwa;
• kushaya "kurovedza" nokuda nenjere.

Neimwe modifiable Zvinhu vanoumba boka zvirwere kuti kukonzera chakasimba kana chirwere okisijeni kushayiwa mu cerebral cortex masero:

• neBP;
• atherosclerosis pakati nhumbi pamutsipa, musoro, uropi;
• lipid muviri;
• chirwere cheshuga;
• mwoyo chirwere.

Kubviswa chirwere kunoderedza ngozi cheAlzheimer.
For correctable - panobviswa chose - zvingakonzera zvinosanganisira:

• neb kurovedza muviri;
• nokushaiwa kukura zvedzidzo, shoma;
• kukundikana zvinoenderana mirayiridzo inokosha utano mararamiro.

Pathologies havasi 100% zvinovimbisa kuti kukura chirwere, asi kazhinji zvinotangira nayo, zvichiita kuti mhedziso pamusoro zvichibvira zvinokonzera njodzi uye kudzivirira.

Makuriro Danho

Masayendisiti akawana kuti cheAlzheimer (chikuru zviratidzo) rinowanikwa mumakore 15-20, kune zvakakomba chiremba mufananidzo, izvo zvinoomesa zvikuru kudzivirira zvirwere. Nhasi, kwakapiwa 3 pathological muitiro matanho:

1. Pre-zvekuchipatara - zvokurwara achiri mucheche, CNS Zvirwere zvinochengetwa.
2. Period kuduku kutyorwa - varwere ungacherechedza kwakaderera mano njere uye ndangariro vanotaura.
3. The kwokutanga mwero dementia - denderedzwa yomukati anotanga kuona chimwe chinhu chakanga chisina kururama. Kakawanda, unogona kusimbisa pamberi chirwere akaora.

Rimwe nerimwe rematanho ine maitiro ayo uye anouya urongwa kurapwa.

Kukura chirwere pane muduku

chirwere Early yeAlzheimer anova pamberi makore 65, zvakaoma rokuongorora panguva yakafanira kune nonspecific kunotoda mufananidzo. Zviratidzo zvokutanga kuonekwa muchimiro yokukanganwa, kutadza kuronga uye kuita zvinhu zvaiva nyore pamberi. Murwere nokukurumidza anoneta basa pfungwa: kuchengeta mashoko ari muyeuko iri kuramba yakaoma.

CheAlzheimer: chinokonzera uye kurapwa vachiri Danho

The kwokutanga Danho hwapedyo mukati makore 7. Initial kuchinja murwere nemamiriro kutora nzvimbo pasi pokudzora dzakasiyana zvinhu. Kana ane chikonzero isingachinji ose ehondo vakatumira ayo kubviswa. Kazhinji, zvomunharaunda kurapwa anopa nemigumisiro yakanaka.

Varwere yeAlzheimer anganyunyuta kuti:

• matambudziko ndangariro;
• chitarisiko kukanganwa;
• kurasikirwa kugona kufunga;
• psycho-mupfungwa zvirwere.

Zvichida yeAlzheimer vakanga vatova pachena nehama. Initial zviratidzo hakusi zvakananga zvinoratidza pfungwa dysfunction, asi vakawanda vachiri kurapwa uye nguva kudzidza nechirwere.

ndangariro Zvirwere vane pfupi uye kwenguva refu hunhu, uye murwere asingagoni kuona kudzikira nguva dzose. Wekumusoro pernicious kukanganwa: Kazhinji vanhu vane yeAlzheimer rworuboshwe pamusoro gasi kana magetsi, izvo kunotungamirira zviitiko zvakanyanyisa hunhu. Zvichida kufirwa okuti vasiri kugadzikana ndangariro muchimiro yokukanganwa zviitiko zvakaitika kare. kudzorerwa ndangariro zvishomanana ndepana neshamwari. ndangariro Zvirwere mberi nekukurumidza; pashure pemwedzi 6 chete, zviratidzo kuva raidudzwa ngozi murwere upenyu.

Kurasikirwa kukwanisa kufunga zvinoenderana padanho ungwaru kuti kukura chirwere. Dzimwe nguva maitiro chiratidzo chinhu unopinza kuchinja zvido: kuona TV panzvimbo kuverenga mabhuku zvakaoma uye dzimwe nguva. Kwakakanganiswa rikurumidze ruzivo uye omumwe ambient kubudiswa kwezvakatipoteredza, mauri murwere akarasika muchadenga uye nguva.

Chepfungwa kufanana yeAlzheimer nokutyaira simba

Serious matambudziko mupfungwa kunogona kukonzera chirwere cheAlzheimer. The zvinokonzera zviratidzo zvakadaro uye kurapwa nhema uropi uye kushungurudzwa conduction tsinga nomunhu. Kushomeka acetylcholine usage inotungamirira paumbwe amyloid plaques. mwoyo Long-izwi kukanganisa kushanda tsinga, uye tikafunga simba webasa dzichiri dementia.

Kutyorwa kunetsa kunokonzera chirwere cheAlzheimer. The kutanga zviratidzo zvechirwere chepfungwa yakaratidzwa simba aramu, kuita zviito hasha uye basa, zvichemo kudzikama uye fitful hope. Dzimwe nguva, vane kurwisa kuti rikwanise psychosis, dzinoratidzwa kutya kutya kutambudzwa, kuora mwoyo. Kutsamwisa ezvinhu akachinja chero hunhu: kubva rearrangement kuti midziyo asati kutamira kune imwe musha. Kuchiita maperembudzi pamwe neshanduko mukuru mwoyo kuti hanya. Human kurapwa zvakaoma. chirwere chepfungwa kunosanganisira zvikuru kushandisa antidepressants uye zvinodhaka psychotropic.

Disease yeAlzheimer: Inokonzera, mabatiro of 2nd Danho

Kukuvara ndangariro, tsika chete chirwere ichi kuva pachena uye zvakawanda yakanyanya Danho rechipiri kukura zvokurwara. Murwere Handiyeuki zvimwe zviitiko, kunyange kana associative nedzimwe rubatsiro kuhama. Chokutanga, varwere wakakanganwa chiitiko ichangopfuura, apo kare kure inoramba iri mundangariro.

Kutyorwa pfupi-rokuti nomusoro kukonzera sizvo wezwi nenguva. Dementia havagoni zvakarurama kuisa nguva penguva mumwe kana chimwe chiitiko. Under mwero chirwere kukura iri kuchengetwa achizadza hazvimo ndangariro Ndangariro izvo angava chinoshamisira kugutsikana.

Kunoita kunotungamirira zvachose kufirwa ruzivo mikwende, zvikurukuru yakabereka vakura uye vane kunzwisisa maumbirwo. Rakaramba unyanzvi chete avo kuti ave nhomba mune muduku uye ari kuramba achidzokorora mukufamba upenyu. Somuenzaniso, kuziva mai parurimi, kukurukurirana nzira nevanhu uye nokuzvidzora basa.

A pachena chinoratidza dementia muna 2nd Danho - ndichengetedze mupfungwa okuyeuka uye kusavapo chaiko. Kazhinji varwere regai kurangarira kana vana kana vazukuru, asi kuonana navo hunokonzera mufaro, mufaro.

kurasikirwa njere

Chikuru chinokonzera 2 nd it padariro - kutyorwa chepfungwa mano, iyo pakupedzisira inotungamirira kurasikirwa rusununguko. Kukudziridza dementia inogona rakakamurwa munyoro, mwero uye yakanyanya.

Kuratidzwa munyoro dementia runoratidzwa nokurasikirwa anogona kushandisa mari: hazvibviri zadza munhoroondo, kuverenga mari kubhadhara. Zvishoma nezvishoma zvaraswa akawana mashoko, zvinova zvishoma. Kazhinji, varwere panguva ino kuita zvepabonde. Akanetseka wakanaka injini unyanzvi maoko, zvichiguma tsamba kusingasaruri. Pane zvakakomba zvivakamutauro zvikanganiso, izvo haana kurarama asati.

Munyoro dementia dzinoratidzwa kurasikirwa kuverenga nekunyora, kazhinji kutaura murwere rinova usinganzwisisiki nokuda kukanganwa mashoko vane unozotevera pakutsiva ne yakafanana-vachiridza. Man anova kuzvibatsira: asingakwanisi vakazvimiririra kuti achigadzirire ekunze, nzira yavo kumba, anokanganwa kuti kudzima chitofu kana mvura. On the 2 nd it padariro cheAlzheimer pamwe mwero dementia murwere waitoda rubatsiro kugara uye kuvapo hama.

zvakakomba dementia

The wokupedzisira pavaipfuura cheAlzheimer kunoratidzwa yakakwana kuvimba nevamwe. Murwere haasi kuita zvokudya zvavo, enda chimbuzi, kuti vaite Utsanana dzokuvhiya. Speech anova incoherent uye zvisinganzwisisiki, anetseka gait, zvichiita kuti zviome tisingatungamirirwi kutama.

Zvishoma nezvishoma anotanga uye pakuparadza dzepanguva. Rufu kunoitika nokuda mazhinji kuneta nokuda sepsis kana zvirwere zvakakomba.

Dementia muna Parkinson chirwere

Parkinson nehosha uye yeAlzheimer nokuda paavhareji munhu ane chiremba mufananidzo yakafanana, kuongororwa zvakarurama kunogona chete nyanzvi. The zvichiguma dementia ane nevamwe zvinhu. chirwere cheAlzheimer kunoratidzwa kutyorwa kwakakomba nomusoro uye ungwaru. Parkinsonism chete tava kuderera kutaura uye pfungwa iri kuchengetwa. A zvakafanana chinoratidza neurodegenerative zvirwere ndiko kuderera kwezvirongwa mupfungwa inoti. Varwere kwenguva refu ari mamiriro mwoyo uye rikwanise psychosis.

Nomufananidzo kuti chirwere cheAlzheimer (yaifananidzira pamusoro) uye chinonzi Parkinson (mufananidzo pazasi) sei uropi pamwero yakasiyana. chirwere Wokutanga ikabuda zvenyama akafukidza uye hippocampus kuitika amyloid plaques kutungamirira kurufu etsinga kwokubatana (uropi anotanga "kuoma panze").

chirwere chinonzi Parkinson disproportionately kunokanganisa zvetsandanyama nemapfupa hurongwa: kuti musana akatsunga zvikuru, murwere ari kuwana yakaderera uye ezasi. Kunetseka kuramba tremor, masangano ave diskoordinirovannymi.

Mabatirwo mangwanani Danho

Taiongorora vakawanda mashoko, kuti ndiye chirwere cheAlzheimer. Inokonzera uye pakurapa chirwere iri pari kwete aizvinzwisisa nesayenzi. Doctors vari kuramba kuita tsvakurudzo kuwana zvinobudirira zvinodhaka, asi mushonga harisati dzakasiyana akamisa, vakakwanisa kukunda zvirwere.

Kurapa kuzvivako zvinosanganisira:

• Mabatirwo chirwere chepfungwa;
• mukuru nokusimbaradza muviri;
• achitanga muviri muuropi;
• achisimbisa midziyo ropa;
• mukuru mishonga yeAlzheimer.

nguva inokosha kutanga kutora mishonga uye nechokwadi kwazvo zvaidiwa zvose kurapwa audzwa. Watch kuchiita hosha kunodikanwa mune simba.

Nokuti Mabatirwo nyoro kuti zvive nomwero dementia kushandisa gadziriro yakadaro:

• "Piribedil" - anovandudza nokupfuuridzirwa etsinga nomunhu ari dopaminergic neurotransmission uye noradrenalinergicheskih CNS. Vandudza ndangariro nekugona.
• "Pentoxifylline," "Vinpocetine" - kunonatsiridza kweropa, kudzivirira paumbwe thrombi mu cerebral midziyo.
• Ginkgo biloba mushoma - kunomutsa kugadzirwa neurotransmitters, inodzivirira masero uropi kubvira muchetura, kunonatsiridza kweropa.
• "Cinnarizine," "Nimodipine" - akudziridze uropi ropa midziyo, kudzivirira masero kubva zvinokonzerwa zvakawandisa karusiyamu.
• Pyrrolidone nezvinogadzirwa nomukaka - anovandudza bhodhoro nerubatsiro uropi hunoita kuti normalization mapuroteni usage mumasero muuropi.
• "Aktovegin" "cere the" - kubatsira kudzorerwa cheni mashoko, kuti ude intracellular chinjanai pezvakaitwa.

kemikari kurapa

Masayendisiti vakabvumirana kuti kukura cheAlzheimer zvinobatsira kuti zvinoderedza acetylcholine usage. Kusaenzana pakati kugadzirwa uye acetylcholine neurotransmitter acetylcholine, izvo zvinoita kuti chinovhiringidza pamusoro neuronal mabasa. Masero kuva rakawunyana, synapse nzvimbo iri vachidurura, uye Tutsinga tunofambisa mashoko utwu kufa. Opening muna 100% Muzviitiko cheAlzheimer inosimbisa. Photo utano uye kurwara uropi achititadzisa kuona zvokurwara kunyange aingovawo munhu.

Neb adzorere acetylcholine usage kunoita kudyidzana pakati Tutsinga tunofambisa mashoko utwu uye kunetesa dzinotsanagura paumbwe amyloid plaques. miedzo Clinical vakaratidza efficacy kuti cholinesterase FIs. In varwere vasanyanye pamusoro dementia, ndangariro anomutswa, kudzoka unyanzvi nokuzvidzora basa uye dzidziso muchadenga uye nguva.

Nhasi richizivikanwa 3 Zvinodhaka kuti tunodzivisa cholinesterase:

• "Aritsept" ( "donepezil" "Aricept") - ane nechepakati nomugumisiro, ndikarangarira pamusoro 5.10 MG pazuva.
• 'Reminyl' (galantamine hydrobromide) - ane vakawanda vanzwe, kushanda vasiri chepfu, zvakanaka kufunga. Shandisa 8-12 MG pazuva.
• "Exelon" ( "rivastigmine") - ane nechepakati kwechirwere, kunobatsira kupfuura zvimwe zvinodhaka ari kukurumidza kufambira mberi siyana cheAlzheimer. Available muchimiro mapiritsi, plaster, dhaka. Kutanga dose - 3 MG pazuva.

Kushandiswa cholinesterase FIs mishonga kupa ndezvomuzana chete zvabuda, asi mumwe murwere manzwiro akasiyana neevamwe kemikari mishonga. Kana mumwe zvinodhaka havana kukodzera, chiremba unotsiva analogue kwayo. Achatonga kusabatsira kurapwa zvinogoneka chete pashure mwedzi mitatu-kosi panguva kunonyanyisa chipimo chemushonga.

Huru contraindications ndivo zvirwere nemudumbu, mwoyo uye Urinary turakiti. Kushandisa Árbol asima uye netsviyo riri haana inokurudzirwa.

Treatment chakakomba dementia

Kusingarapiki kuchinja muuropi kunokonzera chirwere cheAlzheimer. The zvinokonzera chirwere - nyaya dzose achirwadzisa vatsvakurudzi. Pakupedzisira pavaipfuura chirwere zvinoita kushandisa imwe chete zvinodhaka mvumo nenyika zvokurapa - "Memantine". Chinopedza pezvakaitwa mu Tutsinga tunofambisa mashoko utwu hainei mumwe chete cholinesterase, zvinhu hunowedzera kuoma. Uropi astrocytes, vanotanga kubudisa toxin - glutamate, chinouraya Tutsinga tunofambisa mashoko utwu uye astrocytes pachavo.

"Memantine" anoita kupanana glutamate, iyo kunotadzisa mamiriro kudhaka wouropi. vanachiremba vakawanda vanoita kushandiswa "Memantine" pamwe cholinesterase FIs, izvo anowanzopa nemigumisiro yakanaka.

The mushonga kunonzwisiswa zvakanaka nokuda muviri, ine contraindications shoma (pfari uye havachanyatsogoni renal shanda). US uye dzeEU kushandisa "Memantine" nokuda pakurapa cheAlzheimer kwemakore 10.

symptomatic kurapa

Treatment kunobva pakushandisa zvokusarudza kweserotonin reuptake FIs ( "Fluoxetine", "citalopram") uye norepinephrine. Kuwedzera kune pesvedzero inobatsira psyche zvinodhaka kubatsira kubvisa zviratidzo munyoro dementia. Kushandisa mifananidzo antidepressants kungatungamirira chitange cheAlzheimer, saka muna zvikuru mwoyo varayire tricyclic antidepressants.

Kana akashandisa neuroleptics pfungwa zvirwere. Zvisinei, zvinofanira kurangarirwa kuti chiwedzere kutaura dementia. Kuzvishandisa chete Muzviitiko, vanachiremba varayire kushandisa mishonga chete vanyoro migumisiro.