Analogs "Ksarelto": mutengo, mirayiridzo kushandiswa

Mumwe zvinodhaka, raiva pasi pharmacological boka anticoagulant vamiririri, mushonga ndiye "Ksarelto". mushonga uyu kuchititadzisa chinhu Xã, uye, akavapindurawo, ari chezvinonhuwira prothrombin activator uye mumwe zvakamisa hurongwa ichipa nenguva coagulation ropa (zvivako uye analogues "Ksarelto" vakadaro).

Today kuitwa itwa zhinji yokubva mushonga, izvo zvichaita kunodarowo uye nokudaro kupa kushoma pakati nemishonga. Mushure vakawanda unoparadza nguva-kuedza chakakodzera ishamwari - mushonga "Pradaksa". The mushonga - chete chinotsiva kuti zvakakwana anogona kushandiswa pachinzvimbo "Ksarelto" gadziriro. zvachiri vari kunova kufanana kune apa, musiyano chete - zvinoshingaira chirungiso zvirimo, izvo gadziriro vose ndiro rivaroxaban.

pharmacodynamics

analogues All "Ksarelto" kunodarowo. Chinhu badzi chavangagona akasiyana - the quantitative uye Qualitative chokukomborerwa nemishonga. The vakakodzera analogue zvinodhaka chete, ine ndozvinoitawo pazviri, chinhu chinodhaka "Pradaksa".

mushonga uyu uye ayo Russian nerokuti "Ksarelto" vari zvinodhaka zvikuru zvokusarudza zvakananga kuti tunodzivisa kuitwa Factor Xã, kureva tunodzivisa nayo. mushonga uyu ane refu nemumuromo bioavailability, zvisinei enteral nzira chourongwa ndiyo musimboti nawo.

Central muchinangwa kupindana coagulation chinhu X activation chinoita unozotevera biotransformation chinhu Xã to nechinzwano kwokunze coagulation nzira.

umboo

Kazhinji, analogs "Ksarelto" uye kugadzirira pacharo rinoshandiswa zvinotevera ezvinhu:

• Madzivirirwe prophylaxis sitiroko.
• Madzivirirwe ruyamuro kubva systemic embolism.
  
  (Pakadaro, ari medicament unoratidzwa varwere atrial fibrillation, ndiro non-valvular mavambo.)

• Kubviswa kana kudzivirira plugging zvakadzika tsinga thrombi.
• Kudzivirira dzokororo ine pulmonary embolism.

Drug "Pradaksa", riri zvakafanana, ari Akaratidzawo kuti kudzivirira venous thromboembolic zviitiko varwere vanenge inini kuvhiyiwa kutsiva mumwe Hudyu rezasi maoko nemakumbo.

Contraindications

Chero Russian nerokuti "Ksarelto" rine zvinotevera contraindications (vanogona kuva akasiyana, asi chete chiduku pamwero):

• utetsa kana ngozi kuratidzwa neutachiona kuti zvinhu zviri medicament;
• rinoita ropa izvo zvine makuru informativeness nokuda kurapwa kuongororwa (semuenzaniso, intracavitary ropa kana ropa muuropi);

• nezvevashumiri pane mikana yakawanda ropa vhoriyamu, semuenzaniso, panguva kushingaira urikanwi pezvakaitwa ari nemudumbu;
• mushonga jekiseni vehurumende izvo nhaka ehupfumi akafanana - kudzivisa coagulation;
• kushandisa unfractionated heparin pane imwe dose zvakakodzera kuti inogutsa nokushanda anobudisa mushonga zvishoma nezvishoma;
• zvirwere zvakasiyana-siyana chiropa, kukura izvo zvinogona kukonzera ropa zvakasiyana siyana etiology;
• zvose dzomuzana "Ksarelto" vari contraindicated pavarwere vane renal insufficiency, kuitika chero Pasika;
• lactose kusashivirira, kushomeka zviri galactose mumuviri;
• pamuviri uye lactation;
• pamusoro zvinodhaka uye analogs siyana "Ksarelto" pane zera muganhu 18+.

Category vanhu vanogona kutora zvinodhaka ichi nokungwarira uye pasi pokudzora nyanzvi

Nokungwarira uye pasi pokudzora chiremba anokurudzira kushandisa "Ksarelto" mirayiridzo kushandiswa (sezvo analogues) zvinotevera nyaya:

• aibata varwere vane mikana yakawanda ropa pakugadzirwa;
• achangobva akatamisa maronda chirwere ane kubatwa kuti kudzokazve;
• Mabatirwo renal kukundikana kunosiyana madhigirii akabatana zvinodhaka zvinowedzera rivaroxaban kugutsikana mumuviri murwere;
• Varwere achirapwa kurapa mishonga inokwanisa dzekugonesa hemostasis;
• gadziriro izvo vanokwanisa kuwedzera padanho rivaroxaban, semuenzaniso, mishonga antifungal azole boka;
• mushonga uye analogue mahwendefa "Ksarelto" iri contraindicated pavarwere vane HIV, kana ivo chete akatora siyana runovharidzira mamwe FIs kweutachiwana.

Kunwa panguva pamuviri uye achiyamwa

To musi, hazvina zvazviri kutsunga, sezvo simba "Ksarelto" analogues zvinodhaka pamusoro efficacy uye yakachengeteka vakadzi pamuviri.

Kuedza yaiitwa dziri mumarabhoritari mhuka zvakaratidza akadudza toxicity yezviri zvacho ugadzirire zvinenge amai vanepamuviri, sezvo mushonga kunokonzera kwazvo dzokubereka toxicity munhukadzi muviri.

Maererano Murabhoritari zvakabudiswa, mushonga "Ksarelto" analogue kuti zvakafanana kwavari pharmacological chiito anokwanisa kuyambuka placenta, saka mushonga iri contraindicated.

Uyewo panguva kushanda vakadzi "Ksarelto" havafaniri kukanganwa pamusoro inobudirira zviyero pamuviri, kubva pamuviri, izvo kuitwawo Gengi zvinodhaka, anogona kukanganisa fetus.

Objective nokutonga pamusoro kubata zvinodhaka yaishandiswa lactation nguva, panguva hakuwaniki, asi rabhoritari zvidzidzo zviri murabhoritari mhuka dzinoti tichishingaira fuma - rivaroxaban - anokwanisa metabolize uye kwete yabudiswa muna mukaka. Saka, achiyamwa vanofanira kusiya kushandisa zvinodhaka.

Zvichienderana nemashoko Murabhoritari zvidzidzo, tinogona kutaura kuti rivaroxaban asingadi kukanganisa mano zvepabonde akura muviri kuti asike zvimwe mwana ari makonzo, asi vanhu kuedza mhando ichi kunge inoitwa.

Muviri uye kubviswa gwara

For enteral kugamuchira kune vatatu nzira maberekero, izvo anoenderana chimwe muzvitatu uwandu non-rinoita zvinodhaka:

• Urinary excretion;
• excretion ari mutsvina yadzo;
• kubviswa med renal excretion mutsetse (iyi, anenge asina fuma rinoita uye pa unmodified chimiro).

Biotransformation rivaroksaba anoitwa zvigadziriswe kuti vari yakazvimirira cytochrome hurongwa.

The huru gwara - the oxidation a morpholino boka uyewo pakuwedzera amide kusungwa nemvura.

Studies kuitwa ezvokunambira kunze kwomuviri waamai, anogona kutonga kuti rivaroxaban ndiyo hwaro P-glycoprotein uye puroteni kuti rinopa nemishonga oncological zamu chirwere.

Kazhinji, kubviswa metabolites rinoitwa mumaawa 5-9.

nemishonga

Iye anoti gadziriro mirayiridzo kushandiswa: analogues "Ksarelto" kana nokuzvidzora mishonga zvinofanira kutorwa chete mushonga. Murayiridzo pacharo rinotsanangura nemashoko akadzama chipimo chemushonga zvinodhaka, kana ayo analogues. Iva nechokwadi kuti kuverenga mirayiridzo mabiko!

Below zvinoratidza pezvakaitwa vasingadiwi zvose uye maitiro yakanga zvinodhaka "Ksarelto" analogs. Price mapiritsi - kubva 900. rubles. Hazvina chipa paunofunga kuti vazhinji divi Marwadzo kunze kune mutemo.

• Marwadzo kuti yakaonekwa kana kuedza ropa uye nhengo dzinobudisa ezvinhu, tiri kupererwa neropa uye thrombocythemia, anoonekwa Kazhinji.
• Tachycardia - chete kukunakira kana kutora zvinodhaka izvi.
• Ropa.

Ndivo pfungwa contraindications kuti mushonga "Ksarelto" mirayiridzo.

Analogs zvinodhaka izvi zvingaita kuti atadze kushanda zvakanaka pamusoro zvomudumbu turakiti: ropa, vemunyika marwadzo, dyspeptic zviratidzo, dzimwe nguva - muromo yakaoma.

Nokuda okusuma rivaroxaban omunharaunda siyana zvinogona kuitika: fivha, kuzvimba panguva jekiseni nzvimbo kana raitongwa parenterally nzira, simba uye zvakawanda zvive.

The kwaita azvaiitwa kubatsira kugadzirira "Ksarelto" dzomuzana. Mutengo chinodhaka, somunhu mutemo, ndizvo zvinodiwa ose chemishonga ngetani.

Nzira Use uye chipimo chemushonga

Detailed ruzivo pamusoro zvakarurama kugamuchira anogona kupa kune mushonga kana zvachose "Ksarelto" mirayiridzo. Analogues zvinodhaka iyi hakusi vangasimudzira zvakasiyana.

mushonga uyu inowanika piritsi chimiro, saka piritsi chinobviswa enterally. Kana murwere vamwe chikonzero havagoni kumedza hwendefa - inogona zvakohwewa uye hwakakanyiwa yakakodzera mvura (tii, mvura).

Agamuchira mushonga uyu hwobva kutevera kudya.

ovhadhozi

Kutadza kutevedza dzemunharaunda kugamuchira "Ksarelto" zvichibvira ovhadhozi, izvo kazhinji kubatwa symptomatically, sezvo mushonga ane chairo mushonga.

Kuti uderedze adsorption zvinodhaka ari ura duku kunogona kuva chero sorbent, akadai kusashanda kabhoni. Uyewo kuti mhanyisa excretion pamusoro metabolites pakuraramisa rokumanikidzirwa diuresis, iro rinoitwa Via kushandisa yakawanda Urume uye kushandisa diuretics.

mitengo

Zvichienderana mugadziri, mutengo ndiye "Ksarelto" mushonga zvichisiyana 899,00 rubles. nokuti mahwendefa 10, ane 10 MG pamusoro vanoshingaira chirungiso, kuti 1740,49 NZD.

Pasuru, umo 30 pellets, inogona kutengwa nokuda 3300,00 rubles.

Kudeuka pasuru ine 100 capsules, tinorasikirwa 8600 rubles.

Pricing Policy "Pradaksa" chinodhaka kunobva quantitative zviri vanoshingaira wemafuta pa Kamudzira:

• 75 MG - 716,00 kwiza;.
• 110 MG - 1574,00 kwiza;.
• 150 MG - 1676,00 kuzora.