4 (vakasununguka): vasingambooni chakaipa nazvo. Kemikari T4 (vakasununguka): muedzo kuti thyroid mahormone ropa

Zvikuru munyika dzose kushanda ari thyroid shwanu ndiye hypothalamic-pituitary thyroid hurongwa. Inopa kudzora kwetunhu, kugadzirwa uye basa thyroid mahormone.

tsananguro

The hypothalamus secretes mafuta (tireotro-Pin-kusunungura chinhu). It, uyewo, kunomutsa kusunungurwa uye kwetunhu thyroid anotokonya kemikari (TSH - TTG). TSH rinobatanidzwa kwemasayendisiti chokuita nedzimwe steroids. Zvikurukuru, kunomutsa secretion, kuwanda, muviri uye kwetunhu triiodothyronine (T3) uye thyroxine (T4). Over 99% izvi steroids maviri muropa achiparadzira ari akabatanidza chokufambisa mapurotini fomu. Asingasviki rimwe muzana iri pachena chimiro. Vasina kusungwa steroid nhanho vanhu dzakawanda interconnected pamwe dzichipfekeka mamiriro thyroid shwanu.

ehupfumi thyroxine

Kemikari T4 (vakasununguka) hwezvekukurukurirana mutemo kwomuzvarirwo kukura, achivimbisa kwerunyararo tembiricha yomuviri uye pakudaro tiine kupisa buildup. Mukomboni ane zvainoita mumatanho ose carbohydrate muviri, muchidimbu - pamusoro vhitamini uye lipid muviri. Kemikari T4 (akasununguka) zvinokosha pakuderedza huchangotanga utero uye neonatal nguva. Wevasungwa inoratidza kunotoda ezvinhu thyroid mamiriro, sezvo kuchinja mukuru nenhanho thyroxine anogona kukonzerwa kuvhiringidzika basa thyroid shwanu kana kuchinja kwenhamba pakufamba mapurotini. Masikati, kufadza zviri steroid kunotemwa kubva maawa 8 kusvika 12, uye zvishoma - ne 23 uye 3. Mugore, chikuru pamwero 4 (akasununguka) kunosvika kubva September kusvika February, rakadzika - yezhizha. In pamuviri nguva (munguva gestation) thyroxine wevasungwa yakawedzera, richisvika vaifanira pamwero kuti zvishoma nezvishoma rechitatu trimester. Mumazana upenyu thyroxin tigutsikane mune vanhu zvisinei chechikadzi anoramba nekaupenyu rusingaperi. Akaderedza mahomoni kuchengetwa pashure pemakore makumi mana.

Chii angaziva padanho thyroxine?

Kana T4 (vakasununguka) zvakajeka kwakawedzera, zvino anonzi zvinosimbisa hyperthyroidism. Akaderedza yevasungwa chinoratidza hypothyroidism. The rusununguko zviri steroid zviri thyroxine tichisunga globulin, runoita kuti kurishandisa somunhu yakavimbika chirwere bvunzo. Izvi zvinonyanya kukosha ezvinhu kuti vari pamwe nokuchinja kwevari thyroxine-tichisunga globulin,. Izvi zvinosanganisira zvokuudzwa nhumbu (nemumuromo), pamuviri, kuwana androgen kana inonzi estrogen. Kuchinja maitiro uye vaya vane nhaka kubatwa kuwedzera kana kutapudza wevasungwa kuti globulin,. Dhoneta ropa mahara T4 akatikurudzira kuti chirwere mhando hypothyroidism yechipiri nokuda pathologies ari hypothalamo-pituitary chechetere. Muchiitiko ichi TTG kugutsikana haachinji kana kunowedzera. Kazhinji, chakakwirira kwevari thyroxine aigona nokuda yakakwirira kwevari serum bilirubin, kufutisa, uyewo tourniquet, apo iyo bvunzo ropa. 4 (vakasununguka) haachinji pasi zvirwere huru dzisiri thyroid basa. The pamwero zvachose thyroxine anogona kudukupiswa.

Kugadzirira rabhoritari yokuedzwa

A mwedzi usati kupa ropa inosiya rokutarisira mahormone (kana pane mirayiridzo endocrinologist). Nokuti mazuva maviri kana matatu kumisa kushandiswa kuongorora zvinodhaka ayodhini tubhokisi. Ropa anofanira kupfuura asati zvidzidzo radiological vachishandisa musiyano nevamiririri. Pausiku kupa ropa haafaniri kurovedza muviri, kutsakatisa zvinokangaidza. Vasati muchidzidza, hafu yeawa, unofanira kudzikama, kukonzera kufema kune dzose. The kuongorora rinoitwa usina chawadya. With rokupedzisira zvokudya anofanira kuva asina asingasviki sere maawa (asi chinonyanya kudiwa 12 maawa). Hazvina havabvumirwi kunwa kofi, tii kana muto. Vanogona mvura chete.

Kwakaderedza kwevari thyroxine

4 (vakasununguka) (kwomuzvarirwo vakadzi nevarume - 9-19 pmol / l) inogona kuderedzwa ari postoperative nguva, apo hypothyroidism yechipiri (kuzvimba pituitary, tireotropinome, urwere, Sheehan). Achidzikisa wevasungwa zviri kucherechedzwa pahwaro womuchato anabolics, thyreostatics, mishonga anticonvulsant, lithium gadziriro. Thyroxine pamwero zvinoderedza paaishandisa nemumuromo nhumbu, octreotide, methadone, clofibrate. Possible zvinokonzera zvinosanganisirawo zvokudya pamwe shoma mapuroteni, ayodhini kushaikwa, heroin kushandiswa, kuona kutungamirira. 4 (vakasununguka) anogona kuderedzwa pamwe tertiary (tsinga hypothalamus TBI), akawana, vachiberekwa hypothyroidism (pakati zvakadzama resection pakati bundu uye thyroid, autoimmune thyroiditis, endemic goiter).

kuwedzera kuwanda

Padanho kemikari akadai T4 (vakasununguka) (kwomuzvarirwo vakadzi nevarume apa) anogona ngazviwedzerwe kana chepfu goiter, TSH-akazvimiririra hyperthyroidism, kufutisa. Kuwedzera wevasungwa musi pakanyorwa nephrotic urwere, heparin kurapa. Zvikonzero zvinosanganisirawo choriocarcinoma, kugamuchira mumwe thyroxine pamusana hypothyroidism, post-Natal shanduko basa thyroid shwanu, chirwere chiropa chirwere. 4 (akasununguka) inogona kwakasimudzirwa mu thyroid nemishonga chirwere steroids, kuvabereki dizalbunemicheskoy hyperthyroxinemia, inoti, Nokumukira vasanyanye tiroksinsyazyvayuschego globulin, wevasungwa.

Thyroxine uye pamuviri

Thyroid mahormone vanobatanidzwa dzinenge dzose kwacho mumuviri. Sezvataurwa pamusoro apa, mashoko yeimwe inodzora muviri, kukanganisa basa dzimwe steroids. Thyroid zvokurwara inogona pamwe nevasina kuwedzera uye vasanyanye mabasa ayo. Of Kunyanya kukosha zvaipesana nhengo mabasa vane panguva rokubereka vana. The Change of dzichipfekeka mamiriro ari thyroid shwanu kunokanganisa nzira pamuviri, hunhu wake, uye mugumisiro mamiriro achangozvarwa. Kashoma vynashivanie inopfuura kana akaratidza kwemakemikari anobudiswa pathologies. Zvirwere izvi mhando, sezvinoita mutemo, kutungamirira dzokubereka dysfunction, kushaya mbereko. Kakawanda chirwere panguva pamuviri goiter (kuwedzera thyroid diffuse hunhu) pamwe euthyrosis Kuchengetedzwa, uyewo autoimmune thyroiditis, Nokumukira kuchinja hormone background. For pamuviri nguva kunoratidzwa kuchinja dzichipfekeka mamiriro shwanu.

kurumbidza

To nemazvo kududzira migumisiro Murabhoritari nemiedzo panguva yepamuviri vanofanira kufunga dzimwe pfungwa. Kutsunga zvachose T3 uye T4 hakusi anodzidzisa. Izvi imhaka yokuti panguva pamuviri, wevasungwa yavo yakawedzera hafu. Kana vasina kusungwa yokudzidza thyroxine pamwero wevasungwa wayo anofanira kutsunga pavanoparidza zvirimo TTG. Thyroxine zvishoma yakawedzera anenge 2% yevakadzi pamuviri. Mune wokutanga hafu zvisingatomboiti pamuviri nguva akacherekedza kuderera TTG (anenge 20-30% varwere singletons uye zvose zviitiko vakawanda pamuviri). Pakurapa hyperthyroidism T4 nezvokumwe chete (akasununguka). Vasina kusungwa thyroxine dhigiri akazotevera matanho anogona yakambotongwa ipfupi. Nokudaro TSH wevasungwa nekuchengetedzwa mune chakaipa siyana.