"Mesakol": bhuku rekudzidzisa, maitiro, maitiro

Nonspecific ulcerative colitis, pamwe chete neCrohn's disease , inowanikwa mune varwere. Asi, pasinei neizvi, pane mishonga yakawanda yakagadzirirwa kurapa zvirwere izvi. Mumwe wavo ndiye Mesakol. Mirayiridzo yekushandiswa, fomu, mhinduro uye mari yei thuluzi iri ichagoverwa pasi apa.

Kuumbwa, chimiro chekubudiswa, kugovera uye tsanangudzo

Iyo mishonga "Mesakol", iyo inongororwa yakajeka zvikuru, inoenderera mberi kutengeswa nenzira yehwendefa-tsvuku. Iko yakafukidzwa nehuputi e enteric, uye inewo mazamu uye ma biconvex.

Chinhu chikuru chemujenzi iyi mesalazine (5-ASA). Kuwedzera kune iyo, mishonga inosanganisira zvimwe zvikamu segorosi starch, calcium hydrophosphate dihydrate, talcum purified, microcrystalline cellulose, titanium oxide, hypromellose 2208, silicon oxide colloid, povidone K90, sodium carboxymethyl starch, methacrylic acid uye methyl methacrylate acid copolymer, iron oxide tsvuku, Macrogol 6000 uye dibutyl phthalate.

Matethe "Mesakol" anobudiswa muzvigadzirwa zvealuminium uye mapepa emakadhibhodi, maererano.

Pharmacology

Unoziva here kuti Mesakol chii? Mirayiridzo yekushandiswa inoratidza kuti iyi inopesana nekuputira mumiririri, chiito chacho chinowanikwa mumatumbo. Iyi chivako chemishonga inosanganiswa nekwanisiro yekudzivisa basa rekushandiswa kweeukotrienes uye prostaglandin, pamwe neutrophilic lipoxygenase.

Inofanirawo kuonekwa kuti mishonga iri mumubvunzo inopedza kuderedza kubuda, phagocytosis uye degranulation ye-neutrophils, pamwe nekuchengetedzwa kwema immunoglobulin kuburikidza nemarikirini.

Ndezvipi zvimwe zvinhu zvinonzi "Mesakol" zvinodhaka, mutengo waro unoratidzwa pasi apa? Mesalazine ine antimicrobial inopesana nedzimwe checci uye Escherichia coli (mudumbu guru).

Pharmacokinetics yezvinodhaka

Ndezvipi zvinyorwa zvinokonzera mapiritsi eMesakol? Mirayiridzo yekushandisa inoti mushure mokunge muwana, mesalazine inosunungurwa kubva muhombe mushure memauto anenge 115 kusvika ku65, uye mushure memaminitsi 170-230 mahwendefa anopera.

Nemhaka yeiyo firimu, mishonga iri mubvunzo inosunungurwa 60-80% mumatumbo akareba, uye 15-30% mumukomana muduku. Muchiitiko ichi, chinhu chinoshingaira chinopinda mumasaisai e systemic chete muhuwandu hwe10% yemutengo watorwa. Kuiswa kwemasalazine mu plasma kunonyanya kuderera.

Kubatanidzwa kwechigadziro chinoshandiswa nemapuroteni e plasma kune 43%. Mishonga iri mubvunzo, pamwe chete nemasabolites, inopinda mumukaka wemvere.

Metabolism yemeszinezine inoitwa mudumbu uye chiropa. Izvi zvinogadzira N-acetyl-5-aminosalicylic acid.

Iyo hafu-hupenyu hwechirwere ndeyemaminetsi 60-120 (zvichienderana nehana inotorwa). Mushonga unopiwa neitsvo uye kuburikidza nemukumbo.

Zviratidzo zvekutora mishonga

Ndeapi zvirwere zvinoshandiswa naMesakol? Mashoko avanochiremba anotaura kuti mishonga iyi inobatsira chaizvo pakurapa chirwere cheCrohn uye chironda chekuonda.

Inofanira kuve yakanyatsotsanangurwa kuti mishonga iri mubvunzo haishandisi chete kugadzirisa zvirwere zvakataurwa pamusoro apa, asiwo kudzivirira kuwedzera kwavo.

Contraindications kutora mishonga

Hazvikurudzirwi kupa mishonga "Mesakol":

• Nechirusi chechirwere chekudya gumbo;
• Zvirwere zveRopa;
• Kukurira kusakanganiswa kwenhema;
• Hemorrhagic diathesis;
• Muhuduku;
• Kuwedzera hepatic insufficiency;
• Hypersensitivity kune zvigadzirwa zvechirwere;
• Kusina glucose-6-phosphate dehydrogenase.

Nekunyanya kukodzera iyi chiremba inoshandiswa kuratidza kunyoroka kuenzanisa kuoma kwepuro kusakundikana, uyewo nekuenzanisa uye kunyorova hepatic insufficiency.

Mahwendefa eMesakol: mirayiridzo yekushandiswa

Nhengo inofungidzirwa inotorwa muromo chete mushure mekudya.

Kana chirwere chichikura, chinorayirwa muhuwandu hwe 400-800 mg (kureva, mapiritsi 1-2) katatu pazuva. Therapy inoitwa kwemavhiki 9-12.

Kuti udzivise kuwedzerwa, mushonga unoshandiswa pa 400 mg katatu pazuva. Matafura anotorwa sewese, akagezwa pasi nemvura.

Mishonga yeMesakol inofanira kupiwa vana sei? Makese, microclysters nekumira - zviri mumufananidzo uyu zvinoratidza ichi chirwere kumucheche.

Zvakaipa Kuchinja

Zvinosuruvarisa, kutora iyi mishonga inowanzokonzera migumisiro yechirwere. Zvinosanganisira zvinotevera:

• Pericarditis, tachycardia, kushushikana kwemoyo wepfungwa, chirwere chepfungwa, chirwere chemapfupa, hypotension hypotension, palpitations, dyspnea;
• Nausea, yakaderera kudya, kurutsira, kuwedzerwa basa rehepatic transaminase, kuora mwoyo, stomatitis, chirwere, hepatitis, kurwadziwa mumimba, pancreatitis, yakaoma muromo;
• Oliguria, proteinuria, crystalluria, hematuria, nephrotic syndrome, anuria;
• Utsivi, hutema, mazano, tinnitus, kusuruvara, polyneuropathy, kuora mwoyo, kudengenyeka, kuora mwoyo;
• Eosinophilia, thrombocytopenia, anemia (hemolytic, aplastic kana megaloblastic), agranulocytosis, anemia, hypoprothrombinemia;
• Oligospermia, impotence;
• Kushaya simba, photosensitivity, parotitis, kuderera mukugadzirwa kwemasvosve emvura, lupus-like syndrome, alopecia;
• Kushanda kweganda, dermatosis, kutema, bronchospasm, erythema.

Zviratidzo zvekudarika

Zviratidzo zvekuwandisa kwechirwere nemishonga iri pasi pekufungisisa ndizvo zvakadai sekushungurudza, gastralgia, kurutsa, kurara uye kushaya simba. Nokupedza kwavo, gastric rinopisa, zvinokonzera mishonga uye zvirwere zvinoratidzira zvinorayirwa.

Kubatana nemamwe maturusi

Chirwere ichi "Mesakol" chinoderedza chiito che "Spironolactone", "Furosemide", "Rifampicin" uye sulfonamides. Inowedzera hypoglycemic migumisiro ye sulfonylurea derivatives, toxicity ye methotrexate uye ulcerogenicity yeGCS.

Inofanirawo kuonekwa kuti mishonga iyi inononoka kuvhara kwe cyanocobalamin, uye inowedzerawo maitiro euricosuric agents (kureva, tubular secretion blockers) uye inowedzera kushanda kweanticoagulants.

Mazano Anokosha

• Dhairrhea inowanikwa neMesakol kurapwa haisi nguva dzose yechirwere chemishonga. Izvi zvinogona kuva chiratidzo chechirwere chikuru.
• Paunotora mishonga iyi, iwe unofanirwa kuita nguva yakawanda ropa neruzivo rwemuti.
• Kana chirwere chacho chakarasika, zvino chinotevera chinofanira kutorwa chero imwe nguva.
• Munguva yekurapa nemishonga iyi, murwere wemurwere uye teardrop inogona kuvezwa muchero-machena-ruvara.

Mesakol: zvakafanana uye mari

Iwe unogona kutora mushonga uyu nemishonga yakadai seSarazopyridazine, 5-ASA, Tidokol, Asakol, Samezil, Salofalk, Mesalazin, Salosinal, Pentasa.

Mahwendefa eMesakol akawanda sei? Mutengo wemishonga iyi ndeye 600-680 rubles (mahwendefa makumi mashanu).

Customer Reviews

Varwere vanosiya miongorori yakavhenganiswa yakawanda pamusoro peMesakol. Vamwe vavo vanotaura kuti mishonga iyi inobudirira inobata zvirwere zvemukati. Vamwe vanopikisa kuti mahwendefa akadudzwa haabatsiri zvachose. Nokudaro, inogona kugadziriswa zvakasimba kuti "Mesakol" ine zvakasiyana zvakasiyana nevarwere vakasiyana.

Mhedziso huru yechirwere ichi ndehupo hwehuwandu huwandu hwokupikisa uye kusarudzo kwakaipa.