"Farmadipin" (Madonhwe) kubva chii?

Pari zvino pane dzakawanda dzakasiyana mishonga kuti BP uye stenokardicheskie kurwiswa. Mumwe wavo Uyewo zvakadai se "Farmadipin" (Madonhwe) mushonga. Ko mushonga uyu, vakakurukura mberi zvizere.

mamiriro

The achishingaira pazvokudya hazvisi nifedipine (nifedipine). 1 ml ichi mhinduro, zviri mune imwe mari. Kureva pana 100%, inobva rakaoma-mhando fuma - 20 MG. Zvachinja madonhwe matatu.

"Farmadipin" (mumate), mirayiridzo uko application ichakurukurwa pazasi, marongerwo ndiyo kuvapo ebetsero zvinhu zvakadai polyethylene glycol 400 uye 96% panyaya iyi.

pharmacological ehupfumi

mushonga uyu ane pachangu pharmacodynamics. Sezvambotaurwa pamusoro apa, "Farmadipin" (Madonhwe) rine nifedipine fuma rinopa antihypertensive uye Anti-anginal chiito. It anotsigirwa ichivharira kupinda calcium ions kupinda cardiomyocytes kumeso tsandanyama masero mune zvimwe peripheral uye coronary arteries kuburikidza voltage-mhando anononoka dzazvinogara dzokuwana muchitokisi membranes. Izvi pfuma inokosha. Nifedipine rinopawo kutandara pamusoro vascular wakatsetseka tsandanyama, vakawedzera peripheral uye coronary arteries, kubviswa kurwadza kwacho. Izvi kunoderedza BP, systemic vascular nemishonga, cardiac afterload uye myocardial okisijeni kudiwa. Uyewo, kana kutora zvinodhaka uku anoramba kuratidza zvimwe zviratidzo. Kureva, pane zvishomanana kuderera myocardial contractility uye mwoyo kushanda, uyewo zvishoma shoma platelet aggregation.

Pharmacokinetics

Panyaya iyi, "Farmadipin" (Madonhwe), mirayiridzo kushandiswa icho munyaya kwomushumo ichi, ine maitiro ayo. Apo womukati kugamuchira akanga ari zvomudumbu turakiti zvakanaka kunyura. bioavailability Its anenge 40-60 muzana. A zvikuru nokukurumidza kukura kwepasi (pashure 5-10 Nha) kuchengetwa ari Implementation pamusoro sublingual yaitonga. Zvakakosha kuziva. Kazhinji, mukuru zvazviri chinoonekwa maminitsi 30-40. Implementation pamusoro ingestion haina kunyanya kukanganisa mwero Absorção de Água pakati pomutumwa. Nekuratidzwa hemodynamic nokuita zvikaramba kwemaawa 4-6. Saka 90 muzana nifedipine vakasungwa ropa mapuroteni eplasma. It rinoita gadziriro akadai "Farmadipin" (donhwe) ari chiropa. Kuvapo zvachose Clearance ose nifedipine kubva 0,4 kusvika 0,6 l / makirogiramu / hr. Zvinonzi vaziva kubva muviri ainyanya sezvo metabolites akaneta mhando. Nguva hafu-upenyu dzinosiyana 2 kusvika 4 maawa. In vakwegura uye varwere cirrhosis chiropa, nifedipine muviri DZEMUNHU DZINODZORA yekudyidzana. Somugumisiro, vane hafu-upenyu chinoratidza zvinoreva anogona ngazviwedzerwe vanenge 2-mudanga. Muchiitiko ichi zvakafanira kuderedza dose uye vawedzere penguva pakati yemichato ose akati Pfungwa. Nifedipinv muviri hauna cumulated. Uyewo mune zvishoma kunogona zvinopfuura ropa-pfungwa uye placental chipingamupinyi. Muchiitiko chino, zviri yabudiswa muna mukaka.

zvairatidza

Kugadzwa "Farmadipin" (donhwe) zvinotevera nyaya:

• In zvinoitirwawo zvinokosha neBP uye symptomatic.
• Kunorapwa uye kudzivirira stenokardicheskie kurwiswa.
• Kana hypertrophic cardiomyopathy.
• Apo Raynaud chirwere.

kunyoresa

Tora "Farmadipin" (Madonhwe) sublingually. Kana unopinza kuwedzera BP (semuenzaniso, 180 / 100-190 / 110 mm HG. V.), A chete kutanga dose zvinodhaka kuti munhu mukuru kazhinji ndiyo inenge 3-5 Madonhwe (2-3,35 MG). Varwere vakwegura anopiwawo kuchiitirwa chipimo chemushonga. Zvinoti - hapana anopfuura 3 Madonhwe (anenge 2 MG). Uyewo, iyo yakanatsa nhamba anogona kuchadonha pamusoro duku chechingwa yakaoma kana shuga. Murwere yake inofanira kuchengeta kwenguva refu sezvinobvira pamuromo. With kukwana zvichiguma chipimo chemushonga zvinodhaka ichiwedzerwa zvishoma nezvishoma kusvikira yokuora efficacy. Muchiitiko chino, zvose zvinoenderana wacho. Panguva Zvakazoitwa kuratidzwa BP anofanira kutungamirirwa kunyatsoreva yakatarwa dose. Uyewo, pane imwe chokuratidza chaicho. It iri chokwadi kuti kana BP akasimuka 190 / 100-220 / 110 mm HG. v., ipapo achitora zvinodhaka Madonhwe zvinogona kuwedzera zvishoma nezvishoma kusvika 10-15 (6,7-10 MG). Zvinofanira kufunga kuchinja nevamwe murwere kupiwa. Zvakakosha kuziva.

Unofanirawo kufunga kuvapo yakawedzera nehanya mune vamwe varwere kuti zvinodhaka izvi se "Farmadipin" (Madonhwe), izvo wongororo akanaka. Muzviitiko zvakadaro, kuti chipimo chemushonga anosarudzwa nomumwe. Tanga 3 madonhwe, uye ipapo zvishoma nezvishoma voendeswa 2-3 (1,34-2 MG) kusvikira nhambo apo aida kurapwa mugumisiro kunokwanisika.

Zvinofanira kurangarirwa kuti kupfuura kutanga dose zvinodhaka kungaita kuti munhu unopinza kuderera BP!

divi kushanda

In kushanda gadziriro ino se "Farmadipin" (kuderera dzvinyiriro), pangava zviratidzo kuda kurutsa, tachycardia, hypotension, "Maze" ropa kumeso. Mune zvimwe zviitiko, zvingakonzera neutachiona muchimiro gumbo edema, ganda nekumhanyirira. Vanogonawo kuratidza zviratidzo muutera, dzungu, nomusoro.

Contraindications

Negashiro ane mushonga zvakadaro, sezvo munhu "Farmadipin" (donhwe) chinorambidzwa kutakura pamberi yakawedzera aikanganiswa yenhengo dzayo, cardiogenic kuvhunduka, zvikuru kutsemuka uye mitral stenosis, hypotension, tachycardia, uyewo panguva yepamuviri uye lactation.

ovhadhozi

Muchiitiko chino, vamwe kunaka zvingaratidza kuitika. Kureva ovhadhozi zvinodhaka akadai "Farmadipin" (Madonhwe), zvinogona pamwe panowanikwa mwoyo kukundikana, kuvhunduka, metabolic acidosis nokugwinha, rakapinza donhwe BP. Kana kuratidza zviratidzo izvi zvinokosha kushandisa zvimwe kukurumidza zviyero rubatsiro. Zvinosanganisira muna gastric lavage, kusashanda kabhoni, karusiyamu chloride uye okusuma sympathomimetics, symptomatic kurapa.

kushandisa Features

"Farmadipin" (kuderera kumanikidza) kana chinotsiva kuti kuiswa chete chete nokungwarira kunotoda richiona wevarwere vakwegura uye varwere vane:

- kusagadzikana angina.

- zvikuru mwoyo kukundikana.

- hypertrophic cardiomyopathy.

- yakakomba ingabatanidza kutsemuka stenosis.

- zvakakomba pulmonary neBP.

- chenjera sitiroko.

- Diabetes mellitus.

- Renal nerevane chiropa.

The chipimo chemushonga mamwe inoshandiswa nifedipine anofanira kuisa nomumwe. Cardiac glycosides inogonawo kushandiswa panguva negashiro mishonga yakadai "Farmadipin" (Madonhwe), analogs zviri pasi apa murugwaro urwu.

Pamusoro kugamuchira mawa kushandiswa nifedipine pamwe intravenous magnesium sulphate vakadzi vane pamuviri vanofanira kushandisa kungwarira kuongorora kuti BP. Izvi zvinofanira kuitwa nokuti pane mukana BP kuti anogona kukuvadza zvose amai mudumbu.

Varwere havachanyatsogoni hepatic functionality, dzinodawo kungwarira kuongorora. In chakakomba pacho dose anofanira kuderedzwa.

Nifedipine tsitohromichnuyu rinoita nomukombiyuta P450 3A4 hurongwa. Somugumisiro, zvinodhaka kuti inogona kuderedza kana kufurira yakanatsa nzvimbo enzayemu anogona kuchinja kunoita "Kupfuudzwa pakutanga" kana Clearance yacho fuma. Kana kushandiswa concomitant pamusoro nifedipine zvinodhaka izvi mhando kunofanira kudzorwa BP. Kana zvakakodzera, vanofanira kushandisa imwe rutapudzo iri chipimo chemushonga zvinodhaka, se "Farmadipin" (madonhwe).

Kuitisa vakaparadzana kuedza ezvokunambira kunze kwomuviri waamai mukazvizarurira ukama pakati kushandisa karusiyamu mhandu iyi nyaya nifedipine uye nokukanganisika Ivan Kuchin spermatozoa kuchinja kukanganisa Kushatiswa mano ekupedzisira ezvidzidzo muchangosangana.

Kutora "Farmadipin" (Madonhwe), inofanira angarega zvinhu angangokuvadza ngozi mhando, inoda zvikuru nezvayo. Kureva, kana hazvina zvakakodzera kudzinga motokari uye kushanda pamwe nedzimwe nzira, uye zvichingodaro.

kudyidzana

"Farmadipin" (droplet) ane hypotensive chiito. chinhu ichi runogonesa zvinodhaka muchikwata blockers. Ndiko, "Farmadipin" (donhwe) anowedzera β-adrenergic zvinokonzerwa, diuretics, nitrates, uye dzimwe antihypertensive nevasori, kugadzirira uye zvinwiwa zvine doro, tricyclic antidepressants. Mune zvimwe zviitiko, nifedipine kunoderedza quinidine wevasungwa muropa plasma. Asi kudzimwa wake zvikuru anowedzera. Saka, achishandisa wemishonga mishonga inokurudzirwa kuongorora kwevari quinidine wevasungwa muropa plasma.

"Diltiazem" akazoita Clearance zvinodhaka se "Farmadipin" (mumate). "Fentanyl" Sezvineiwo runogonesa kuratidzwa hypotensive maturo. Somugumisiro, risati kwokubatsira mushonga (maawa asingasviki 36.) Vanofanira regedza kugamuchira "Farmadipina". Joint Kushandisa β-blockers pamwe nifedipine kungatungamirira hypotension. "Farmadipin" (anosiya) anovandudza wevasungwa pamusoro theophylline, carbamazepine uye digoxin muropa. "Rifampicin" inotungamirira kwakaderera ari kuchirapa mugumisiro nifedipine, nokudaro rikurumidze nomufambiro waro muviri. "Cimetidine" kunonatsiridza wevasungwa "Farmadipina" iri plasma.

Terms uye mamiriro ezvinhu okuchengetera

Muchiitiko chino, pane mamwe zvinodiwa. Store "Farmadipin" (donhwe) anofanira kuva ari mukamuri tembiricha panzvimbo yakaoma. The mushonga inofanira kuchengetedzwa kubva chiedza uye pasingasvikirwi nevana. Storage zvinodhaka ichi rakagadzirirwa kusvika 1 gore uye 6 months. Kamwe akazarura chinu - mazuva 28.

zororo

"Farmadipin" (anosiya) inogona bedzi kuzadzikwa mushonga.

chiputiriso

In ndiro 25 Rine mamiririta kana 5 Rine mamiririta. Ivo paakapiwa ari rongedza.

"Farmadipin" (Madonhwe) analogues muRussia

Kune Sevamiririri zhinji kuti zvinodhaka. The zvihombe ndiwo:

- "cordipin".

- "Nifedipine".

- "Adalat".

- "Kordafleks".

- "Corinfar Uno".

- "Kordafleks RD".

- "fenigidin".

- "Osmo-Adalat".

- "cordipin kutadzisa."

- "cordipin XL".

mhedziso

Zvino kuti unoziva zvinorehwa akadai "Farmadipin" (donhwe) mushonga, izvo zvinobatsira uye chii zvivako. Chero zvazvingava, asati kutora zvinodhaka uku kunofanira bvunza chiremba anokwanisa.