"Esomeprazole": mirayiridzo kushandiswa, dzomuzana chaiwo

"Esomeprazole" - mushonga rwevharanda Organotropona gastrointestinal zvinodhaka. The mushonga une antiulcer chiito uye hwepurotoni pombi inhibitor.

Murwiyo, kusunungurwa chimiro "esomeprazole" chinodhaka

The mushonga inowanika muchimiro mahwendefa ane chipimo chemushonga 20 uye 40 MG ine basa chirungiso esomeprazole, uyewo mune muchimiro upfu akaronga kuti mhinduro kuti jekiseni (40 MG chinu). Coated pamahwendefa, nemukuparadzwa zvinotora nzvimbo ura.

Pharmacological chiito "esomeprazole" chinodhaka

Chii chinodhaka "esomeprazole"? Mirayiridzo dzokushandisa kunoratidza kuti ichi antiulcer mumiriri, izvo, kuva simba chawo, anogamuchira basa fomu pashure ingestion. "Esomeprazole" kunoita kuti kurwadziwa kuve enzayemu H ⁺ -K ⁺ -ATPase basa, uye secretion pamusoro hydrochloric asidhi (dzinovhurika, basal). Zvakafanira chiito kunoitika mukati kweawa pashure ingestion zvinodhaka. Kana kugamuchira "esomeprazole" akaita zuva nezuva, kwemazuva mashanu, zvinobvumidzwa zuva dose - 20 MG pashure kurudziro kupfurikidza pentagastrin kunonyanyisa pamwero hydrochloric asidhi ipfupi substantially (anenge 90%).

Pharmacokinetics

"Esomeprazole" mirayiridzo kushandiswa kwakafanana mushonga iyo, rakapinza mukati mumuviri, nokukurumidza uye zvakanaka kunyura, runokusunganidzai kuti mapuroteni anenge 100% (97%). The bioavailability yakawedzera nekushandisa kuramba zvinodhaka kubva 64 kusvika 89%. The medicament anotora chimiro metabolites uye yabudiswa achinyanya iri weti, mugove kuduku dzaro zviri mutsvina yadzo.

Zvairatidza "esomeprazole" gadziriro

"Esomeprazole" analogues yaishandiswa varwere gastroesophageal reflux chirwere kurapwa uye kuitazve ekudzivirira. The chishandiso inoshandiswa mukurapa nemaronda mudumbu kana duodenum, yokudzivisa chirwere anomuka nokuda NSAIDs.

The mushonga inoshandiswa peptic urikanwi kana kukanganiswa duodenum kana mudumbu. Inogona kushandawo kune varwere vanenge vaporeswa esophagitis, panguva kwenguva refu ekudzivirira wava kusvutazve. Bvumidzwa kwemajoini Chikumbiro pamwe rinoreva "esomeprazole" zvinodhaka antibacterial. Mahwendefa uye jekiseni iri kunzwisisa kurapa pane iyi kubvumira kuparadza Helicobacter pylori.

Contraindications kugamuchira "esomeprazole" chinodhaka

Contraindications zvinosanganisira zera asingasviki gumi nemaviri, hypersensitivity kuti esomeprazole, nguva achiyamwa. Migumisiro kurapika vasina dzakatangwa panguva yepamuviri.

zvinodhaka Usage

The mushonga rinoshandiswa nenzira nezuva dose pamusoro 20-40 MG. Ya ARV vakatsunga zvairatidza zvaiitwa uye kugamuchirwa kunyatsoshanda medicament "esomeprazole". Mahwendefa uye zvakaoma ruchiyerera mhinduro pa renal insufficiency vachishandisa kunonyanyisa dose 20 MG.

Erosive reflux esophagitis kurapwa kwevhiki mana ane zuva dose 40 MG. Munguva kwenguva refu kudzivirira dzokororo inobva mabiko zvinoreva murwere umo esophagitis akanga aporeswa, nezuva dose yakaitika kuwanda 20 MG.

In kurapa reflux oesophagitis, zvainanga kugadzirisa dambudziko chirwere zviratidzo, achitora 20 MG zvinodhaka "esomeprazole". Kugadzirira muchimiro mahwendefa uye upfu inoshandiswa kuuraya H. Pylori, kana pane kukurukura duodenal urikanwi, mune mubatanidzwa kurapa - "esomeprazole" (20 MG), "Clarithromycin (500 MG)," amoxicillin "(1 g). mishonga All atora kaviri pazuva.

Dumbu nemaronda anokonzerwa NSAIDs, Zvinokurudzirwa kubata 20 MG "esomeprazole" pazuva. The aida dose anogara ndinoshanda chiremba kufungisisa utano murwere, chirwere, kwokuomerwa vadzore, uye zvimwe zvinhu zvinokosha.

Side Inovapo "esomeprazole" chinodhaka

Varwere vari kushandisa zvinodhaka izvi kwenguva refu, vari tichikurumidza kuti paumbwe glandular cysts mudumbu pane vamwe varwere. Zvikuru kakawanda yaivhuvhuta kuratidzwa muviri panguva kurapwa rinoreva "esomeprazole" mirayiridzo iri kushanda allocates nomusoro uye zvimwe zvinoitwa kunaka kubva nemudumbu, akadai: kupatira, flatulence, manyoka, kuda kurutsa, kurutsa, pamberi kurwadziwa mudumbu. By vashoma divi anokonzerwa zvinosanganisira nokuomesa pamusoro mucosa mumuromo, dzungu, urticaria, kuvaviwa, dermatitis. Kumwe kuita zvinogoneka, saka kurapwa kunofanira kuitwa zvachose pasi pokudzora nyanzvi.

Ovhadhozi achabatsirwa vakawanda simba, kuwedzera kuitika nemishonga, kusanganisira pamusoro chikamu zvomudumbu turakiti. Muzviitiko zvakadaro, kurapwa rinoitwa kusava zviratidzo ovhadhozi nokuchengetedza mishonga. Dialysis ane anenge asina zvinozoita, hapana mushonga.

Zvokungwarira

Pregnant vakadzi "esomeprazole" analogs raitongwa nokungwarira zvikuru. Treatment panguva yepamuviri inofanira raitarisirwa chiremba. kuti mushonga wacho ushandiswe vakadzi vane pamuviri chete idzodzo zviitiko apo pesvedzero inobatsira miviri yavo yekudyidzana akapfuudza zvinogona kukuvadza mwana asati aberekwa. Nhungamiro kwazvinoita kubata zvinodhaka riri embryo harisati, kure sezvinobvira havafaniri kurapwa pamwe nemishonga iyi. Kushandisa zvinodhaka "esomeprazole" kana uchiyamwisa hakubvumidzwi.

Kana kuputswa chiropa kwazvo yakatarwa dose ndiyo utano (kana kutyorwa ava zvakakura).

Kana murwere zviratidzo anozivikanwa chiratidzo, akadai hematemesis, dysphagia, kuda kurutsa, zvinokosha zvinoderedza uremu muviri panguva kurapwa nguva "esomeprazole" kuti kubvisa kana urikanwi nokuda vachitungamirira mushonga iri pamberi vanofungidzirwa chirwere, malignancy zvinofanira dzadzimwa. Kuziva akaipa zvisikwa anomera zvakafanira kuti azodzidza.

Varwere vane kusava sucrase-isomaltase, nhaka fructose kusashivirira hunhu rambidzwa kugadza "esomeprazole" anoreva zvakafanana.

Kudyidzana "esomeprazole" nevamwe zvinodhaka

Tiine mawa kushandiswa kwezvinodhaka ne "citalopram", "clomipramine", "imipramine" zvichibvira potentiation pamusoro vamiririri izvi, kuvandudzika yezviri fuma muropa. Parinoshandiswa pachiimbwa "esomeprazole" akaderedza kunyatsoshanda "ketoconazole" "Itraconazole" Zvinoipisisa Absorção de Água yavo.

Kana kubatanidza "esomeprazole" ne "ATV" kwave kuchikosha vasanyanye nokufumura zvinodhaka ichi. "Esomeprazole" uchishandisa mirayiridzo isina varumbidzwa kushandisa panguva imwe chete chete "phenytoin", "clomipramine", "imipramine" uye zvinodhaka zvakadai "citalopram", "Diazepam", "Nelfinavir" uye "Atazanavir". The pamwero zvinodhaka izvi anokwanisa kusimuka muropa, saka kungava kwakanaka kutapudzwa mishonga yavo. Concomitant Kushandisa «esomeprazole" uye rinoreva "clarithromycin" zvinotisvitsa nouchapupu vachinje dzokupisa "esomeprazole" rikauya kuwedzera ayo chokuita chinovhiringidza kuti muviri yacho zvinodhaka. Izvo zvinofanira nokungwarira vaiona instrukiyu kune zvinodhaka uye kunobvunza nyanzvi.

Mari chinodhaka, akaongororazve pamusoro zvinodhaka "esomeprazole"

The mushonga kunyanya awana piritsi fomu. Pharmacies "esomeprazole" dzinogona kuwanikwa pasi nemugwagwa mazita "Nexium" uye "Emanera". Kana iwe kutenga zvinodhaka "esomeprazole" mutengo kunoenderana dose yezviri fuma racho sezvamunoita. Mari mushonga ari chipimo chemushonga 20 MG ( "Emanera") anenge 500 rubles. nokuti mahwendefa 28 uye pakutsvaga mugadziri. Mishonga ine dose 40 MG yezviri chirungiso ( "Nexium" Mahwendefa 28) inogona kutengwa nokuda 3000 rubles.

"Esomeprazole" rine wongororo vainyanya akanaka. Vakaona zvinodhaka pfuma kutitadzise iine acid secretion, zvose basal uye dzinovhurika. The mushonga akaratidza yakakwirira efficacy pakurapa ezvinhu kuenzana zvinoratidza zvakajeka mirayiridzo. Panguva mushonga, ichi zvinoreva pane zvishomanana ndingangokuvara nemishonga. Havasi vose nyore kuwana mushonga mune Pharmacies, vamwe varwere vakanga vawedzerwa "esomeprazole", mitengo sokuti kumusoro.

Vaya akatora mishonga waakaudzwa nachiremba pashure chaiwo tsanangudzo nechirwere uye zvavakabvumirana dose, tara chinokosha kuvandudza utano. Sezvo ongororo, "Nexium" zvikuru akakurumbira pakati varwere pane "Emanera". Apo "Nexium" gastric inopa pakuonekwa unodikanwa mugumisiro pashure anenge mumwe mwedzi pashure mharuro mushonga. Kuvandudza mamiriro anogona kuitika mushure memasvondo 1.5 pakurapwa. Side Marwadzo mashoma chaizvo. Drug "Nexium" zvinobudirira, zvinobatsira nemashoko kuchaitwa mamiriro ezvinhu anotaurwa mirayiridzo. Kuti zvaiita yakanaka, zvinokosha kupedza kosi uye zvakazara vanoomerera chiremba audzwa.

Analogs "esomeprazole"

Pfungwa dzinotevera zvinogona kupatsanurwa kubva analogues zvinodhaka:

• "Omeprazole" - hunonziwo "Losek", "Omez", "Ultop";
• "Rabeprazole" - imwe gadziriro anozivikanwa pasi mazita "Ontaym", "Zulbeks", "Noflyuks" "Pariet", "Hayrabezol";
• "Pantoprazole" ( "Sanpraz", "Kontrolok", "Nolpaza");
• "Lansoprazole" ( "Lanza", "Lanzoptol").

zvinodhaka zvose izvi zvakafanana migumisiro, asi ivo vakasiyana mumwe nomumwe kukosha kwavo.

Enzana "esomeprazole" uye "Omeprazole". Kusiyana zvinodhaka ava pachena. "Esomeprazole" ane isomer "omeprazole". gadziriro iyi, kubvira zvokurapa mabhuku data, ane yakawanda zvinobatsira, asi akafanana kuitwa medicaments. "Omeprazole" ndiwo mushonga Muongororo yekutanga ukoshi kune vakawanda nemishonga. Kana tikafunga ehupfumi ari "esomeprazole", mushonga inopiwa nani shanduro "omeprazole", mutengo izvo mwoyo varwere vakawanda. Zvisinei, "esomeprazole" kashoma kuti pasingadiwi siyana, saka kutenga kwaro anonzi mari yakawanda pane kutenga "Omeprazole".

"Rabeprazole" uye "esomeprazole" vane makemikari anoumba yakafanana, zvavanoitira chirwere chete. Asi nyanzvi dzinodavira kuti zvimwe zvirwere, zvakadai gastroesophageal reflux chirwere, "Rabeprazole" anobvisa zvinobudirira, izvozvo anobvisa zviratidzo nani, izvozvo zvinoita kuti nokukurumidza kuzoita yegurokuro mabasa. Kushaya kunobatsirawo pakurapa "esomeprazole" anogona chokuita nomumwe zvechadenga muviri.

Kana zvakakodzera, sarudza kuti analogue vanofanira kubvunza chiremba. Itirawo zvakawanda dzakateerera utano hwavo, uye kukunda muedzo nguva, ipapo kupora achava nokukurumidza uye iwe uchava kudzivisa matambudziko akawanda.