Embryonal rhabdomyosarcoma: kurapwa, fungidziro

Rhabdomyosarcoma anoreva muchimiro sarcoma - kenza rinenge munyoro, pfupa kana connective tishu. Bundu iri unganyanya kuitikira ari tsandanyama dzakabatana mapfupa. Rhabdomyosarcoma - malignancy rwupi ari skeletal tsandanyama. Vanotanga mune chimwe chikamu muviri kana munzvimbo dzakawanda.

Microscopically rhabdomyosarcoma nedzevakuru ane chimiro masero elongated kana vakagumisa noshamisa. More chinoratidza bundu iri vaduku.

mhando rhabdomyosarcoma

Rhabdomyosarcoma of womukati mamiriro vari rakakamurwa mifananidzo:

1. Embryonal rhabdomyosarcoma masero chinosanganisira kunhivi uye fusiform ane kuongorora cytoplasm anoratidza longitudinal kana transverse striations. Izvi mhando rhabdomyosarcoma anowanikwa kakawanda. Rinooneka embryonal rhabdomyosarcoma muvana uye kuyaruka. Zvinonzi munzvimbo pamutsipa kana musoro, pamusoro sikarudzi, ari nasopharynx. The aikanganiswa anomera kuti nemwaranzi kurapa, asi asingatani nokukurumidza wava kusvutazve.

2. Alveolar rhabdomyosarcoma rinoumbwa boka masero yakapoteredza uye denderedzwa, izvo wakakomberedzwa septa pamusoro connective tishu. Nokuti ichi mhando anomera inozivikanwa chitarisiko pamusoro makumbo kana maoko, dumbu, mazamu, mumagaro kana sikarudzi. Kazhinji anogona kuwanikwa kuyaruka uye vakuru pamusoro maoko nemakumbo. Fungidziro murombo.

3. Zvinoumba pleomorphic rhabdomyosarcoma - polymorphic chokurukisa-zvakaumbwa, Ribbon-kufanana, nyeredzi serin'i mumasero bundu iro kuonekwe pamakumbo kana maoko avanhu. Kazhinji, rhabdomyosarcoma kukura kunoitika nokukurumidza uye haakonzeri marwadzo uye dzichipfekeka zvirwere. Zvinoitika chete mutsinga. Kazhinji kukura kuburikidza ganda uye azere namaronda, achiumba exophytic, ropa bundu.

zvinokonzera njodzi

Pakati zvakatipoteredza zvinhu akawana vakadaro, kuti vawedzere ndingangokuvara panowanikwa bundu iri. Izvi zvakasiyana zvikuru nekenza rhabdomyosarcoma.

Nokuti asina chaizvo kuzivikanwa zvinokonzera bundu kukura, hatingagoni kupa chero zano zvokusaita inotungamirwa kwayo. Zvisinei, tinofanira kuyeuka kuti zvakakwana kurapa varwere rhabdomyosarcoma anogona dzimwe nguva kupera zvachose.

Njodzi zvikonzero kuonekwa embryo rhabdomyosarcoma vari majini vakatsunga zvirwere zvakadai:

1. Li-Fraumeni chirwere haiwanzowaniki chirwere umo nhaka unhu, kukuvara Gene kana kunyorwa mubereki refu maitikiro siyana bundu mhando akasimuka. Nhaka zvokurwara ichi vanyore specificity kuti bundu rinenge siyana apo zvinoshamisa kunowedzera ndingangokuvara dzichiri anomera pazera duku (Makore 30).

2. Neurofibromatosis mhando rokutanga - rakajairika nhaka chirwere kuti hunokonzera nezve kubatwa kuti malignancy.

3. Syndrome Beckwith-Wiedemann - zvokurwara, iyo inozivikanwa nokuva macrosomia, macroglossia uye omphalocele. Uyewo pachena zvikanganiso zviri vana rusvingo pamberi ari mudumbu heniya, neonatal hypoglycaemia, kuti kusiyana uku kunoita pamusoro rectus netsandanyama.

4. Costello chirwere - isingawanzowanikwi chirwere, iyo inozivikanwa nokuva vachiberekwa malformations: kukura retardation, zvinonyadzisa chiso features, ganda kuchinja.

5. Noonan kuti chirwere - chirwere chokugara nhaka dzinoratidzwa nomumhu iro zvarakasiya uye somatic kukura. Inogona kuitika mumhuri kana nhengo dzayo.

Babies vaiva pakuberekwa uremu uye kukura, vane kupfuura vamwe, mukana embryonal rhabdomyosarcoma. Zvisinei, sezvo mutemo, zvinokonzera embryonal rhabdomyosarcoma harizivikanwi. A chiratidzo chirwere ndiye nechitarisiko bundu kungoramba.

zviratidzo

Symptomatology chirwere kenza akatsunga. Panodiwa pakarepo bvunza chiremba kana vana zvawanyora zviratidzo kenza:

• edema kana kuzvimba, kuwedzera kukura kana kwete kupfuura, dzimwe nguva kurwadza;
• bulging meso;
• anotemwa nemusoro;
• zvakaoma defecation uye weti;
• ropa iri weti;
• ropa ari mugaranhoko, mhuno nepahuro.

Diagnostics

To musi, akakudziridza nzira kuti kusarudza rhabdomyosarcoma kusvikira ayo dzakajeka zviratidzo zvokutanga.

The tanga Zviratidzo kenza - dzeko kuzvimba kana induration, haakonzeri matambudziko pakutanga kana kurwadziwa. chiratidzo ichi runozivisa rhabdomyosarcoma, maoko, makumbo uye mutumbi.

Kana bundu iri mupasi mudumbu kana pelvic nharaunda anogona kukonzera abdominal marwadzo, kurutsa kana kupatira. It embryonal rhabdomyosarcoma pamusoro retroperitoneal nzvimbo. More kashoma, kukura biliary turakiti, rhabdomyosarcoma kunokonzera jaundice.

Kana paine fungidziro kuti nebundu ichi, zvinokosha kuti kuitisa biopsy, izvo zvichaita tsanangurai kuti rhabdomyosarcoma mhando yakatanga.

Kazhinji, rhabdomyosarcoma ichibudira munzvimbo zviri nyore kuona, Somuenzaniso, nasal mhango kana kunze yeziso. Kana bulging meso, kana nasal secretions kuonekwa, iwe unofanira pakarepo bvunza chiremba nebundu vanofungidzirwa kuti uonekwe vachiri padanho kwayo kukura. In apo rhabdomyosarcoma anozviratidza pamusoro pemvura muviri zvazvingava, zviri nyore kuona pasina kunyatsoongorora. Izvi zvinonzi embryonal rhabdomyosarcoma nyoro tishu.

Muna 30% varwere embryonal rhabdomyosarcoma vari vachiri Danho kana inogona chose kubviswa. Asi ruzhinji varwere detailed bvunzo inoratidza metastases diki, kurapwa izvo zvinoda kuvapo mishonga.

Embryonal rhabdomyosarcoma, izvo dziri munzvimbo jende munharaunda kazhinji achibudiswa vana vaduku uye akawana vabereki vomwana kana kugeza. Kana namamota kuitika mune Urinary turakiti, vanovakonzera kunetseka weti kana ropa kubuda - zviratidzo kuti hazvigoni kungotariswa.

mota rwakazara

1. Danho rokutanga. Bundu angava chero size, asi harisati kupararira kusvika node nodes wegadziriro uye riri muna rimwe prognostically zvakanaka nzvimbo muviri:

- meso kana periocular nharaunda;

- musoro uye mutsipa (dzakakudzingai zvinyama muuropi uye musana nharaunda);

- the bile ducts uye nenduru dundira;

- in dumbu kana manhu.

Places kunze vakanyorwa, vanoonekwa zvisingafadzi. nzvimbo.

2. Danho rechipiri. Kuzvimba ndeimwe vanoshorwa zvikamu (zvikamu izvo zvisipo mune zvakanaka). Bundu saizi idukusa 5 masendimita uye haina kunyenga kusvika node nodes kwakaitika.

3. Danho rechitatu. Bundu iri mune nzvimbo utsinye uye kusangana mumwe anotevera ezvinhu:

- kukura bundu asingasviki 5 cm uye vakapararira pamusoro rinotevera node nodes;

- bundu Yakakura kupfuura 5 cm uye pane mukana kuti zvichaita kupararira pedyo node raiva pedyo nebundu.

4. Danho wechina. Bundu saizi kunogona kuva chinhu, uye yakanga yakapararira kune node nodes inotevera. Pakave kupararira kenza kunzvimbo muviri kure.

mapoka njodzi

Basa boka pangozi murwere anosarudza mukana wokuti dzokororo ine rhabdomyosarcoma. mwana Chero anogamuchira kurapwa kubva embryonal rhabdomyosarcoma, anofanira kugamuchira mamwe mishonga kuti kudukupiswa mukana wokuti bundu dzokororo. View anticancer mushonga, chipimo chemushonga uye uwandu ezvidzidzo - izvi zvose zviri pakutsvaga ngozi chero mwana kunotaurwa - pasi, zvenguva kana mukuru.

marapirwo

Varwere embryonal rhabdomyosarcoma zvinogona kurapwa nenzira dzakasiyana.
Treatment kunosanganisira nyanyisa mapundu vakaparadzana methodologies riri kuonekwa chetsika. Other nzira dziri pasi nemiedzo zvekuchipatara. miedzo Clinical kunge vava kuvandudza yaivapo nzira kurapa kana kuwedzera uwandu mashoko ari Newest nzira kurapa varwere vane rhabdomyosarcoma. Kana somugumisiro nemiedzo kurapwa, zvinoita sokuti nzira itsva kurapwa vari nani kupfuura tsika, kurapa itsva achipinda muchikwata tsika.

Sezvo nyanyisa mapundu vanowanzotevedzera azviise siyana nzvimbo muviri, zvinoshanda vakawanda nokurapwa. Mabatirwo rhabdomyosarcoma muvana raitarisirwa chiremba oncologist.

Pakati nzira kurapwa, pane mamwe kuti inogona kukonzera marwadzo, kunyange kana kurapa pakasiyiwa refu.

sejari

nzira zvomusejari, kana kubviswa bundu, iri kushandiswa pakurapa rhabdomyosarcoma. oparesheni iyi inonzi "paupamhi womunharaunda excision". kukanganiswa Ichi kubvisa chikamu bundu uye dzakapoteredza zvinyama pamwe node nodes kuti uyewo inobata rhabdomyosarcoma. Treatment dzimwe nguva ndiko kuvhiya wandei. Chisarudzo pamusoro kugadzwa hwokushanda wayo mhando kunobva zvinhu zvinotevera:

- isa chepakutanga nzvimbo bundu;

- chero mwana mashandiro anoita muviri sei bundu;

- bundu Kupindura radiotherapy kana mishonga, iyo inogona kushandiswa iri panzvimbo yokutanga hwaro.

Vazhinji vana kubviswa rose Vhoriyamu bundu kubudikidza pakuvhiya hazvibviri.

Embryonal rhabdomyosarcoma nyoro zvinyama ruchigona kuumbwa panguva dzakasiyana-siyana dzomuviri, chimwe nechimwe kunoda yayo nokushanda. Kuvhiya kupindira zvinoratidzwa pakuparwa rhabdomyosarcoma sikarudzi kana maziso, kana biopsy akasimbisa chirwere. Pamberi oparesheni anogona kupiwa mishonga kana radiotherapy kuderedza mapundu makuru, zvisingagone kuvhiyiwa, kurerutsa basa nokubvisa kenza.

Kunyange kana chiremba anogona kubvisa bundu rose, varwere pakupera hwokushanda anofanira pasi mishonga kudzvinyirira masero kenza kuti varambe vachirarama. Pamwe mishonga, nemwaranzi kurapa inoshandiswa. Treatment zvainanga kuderedza ngozi dzokororo chirwere chinonzi adjuvant kurapa.

nemwaranzi kurapa

With ichi mhando kurapwa akashandisa X-ray kana zvimwe kupisa. Radiation jekiseni kutaurirwa chinhu, kuuraya bundu masero kana kuti kurega kukura kwayo. Chikumbiro chacho mushonga vakawana nzira mbiri radiotherapy - kwokunze uye dzakawanda.

External anoshandisa nemwaranzi panobva kunze muviri kuti irradiating bundu. Internal nemwaranzi jekiseni kana brachytherapy irradiates bundu pamwe placement pakati radioactive zvinhu munguva pfupi kunharaunda mukati womunhu muviri. Rinoshandiswa kurapa kenza dundira, musoro uye mutsipa, prostate, vulva.

Type nemwaranzi mishonga uye dose pakutsvaga mwana nezera uye mhando bundu, kwayo kwokutanga localization asiwo pamberi residual bundu uye ukuru bundu okuverengwa pedyo node nodes pashure kuvhiyiwa.

mishonga

kenza mabatirwo ichi kuti anoshandisa mishonga kumisa kukura nemasero kenza. Mishonga zvinodhaka zvinobatsira kuuraya masero aya kana kuti kudzivisa nokupesana kwavo. A systemic mishonga zvinodhaka vanobviswa nomuromo kana jekiseni nomutsinga kana intramuscularly. Pandakangosvika ropa, zvinodhaka sei masero kenza yose muviri. Kana zvenharaunda mishonga zvinodhaka jekiseni zvakananga kunyika mapazi uye muviri in, uyewo mune cerebrospinal mvura. Combination mishonga inowanzoshandiswa, inova kurapwa rinoshandiswa kanopfuura imwe Anti-kenza zvinodhaka. mishonga nzira anosarudzwa zvichienderana mhando uye padariro Kugadzirwa neoplasm.

Mishonga inoratidzwa mwana wose ari kurapwa rhabdomyosarcoma. Kunoitawo kuti kurerutsa mukana wokuti chirwere dzokororo. The kusarudza mishonga, iyo dose uye uwandu nzira yakajeka boka pangozi rhabdomyosarcoma.

kurapa New

Mhando New kurapa rhabdomyosarcoma, Rwaipfuura bvunzo:

• mishonga makuru mishonga pachiimbwa pakuita hunde sero nokuisazve. Nzira zvinoita kuti aronge yokutsiva masero hematopoietic kuti vaparadzwa munguva kenza kurapwa. Masero saibva ropa vanobviswa asati Mabatirwo mwongo kana ropa murwere uye akachengetedzwa. Pakazopera mishonga raskonserviruyut conserved hunde masero uye vakadzokera murwere nokuda aizomupa. Saka masero ropa kuti panoda.
• Immunotherapy. Kana kurapa kworudzi urwu kurwisa kenza achishandisa rokuzvidzivirira murwere. Raitongwa mishonga kuvandudza kana kudzorera kwomuzvarirwo kuzvidzivirira pamusoro kenza. kurapwa iyi inonzi biotherapy anomera.
• Vanosarudzwa mushonga. Izvi rworudzi ARV kunangana metastasis. Vanosarudzwa kurapa kunobva pakushandisa antibodies chaizvo kuti vasunge kune masero kenza. antibodies izvi akafanana kwakajairika antibodies evanhu muviri. Saka vanomiririra yepamusorosoro zvinodhaka. Nemhaka zvakanangwa kurapa pakurapa "kemisitiri" rinogona kuwanikwa kudenha kenza chete tisingazvikuvadzi masero utano. Kana rhabdomyosarcoma mu angiogenesis FIs anoshandiswa sezvo chipfuro mishonga. zvinodhaka izvi zvisaitika paumbwe midziyo ropa namamota. Izvi zvinotungamirira kuti bundu starves uye kwamira kukura. Angiogenesis FIs uye monoclonal antibodies - mhando nevamiririri nemiedzo zvekuchipatara Panyaya embryo rhabdomyosarcoma.