"Dopamine": mirayiridzo yekushandisa, kuongorora, tsanangudzo, zvakafanana

Chirongwa chezvemishonga chemishonga "Dopamine" inokonzerwa nehutano hwayo mu adrenergic zvinhu uye inoderedzwa kusvika pakuwedzera kwezwi, kukurudzira kwemutsipa wemwoyo nemidziyo yeropa, kushandiswa kwezvirongwa zvinowanikwa munharaunda yepamusoro yenheyo. Saizvozvowo, muviri unopindirana nehutachiona hwemahydone dopamine, iyo pasi pemaitiro akazara inogadzirwa nemasero eropi. Kushandiswa kwechirongwa ichi mukurapa kunorondedzerwa nekudiwa kwekugadzirisa zvakakonzerwa nemigumisiro yemamiriro ezvinhu anotyisa, zvirwere zvepfungwa (arrhythmia, kusanganisira), chepfu yekudya uye kuora mwoyo.

Metabolism uye kinetics

Maererano nemirayiridzo yekushandiswa, Dopamine, zvichienderana nemutero, inogona kuita se causative agent ye beta uye alpha-type adrenergic receptors, zvine simba kukurudzira systemic hemodynamics uye kuvandudza kushanda kwemuviri wemitsetse yeropa uye itsvo. Nhengo inoshanda inopararira kuburikidza nemuviri pamwe chete, asi chikamu chemagadzirirwo akayambuka ropa reuropi.

Kurapa kunopera mukati maminitsi mashanu mushure mekutungamirirwa kwemishonga uye kunopedza maminitsi anenge gumi. Maererano nemigumisiro yemetabolism, iyo inowanikwa muropa, itsvo uye zvishoma mu plasma, mapoka asingashandisi anoumbwa. Inenge 80 muzana yemutengo yakanyanyiswa kubva mumuviri nemugove nenzira ye metabolite sekutanga kwezuva rokutanga.

Inguva ipi inorayirwa kushandisa Dopamine?

Mirayiridzo yekushandisa inogadzirisa runyora rwakadaro rwemhosva:

• Kushungurudzwa kwemajini akasiyana-siyana (kusanganisira mamiriro ezvinhu akakonzerwa nokushandurwa kushandiswa kana chirwere cheshuga, pamwe nehutano hwemwoyo);
• Kuora mwoyo kwepfungwa (maitiro akaoma);
• Zvakawanda kana zvinokonzerwa nehupfu hwekudya (zvinodhaka zvinowedzera diuresis, iyo inobatsira zvakanakisisa muzinga wekubvisa kubvisa);
• Arterial hypotension.

Kushandiswa uye kuwedzerwa kwe "Dopamine"

Mishonga iyi ndeyeboka rezvinodhaka zvekudzivirira kwepirati. Nhamba yacho inotaridzirwa ichifunga nezvekutyisidzira kwechokwadi uye nekugadziriswa kunogadziriswa kweropa. Mukuwedzera, mutevedzeri wemurwere kune kukanganiswa kwese zvakatorwa.

Zvakakosha kunzwisisa kuti muroti (mg) haisiyo mutsara chete mukugadzirisa kwekufananidzira. Mhedzisiro yekupedzisira inowanzoenderana nekukurumidza kwokuti mushonga we "Dopamine" uchagoverwa. Mirayiridzo yekushandiswa inosimbisa izvi zvinetso:

• Kuwedzerwa kwekuita urinary kubva pa100 kusvika 250 μg / min;
• Therapy, pamwe nekupindira kwokuvhiya - kubva ku 300 kusvika 700 mcg / min;
• Dambudziko remwoyo kana kushamiswa kunoshamisa kwechimiro cheputi - kubva 750 kusvika 1500 μg / min.

Kana chironga chemwoyo chikaonekwa kana kamukira kadiri kacho kwaitungamirirwa, chirwere hachina kuwedzerwa. Kune varwere-vana yekugadzirira kunodonhwa nekuwedzera kubva 4 kusvika 6 mkg / kg / min. Speed inosarudzwa mumwe nomumwe, zvichienderana nemamiriro ezvinhu ekugadzirisa zvakanakisisa kuita.

Izvo zvakanyanya kuisa dopamine kune murwere mumwechete zvinogona kunge zvakasiyana - chinangwa ndicho chinangwa (kufungidzirwa kwechimiro chetsvo, midziyo, moyo, nezvimwewo). Asi kuwedzera kuwedzera kwemishonga kune 30 μg / kg / min uye zvakawanda hazvibvumirwi, sezvo izvi zvingakanganisa mamiriro ekurapa.

Contraindications ku "Dopamine"

Nezviitiko apo kushandiswa kwemishonga kunopesana, inozivisa mirairo yose yakafanana yekushandiswa. Dopamine, kunyanya, haisi kurongerwa kune varwere vane chirwere chakaoma chechirwere chetachiona kana kuti vane zvirwere zvisingaperi zvinokonzera matanho adrenal. Zvechokwadi, kusawirirana kwomunhu mumwechete kwezvikamu zvechirwere kunofanira kuva mumiririro.

Kuparara kwemwoyo rhythm mumurwere kana kufambira mberi kweherosclerosis zvimwe zvinhu zviviri zvakakomba zvinogona kuderedza chikonzero chakakosha chechiremba pamusoro pekusagadzirisa kwemugadziriswa. Mukuwedzera, iyo isingadikanwi zvakanyanya kushandiswa pakurongeka kwechidonho neDopamine, kana zviitiko zvinotevera zvichiitika:

• Thyrotoxicosis;
• Diabetes mellitus;
• Pheochromocytoma.

Hazvifaniri kunge zvichibvira panguva imwechete kutungamirira mishonga ne anesthesia majeri akaitwa maererano neshoko re halogen (kana zvarinowana). Nezvekugadzwa kwemishonga kuvakadzi vane pamuviri, chisarudzo chinoitwa nechiremba anoenda.

Zvimwe zvinokanganisa: zviratidzo uye kupera

Mushonga we "Dopamine" (mirayiridzo inoshandiswa zvakananga pane ino inoratidza) ndeyechibvumirano chakakosha chekubata pamuviri wemunhu. Uye mutemo unobvumirana pakati pemigumisiro inobatsira uye mamiriro ezvinhu, apo kukanganiswa kunokonzera kukura kwemigumisiro yakaipa, kwakanyanya kudeteka zvokuti chokwadi chaiwo chekushandisa mushonga chinogona kusarudzwa semuongorori wevanyanzvi vane ruzivo uye vakakwirira.

Semuenzaniso, kubudirira kwekuedza kuita kuti mwoyo yehutano ishanduke kuva nharo kana maitiro akaoma (pane kukwira kwakapinza muropa, kusuruvara kwakanyanya kwekusiyana zvakanyanya muchechi chechifu, nezvimwewo). Pakati pezvimwe zvirwere zvinokonzerwa nemararamiro - maronchial spasms, keusea, misoro yakakomba, yakashungurudzika, inoteverwa nekufunganya kusinganzwisisiki, dyspnea.

Dzimwe nguva pane zviduku zveganda necrosis, musuru uye gastric kubuda ropa. Nekunyanya kudarika, kujekeswa kwemigumisiro hakusi kwakaoma. Zvisinei, kuwedzerwa kwechikonzero chakakodzera chakakosha (mg) mumaduku maduku kunogona kutungamirira kuzvinhu zvakavanzika zvisingawaniki nyore nyore, izvo zvinoomesa kusagadzikana kwemigumisiro yakaipa yemigumisiro inopinza yeDopamine.

Special instructions

Imwe nzira yekusarudzo inogadzirisa mamwe mamiriro ekushandisa kwechirwere "Dopamine". Mirayiridzo yekushandiswa inowanikwa:

• Usati watungamirira chirongwa chemurwere mune dambudziko, zvinoda kugadzirisa hypovolemia nekujova ropa rinotsiva mvura;
• Varwere vakagamuchira monoamine oxidase inhibitors nguva dzose kwemavhiki mashomanana apfuura vanorayirwa kuti vasapfuure ne10% yezana rinowanzoitwa;
• Kuvhiringidzika kunofanirwa kuendeswa nekutenderwa kudzora kwekuvhenekera uye kukwira kwemwoyo; Uyewo kutarisa kuwedzera kweropa (kugadzikana mutoro pamisasa yeropa ine kuderedzwa kwakaratidzwa mu diuresis - chiratidzo chokuti chido che "Dopamine" chinofanira kuderedzwa);
• Varwere vari pasi pezera remakore gumi nemasere vanongopinda muboka risina ngozi, nokuti iri boka rezera iri harina kumbobvunzurudzwa zvakanyanya pamusoro pemhinduro yezvikamu uye maitiro kune zvikamu zvechirwere;
• Kuiswa kwemugadziro mumuviri, kana zvichibvira, kunofanira kuitwa kuburikidza nemitsara yakawanda yeropa (kuderedza dambudziko rekugadzirwa kwechibage); Kana kusunungurwa kweropa kubva mumidziyo muzvivara zvichiitika, zvinokosha kutora matanho ekukurumidza kupinda mukati;
• Pokukanganwa kwekutanga kwekuvandudzwa kwenharaunda ischemia, kushandiswa kwechirwere kunopedzisira.

Kuwirirana nemimwe mishonga

Kufambira mberi kubva pane zvakasiyana-siyana zvemakemikari zvakagadzirwa nemishonga "Dopamine" (tsanangudzo yemishonga inopiwa pamusoro), inogona kugumiswa kuti iyo inoshandiswa nepamusoro pemasikirwo inoenderana. Kunyanya, sarudzo inopinda zvisina kunaka kune zvinokonzerwa ne-alkaline (kubviswa kwezvikamu), pamwe neyimbi yehuni uye thiamine (iyo yekupedzisira inoputsa malekoro e vitamini B1). Izvozvo zvinokonzerwa nehuwandu hwekukanganiswa kunoitwa damped kana, zvakafanana neDopamine, nzira yekurapa inosanganisira meqylamine (kana kuti yakagadzirwa).

Kushandiswa kwechinyorwa kwechirwere ichi ne levodopa zvinotsigira kuti kuitika kwekugadzirisa arthmia. Nekudaro, zvinhu zvinoshingaira, zvakadai se ergometrine uye ergotamine, zvinogona kukonzera mhirizhonga, uye mukunyanyisa kudarika kweDopamine - uye kunokonzera kusagadzikana kwemahymorrhage.

Pane kunaka kwakakwana ne glycosides inoshandiswa mu cardiology, uye diuretics.

Mifananidzo yakakurumbira ye "Dopamine"

Mazita emabhizimisi emishonga, iyo inoshandiswa inoshandiswa iyo inofananidzwa nechimiro chechirwere "Dopamine" (zvakafananidzwa zvinowanikwa muchirongwa, zvichiratidza kuwanda kwekuwanika kwavo mumusika wemisika):

• "Dopamine", nyika inobereka iri Russia.
• Dopamine-Admeda, Germany.
• "Dopamine-Solvay 200", Germany.
• "Dopamine-Solvay 50", Germany.
• Dopamine-Hydrochloride, Poland.
• "Dopmin", Finland.

"Dopamine": maonero nemashoko

Nokuda kwehuwandu hwezvinodhaka, hazvisi nyore kuti uzive maonero evarwere pamagariro ayo (varwere vanopinda mukurumbira, vari mumamiriro ezvinhu anotyisa, vari muimba huru yekuchengetedza kana kuti pane imwe patafura yekushandisa). Nharo dzezvematongerwo enyika, dzakapararira pamapeji emaforamu, dzinoitwa kunyanya neanesthesiologists nevashandi vekurapa kwekukurumidzira.

"Dopamine", inorondedzera pamusoro payo muhuwandu hwandisinganzwisisi zvakawanda kune munhu asina dzidzo yakakodzera ndeye mishonga ine nzira isiri yekuchengetedza nzira yekugadzirisa: iyo nzira yezvinoitika inotungamirirwa kubva panguva yekuiswa kweiyo mubairo wekutanga kusvika pakubudirira kwechikonzero chaidiwa, kureva, kupfuura urefu hwose hwemukati wenguva. Uye chiremba kuburikidza nekugadzirisa huwandu nekukurumidza kwechigadziriswa kuburikidza nemudonho unogona kuchinja vector yemishonga yayo.

Inonzi hormone dopamine uye vanorwisana nayo

Zita risingazivikanwi re dopamine rinonzwika sehomoni yekutiza. Iyi yakaoma makemikari inoumbwa inogadzirwa nemasero eropi uye inopa zvinhu zvakajairika (zvinowanzo mukunzwisisa kwevanhu) basa remapoka ose emasumbu uye kwete chete. Kunakidzwa, kusununguka, kugadzirira chero mimwe miedzo - iyi ndiyo nzira iyo psychophysical portrait yemumwe munhu inotarisa mumhuka iyo hormone yakabudiswa. Kana iyo inenge isina kukwana, "dambudziko rinotyisa" rinotanga: mune mufambiro, masangano anoonekwa, kusada kubvuma zviri kuitika zvakapoteredza, kufamba kunomanikidzwa, pfungwa dzekufunga dzinodziviswa.

Dzimwe nguva kune chido chekuvhara maitiro ezvinyorwa zvinogadziriswa nehomoni yekutiza. Basa rekudzivirirwa kusingagoneki kunoitwa nevanopikisa dopamine. Mishonga yeboka iri haisabviri mukana wokuwana "kugutsikana kwepanyama", kureva kuti, chaizvoizvo, kudzimisa basa rehupfungwa hwepfungwa. Murairo wevadzivisi vei hormone inonzi yakakodzera schizophrenia, kurapwa kwemishonga yekuderedzwa kwemishonga, kusingaperi migraines, kushungurudzika kwepamu.