The mushonga 'karusiyamu pantothenate': unhu uye kushandiswa mushonga

Pantothenic asidhi (chipimo chemushonga fomu - mushonga "karusiyamu pantothenate") muboka vhitamini B. iyi jikichira, optically kushingaira mvura, zvikuru soluble mu mvura, iri nyore wakanamatira pasi zvinoitwa kupisa, acids uye alkalis.

Pantothenic asidhi inowanikwa zvokudya uye synthesized ne intestinal microflora (Escherichia coli). Pashure Absorção de Água inopinda muropa uye achaendeswa mapazi ose uye munyama, iri iiswe chiropa, pamwe mu myocardium, itsvo uye skeletal tsandanyama. Mumuviri, kunyanya asidhi chokuita mapuroteni uye chikamu CoA (coenzyme A). Kuparara zvibereko zvinodhaka "karusiyamu pantothenate" yabudiswa muna weti uye mutsvina yadzo. Zvinofanira akati kuti uwandu wasarudza pantothenic asidhi nguva dzose kupfuura izvo akapinda muviri nezvokudya. Izvi imhaka yaro kwemabhakitiriya kwetunhu.

Pantothenic asidhi ari chezvinonhuwira CoA randinogara zvikamu zvitatu: vakasara tiolamina, pantothenic acid, 3-phospho-5adenozin-5-diphosphate. CoA chinokosha chinhu muviri, paChikoro kushanda ari Krebs kutenderera ari chaivo kwetunhu uye oxidation pakati makabhohaidhiretsi, lipids, glucosamine inotungamirwa, acetylcholine, hippuric acid, porphyrins, etc.

Drug "karusiyamu pantothenate" - zvishoma yellowish kana chena upfu ane shungu kuravira, odorless, soluble mumvura. Aqueous zvingaitwa kuti thermally kugadzikana, asi nokukurumidza kuputsa kana vachibatwa asidhi uye alkali. The mishonga kugadzirira rinobudiswa sezvo mapiritsi, upfu uye negadziriso mune ndiro.

pharmacological Zviito Its kugadzirira "karusiyamu pantothenate" kunoratidza pashure pantothenic asidhi tinoshandurirwa coenzyme A, iyo inopa Beta-oxidation, mafuta iine acid usage, oxidative decarboxylation, uye vachichinja pyruvic asidhi uye ketoglutaric acetyl. Inobatsira Absorção de Água kuti shuga iri ura, anowedzera padanho glycogen ari chiropa, normalizes kwemakemikari omuviri mamiriro nhengo, kunyanya panguva yepamuviri.

At kushayiwa pantothenic asidhi mu muviri chinovatadzisa kemikari basa pituitary, adrenal shwanu uye rwatata. The adrenal mumasero akazoita pachiyero steroid mahormone, izvo zvinopa pigmentation bvudzi uye ganda. Metabolic chirwere chinokurwadzai dermatitis, ganda depigmentation. Chinopedza kuchinja akaona adrenal omumuviri uye huta tishu. Vanogonawo kuva akaputsika gwenya kufambisa, achiipa cheitsvo, mwoyo, ura uye dumbu. The chikuru zvinokonzera vhitamini pokuperevedza havakwanisi yakawanda vhitamini iyi zvokudya, bowel chirwere, uye kushandisa yakareba inorwisa mabhakitiriya (sulfonamides, mishonga inorwisa mabhakitiriya).

The chikuru zvekuchipatara zviratidzo kusava pantothenic asidhi pamuviri - mwoyo, kurukutika, kurukutika, kushaya hope, nomusoro uye tsandanyama kurwadziwa, kuda kurutsa, manyoka, Flushing ganda chemabhazi, duodenal urikanwi. At kushayiwa vhitamini kwakaderedza immunological nemishonga yacho muviri. Against ichi kumashure, zvikuru kazhinji pane zvirwere kufema.

kazhinji, vanachiremba akarayira kuti zvinodhaka "karusiyamu pantothenate" nokuti mutemo metabolic kwendangariro. Kubvuma akati medicament polyneuritis, paresthesia, neuralgia, bronchitis, eczema, dermatitis, kutsva, trophic maronda, pamuviri toxicosis, tibhii, hypothyroidism, pfungwa nomuviri zvemwana asati, gastroduodenitis, etc. Medicine "karusiyamu pantothenate" zvakanaka akashivirira pachitunha. For enteral Kutarisirwa anogona dyspeptic zviratidzo, kubudikidza parenteral (intramuscular jekiseni) - soreness.

Oversupply calcium (hypercalcemia) anogona kuitika nokuda dysfunction pamusoro kwemakemikari anobudiswa mumasero (parathyroid gland). Hypercalcemia rinonyoreswa mune vakwegura. hypercalcemia Clinic anogona kuratidza sezvo vakawanda simba, kurasikirwa kudya, dzimwe nguva akacherechedza chinyamunhari chinorwadza uye kupatira.