Alpha-blockers: tsananguro uye kupatsanura

Pamusana kwesainzi mumunda Pharmaceuticals nguva dzose ari kudzidza kuita mishonga, kusunungurwa zvakawanda zvemazuva mukuru-waivako zvinodhaka. Asi kune zvinodhaka zvakawanda nezviito kuti inokosha kwemakumi emakore. Izvi zvinosanganisira Arifa-blockers.

Most kazhinji zvinoshandiswa zvinodhaka Mabatirwo BP, nokuti BP uyewo dzinoverengeka Urological zvirwere, semuenzaniso, chisingaperi prostatitis uye benign prostatic anomera.

History yakawanikwa

Kuwanikwa Alpha-blockers ari Russian neindasitiri inogadzira mishonga yakaitwa muna 1976. Sezvo vaionekwa mishonga inoshanda izvo kuderedza BP. Asi avo kushandiswa haisi nguva dzose kwakakodzera nokuti zvakawanda nemishonga. Imwe mishonga vokutanga boka iri raiva "Prazosin". Next, zvakanga kwakatangwa kugadzirwa mamwe Alpha-blockers akadai "Doksasozin" uye "Terarozin". Vose zvavo, uyewo "Prazosin", anoshandiswa kurapa BP, asi akasiyana nayo chiito yakawanda kwenguva yakareba.

Asi zvakasiyana ukuru localization nzvimbo uye chinangwa dzichipfekeka yeAlpha-blockers. Kugadzirira zvichakurukurwa pazasi.

mhando

Adrenergic receptors vari rakakamurwa subspecies maviri:

• Kanotokonya Arifa-1, izvo riri pamusoro pemvura Kamudzira ari postsynaptic dzouropi anokonzera anonongedzera Kwaiitirwa kushandisa catecholamines pamusoro dzimwe Tutsinga tunofambisa mashoko utwu kana effector mumasero, kusanganisira masero vamwe nhumbi. Mhedzisiro nebasa receptors izvi ndizvo vasoconstriction.
• Alpha-2 receptors, izvo riri pamusoro pemvura Kamudzira ari presynaptic dzouropi kutungamirira chizvarwa norepinephrine ari synaptic mumukaha Via zvakaipa inofambiswa, nokudaro kuderedza kugadzirwa noradrenaline, vaunganidza munyika synaptic mumukaha.

Implementation Kanotokonya blockade yeAlpha-1 vascular kumeso tsandanyama vasoconstriction anobvisa wakatsamwisa catecholamines. Zvadaro Alpha-2 receptors iri presynaptic Kamudzira pakati dzouropi, kwete rakavharidzirwa, ipapo panoita kuvimbika dzinovaka mashandiro, wakatsamwiswa nokubudiswa noradrenaline.

Kusarudza 1 (blockers) muri mhandu ose postsynaptic receptors. Kwakadaro medicaments kubvisa Kanotokonya basa nokuda zvinokonzerwa catecholamines kusunungurwa riparadzirwe, uye Tutsinga tunofambisa mashoko utwu.

mabasa

Mukuwedzera kukuvara BP rutapudzo, Alpha blockers (zvinodhaka dziri pazasi) nevamwe mabasa. Etokardialnye, metabolic, extracardiac kuchirapa migumisiro. Sci yakakwirira kunyatsoshanda boka iri zvinodhaka pakurapa zvachinja myocardium, coronary hurongwa, mune bata mapuroteni ari prostate.

extracardiac

• Kweiyi neitsvo.
• Wokunatswa Árbol sepombi.
• Improvement kuti metabolic pezvakaitwa munyika urogenital ezvinhu panguva prostate benign bundu.

Alpha-blockers vane kunobatsirawo mukuderedza bundu kukura uye ukuru kwokuomerwa kusabetsera.

cardiac

• Kuderera kwemitambo myocardial hypertrophy.
• Chengetedza mwoyo mutinhimira.

Nokungwarira nokuda kunambwa inoshandiswa mwoyo nokukundikana uye angina.

metabolic

• Yekuzvidzivirira remafuta akawandisa plaques.
• Usanyanya ropa shuga yomuropa (jekiseni) muropa.

Sezvataurwa pamusoro apa, kazhinji Alpha-blockers inoshandiswa pakurapa zvirwere kweprostate gland nevanhu.

Mukono Vagari pamusoro makore 50, kazhinji vanotambura ichi Chirwere, rokutanga inova prostatitis uye yeprostate adenoma.

zvirwere izvi vane inokanganisa munhu mararamiro yose. Persistent nezvinetso weti, kusagadzikana, mberi kusabetsera mamwe matambudziko kuvanhu vemazera. Mukuwedzera, zvirwere-ataurwa pamusoro vanoonekwa kuti kuwedzera. Kazhinji anogona kuita pasina kuvhiyiwa. Kumisa chirwere rikwanise kutotanga aishandisa zvinodhaka.

Kwezvokurapa kupindira rinoshandiswa a-blockers, FIs 5-Alpha-reductase.

Zano iri mishonga mugumisiro FIs

Kukura tsandanyama rinenge riri prostate kunouya anonyanya hormone. Steroid 5-Arifa reductase anokurudzira mhango mu kweprostate gland kemikari testosterone kushanduka kupinda dihydrotestosterone. Vapedzisira, iyewo Kunobatanidza kuti zvenyukireya androgen Kanotokonya muna kweprostate gland uye zvinoita secretion pamusoro paracrine kukura zvinoita, Vanewo vasapinda kweprostate. Alpha-blockers, FIs 5-Alpha-reductase vanokwanisa kubatsira mumamiriro ezvinhu aya.

Kunwisa kugadzirwa dihydrotestosterone kunokonzera nhamba nehosha dzakaipa dzakadai benign prostatic hypertrophy, kenza namamota, prostate zvimwe Urological zvirwere. Panguva ino mune akashandiswa FIs 5-Alpha reductase FIs pakurapa kosi kuchipatara. Dzavo kuchirapa zvazviri ndicho blockade reductase, izvo zvinozoita lowers ari kwevari DHT, izvo chinoita diffuse yeprostate kuchinja.

Kupfuura mukurumbira zvinodhaka muboka iri ndivo "Finasteride" uye "Dutasteride". Vane muviri nomugumisiro yakafanana, zvakasiyana kuona nguva uye zvaiitwa.

Blockers, FIs 5-Alpha-reductase inogona kutengwa chemishonga pamusoro mushonga.

Asi pasinei mukuru kunyatsoshanda, zvinodhaka kushandiswa nokungwaririra uye kwete zvose nyaya nokuda vakawanda kuratidzwa kunaka uye contraindications.

Major divi migumisiro vachitsigira

• Pashure kushandiswa kwezvinodhaka kuti akaderera BP angangoda hypotension.
• Kuda kurutsa, nomusoro uye dzungu.
• Heart palpitations, kupfupika mweya.
• Muscle marwadzo, utera.
• Nyaradzo.
• Urume chengetedzo, edema.
• Marwadzo mudumbu uye ura.
• Mhino, kupfupika mweya, nyota.
• More kakawanda nehadzi hafu yevanhu zvinoratidza kweiyi dundira simba, kuita weti kakawanda.

Naizvozvo, Alpha-Beta blockers anofanira kushandiswa nokungwaririra.

Chimwe chezvinhu migumisiro iri postural hypotension, izvo zvinogona kutora nzvimbo kare panguva chete dose. Zviratidzo vake kutanga kuonekwa mushure hafu yeawa kana awa mushure pakugamuchira medicament. Izvi zvinoshandawo kuchitendero "prazosin". Kuti izvi zvisaitika divi Chaizvoizvo, mushonga kunofanira kutarisirwa kuwedzera zvaiitwa uye zvinganaka usiku hwose.

Nezvokumutswa yekunwa divi migumisiro Alpha blockers ushandiswe akabatana diuretics kudzivirira Urume chengetedzo uye inonyaradza marwadzo omusoro kuderedza marwadzo zviratidzo.

Medicaments veboka iri basa sezvo yakazvimirira kurapwa kana panguva imwe chete nevamwe mishonga kurapa zvirwere zvakasiyana-siyana.

chirwere

zvirwere zvakawanda, nokuti mishonga izvo Alpha-blockers anoshandiswa:

• In kudzora chirwere cheBP zvirwere yakasanganiswa kurapa senzira vabudirire nokukurumidza kuchirapa kushanda.
• Benign growths mu kweprostate gland.
• Diabetes mellitus.
• Pheochromocytoma.
• Nyanyisa neoplasm kweprostate gland.

Contraindications

In chii Muzviitiko regai taurira alpha- uye Beta-blockers?

Huru contraindications pakugamuchira kugadzirira vari:

• pasi BP;
• kupera muviri;
• kurapa pamwe diuretics;
• siyana cardiac malformations;
• chisingaperi mwoyo kutadza;
• asima;
• mwoyo mutinhimira vachivavhiringidza.

Regai taurira zvinodhaka ichi mhando panguva gestation uye panguva lactation, sezvo chairo rabhoritari zvidzidzo panyaya iyi kunge inoitwa.

Alpha-blockers adenoma

mishonga inokosha boka iri inoshandiswa nokurapa adenomas:

• "Uroksataral".
• "Cardura".
• "Gitrin".
• "Rapaflo."
• "Flomaks".

Munzvimbo Alpha-blocker mishonga mashoko. The mazita anoenderera mberi.

mashandiro chiito

The mashandiro chiito zvinodhaka izvi pakurwisa adenoma iri nyore, vanotora mataurire tsandanyama kweprostate uye dundira, zvobatsira kuti kuderedza weti.

Taurira kosi mishonga kurapa kwakadaro nomumwe chipimo chemushonga, kutora rimwe kana maviri kanomwe pazuva.

Mishonga Categories varwere yemhando chirwere vanonetseka nokuchengeta weti, uye zvinodhaka simba vasina achida kushanda.

Huru kuchirapa zvazviri anotanga kuoneka pashure pavhiki kurapwa. Mumazuva 14-21 pane chinokosha ruyamuro kumurwere.

Zvokungwarira

Nokuti mukuru kuchirapa zvazviri awana peya Arifa-blockers uye FIs 5-Alpha-reductase. Yakakwirira kunyatsoshanda wokushandiswa aiwanzopiwa wokushanda zvinodhaka zvinobva mumiedzo zvokurapwa zvekuchipatara.

Hazvina akakurudzira nokubatanidza pamusoro mishonga Panguva zvinodhaka kana BADami kusabetsera. Anogona kuwedzera muviri chaizvoizvo blockers, inova zvisingadiwi. Mugumisiro aigona kuva unopinza kuderera BP.

Chimwe akaipa mugumisiro kwokubatsira Arifa blockers nekuda pakurapa Urological zvirwere zvinogona kuva ejaculation kupinda mhango pakati dundira. Chinokonzera hapana zvakaipa nokuda kunopindirana utano.

Kana uchishandisa boka iri medicaments kuti rokurwisa adenoma yakarumbidza kuderedza zvimwe zvinodhaka kweropa. Accepted ive chinhu kunzwisisa kurapa kungava kunyanya kubudirira nokurapa neBP.

For varwere vanenge vane chirwere cheBP chirwere kana pakugadzirisa nokuchinja kweprostate gland Arifa-blocker inokurudzirwa kungoramba kuongorora BP mumatunhu.

Patinoungana kushandisa zvinodhaka

• Mishonga Alpha blockers akashandisa chete ushandiswe nachiremba. Chiremba vanofanira kuona chipimo chemushonga, nguva kugamuchirwa.
• Treatment zvinodhaka izvi kuva pasi pokudzora chiremba kana wezvokurapa Zvivako pamadziro.
• Kana kuratidzwa nemishonga kurega kutora zvinodhaka uye chiremba.
• Hapana nyaya regai kushandura chipimo chemushonga kumusoro tisingatungamirirwi.
• Other mishonga panguva imwe chete Alpha-blockers kubvumirana nachiremba.
• Usashandisa Alpha-blockers sezvo pakaita kurapa chirwere cheBP nepfungwa pasina mvumo chiremba.
• Havabvumi zvinodhaka apera kana vakadhakwa chiputiriso, kukuvara zvakaoma deko tablet.
• Purchase mishonga chete marezenisi Pharmacies.
• Kana muchigamuchira boka mishonga-yambotaurwa nguva yose zuva uye panguva yokurara kuyera BP.
• Kunwa mushonga cheBP munguva pamuviri, iva nechokwadi kuti anobvumirana nachiremba.

Zvakakosha kunzwisisa kuti ive ovhadhozi zvinodhaka izvi kungaita kuti varwadziwe.