The mushonga "Baraklyud": mirayiridzo kushandiswa, description, akafanana uye wongororo

"Baraklyud" rinoreva Anti-retroviral zvinodhaka, chikamu boka nucleoside analogues anodzivirira. Nachiremba pakurapa chirwere HBV-hweHIV. The kushingaira wemafuta zvinodhaka entecavir nokukurumidza anovanza nemavhairasi kuberekana kubva nehepatitis.

Zvinofanira hako kudzidzwa Musumo asati achitora zvinodhaka. Sezvinoratidzwa mirayiridzo kushandiswa? "Baraklyud" (Baraclud) - mushonga iyo zvichiitirwa tatanga backflow kuti fibrotic pezvakaitwa vari varwere chiropa cirrhosis.

mushonga

The mushonga inowanika maviri chipimo chemushonga aanoda - 0.5 uye 1 MG entecavir kushingaira zvinoriumba nemaziso akasiyana mune dhayi ruvara (chena kana Pink, ukuwo).

Kugadzirira zvinosanganisira:

• polysorbate;
• magnesium stearate;
• lactose monohydrate;
• Valium;
• povidone;
• colorant Opadry.

Pharmacological migumisiro

The rinoita chirungiso ndiyo entecavir ndiro analogue ari nucleoside guanosine, wakareva kuti nehepatitis B. basa anyatsosarudza

Entecavir ari phosphorylated kuti chinoshingaira triphosphate pamwe nehafu-upenyu maawa anenge 15, ari intracellular zviri izvo chokuita wevasungwa pamusoro entecavir kunze masero. Kana ichi haina kuchengetwa kuti munhu kuunganidza basa fuma pamuviri. Medicine "Baraklyud" mirayiridzo kushandiswa izvo zvinoratidza yakakwirira kunyatsoshanda kwayo, anovanza basa nemavhairasi polymerase, impacting panguva imwe chete riri zvitatu zvinokonzera:

• kwetunhu zvakanaka DNA HBV;
• harungashandurwi transcription akaipa neshinda pregenomic mRNA;
• HBV priming enzayemu.

Triphosphate haisi retarders simba makemikari cellular DNA, kunyange ane nouchapupu kugutsikana maturo pamusoro mitochondrial DNA usage.

Chaizvoizvo zvinodhaka

The rinoita kwezvinodhaka fuma anokwanisa pfupi nyura kubva zvomudumbu ino uye kunosvika kufadza zvayo zviri mumaminitsi 30-90 mushure aine mahwendefa.

Kuenderana nokuwedzera Cmax uye AUC indices kunoitika mukushandisa dzairamba dzichiitika 0.1-1 MG kuti medicament "Baraklyud". Mirayiridzo kushandiswa kutaura kuwana mwero iri 6-10-fung zuva rimwe chete dose zvinodhaka pazuva. Kushandisa mafuta zvokudya yekudyidzana zvinoomesa entecavir Absorção de Água muitiro, Tikabvisa Codes Cmax uye AUC kubudikidza 45% uye 20% azvaitwa.

The mushonga yava kunyura ari zvinyama uye 13% vakasungwa mapuroteni eplasma. The rinoita zvinoriumba zvinodhaka hakusi kushandiswawo substrates, enzayemu FIs kana inducers kuti P450 hurongwa. Zviri anokwanisa kuunganidza mumuviri uye goho kuburikidza renal maitiro achishandisa glomerular filtration uye tubular buditsa.

zvairatidza

Medicament "Baraklyud" varumbidzwa kupinza kunzwisisa Mabatirwo nehepatitis B:

• With mamiriro zviratidzo nemavhairasi kuberekana uye zvibereko mwero webasa transaminases vari serum, pamberi histological kuratidzwa yaipfuurira kuzvimba chiropa.
• Unrecovered chiropa maronda.

Chinokosha ruyamuro kuti chiropa chirwere zviratidzo kuitika mushure zvinodhaka kutarisira "Baraklyud". Mahwendefa kurairira Chinyorwa anokurudzira kuti varwere chisingaperi chiropa B, chiropa chirwere kuoma nemashoko anotevera:

• chiri decompensated;
• pathological chiropa ezvinhu ari muripo danho kana yakaiswa nemavhairasi kuberekana chirwere kuratidzirwa chiropa fibrosis pamwe zvakawedzera AST uye alt.

Contraindications

The mushonga "Baraklyud" rine zvinotevera contraindications:

• yakawedzera susceptibility kune entecavir nezvimwe zvinhu zvaisanganisira muna zvinodhaka nziyo;
• nhaka lactose kusashivirira, shuga-galactose malabsorption, kukanganisika kana kusavapo mumuviri womunhu enzayemu lactase ;
• zera isingasviki makore 18.

Vanhu vane itsvo kutadza vanofanira kutora mushonga uri mushonga uye pasi chenguva zvokurapa achitarisirwa.

Kugamuchirwa "Baraklyuda" panguva pamuviri haina varumbidzwa panguva kurapa vanofanira kurega achiyamwa.

nemishonga

Pangave zvakasiyana siyana zvinetso zviri zvomudumbu ezvinhu panguva zvinodhaka kurapwa "Baraklyud". Mirayiridzo dzokushandisa zvinotsanangurwa zvakajeka marwadzo:

• nomudumbu;
• manyoka;
• svoto uye kurutsa;
• dyspepsia.

Ungazvidyawo kusangana nomusoro, kushaya hope kana hope, kurasikirwa kudya, uye neutachiona.

Kushandisa mishonga senzira bedzi kuchirapa mumiririri kana akabatana nevamwe zvinodhaka yemaARV anogona kukonzera zvikuru hepatomegaly pamwe steatosis, izvo zvingaita kuti murwere afa.

In varwere decompensated maonero laktatsiadoz maronda zvingaitika chiropa, iyo inozivikanwa nokuva:

• talk tsandanyama simba;
• nokukurumidza kufema uye chitarisiko kupfupika mweya;
• svoto;
• chinokosha rutapudzo kurema muviri;
• marwadzo ari peritoneum, epigastric.

Uyewo, kuti mushonga anogona kukonzera siyana siyana uye muviri:

• vakawedzera dziine hepatic transaminases;
• ganda upundu;
• anaphylactoid kuita.

The varwere kutamburawo decompensated chiropa chirwere, mukuwedzera, siyana zvakadai vakaratidzawo muviri:

• renal kukundikana (mu zvisingawanzoitiki zviitiko);
• yakawedzera bilirubin tigutsikane muropa;
• . Achideredza of platelet kuverenga kusvika 50 zviuru / mm ³ zvichidzika;
• kuderera kwemitambo bicarbonate muropa;
• Zvakawanikwa alt;
• kupfuura-nedanga matatu nokuwedzera basa lipase;
• kwakaderedza kwevari sealbumin.

Medicament "Baraklyud": chipimo chemushonga uye adhimini

The mushonga zvinofanira kutorwa usina chawadya, nguva nguva kubva wokupedzisira kudya asati dosing vanofanira kuva maawa anopfuura maviri.

Kana ndanyarara hangu chiropa kukuvadza yakarumbidza kugamuchira "Baraklyuda" 0.5 MG daily. Panoongororwa kuramba lamivudine chipimo chemushonga zvinofanira kaviri.

Varwere chiropa maronda unrepaired ushandiswe yaunodya zuva nezuva 1 MG. Vakwegura uye varwere renal insufficiency, kuti dose inofanira kuchinjwa zvichienderana padanho CK (creatinine wevasungwa) muropa.

ovhadhozi

Information pamusoro nyaya zvinodhaka ovhadhozi hazvikwani.

Vazvipiri, iyo akaora kwakaedzwa, akapiwa zuva chipimo chemushonga 20 MG kwevhiki mbiri ivo vakapiwa chete yepamusoro dose - 40 MG zvinodhaka "Baraklyud". Mirayiridzo Use inoti Migumisiro vakanga dzakaonekwa.

Recommended posindromnoe kurapwa pasi pokudzora yokuora kuratidzwa.

Kudyidzana nevamwe zvinodhaka

Nokuti kuti yezviri zvinoriumba entecavir iri yabudiswa zvikurukuru kuburikidza renal hurongwa, kunzwisisa kurapa akabatana nevamwe zvinodhaka kuti zvinopa zvakananga kana zvisina kunanga zvinosuruvarisa itsvo nerevane kukanganisa tubular secretion, kunogumawo nokuwedzera nomuviri entecavir uye zvinoshingaira zvinhu zviri zvinodhaka.

Kudyidzana "Baraklyuda" pamwe adenovirom, tenofovir, lamivudine havana kunyorwa.

matanho okudzivirira

Kugamuchira zvinodhaka varwere husingakwanisi lamivudine kunotungamirira mukana kuramba.

Uyewo, pane uchapupu panowanikwa exacerbations ose nehepatitis B pashure discontinuation zvinodhaka "Baraklyud". Mirayiridzo yokushandisa rinotsanangura zvakazorodza exacerbations pasina zvimwe kurapa.

Zvokungwarira

Kugamuchirwa "Baraklyuda" iri gadziriro monotherapy uye unobatanidzwa kurapwa nezvimwe yemaARV vamiririri, anogona kukonzera lactic acidosis, hepatomegaly pamwe steatosis. Muchiitiko chino, pane mukana rufu.

Pangozi varwere zvinosanganisira zvinotevera Categories:

• kutambura kubva hepatomegaly;
• kubatwa nokushandiswa nucleoside analogues anodzivirira;
• kuva remesa;
• varwere munhukadzi.

Mirayiridzo kushandiswa zvinodhaka "Baraklyud" inodaro mukana inotungamirwa nemishonga nemavhairasi utachiona. Active chirungiso entecavir mushonga hauna anokurudzirwa kuti kurapwa kwevanhu immunodeficiency utachiona nokuda kunyatsoshanda aro mirayiridzo iyi asi haana kudzidza zvakazara.

In pakurapa varwere pamwe zvokurwara pamusoro renal ezvinhu, kugadzirisa zviri dose.

The kuchengeteka uye Kushanda kushandisa "Baraklyuda" nokuda pakurapa varwere pashure chiropa transplantation havasi kuzivikanwa uye inoda anokosha kutarisirwa abvume matanho.

Storage mamiriro uye mutengo

Storage uye kutakurwa pellets yaifanira ari tembiricha siyana 15-25 ° C. Kugadzirira wakafanira kushandiswa kwemakore maviri kubva musi gadzira.

The mushonga Rinowanikwawo ari oga boka mishonga zvinokosha, uye nekuti vamwe Mapato vemunyika akasunungurwa chokuendesa mashoko zvinodhaka "Baraklyud". Mirayiridzo dzokushandisa rinoburitsa chokwadi ichi.

Price nzira muMoscow Pharmacies inotanga kubva 12 zviuru. Rubles.

Views wevarwere

Inoratidza yakakwirira efficacy zvinodhaka "Baraklyud" mirayiridzo Chinyorwa. Price, wongororo iro akaratidza kuti akanga democratic tichienzanisa analogues zvinodhaka, zvichisiyana pakati 12-17 zviuru chete pasuru, umo pellets 30. Izvi zvinoita mushonga ane mukurumbira chaizvo uye ari kudiwa pavarwere nokuda nokurapa nehepatitis B.

In akaipa inofambiswa kunyanya aitaura proitvopokazaniya uye divi Migumisiro zvinodhaka, zvakadai hope, uye svoto.