The mushonga "Aspekard": mirayiridzo kushandiswa, analogs, wongororo

Acetylsalicylic asidhi (Asa) rinoreva zvinodhaka antipyretic, Anti-anogumbura uye antiplatelet nemigumisiro. In okurapa rinoshandiswa makore anopfuura 125, nekuti mumwe kupfuura kudzidzwa mishonga. Pakazoti Asa rava kuwanikwa ari kardioformy kuderedza ngozi coronary tsinga thrombosis, izvo zvinokanganisa kukura myocardial infarction. Muenzaniso uri kugadzirira "Aspekard" ine acetylsalicylic asidhi ari dose Zvakanyanya Kunaka Panguva Yepamuviri kuti antiplatelet maturo.

Information pamusoro vasunungurwe chimiro uye Manufacturer

The mugadziri zvinodhaka ndiko Ukrainian kambani "Stirolbiopharm". Saizvozvowo, kugadzira michina inoshandiswa, anogadzirwa muchimiro zheludochnorastvorimoy siyana ari dose pamusoro MG 100 paminiti piritsi. Nzira Mahwendefa marongerwo:

• katoni Mahwendefa 120 (10 kusvika 12 Maronda akasiyana Tab.);
• polymeric mudziyo Mahwendefa 100.

Piritsi "Aspekard" rine 100 MG aAsa, microcrystalline cellulose, croscarmellose yavaibvisa, colloidal nesilicon dioxide, stearic acid.

Recommendations kugadzwa

Mukugadzirira "Aspekard" kushanda yakamanikana zvakakwana, kunyange rine mirayiridzo vanorumbidza kunorapwa zvirwere zvakawanda, kusanganisira rheumatic zvirwere. Mugadziri akakurudzira "Aspekard" uye somunhu antipyretic mumiririri kana marwadzo. Kutaura zvazviri, mune chipimo chemushonga pamusoro acetylsalicylic iine acid mushonga unogona chete zvinobudirira kushandiswa mushonga kuti kunotadzisa platelet aggregation.

Zvairatidza "Aspekard"

On kugadzirira "Aspekard" mirayiridzo chikumbiro, akaongororazve chiremba tsvakurudzo nyanzvi uye kupa zvakawanda kwakabatana antiplatelet kurapa. Zvinonzi zvinoratidzwa zvinotevera ezvinhu:

• kana (ACS), chenjera coronary syndrome (pa danho rikwanise pakukwirira myocardial infarction, mwoyo kana sanganisika ST chidimbu nzvimbo, mune kusagadzikana angina);
• pamwe kamwe (ischemic sitiroko kana zvinopfuura ischemic kurwisa);
• pakuparwa nekusimba coronary tsinga chirwere senzira kudzivirira chakasimba coronary chirwere uye nesitiroko;
• ari kudzivirira idzokororo Zvikamu ose chakasimba coronary chirwere uye nesitiroko;
• pamwe pamberi varicose mutsinga;
• kuzvidzivirira mumiririri, rokunyevera shunt thrombosis pashure CABG;
• pamwe neBP kune mukuru zvemwoyo ngozi.

High zvemwoyo ngozi chiri uwandu hwezvinhu zvose zvabatanidzwa. pfungwa kuti zvinosanganisira kuvapo chipfuro nhengo kukuvara mu neBP uye vakarondedzera zvirwere: chirwere cheshuga mellitus, coronary tsinga chirwere, TSVB.

Features chipimo chemushonga regimens ndakarumbidzwa ari mugadziri

Mukugadzirira "Aspekard" mugadziri kurairirwa hakusi utungamiriri chikuru murwere kurapwa. Rine mashoko pamusoro kwokubatsira mushonga akasiyana zvekuchipatara ezvinhu kubvira kudzivirira atherothrombotic zviitiko CHD uye TSVB uye anopera chakasimba kusagadzikana chepfungwa anotengeswa uye mwoyo. kusavapo uku anonzi vakaregeredza uye unprofessional mafungiro nenhau zvinodhaka uye avo muchiridzira ruzivo zvinhu. Rinotaurawo anosika preconditions kuti vakawanda bhuku nyaya umo zvavakabvumirana dosages zvinosiyana.

Dosing regimens maererano audzwa dzakawanda

Pahwaro dzakawanda mirayiridzo yakatanga neEuropean Community pamusoro Cardiology (ESC) uye American Heart Association (Hekani) uye chakatorwa na Ministry of Health, ivo modes zviri kushanda acetylsalicylic asidhi ndeinotevera:

• tichifambirana okukurumidzira panguva chakasimba coronary urwere kunoda kupa murwere kutsenga mapiritsi 3 "Aspekard 100". Mirayiridzo unoshandiswa kuteerera, uye chete dose 300 MG;
• chisingaperi cardiac ischemia (CHD) pa kugara kugamuchira basa rimwe pahwendefa 100 MG manheru pashure kwemanheru;
• pamwe neBP varwere vane yakakwirira pangozi zvemwoyo yematambudziko, uyewo venous varicose nguva nevamwe MG 100 (1 piritsi) manheru pashure kwemanheru.

Dzimwe nzira zvinodhaka kutarisira "Aspekard" kurayira ESC uye Hekani haripi. Zvinokoshawo kuziva kuti mutemo dose "Aspekard" ndizvo 100 MG kwaAsa. Nokuti kudzivirira pamusoro zvirwere, maererano nemirayiridzo ESC uye hekani, vakashandisa dose pamusoro 75 MG. Zvisinei, 100 MG basa varwere pashure CABG kudzivirira thrombosis yacho shunt. Mune zvimwe zviitiko zvakanga yakarumbidza kushandisa 75 MG, i.e. uwandu Asa, iyo inopa yakakwana antiplatelet zvazviri uye ane risingamboshandisi ngozi gastrotoxicity.

Uyewo, kuti mugadziri haripi mashoko anokosha pamusoro abolition zvinodhaka. Maererano nenhamba, nokukundwa kumira mhaka 10.2% ine chakasimba zvemwoyo zviitiko. Uye zvinowanika pashure pemazuva anenge 10.6 kubva musi Kudzimwa kwaAsa. Nguva iyi ndiyo Paavhareji uye inoratidza nguva iyo yose vakawanda ipfupi platelet cyclooxygenase inoshanda. Somugumisiro, zvingangoita ropa clots yakadzorerwa. Nokuti mushonga unofanira kutorwa ichi-, apo kugadzwa imwe antiplatelet mumiririri pane "Aspekard" chitarisiko yematambudziko kubva nemudumbu kunodiwa.

Contraindications "Aspekard" gadziriro

The kuchengeteka zvose mishonga zvigadzirwa ihama, nekuti vane marwadzo. Panguva iyoyo vasingagumbusi vamwe contraindications. In zvikuru:

• mune zvinetso ropa coagulation (Hemorrhagic diathesis, hemophilia A uye B);
• mune kusagadzikana mudumbu zvinhu (erosions, chenjera nemaronda mudumbu uye duodenum 12);
• munguva trimester pamuviri uye lactation wokutanga;
• kwazvo renal kana hepatic vanotaura;
• kana neutachiona kuti salicylates;
• Vana vaduku kupfuura makore 18;
• pamberi Árbol asima;
• pakurapa methotrexate.

contraindications ava mhedziso, kunyange zvazvo vamwe nguva: lactation, pamuviri, uye anozoumbiridzwazve maronda ari nemudumbu, mucheche. Uyewo pane boka rinoti, kuvapo chinoda kuramba zvichiongororwa nachiremba. Izvi kushandiswa mawa pamusoro antiplatelet mishonga pamwe anticoagulants, uye mabatiro wevarwere pashure coronary tsinga ndavhiyiwa. Kana itsvo basa kureva mushonga "Aspekard" mirayiridzo kushandiswa zvinoda chipimo chemushonga rutapudzo kana kupedzisa zvishoma nezvishoma abolition zvinodhaka.

Joint migumisiro "Aspekard"

Acetylsalicylic asidhi ane uwandu zvinokonzerwa hunowedzera kana inoodza mwoyo kuitwa zvinodhaka zvakawanda. In zvikuru:

• Asa runogonesa zvinoita chero anticoagulants uye antiplatelet vamiririri;
• Asa runogonesa antipyretic uye marwadzo mugumisiro NSAIDs, anotowedzera kumukomborera antirheumatic mugumisiro "Meloxicam";
• kana pamwe cytotoxic zvinodhaka kunonatsiridza gastrotoxicity yavo;
• kana kubatwa doro pangozi urikanwi yematambudziko kana svota kunowandawo;
• glucocorticoids kuwedzera gastrotoxicity "Aspekard";
• ACK attenuates diuretic mugumisiro kana pamwe diuretics "Furosemide", "torasemide", "spironolactone".
• "Aspekard" simba mugumisiro uricosuric vamiririri, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable antacids kuderedza mashoko Absorção de Água kuti "Aspekard".

Mukana ane ovhadhozi yayo zviratidzo

Tichishandisa zvinodhaka "Aspekard" mirayiridzo, inofambiswa uye kushandisa nhamba asimbise yakakwirira zvakakwana azvipire kuchengeteka pamabiko maererano zvinoratidza uye contraindications anosara. Izvi zvinoreva kuti ushandiswe dose 100 MG zvinodhaka yakachengeteka zvakakwana, kunyange zvazvo kudzorwa mamiriro utano kunokosha. Uyezve, nemhaka Boka varwere vachida kuzviuraya, uyewo nengozi kuti mahwendefa Asa kutora mwana, oudzame kwaida mukana ovhadhozi uye ayo zviratidzo.

Munyoro chepfu salicylates, kushatiriswa pokushandisa kugadzirira "Aspekard" pasina chiremba vanorumbidza zviratidzo ndeizvi rinoti: dzungu, kurwadziwa fossa podlozhechkovoy, ari achiine rukuvhute nzvimbo, dzimwe nguva marwadzo, kunyanya pavarwere vane chirwere cheitsvo. Kana ovhadhozi sezvo kune sekubvunda, kurutsa, dzimwe nguva chete reropa mitaro. Anotanga nomukombiyuta hazvizivi induction pamusoro emesis: zvakawanda inotonhora zvinobata, neactivated charcoal nzira uye ehnterosorbentov Delivery murwere muchipatara.

Pazvese, kuti chepfu mishonga "Aspekard" kurayira Chinyorwa haritauri. Zvakasiyana zvakasiyana uremu uye zera murwere. Somuenzaniso, mune mukuru dzevanhu ovhadhozi nyoro zviratidzo Asa kuitika chete kubvuma anenge 5-7 magiramu acid. Vana vane kukwana kuti ovhadhozi kuti 1,5 d chete dose. A wandei ovhadhozi kunoitika apo kushandisa 7-9 magiramu vakuru nevana 2-2.5 giremu Asa.

dhigirii ichi zvinodhaka ovhadhozi kwakaratidzwa pamusoro zvinetso chokuita zvishande mabasa. Kurasika chitsamba kunotanga tinnitus mafungiro inofambidzana vakavhiringidzika, matauriro incoherent. Kurutsa zvinowanzoitika, murwere nokukurumidza anorasikirwa Urume kubva kurutsa, kufema unoraramisa, pane chakasimba Urinary chengetedzo, vakawedzera tembiricha muviri. Batsirai murwere mumamiriro ezvinhu akadaro hazvibviri vakazvimirira - pakukurukura kunodiwa ari NICU kuti aizomupa kurapa bicarbonate, yavaibvisa lactate.

Zvinoumba kuchirapa chiito "Aspekard"

Vasiyana mushonga "Aspekard" kushanda mirayiridzo unotora rairatidza negashiro piritsi rimwe pazuva (100 MG / zuva). dose ichi Asa zvakakwana kutitadzise platelet cyclooxygenase. Mugumisiro ndiyo chinovhiringidza kuti kwetunhu thromboxane A2, izvo zvachose kuchititadzisa mano masero kuti platelet aggregation. Izvi anobvisa mukana thrombosis, unova mhaka myocardial kana chepfungwa infarct.

Kupa antithrombotic mugumisiro acetylsalicylic asidhi inofanira nyura kupinda ropa. Zvisinei, dzimwe anoita mudumbu uye zvichivhiringidza cyclooxygenase-1 aro isoforms ari mucosa ari nhengo. Mugumisiro mashandiro iri rutivi chaizvoizvo - akaderedza kugona muco-unodzivirira chipingamupinyi carbonate. Izvi zvinowedzera njodzi erosions uye maronda mudumbu, zvinosimudzira gastrointestinal-ropa. Enteric Formulations dzava kukwanisawo kufurira ropa, asi kakawanda iri divi maturo, vane diki chaizvo.

Pregnancy uye lactation

Nyanzvi mafungiro, inobva Statistical Kukoshesa uye dzakatevedzana kuedza, vachibvumira kuti uve kunyatsonzwisisa kushanda "Aspekard" mushonga panguva yepamuviri. Zvikurukuru, 1 trimester kushandiswa kwayo hakubvumidzwi. Pana 2 uye 3 trimester chikumbiro anobvumirwa, asi pashure kunyatsoongorora ayo kuchirapa kushandiswa uye kuenzanisa mabiko ngozi. In oruzhinji kurapwa ezvinhu kugadzwa Asa buda, kunyange dzimwe NSAIDs dzava kukwanisawo kuwedzera ngozi yokubva pamuviri yakakura.

Panguva lactation, shandisa mushonga "Aspekard" analogues naye, generics, uyewo mishonga dzose acetylsalicylic asidhi mu murwiyo hakubvumidzwi. Chikonzero ichi ndiko yakarova mushonga mu mukaka. panoparadzana mwoyo kunyange naye mumuviri vomwana. Uye ngozi zvayo zvakakwirira pangozi yokuita Reye kuti chirwere - chinhu chaizvo kwazvo hepatic encephalopathy, izvo zvinokonzera uropi kuzvimba uye rufu mwana. Nokuda kwezvikonzero zvakafanana, wairambidza kushandiswa kwezvinodhaka pamberi makore 16-18.

Magadzirirwo anodzokorora nyanzvi uye varwere

Zvinoratidza mushonga "Aspekard" murwere inofambiswa muzviitiko zvakawanda nekambani. Chokwadi vakafunga mutengo chinodhaka, sezvo anenge rakadzika vezera. Zvisinei, mashoko chokuita hunoshanda pokushandisa zvishoma anoratidza nekusagona kuongorora mwero varwere yekuzvidzivirira vascular thrombosis. In mashoko divi anokonzerwa kushumwa nevarwere, mushonga inozivikanwa se zvakakwana ngozi.

Zvinofungwa nyanzvi dziri pachena: Chokutanga, mushonga unoshanda pakuderedza njodzi thrombosis, uye chepiri varwere kutevera antiplatelet kurapa wakakwirira nemhaka pasi "Aspekard" mutengo zvinodhaka. Analogs vekirasi antiplatelet yomuchipatara vari yekudyidzana yepamusoro. Domestic enteric kugadzirira "Atsekardol" anodhura ne50%, ukuwo mari kupinzwa yakakwirira nokuda 7-10 nguva. Asi kwakavakirwa zvishoma nemishonga enteric vamiririri, uyewo zvoupfumi zvakawanikwa, zviri chinodiwa kupa kukoshesa "Atsekardolu". Mari pamwedzi kurapwa vachava rubles anenge 20.

Chinangwa kushaya kardiopreparata "Aspekard"

Vasiyana mushonga "Aspekard 100" mirayiridzo Chinyorwa anoti mushonga inowanika pamahwendefa. Ivo mudutu mudumbu uye kubereka yakakwirira yevasungwa. Kupa yomunzvimbo gastrotoksichesky Chaizvoizvo, mushonga anorasikirwa Safety Other zvinodhaka, kureva enteric. gastric ropa nengozi kana kushandisa ekupedzisira iri shoma zvikuru.

Mienzaniso zvinodhaka njodzi ndeinotevera: ". Asipurini Cardio" "Atsekardol", "Polokard", "Cardiomagnyl", Uyezve, akati zvinoreva uyewo vanoumba magnesium hydroxide, anokwanisa kudzivirira mucosa kubva zvinokuvadza acetylsalicylic acid. Kunyange zvakadaro, mashoko zvinodhaka "Aspekard" anogona kushandiswa kudzivisa thrombus inotungamirwa, kunyange mitemo. Zvisinei, varwere vane mucosal kukurwa kwevhu, urikanwi 12 duodenum kana dumbu, kusanganisira chirwere, Zvinokurudzirwa kutora enteric kardioformy acetylsalicylic acid.

Vneotraslevoe Chikumbiro kardiopreparata "Aspekard"

Vazhinji mirayiridzo zvishandiswe zvichiratidza antiinflammatory uye antipyretic zvivako zvinodhaka "Aspekard 100". Kutaura zvazviri, mushonga yakazara ane kuchirapa Migumisiro ndiyo 5 nguva chete dose - 500 MG. The chipimo chemushonga 100 MG ndiyo chete cardiac, uye zvainoita harine huni zvinobudirira kuderedza tembiricha iri zvirwere.

gadziriro Kardioforma kugadzirwa imwe dose 100 MG, zvakakodzera kurwadziwa uye nefivhiri rokuyamura chete chete dose 5 Mahwendefa. Saka predominance selectivity nokuda cyclooxygenase 1 anosarudza kuvapo muzvizhinji padivi siyana. Naizvozvo, somunhu febrifuge "Aspekard" mapiritsi, Chokwadi, tiri dzakakodzera. Zvisinei, panguva iyoyo pane nhamba vanoverengeka zvinodhaka njodzi nedzokunze zvikuru selectivity nokuda cyclooxygenase 2. Vane zvishoma divi migumisiro chokuita kutyora kuwandisa gastrointestinal epithelium.

Safety kirasi dzomuzana "Aspekard" chinodhaka

Zvakafanana kuitika yaiitwa mishonga rheumatic zvirwere. Uye dzakabatana mushonga "Aspekard" mirayiridzo kushandiswa rine ruzivo pamusoro kurapwa kwavo. Zvisinei, zvavakabvumirana dose iri sezvakarayirwa 5-8 magiramu pazuva.

Mukuwanda kwakadaro, acetylsalicylic acid inoratidzira kusagadzikana kwegastrotoxic yakasimba kudarika kushandiswa kwemishonga yakadai saLeloxicam, Celecoxib, Roferoxib, nevamwe. Uye se-antipyretic agent, iyo inokosha kupfuura imwe yenzaniso yeIbuprofen.