"Pradaksa" - analogues. "Warfarin", "Ksarelto": wongororo, mitengo

Pakati antithrombotic yomuchipatara rinoshandiswa kubvisa thromboembolism ari mutsinga pashure pokuvhiyiwa, kupfuura vakarongeka kunoratidza kugadzirira "Pradaksa". analogues Its vane yakakura zvairatidza kuti kushandiswa uye marongerwo vane akasiyana unorapa. Anticoagulants zvinowanikwa hwakasimba chipimo chemushonga muchimiro pamwe dosages zvakasiyana.

Description "Pradaksa" chinodhaka

Mugadziri antithrombotic nemishonga anticoagulant "Pradaksa" ndiyo kambani "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". Available zvinoreva muna rakaoma capsules, iro raiva mukati diki tsvuku pellets. The rinoita fuma dabigatran etexilate vaiona akaneta chimiro, uwandu iyo anosarudza kuti chipimo chemushonga kurapwa. Zvingava 75 MG, 110 MG uye 150 MG.

Chii mushonga "Pradaksa" rinoshandiswa

Chinangwa chikuru capsules chokuita kudzivirira venous thromboembolism pashure pokuvhiyiwa madhipatimendi ari zvetsandanyama nemapfupa ino.

Sei chishandiso "Pradaksa"

Rinobatanidzwa ne kudzvinyirira pamusoro thrombin basa mashandiro chiito zvinodhaka "Pradaksa". Analogs kuratidza ehupfumi siyanei. Kuva chiduku Morekuru, dabigatran etexilate haana pharmacological chiito.

Chete wakapinda womunhu, nefuma yatovapo paradzanisa pashure hydrolysis kune vakasununguka dabigatran Vanoshingaira reversible zvakananga zvemakwikwi inhibitor pamusoro thrombin enzayemu. Basa thrombin anosunga kuti fibrin, thrombin, kuderedza sero aggregation kuti platelet kunokonzerwa thrombin basa.

Ezvemutauro izvi

Iva zvinodhaka "Pradaksa" dzomuzana. Asi ayo sezvamunoita, havaiti dzine dabigatran etexilate, zvinonzi yakatsiva nezvimwe anticoagulant nevamiririri. Saka, zvinoshingaira kuchatibatsira yakafanana rinoreva "Warfarin" ndiko warfarin, ari medicament "Ksarelto" rine rivaroxaban. Anoreva zvakafanana kugadzirira "Pradaksa" kodzero "Marcumar" uye "Fenilin" anosanganisira phenprocoumon uye phenindione azvaitwa.

Description "Warfarin" chinodhaka

Takatodzidza dzakanyorwa, vane mushonga "Pradaksa" dzomuzana. Iye zvino ngatikurukurei muudzame mumwe wavo.

The medicament "Warfarin" anogadzirwa muchimiro mahwendefa ane uwandu husingakuvadzi kuti vanoshingaira chirungiso, 2.5 MG. The mugadziri zvinodhaka ndiko kambani Russian "Kanonfarma kugadzirwa."

Pane dzimwe chipimo chemushonga (1 MG, 2 MG, 3 MG uye 5 MG) wokumwe yakavakirwa mishonga warfarin. The chimiro, ruvara uye kukura mahwendefa chakasiyana pamusoro kana kudivi Zvakarurama dose mu MG.

Nokuti izvo zvinodhaka inoshandiswa

Kugamuchirwa "Warfarin" kunobvira:

• thrombosis of venous gadziriro kana kubatwa;
• nokuti prophylactic dambudziko thrombosis uye thromboembolism;
• mu chenjera venous thrombosis panguva uye embolism muna bapu tishu;
• panguva postoperative thrombosis;
• chenjera myocardial pomwoyo;
• pakuvhiya uye thrombolytic kurapa pamusoro thrombosis;
• pamwe zvinopfuura ischemic kurwisa;
• nokuti kwenguva refu Mabatirwo idzokororo venous thrombosis;
• munguva prosthetic vharafu mumwoyo.

How pomutumwa

Dzakananga pezvokuvamba kwenyaya "warfarin" kuderedza kweropa zvikonzero tunodzivisa kugadzirwa (X, IX, VII, II), vhitamini K-nemataundi ropa uye chikonzero coagulation. Hepatic Anticoagulant mapuroteni C uye S vari synthesized kuti muduku zvakadini pasi pokudzora kwomudzimu zvinodhaka. izvi zvose akazoita paumbwe clots ropa kuti tipedzisire paumbwe ropa.

Kubvisa venous thrombosis vanachiremba varayire kurapwa pamwe isina kunanga anticoagulants. Izvi hazvirevi kuzodzosera nounhu thrombosis, izvo zvinogona kukonzera matambudziko.

Kukarukureta of dose pakati warfarin pamwero yakasiyana INR

Kugadzwa "Warfarin" chinodhaka zvichibvira pashure zvakawanda ongororo, panguva iyo inozivisa zvose contraindications. The Kuongororwa kuti mamwe marapirwo yasarudzwa zvinodiwa huwandu medicament "Warfarin". The dose pazuva haafaniri kupfuudza 5 MG huru yezviri nefuma. With kukwana kuchirapa mugumisiro kurapa kuitwa kururamiswa. Zvinokurudzirwa kunyora vakagamuchira dose, INR nhanho uye zvinokonzerwa yomuka kuti Kuongororwa yokurapa.

Mukutonga INR (dzakawanda normalized reshiyo) kwaimiririra mureza kuziva nezvebasa pakugwamba ropa zvinhu. kweropa Zvinhu zvinobatsira kukosha chinoratidza. Zvinokosha kuti kuongorora INR apo kugamuchira "warfarin" nokugoverwa riri inversely Proportional kuti kweropa. Saka, panguva yakakwirira normalized reshiyo DZEMUNHU DZINODZORA pakugwamba uye inowedzera hypocoagulation.

Kana zvakasiyana inoti zvinofanira kuongororwa mune zvimwe INR.

1. Nokuti muviri utano, ayo ndeyokuva anenge 1.0 (kana dzikatsauka zvishoma - kubva 0,85 kusvika 1.25).
2. Chirwere atrial fibrillation apo kugamuchira "Warfarin" pellets kunofanira kubatana normalized nhamba 2.0 kusvika 3.0 dzakabatana.
3. Zvokuimba vharafu prosthesis ichazivikanwa noku INR kuti 2.0 kusvika 3.0, zvokuimba prosthetic mitral vharafu kubva 2.5 kusvika 3.5.
4. Pakurapa thromboembolism muna pulmonary tsinga uye vamwe mwoyo zvikanganiso vanoda indekisi pamwero 2.0 kusvika 3.0.
5. Kuti adzivise thrombosis pakadzika mutsinga pashure pokuvhiyiwa uye kuti vabatwe venous thrombosis, vanoomerera tsika 2.0-3.0.

The mushonga "Warfarin" yaifanira tichinyatsodzidza richiona nezvezvabuda INR indekisi uye kunyatsoteerera zvokurapa cherechedzo, kuti kukwanisa kuchinja chipimo chemushonga. Kudzikamiswa normalized reshiyo uye pakusarudza runodiwa huwandu medicament rinoitwa kuti rimwe vhiki, uye ipapo ose 4 mavhiki ukoshi iyi ndakaongorora.

Kuuya kubva nokuitika kushanda "Warfarin" zvinodhaka, sei kutora pane kusuka pasi uye kana wemishonga zvokudya, unofanira kuziva. Mahwendefa kunwa kaviri pazuva, kwete kubatanidza pamwe kudyiwa zvokudya. Vaishambidza pasi nemvura uye vatora panguva imwecheteyo. Mukuwedzera, chokuendesa Analyses pamusoro INR vanofanira kuva muawa uye zvechigarire murabhoritari. Kana kurovha mishonga zvakakodzera kuita rakatevera mugove mutambo nguva.

At prices asingasviki 2.0 INR anonzi ropa mikobvu, kuti mushonga uri basa, saka, zvakakodzera kushandisa yepamusoro chipimo chemushonga "warfarin".

Maererano zvinopfuura 3.0 INR riri kuonekwa mvura ropa, ropa kunogona kuitika, saka zvakakodzera kushandisa pane mukuru chipimo chemushonga zvinodhaka.

Nomutengo mushonga "Warfarin"

In tichienzanisa German zvinodhaka "Pradaksa" Russian nerokuti ayo "Warfarin", mutengo unobva 80 rubles por rongedza, zviri isingadhuri zvikuru uye nyore.

Description "Ksarelto" chinodhaka

At medicament "Pradaksa" analogs ave anticoagulant ehupfumi, ane zvakananga simba. zvinodhaka "Ksarelto" rinoreva kwavari. Yakabereka payo muchimiro kumativi firimu zvemapuranga mahwendefa kambani German "Bayer".

The sezvamunoita ane rivaroxaban mu micronized chimiro. Mahwendefa "Ksarelto" vari zvinotevera dosages: 2.5 MG, 10 MG, 15 MG uye 20 MG.

mashandiro chiito

Rivaroxaban anonzi zvikuru kusarudza zvakananga chinhu Xã FIs kuti ave bioavailability aona pashure nomumukanwa yaitonga.

The coagulation Pazvinoitika achiumbwa kubudikidza activation kuti chinhu X, iyo, nokuda nechinzwano zvokunze coagulation gwara iri dzikwanise chinhu Xã. chikamu ichi rinobatanidzwa paumbwe prothrombinase mukomboni kwomudzimu iyo prothrombin iri vatendeukira thrombin. azvaiitwa dzinoumba fibrin clot, uye zvaanopa simba maplatelet. Pane "dzinokaroparuka" umo nokuda pave Xã Morekuru vari synthesized chiuru masero aya ropa.

Kushandisa FIs vanosarudza kuti kuderedza basa activator kunoitika kumisa "thrombin kuputika". Action rivaroxaban yakatungamirira kushandura migumisiro chaiyo kana vakawanda rabhoritari kuongorora kupfurikidza kupima ezvinhu ari coagulation hurongwa. Factor Xã basa dzinosiyana-siyana zvichienderana inhibitor dose, iyo inoshanda sezvo mushonga "Ksarelto" (15 MG mahwendefa kana mamwe chipimo chemushonga izvozvo).

Kuti ikarapwa neizvi kwezvinodhaka

Chinyorwa rinotsanangura kushandisa medicament nokuda kudzivirira rufu pashure zvemwoyo chokuita myocardial pomwoyo uye rikwanise coronary syndrome. Medicine "Ksarelto" zvakanaka hunhu ratings vakawana kuti chinobudirira wemishonga mishonga pachiimbwa asipurini kana asipurini uye thienopyridine.

How kutora akasiyana mishonga zvinodhaka

The mushonga ari dzaizopiwa pezviri kushandiswa. Mahwendefa mishonga zvose kunwiwa.

Kuti kubvisa chakasimba coronary chirwere vari zano kutora rimwe pahwendefa 2,5 MG kaviri pazuva. Pamwechete pakugadzirira "Ksarelto" (ratings anoratidza kubudirira akadai mubatanidzwa kwayo) inogona dzakabatwa acetylsalicylic asidhi mune zuva dose inobva 75 kusvika 100 MG, uye wemishonga asipurini uye clopidogrel mune mari 75 MG pazuva. mushonga uyu zvinoda kugara vezvokurapa achitarisirwa kuti kuchengetwa nepakati, iro zvaizopedza rimwe divi zvinogona kukonzera ischemic kana ropa matambudziko. Kutora zvinodhaka refu uye zvinotora anenge rimwe gore, mune vamwe varwere kusvikira makore maviri.

Mahwendefa chipimo chemushonga 10 MG rivaroxaban kutora rimwe nguva rimwe zuva. The chokunwa rokutanga pashure maawa 6-9 womunda kuvhiya pamwe zvinobudirira hemostasis. Ya kurapwa akatsunga zvakadaro svinga zvinodhaka nerimwe murefu nomumwe, zvichienderana pangozi venous thromboembolism, kunzwisisa uye mhando oparesheni.

Kana rokuti chinodhaka kutarisira "Ksarelto" hudyu yokutsiva (10 MG pamahwendefa) kwazvinogumira kusvika 5 masvondo, panguva ibvi arthroplasty rakundwa 14 days.

Kana murwere anokanganwa kuti anwe imwe dose pamusoro rivaroxaban, zvinofanira pakarepo kuparadzwa, uye zuva rakatevera kuramba kurapwa, 1 piritsi.

Higher dosages 15 MG kana 20 MG uyewo haana zvinokubatai usina chawadya.

Kuitira kudzivisa mamiriro sitiroko uye systemic embolism hunhu nevasiri valvular atrial fibrillation dzinongoitika mwoyo atrial uchishandisa imwe piritsi dose 20 MG kamwe pazuva.

In renal kukundikana, kana mwero creatinine kuchaitwa hafu youpenyu asingasviki 30 Rine mamiririta 1 miniti achishandisa dose pamusoro 15 MG 1 nguva pazuva.

Ya kurapwa kunoenderana pamberi kutyisidzira sitiroko uye thromboembolism mamiriro hurongwa.

Kufadza zvinotonzi daily chipimo chemushonga hakufaniri anopfuura 20 MG rivaroxaban.

Thrombosis, yakadzika tsinga bata, nokuti kudzivirira dzokororo chirwere uye thromboembolic kukanganisa pulmonary tsinga, uchishandisa kwokutanga dose 15 MG kaviri pazuva panguva yokutanga vhiki nhatu. Naizvozvo kutamira pamahwandefa 20 MG rivaroxaban kamwe pazuva kurapa-refu uye kudzivirira kunenge thrombosis uye idzokororo pulmonary embolism.

Hazvibviri nguva varwere kumedza hwendefa rose, kunyanya hombe saizi, zvino anobvumirwa kukuya nokusanganisira nemvura yakachena kana mvura zvokudya pamberi rinodyiwa. Pakarepo mushure kutora zvinodhaka murwere adye.

Zvingadarowo kuzozivisa vanonetseka mapiritsi kubudikidza gavage, nzvimbo iyo ari zvomudumbu kwava kwakarongeka pachine wako chiremba. Terms kuita yakapwanyika mahwendefa iyi nzira kunoratidzwa nokusanganisa zvinodhaka pamwe shoma mvura uye hunotevedzana kuti kutarisira. Pashure paizvozvo izere zvishoma mvura kubvisa zvinodhaka residues kubva vachiongorora. Zvichitevera mishonga zvakakodzera kuita enteral zvokudya yaunodya.

Mutengo zvinodhaka "Ksarelto"

chokushandisa ichi zvinoshanda kupinza zvinodhaka kudhura. Somuenzaniso, mushonga "Ksarelto" mutengo duku dose achava 56 pellets anenge 950 rubles. Zviri zvakawanda zvinodhura pane ayo Russian analogue - mishonga "Warfarin". In mushonga "Ksarelto" mutengo kunowedzera zvichienderana kuwedzera uwandu husingakuvadzi. Saka, mari mahwendefa 14 15 MG rivaroxaban ichava pamusoro 850 rubles, uye nokuda kavha (zvidimbu 28 zvemahwendefa) pamwe chepamusoro dose (20 MG huru vanoshingaira chirungiso) vachava kubhadhara 1450 rubles.