"Octagam": mirayiridzo kushandiswa, zviratidzo, nemishonga

Rinoreva mushonga runogonesa dziviriro yezvirwere mumuviri, "Octagam". Mirayiro anofanira akayeuka kuti ichi chinhu chakakura chinodhaka, uye akatanga chete muchipatara, kunoparirwa mushonga. Yaishandiswa yokutsiva uye immunomodulatory kurapwa.

Form kusunungura zvinodhaka uye ayo sezvamunoita

It anogadzirwa chete muchimiro mhinduro kuti aizomupa gadziriro "Octagam". Mirayiridzo kuda uye zviri pasi fanira kudzidza vasati kushandisa. The mhinduro kwakanyatsojeka, ane yellowish tinge. The mushonga anogadzirwa girazi ndiro 20, 50, 100, 200 Rine mamiririta, izvo akavharwa aine rabha chimiso uye aruminiyamu burnishing rakazara mune makadhibhokisi bhokisi, apo Kuwedzera murayiro kushandiswa chinhu mapurasitiki-pajira riya pedhi.

The medicament rine muna 1 ml kanenge 95% immunoglobulin G. The chakarurama kwakafanana uwandu mapuroteni iri kwevanhu plasma. Zvimwe zvinhu zviri Kuronga zvinodhaka vari:

• maltose;
• octoxynol;
• tributyl phosphate;
• mvura majekiseni.

The mushonga haafaniri -oma kana pachena kuti chiedza chezuva. It inochengeterwa panguva tembiricha kuti 2-8 ° C, pasingasvikirwi nevana.

Pharmacology uye pharmacokinetics

Drug "Octagam" (Chinyorwa anonyevera pamusoro contraindications uye zvichiita nemigumisiro kushandisa zvinodhaka) kunokanganisa masoja yevanhu emuviri uye richireva immunoglobulins.

Mushonga chikamu immunoglobulin mukirasi G, izvo zvibereko antibodies kune zvakasiyana-siyana zvinotapukira pezvakaitwa mumuviri. The mushonga rine subclasses ari immunoglobulin G, akafanana kuti yeplasma kwevanhu, dzokorora ose zvivako zvayo uye unhu. Musumo zvinodhaka mumuviri anodzoreredza kwakaderedza kwevari IgG, inotungamirira naye hwandaiva ezvinhu. IgG mamorekuru nokuda enzymatic uye kwemakemikari nokufumura handishanduki. Basa antibodies aikwanisa kuponesa zvakakwana.

Mukugadzirira "Octagam" haasi anopfuura 3% polymer, chasara rwunoverengerwa kuti kubudikidza monomers uye dimers anenge 90%.

Kana iwe akasika chishandiso akashandisa ropa 3500 zvachose utano vaipa. Antibodies vakanga varipo vari plasma vanhu ava vakagara vachigadzirira ichi kuchinja uye kuramba zvizere kushingaira.

Pashure zvinodhaka Kutarisirwa kuva tsinga immunoglobulin G pakarepo anopinda systemic riparadzirwe, riri kuparadzirwa pakati vascular nzvimbo uye plasma. In nokushandisa "Oktagama" murwere nemamiriro nani mukati memazuva 3-5. Yaiwana mushonga musi 24-36 zuva fung. The hafu-upenyu chakasiyana munhu wose uye zvinoenderana murwere zera, mwero immunodeficiency. Immunoglobulin G kana zvimwe zvirwere zvivako zvine basa zvinoriumba, zvinoparadzwa reticuloendothelial hurongwa.

Kana kushandisa "Octagam"?

Ndikarangarira "Octagam" yokutsiva mushonga, kana paine chikuru immunodeficiency syndromes, pakutanga kwezvose, a vachiberekwa hypogammaglobulinemia, agammaglobulinemia uye Wiskott-Aldrich syndrome. Izvi zvinosanganisira shanduka unclassifiable immunodeficiency mhando uye immunodeficiencies zvabatanidzwa.

The chiratidzo nokuti mushonga wacho akaronga vakawanda myeloma, lymphocytic chisingaperi chimiro. Akamuraira mushonga varwere idzokororo utachiona, uye chirwere HIV muvana.

The mushonga wakawana kushandiswa kwayo kurapa. Kureva kuti rinoshandiswa idiopathic thrombocytopenic purpura (ITP), achiperekedzwa mikana yakawanda ropa. Uyewo, kuti mushonga unoshandiswa asati avhiyiwa kuti normalize platelet count. Ushandiswe mishonga pamwe Guillain-Pazvibato zvechizarira syndrome. Inoshanda sechiratidzo nokuda Kawasaki chirwere mune vana nevakuru.

Shandisa "Octagam" (User kushanda rinotsanangura nemashoko akadzama nzira chourongwa uye chipimo chemushonga zvinodhaka) mu allogeneic mwongo transplantation.

Contraindications nokuti infusions

Rinonyevera kuti zvinokosha kufunga contraindications asati kushandiswa "Octagam" gadziriro mirayiridzo. Havashandisi mushonga pamberi hypersensitivity kwayo constituent zvinokuvadza kana kuti homologous immunoglobulins.

With rokumavirazuva kutarisirwa kugadza varwere mushonga vari vakafutisa. Vane kubatwa kutanga thrombosis. Rinoreva ari contraindicated kana paine "chirwere kuti BP," chirwere nechirwere cheshuga, zvirwere kumwoyo, akawedzera kugara pasina motokari, kuwedzera mune viscosity ropa.

Apo mukuru viscosity pamusoro yeplasma immunoglobulin, kupinda muropa, Nokumukira pangozi myocardial infarction, pulmonary embolism, sitiroko, venous thrombosis.

Zvokungwarira vanofanira kushandisa zvinodhaka ichi, varwere renal kukundikana uye varwere mishonga hypovolemia kuwana nephrotoxic nevamiririri. Kana paine chinhu rikwanise kwokubatsira immunoglobulin-Danho renal chirwere, ari "Oktagamom" kurapa akamira.

Varwere chenjera renal kukundikana mu chimiro uyewo vanhu vane thromboembolic matambudziko anoitika intravenous donhwe kana jekiseni, kuti mushonga chinotarisirwa zvishoma nezvishoma uye shoma mari.

The pamasimba mushonga vakadzi vane pamuviri uye lactating vasina kudzidza, saka nguva yakaratidza mishonga inofanira kushandiswa nokungwarira zvikuru. Pasinei neizvi, muitiro rinoratidza kuti kushandiswa immunoglobulins hakuitiki chero Migumisiro panguva yepamuviri. The mushonga hakuna zvainoita azvarwa uye asingauyi kukanganisa mwana kuburikidza mukaka waamai. Immunoglobulins, achipinda mukaka, regai kukonzera zvakaipa kuti achangoberekwa, uye antibodies zviri mukati, chete kubatsira kuti paumbwe simba kutapata.

chipimo chemushonga

"Octagam" chinodhaka chinotarisirwa chete nomutsinga. Asati atanga kuti kudziyirwa mumba tembiricha, mumushonga nzira. The mvura inofanira kuva zvachose yakajeka uye hatina precipitate uye turbidity.

Mumwe mushonga Kutarisirwa wakanyorwa munhoroondo chirwere. Pane kuita zvinodhaka batch mangé nhamba uye zita. Izvi zvinoitwa kuvandudza richiona murwere wacho nemamiriro. The chinodhaka yasara mushure aizomupa, hazvigoni kuchengetwa uye unofanira kuparadzwa.

Mwero Sumo kutanga sostvlyaet 0.01 kusvika 0.02 Rine mamiririta / makirogiramu muviri uremu mune miniti imwe, uye zvichingodaro kwehafu yeawa. With tolerability chakanaka medicament zvazvingava zvishoma nezvishoma zvinogona ngazviwedzerwe 0,12 Rine mamiririta / makirogiramu uremu muviri paminiti.

Huwandu zvinodhaka uye nguva yokurapa takatsunga mumwe nomumwe nomumwe murwere. Zvose zvinoenderana kunotoda mhinduro imwe murwere, mugariro wake uye chirwere zvirwere.

Kuzvitsinhanisa immunomodulating mushonga mu chikuru immunodeficiency kunosanganisira kuwedzera uwandu immunoglobulin G kuti 4.0-6.0 g / L, zvakanzi akayera asati mumwe aizomupa. Kuti vabudirire mufananidzo yakadaro zvinoda 3-6 mwedzi kurapwa. Initial dose Kutarisirwa ndiyo 0.4-0.8 g / makirogiramu. Naizvozvo mushonga chinotarisirwa varwere ose vhiki nhatu pa 0.2 g / makirogiramu. Kuti vabudirire nangananga immunoglobulin 6.0 g / L, murwere unofanira kuiswa pamwedzi 0.2-0.8 g / makirogiramu zvinodhaka. Kana murwere anodzoka kune dzose mamiriro, mushonga anoramba kupiwa ose 2-4 mavhiki, pashure kuyera wevasungwa kuti immunoglobulin G muropa. Izvi zvichakubatsira kusarudza Zvakanyanya Kunaka Panguva Yepamuviri chipimo chemushonga.

Kuzvitsinhanisa mishonga kurapa chiri kuitwa chisingaperi lymphocytic neleukemia, izvo zvinopfuura kuti hypogammaglobulinemia yechipiri kwazvo chimiro, mune vakawanda myeloma, uyewo nechirwere kuti "HIV positive" muvana vane idzokororo uye zvirwere kwendangariro. Saka chipimo chemushonga fluctuates kumativi 0.2-0.4 g / makirogiramu. Multiplicity okuzivisa - ose 3-4 mavhiki.

Munguva pakurapa chakasimba Zvikamu ose idiopathic thrombocytopenic purpura (ITP) rinoshandiswa nenzira chipimo chemushonga zvinodhaka 0.8-1.0 g / makirogiramu kana raitongwa Nezuva rokutanga. Kana zvakakodzera, kuti shandisazve kuti medicament anobudiswa pa 2-5 zuva iri mari 0,4 g / makirogiramu. Kana nyaya exacerbation chirwere chacho recur, mushonga chinotarisirwa zvakare.

Guillain-Pazvibato zvechizarira chirwere kurapwa kunosanganisira pa 0,4 g / makirogiramu zvinodhaka pazuva kwemazuva 3-7. Muchiitiko chino, kushandiswa kwezvinodhaka nokuda vana ipfupi chaizvo.

Kawasaki chirwere muvana uye vakuru kubatwa ane uwandu husingakuvadzi kuti 1.6-2.0 g / makirogiramu. The mushonga chinotarisirwa mune imwe dose pamusoro mazuva 2-5. Vakabvumira chete mushonga Pfungwa imwe mari 2.0 g / makirogiramu. Munguva kuramba kurapwa murwere panguva imwe chete yebhuku "Oktagama" zvakakodzera kushandisa asipurini.

Immunoglobulin rinoshandiswa pashure allogeneic mwongo transplantation regadziriro kurapwa. Administration mumwe mushonga kunodzivisa panowanikwa neutachiona uye kukura urwere pakati "batanidza maringe hondo". The chipimo chemushonga nerimwe murwere anosarudzwa nomumwe. Zvinokurudzirwa kuti kutanga kubva dose pamusoro 0,5 g / makirogiramu pavhiki. jekiseni nzira inofanira kutanga vhiki pamberi kuuya nhengo transplantation. Zvipatara mberi kwemwedzi mitatu pashure kuvhiyiwa. Kana pane kutadza immunoglobulins, mushonga rinoshandiswa 0,5 g / makirogiramu ose mwedzi semazuva avo kugutsikana haridzoki kufirwa nhanho.

nemishonga

Subject kune fanira kudzidza asati nokushandisa mushonga "Octagam" mirayiridzo Chinyorwa. Kukura nemishonga kana uchishandisa mushonga kunobva dose uye mwero chourongwa.

Intravenous jekiseni pamwe mushonga kunogona kukonzera leukopenia, hemolysis uye reversible hemolytic kupererwa neropa. In pakurapa zvingangoitwa dziviriro yezvirwere mumuviri, varehwa mu kuratidzwa hypersensitivity. Mune zvisingawanzoitiki Muzviitiko simuka anaphylactoid uye anaphylactic siyana, puffiness chiso, angioedema.

HIV kurapa muvana uye mabatiro nezvimwe zvirwere kunowanzokonzera nomusoro. Kashoma chepfungwa wokufambisa ropa, kunyanya kufara, aseptic yomumuzongoza. The mushonga anogona kukonzera nemusoro, paresthesia uye vertigo.

Panguva kurapwa, pane ndingangokuvara panowanikwa myocardial infarction. Panogona kuva wakawedzera kurova kwehana uye tahikradiya. Dzimwe nguva ainetseka cyanosis, hypotension uye thrombosis. Zviri zvisinganyanyi kuitika kweropa insufficiency, yakadzika tsinga thrombosis, BP.

The mushonga zvinogona kuita maitiro wakakomba pamusoro chikamu kufema hurongwa. Ichi kufema kukundikana, pulmonary edema, kupfupika mweya. Nemigumisiro yakaipa vari kutaurwa Achiviruka vangakosora, bronchospasm, pulmonary embolism.

The kunokwanisa kukonzera kuda kurutsa, kurutsa dzepanguva, abdominal marwadzo, manyoka. Mune zvisingawanzoitiki kacho pane eczema, urticaria uye kuvaviwa. Mune vamwe varwere, pashure kushandisa zvinodhaka akasimuka dermatitis, alopecia, uye pruritus.

Zvinonzi kashoma vakacherechedzawo siyana dzakadai marwadzo kumashure nzvimbo, myalgia uye arthralgia. More pakurapwa zvingamuka renal insufficiency, wakawedzera serum creatinine, kunokanganisa fivha, zvakanyanyisa kuneta, kusagadzikana zvakaitwa kuitika panguva jekiseni nzvimbo. Pakati yaivhuvhuta zviitiko nguva nenguva akacherechedza chills, marwadzo ari mubhokisi, Flushing, zvakawanda zvive, mapundu uye pyrexia. Mune zvisingawanzoitiki ezvinhu, varwere vane yakaderera BP, anaphylactic kuvhunduka.

The pakuonekwa zvingakonzerwa nemishonga Varwere, kwokubatsira mushonga akashivirira kare zvakanaka. "Octagam" rinoita kuwedzera chiropa makemikari uye shuga kuwanda muzvidzidzo murabhoritari ropa.

Kana vakasarudzwa zvakanaka dose zvingaitika overdosing zviratidzo. Kazhinji mvura chengetedzo mumuviri, kuwedzera viscosity ropa, icho kuchengetwa vanhu vane chirwere cheitsvo, uye varwere vakwegura.

In ose pamusoro nyaya, symptomatic kurapwa inokurudzirwa.

Zvokungwarira

The mushonga anokwanisa kuderedza mhenyu attenuated utachiona yokudzivirira kwenguva vhiki nhanhatu kuti mwedzi mitatu. Kuti izvi zvisaitike, unofanira kumirira pashure kushanda "Octagam" mitatu kugadzirira. Mishonga akazoita kubudirira gwirikwiti mushonga mugore, saka pamberi inoshandiswa pakutsigira kuti kubaya ichi rinofanira kuongororwa titer gwirikwiti antibodies.

Treatment pamwe mushonga uyu zvinogona kukonzera zvinoverengeka nemishonga, saka zvakakodzera kuita kungoitira chete mirayiridzo chipimo chemushonga uye Kutarisirwa unodiwa. Nokufamba mishonga zvakakodzera nguva dzose kuongorora utano wevarwere.

Varwere vari kutarisirwa intravenous immunoglobulin, vanofanira kugamuchira zvakakwana hydration risati nzira, kuti kuitisa richiona nezvezvabuda weti goho uye ropa creatinine. Zvakakodzera kubvisa zvachose pokushandisa "loop" diuretics.

Kana pane akaipa akadaro anodiwa kuderedza mwero zvinodhaka kuunganidza kana zvachose kurega kushandisa. The kurapa kunobva zvachose kukuvadza uye hunhu kumuvengi zviitiko. Kana paine kuvhunduka, zvakakodzera kushandisa Anti-kuvhunduka kurapa, izvo zvinofanira pamwe kurapwa.

Kakawanda kunokonzera nenjodzi mwero nokukurumidza chourongwa, kunyanya mu hypo- uye agammaglobulinemia uye kushandisa chepuraimari immunoglobulin. Nemishonga zvingaitika kana tama murwere chete immunoglobulin rimwe mugadziri mumwe mushonga, uye kana nguva yakawanda yakapfuura kubva rokupedzisira aizomupa.

Kudzora varwere izvi (uye izvi zvinosanganisira varwere HIV chinzvimbo) yaifanira ichi- yose nguva aizomupa kekutanga, kunyanya panguva yokutanga maawa pashure nzira. Varwere vasina nemishonga, zvinofanira pasi chiremba ndiye aitungamirira basa pashure aizomupa "Oktagamom" Maminitsi 20 yokutanga.

Panguva mushonga vanofanira kutora mureza matanho kudzivirira zvirwere kuti zvinokwanisika kana kushandisa mishonga wakaita neropa revanhu kana plasma. Izvi zvinosanganisira kusarudzwa yakakodzera vaipa, vachiongorora nomunhu huwandu uye plasma madziva kuti dzakananga zvezvinangwa chirwere. Izvi zvinofanira kusanganisira zviyero nokuda inactivation / kubviswa wanda.

Pasinei nezvose zvokungwarira pakurapa mishonga yakadaro, hatigoni kudzivirira kubata kuchinjwa wandei vaishandira zvirwere, nemavhairasi uye nezvimwe utachiona. Zvose pamusoro zviyero vanoshanda kutsunga wakafukidza nemavhairasi HIV, hepatitis B uye C. The vanotomboti kusarudza mutakuri parvovirus B19 uye gipatita A. Clinical ruzivo kurapwa nevasori ine immunoglobulin munhu kunoratidza kuti parvovirus B19 uye nehepatitis A pakurapa mishonga asina zvitange mashoko. Zvikuru muna antiviral kuchengeteka ndiyo kuvapo ari somushonga chigadzirwa tsamba antibodies.

Munguva ndima kuchirapa kosi tinyerere Kutamiswa antibodies muropa murwere anogona kupa migumisiro venhema kana kuita serologic nemiedzo. Maltose huri kugadzirira anokwanisa kukanganisa nhema ropa shuga revarombo.

Enhanced waivako muropa shuga wevasungwa aona panguva nokubviswa zvinodhaka kubva muviri kana maawa gumi namarudzi kuvhara. Muchiitiko chino, pane mukana kururama chinangwa jekiseni dose kuti kungakonzera yomuropa. Naizvozvo, chete glyukozospetsificheskie nzira nokuda Pakusarudza padanho shuga muropa kuti kushandiswa pakurapa "0ktagamom". Test Kits nokuti kuongorora ropa shuga vanofanira kukwanisa kuziva parameter ino varwere kutora mishonga pamwe maltose.

Kana asina apera, vakabvumira yokuchengetera zvinodhaka "Octagam" (50 Rine mamiririta uye 100 ml) pa tembiricha kusvikira + 25 ° C kwemwedzi mitatu pasina yechipiri Akariyanika mufiriji. Tsva kwenguva yakati nguva, mushonga unofanira kuparadzwa.

Mishonga hazvirevi kukanganisa kukwanisa kudzinga uye kuita zviito zvinoda vainyatsotarisirwa zvaiva uye nokukurumidza psychomotor zvavaifunga.

Drug "Octagam": dzomuzana

mushonga uyu ane uwandu analogues anogona kutsiva naye kana kubatsirwa, ndiko:

• "Biaven VI."
• "Veegum-liquidity."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

Sevamiririri Russian vari isingadhuri zvikuru kupfuura zvavo dzimwe dzomuzana. Chero zvazvingava, zvinodhaka zvose izvi zviri kwazvo zvakakwana tonotora uye anofanira kutsiviwa chete nachiremba, kunobva murwere ezvinhu.

"Octagam" Medicine: mutengo

Mari zvinodhaka zvakakwirira zvikuru. Inogona kutengwa nokuda 9,5-12 zviuru rubles uye 50 ml mushonga "Octagam". 100 ml Price iri kumativi 20-24 zviuru rubles.

Maonero kuvarwere uye vanachiremba

Drug "Octagam" rine wongororo vainyanya akanaka. Kunyanya kukosha kwayo unhu vanhu, vaakanga akabatsira kudzorerazve pamwe immunodeficiency uye Guillain-Pazvibato zvechizarira syndrome. It rinowanzoshandiswa vanhu vane AIDS vaine utano hwavo. Akaratidza kuti vabudirire chisingaperi lymphocytic neleukemia, myasthenia gravis. Women vanoshandisa mushonga uyu kuti ave nepamuviri uye uchabereka mwana.

Vazhinji varwere vasingagutsikane Mari chinodhaka, ivo dzinoti kuti zvakaoma kutenga mu Pharmacies. Vamwe akaritumidza utera, nemusoro, uye mukuru zvakawanda zvive.

Vanachiremba vanoti kuti ndicho yakaisvonaka gadziriro, zvinonzi zvakanaka yokuita zvinoitwa muviri, uye kusafanana mudzimba immunoglobulins kashoma kukonzera Kurwara.