"Novorapid" (jekiseni): mirayiridzo kushandiswa, chipimo chemushonga, Kutarisirwa unyanzvi, wongororo

Drug "NovoRapid" (jekiseni) ndiye mushonga itsva. Up nokuti kwaiva jekiseni kwevanhu uye ane vanoverengeka zvakanakira pamusoro mamwe marudzi mahormone. Akakurumidza takabatikana uye kunoderedza shuga pakarepo. Inogona kushandawo pasinei kudya. It anonzi ane ultrashort jekiseni.

Zvinoumba shuga yomuchipatara

Zvinoreva kuti chirwere cheshuga "NovoRapid" (jekiseni) inogadzirwa kaviri - munhu replaceable cartridges "Penfill" uye akagadzirira nepeni "FleksPen".

Kuronga katuriji uye mubato chete - a läpinäkyvä mvura kuti jekiseni, apo 1 Rine mamiririta rine basa pazvokudya mari insulin yakakodzera aspart 100 U. Mune imwe kuchinjaniswa katuriji sezvo mumwe mubato chikamu anenge 3 ml kugadzirisa kuti muzvikamu 300.

Cartridges akaita kubva girazi mukirasi hydrolytic I. Akadzivira pamusoro rimwe divi mavhiri polyisoprene uye bromobutyl rabha, zvakasiyana - inokosha rabha pistons. The aruminiyamu mhoni iri shanu yokutsiva cartridges, uye muzvivako atorwa imwe mhoni. Saizvozvowo akaitira chinyoreso "FleksPen". Vane kuraswa uye akagadzirirwa vakawanda mishonga. Atorwa zvezvimedu shanu.

Kugadzirira anochengeterwa inotonhorera nzvimbo 2-8 ° C. Hahugoni kuisa parutivi furiza uye Ndinoda. Uyewo, bvisika cartridges uye mudanga anofanira kudzivirirwa kubva chafariz anokonzerwa chezuva. Kana jekiseni "NovoRapid" (katuriji) razaruka, hazvigoni kuchengetwa mufiriji, asi anofanira kushandiswa mukati memasvondo mana. Tembiricha kuchengetwa, haafaniri kuva mukuru 30 ° C. Pasherufu upenyu unopened jekiseni mwedzi 30.

pharmacology

The medicament "NovoRapid" (jekiseni) ane hypoglycemic chiito, uye kushingaira chirungiso - jekiseni aspart - iri pfupi-kuita kemikari analoginen zvinoberekwa murume. Izvi zvinhu rakagadzirirwa nokushandisa inokosha recombinant DNA hwokushandura zvinhu zvipenyu. Pano wakawedzera tisawirirane pamusoro Saccharomyces cerevisiae, uye amino asidhi rinonzi "proline" kwenguva ne aspartic.

The mushonga anosunga kuti receptors rokunze yeplasma Kamudzira masero iyo inowanikwa chisinganzwisisiki insulin yakakodzera harinzwi zvaanopa simba pezvakaitwa zvose mukati muchitokisi. Mushure kuderedza uwandu shuga iri yeplasma chinhu kuwedzera intracellular chokufambisa, kuwedzera digestibility kuti munyama siyana, activation kuti lipogenesis uye glikogenogeneza. Kwakaderedza mwero shuga kugadzira nokuda chiropa.

Yaitsiva amino iine acid proline panguva aspartic pasi zvinoitwa jekiseni aspart saasipo, zvivako zviri mamorekuru kuti kusika hexamers. Izvi mhando wefodya kemikari subcutaneous mafuta nani, kunokanganisa muviri kupfuura mugumisiro soluble kwevanhu jekiseni mureza.

Panguva maawa mana pashure zvokudya rokutanga, jekiseni aspart nokukurumidza lowers ropa shuga yomuropa mu yeplasma pane soluble dzevanhu kemikari. Asi mugumisiro "Novorapid" subcutaneous Kutarisirwa rakapfupika kupfuura soluble munhu.

How mabasa mazhinji "NovoRapid"? mubvunzo uyu anonetseka vanhu vakawanda vane chirwere cheshuga. Saka, Zvakaitwa zvinodhaka kunoitika pashure 10-20 maminitsi mushure jekiseni. The soro Kuwanda kemikari muropa vakachengeta pashure maawa 1-3 mushure kushanda zvinodhaka. It Zvinoitika muviri kwemaawa 3-5.

Studies vanhu vane Type I cheshuga vakaratidza vasanyanye nengozi kuzvirotera yomuropa kanoverengeka ari kushanda, "NovoRapid", kunyanya sezvo zvichienzaniswa kwokubatsira soluble kwevanhu jekiseni. Uyezve, paiva rinokosha zvinoderedza postprandial yeplasma shuga kana jekiseni nayo jekiseni aspart.

Zvairatidza uye contraindications

Medicine "NovoRapid" (jekiseni) akanyorerwa vanhu vane chirwere cheshuga sezvo mhando 1, inova jekiseni, uye varwere chirwere cheshuga mhando 2 - jekiseni zvaanoda (padanho kuramba hypoglycemic zvinodhaka akatorwa nomuromo uye intercurrent zvirwere) .

Contraindications kuti kushandiswa medicament ndiyo yomuropa uye kunyanya aikanganiswa jekiseni aspart, Excipients kugadzirira.

Usashandisa "NovoRapid" vana pasi pemakore matanhatu nokuda kwokushaya miedzo zvekuchipatara.

Medicine "NovoRapid": mirayiridzo kushandiswa

Kugadzirira "NovoRapid" ane analogue insulin yakakodzera. Zvinotora zvazviri pakarepo mushure jekiseni. The chipimo chemushonga mumwe nomumwe murwere uye chiremba akasarudzwa. Nokuti migumisiro yakanakisisa, nokubatanidza pamwe insulin kana refu avhareji ya chiito.

Kuti kuzvidzora glycemia, dzose kuyera uwandu shuga muropa uye nokungwarira vakasarudzwa dose insulin yakakodzera. Kazhinji, nezuva dose kuti vakuru nevana iri kuwanda 0.5-1 U / makirogiramu.

Kana Kubayiwawo jekiseni rine mushonga "NovoRapid" (murayiridzo Chinyorwa rinotsanangura nemashoko akadzama nzira kuti jekiseni) jekiseni zvinodiwa nevanhu inopiwa 50-70%. Zvakasara akasangana nokuda kwokubatsira jekiseni refu (mazhinji) chiito. Vakawedzera basa rinoda murwere uye kuchinja zvokudya, uyewo huripo comorbidities kazhinji kuita zvakakodzera kushandura dose raitongwa.

Kemikari "NovoRapid" vakasiyana soluble munhu anotanga kuita nokukurumidza, asi kwete nguva dzose. Kuratidza kunonoka jekiseni insulin yakakodzera. jekiseni algorithm kunosanganisira kushandisa mishonga pakarepo pamberi kuzodya, uye kana pane kudiwa kwokukurumidzira, mushonga unoshandiswa pakarepo pashure zvokudya.

Nokuti kuti "NovoRapid" zvainoita muviri kwenguva pfupi, pangozi yomuropa usiku pavarwere chirwere cheshuga ari yekudyidzana ipfupi.

In varwere vakwegura, uyewo vanhu vane renal kana hepatic insufficiency kudzora ropa shuga wevasungwa inofanira kakawanda, uye uwandu jekiseni aspart anosarudzwa nomumwe.

Vana "NovoRapid" kutsiva munhu soluble jekiseni, asi kana zvakafanira kugadzirira pamwe kutsanya chiito chete. Rinoshandiswa kana mwana asina kuramba runodiwa penguva pakati majekiseni uye zvokudya. Kana murwere rinoshandurwa kuti "NovoRapid" nevamwe kugadzirira ane jekiseni dose kuchinja kunodiwa, uyewo basal jekiseni.

Subcutaneous jekiseni insulin yakakodzera (kushandisa algorithm kemikari majekiseni chinorondedzerwa zvizere mune mirayiridzo kushandiswa) kunosanganisira jekiseni Pfungwa iri pamberi munharaunda mudumbu, chidya, uye fudzi deltoid tsandanyama, uyewo mune magaro. Nzvimbo yacho majekiseni, anofanira kushandurwa kudzivirira lipodystrophy umo.

Kana achiita mukati Anterior mudunhu kemikari zvinodhaka wefodya dzichimhanya peritoneum, tichienzanisa majekiseni munzvimbo dzimwe nhengo dzomuviri. Mahomoni anoita ya kushanda dose jekiseni nzvimbo, ukuru ropa kuyerera, tembiricha muviri, pamwero kwebasa murwere.

Rinoreva "NovoRapid" kushandiswa kwenguva refu subcutaneous infusions, ayo kuitwa chinokosha pombi. Raitongwa mushonga pamberi peritoneum asi nguva nenguva kuchinja nzvimbo. Kana jekiseni pombi rinoshandiswa, ari "NovoRapid" rirege kuvhenganiswa mamwe marudzi jekiseni. Varwere kugamuchira kemikari uchishandisa aizomupa Hurongwa vanofanira kugoverwa mishonga breakage midziyo.

"NovoRapid" anogona kushandiswa intravenous kutarisira asi nzira inofanira kuitwa utano anokwanisa nyanzvi. Nokuti ichi mhando chourongwa pacho rinoshandiswa aizomupa mugadziriro, apo jekiseni zvirimowo mune mari 100 U / Rine mamiririta, uye ayo yevasungwa ndiyo 0.05-1 U / Rine mamiririta. The mushonga wakange rakasanganiswa muna 0,9% yavaibvisa chloride, 5 uye 10% dextrose mhinduro ine potassium chloride kusvika 40 mmol / l. Akati zvinoreva twakachengetwa nzvimbo tembiricha kuti haana kupfuura zuva rimwe. Kana jekiseni aizomupa anofanira kugara kupa ropa rayo zviri shuga.

How kuverenga jekiseni dose?

Kuverenga chipimo chemushonga aida kuziva kuti jekiseni unobatanidzwa, refu (kwenguva), unosvikirwa, pfupi uye Ultra-pfupi. Wokutanga kunotungamirira kwomuzvarirwo ropa shuga. Ivepo usina chawadya. Zvinoratidza vanhu vane mhando 1 chirwere cheshuga uye mhando 2. Kune vanhu vanoshandisa rimwe chete mhando jekiseni - unoratidzwa. Vamwe vanhu vari "NovoRapid" rinoshandiswa kudzivisa anongoerekana RINOFAMBIRA kuti shuga. Pfupi, refu, jekiseni zvingashandiswa panguva imwe chete ari pakurapwa kwechirwere cheshuga, asi vari kutarisirwa panguva dzakasiyana. Vamwe varwere chete kushandiswa zvinodhaka zvabatanidzwa kunobatsira kuita zvinozoita.

In kusarudzwa refu-kuita jekiseni zvinofanira kufungwa zvimwe nuances. Somuenzaniso, unofanira, pasina jekiseni kemikari inonzi uye pfupi chikuru zvokudya shuga vakasara rose zuva pane imwe pamwero chete nokuda zvinoita refu jekiseni.

Selection dose insulin yakakodzera chakazara riri sezvinotevera:

• Mangwanani, hapana kudya kwamangwanani, kuyera padanho shuga.
• Lunch, idyai, uye pashure maawa matatu shuga dhigiri plasma. Next nekuyera rinoitwa ose awa pamberi yokurara. Zuva rokutanga kusarudzwa zviri dose asipo kudya, asi kwemanheru.
• Pazuva rechipiri akabvumidza zvemangwanani uye masikati, asi kwete kwemanheru. Sugar, uyewo pazuva rokutanga, unofanira kudzora ose awa, kusanganisira usiku.
• Pazuva rechitatu tichiita nokuyerwa, udye kazhinji, asi regai kupinda pfupi jekiseni.

Perfect mangwanani zviratidzi ndiwo:

• pana zuva 1 - 5 mmol / L;
• panguva Day 2 - 8 mmol / L;
• pa zuva 3 - 12 mmol / l.

Kwakadaro shuga tsika atorwe pasina pfupi-kuita kemikari. Somuenzaniso, kana ropa shuga mangwanani iri 7 mmol / L, uye madekwana - 4 mmol / L, inoratidza kukosha kuchiderera dose kemikari inonzi pakureba 1 kana 2 dzakabatana.

Kakawanda varwere kuona nezuva dose achishandisa nzira Forshema. Kana ropa shuga fluctuates mukati 150-216 MG /%, rimwe chakayerwa ropa shuga pamwero kutora 150 uye vagovane nhamba kuti 5. Zvinoguma imwe dose ane refu kemikari. Kana ropa shuga kwazvo 216 MG /%, shuga iri subtracted kubva akayera 200 uye mugumisiro yakakamurwa 10.

Kuziva dose insulin yakakodzera pfupi, zvakakodzera kuti vhiki kuyera ropa shuga. Kana vose nezuva zviratidzi vari kuipa, kunze manheru, zvadaro pfupi jekiseni chinotarisirwa asati adya chisvusvuro. Kana shuga ropa akasvetuka pashure nerimwe kudya, kuita majekiseni asati kudya.

Kuti tizive nguva iyo kemikari chinofanira kutarisirwa, zvakakodzera kuyera shuga maminitsi 45 tisati zvokudya. Zvinotevera kuzvidzora shuga ose maminitsi mashanu kusvikira kwayo sandara rinosvika pachiyero 0.3 mmol / L, chete pashure trapeznichat. Izvi zvichaita kuyambira kutanga yomuropa. Kana pashure maminitsi 45 shuga achadonha, zvakakodzera kuti kumirira kudya kuti chero shuga asingadi vachiwira achida chiratidzo.

Kuziva dose insulin yakakodzera ultrashort vanhu vane mhando 1 chirwere cheshuga uye kutaipa 2 mazano kwevhiki kuchengeta zvokudya. Monitor, sei uye rudzii zvigadzirwa ivo zvinodya. Haafaniri kupfuudza mari kubvumirwa zvokudya. Uyewo funga kurovedza muviri murwere, kurapwa yaunodya, kuvapo chisingaperi zvirwere.

Ultra-jekiseni chinotarisirwa kwemaminitsi 5-15 pamberi kudya. Sei kuverenga dose kuti "NovoRapid" jekiseni iyi? Zvinofanira kurangarirwa kuti zvinodhaka izvi kunoderedza padanho shuga muna 1.5 nguva kupfuura ayo pfupi Sevamiririri. Naizvozvo, uwandu "Novorapid" ndiyo 0,4 dose pfupi kemikari. Munoda kunyatso-bvunzisisa inoenzanirana anogona chete kuva achishandisa yetsvakurudzo.

Kana Pakusarudza jekiseni dose vanofanira kufunga dhigirii zvirwere, uye kuti kudiwa chero kemikari mune chirwere cheshuga kwete kupfuura 1 U / makirogiramu. Zvikasadaro, zvinogona kukonzera ive ovhadhozi uye kuti nhamba yematambudziko.

Dzinokosha mitemo Pakusarudza dose shuga kuti chirwere cheshuga:

• Vachiri padanho mhando 1 chirwere cheshuga kemikari dose haafaniri kupfuudza 0,5 zviyero / makirogiramu.
• In cheshuga mhando 1, riri kuchengetwa murwere gore kana kupfuura basa yevanhu jekiseni riri 0,6 nepfambi / makirogiramu.
• Kana mhando 1 chirwere cheshuga ari pamwe anoverengeka nehosha dzakaipa uye ane kusagadzikana parameters ropa shuga sandara, uwandu kemikari akaenzana 0,7 Iu / makirogiramu.
• In decompensated cheshuga jekiseni iri 0,8 nepfambi / makirogiramu.
• Kana cheshuga aine ketoacidosis kuti kunodiwa kusuma anenge 0,9 U / makirogiramu kemikari.
• Panguva pamuviri, mumwe mukadzi ari wechitatu trimester vanoda 1.0 zviyero / makirogiramu.

Nokuti kukarukureta rimwe chete dose insulin yakakodzera kunofanira zuva dose kane muviri uremu uye chakaparadzanisa vaviri, uye kumativi kumusoro yokupedzisira nhamba.

Kushandiswa "NovoRapid FleksPen" chinodhaka

Nhanganyaya kemikari inonzi inogona kuitwa uchishandisa sirinji-chinyoreso "NovoRapid FleksPen". It ane ruvara coded dispenser. The dose insulin yakakodzera Ingasiyana kubva 1 kusvika 60 U, mumwe nhano akaenzana 1 Iu sirinji. Mukugadzirira "NovoRapid" tsono akashandisa TM "Novotvist" kana "Novofayn" 8 mm. Kana uchishandisa peni, yeuka kuti nguva dzose unofanira kuva musana-up marongedzero nokuda jekiseni - chete kana, kana sirinji dzaparadzwa kana varasikirwa.

Pamberi kutanga rezvipfuwo kemikari chinodiwa:

• Verenga Chikwata uye nechokwadi chokuti "NovoRapid" ndiyo chaiwo jekiseni rwaunoda.
• Bvisa sirinji kubva nepfundo-chivharo.
• Bvisa chinamirwa riri pamusoro chenhando tsono.
• Sikuruwa tsono kuti mubato. Nokuti mumwe jekiseni kuva tsono itsva kudzivisa kwemabhakitiriya kukura. The tsono haafaniri kuva hwakakungwa kana kukuvaradzwa.
• Kuti tidzivise netsaona tsono padenga tsono chivharo pashure kwokubatsira jekiseni asingadi kupfeka.

Jekiseni mudanga "NovoRapid" ingasanganisira zvishoma shoma mhepo mukati. The okisijeni matema regai kuunganidza uye dose yave nemazvo akaiswa, zvakakodzera vanoomerera zvimwe mitemo:

• ED kemikari raundi 2 kutenderera ari metering selector.
• Tsvaka tsono mudanga mudenga uye vawane mashoko katuriji munhu munwe. Sezvo mhepo matema vanozoona chokumusoro nharaunda.
• Wakabata sirinji "FleksPen" tsono kumusoro, achizviendesa kutanga bhatani kusvikira anomira. Metering selector panguva ino vachadzoka "0" nzvimbo. Trainspotting achava donhwe kemikari. Kana harungaregi, muitiro inogona kudzokororwa katanhatu. Kana jekiseni haauyi, ipapo sirinji iri chakaremara.

Usati kuisa mushonga uya waunenge vanofanira nechokwadi chokuti chipimo chemushonga selector yakaiswa kuti "0". Zvinotevera kunodiwa kuti dhayira nhamba vezvikwata, chitsama zvinodhaka riri nokudzorwa selector mune zvose kumativi. Kana kuisa mushonga uya waunenge kungwarira uye musaedza netsaona kubata kutanga bhatani, zvikasadaro pachava vakurumidze kusunungurwa kemikari. Regai dzishandise Chero mukuru kupfuura munhu ari chigadzirwa, "NovoRapid." Uyewo, regai kushandisa nepakati chikero kuti asarudze kemikari dose.

Munguva kwokubatsira jekiseni subcutaneously anoteverwa unyanzvi ndakarumbidzwa nachiremba wako. Nokuti jekiseni, achizviendesa kutanga bhatani. Ramba wakadaro sokuvapo chipimo chemushonga selector asingadi kutora nzvimbo "0". Munguva jekiseni abate kutanga bhatani chete. Chaiye kutenderera Pointer chipimo chemushonga jekiseni pakukurukura hakuitiki.

Mushure jekiseni, tsono pasi ganda inofanira kuitwa kwemamwe masekonzi matanhatu pasina kusunungura chikungiso bhatani. Sezvo jekiseni dose wakapinda chose. Mushure tsono jekiseni inoendeswa rokunze chivharo, uye kana achipinda mariri, zvinonzi unscrewed uye achirasa, kuita zvose zvokungwarira. The sirinji yakanga dzavhara. The tsono chinobviswa pashure nomumwe jekiseni uye kwete kuchengetwa nepeni. Zvikasadaro, Urume leakage chichaitika, izvo zvinogona kunotoreva kutungamirira ane kururama chipimo chemushonga. Kuti mashoko sei kuti anobaya jekiseni "NovoRapid" kukuudzai zvakawanda mirayiridzo kushandiswa.

nemishonga

Drug "NovoRapid" kunogona kukonzera zvinoverengeka nemishonga. Hazvina yomuropa, izvo kunooneka pacharo muchimiro kunyanya vangadikitira, ganda rakachenuruka, kutya, rusina kufunganya, tremor wamativi, utera mumuviri, nekuvhiri- ngika uye kuderedzwa yevasungwa. Uyewo, pane dzungu, kunzwa nzara, mumwe atadze kushanda zvakanaka pamusoro kuona midziyo, kuda kurutsa, nomusoro, uye tachycardia. Glycemia anogona kukonzera kurasikirwa pfungwa, nezvipusha, uropi uye rufu.

Kazhinji, varwere vanoti pamusoro zvakadai neutachiona sezvo mikoko, rashes. Possible nokuvhiringidzirwa mudumbu uye ura, panowanikwa angioedema, tachycardia, kupfupika mweya. In varwere vakacherechedza richikwidibira pamusoro BP.

Local siyana vakachengeta kuvaviwa munzvimbo jekiseni, akatsvuka, kuzvimba ganda. Kazhinji yakaitika lipodystrophy zviratidzo. The chinodhaka kungaita kutanga kwekupwanyiwa kurapa edema uye kutyora refraction.

Vanachiremba vanoti kuratidzwa ndezvenguva duku zvakasikwa uye vakachengeta kunyanya varwere dose-zvaanoda uye nokuda kuitwa mishonga jekiseni.

analogs

Kana kemikari hakukodzeri, unogona nguva dzose kutsiva chigadzirwa "NovoRapid FleksPen". Analogs, Chokwadi, kusarudza mumwe chiremba. Wekumusoro mukurumbira inosanganisira:

• "Novomiks".
• "Apidra".
• "Humalog".
• "Actrapid."
• "Rayzodeg".
• "Protafan".
• "Gensulin H".

Mari kemikari

Iri kutengeswa kunoparirwa inonyorwa mishonga, "NovoRapid." Mutengo cartridges shanu "Penfill" riri kumativi 1,800 rubles. Mari kemikari "FleksPen" ndiyo 2000 rubles. Mumwe rongedza rine shanu jekiseni jekiseni matanga "Novorapid". Price zvichienderana zvokutengeserana pomumbure anogona siyana zvishoma.

Testimonials

Ndezvipi "NovoRapid" gadziriro wongororo? Vanhu vanoti ichi chinhu chakanaka uye munyoro jekiseni. It anoita nokukurumidza. Akakodzera pakurapa chirwere cheshuga mhando 1, apo ropa shuga rakaoma kuderedza. Vazhinji varwere ake vanoshandisa pakurapa mhando 2 cheshuga. chirwere cheshuga Most vanzwe vakasununguka chaizvo kunyora "FleksPen". Kubvisa kudiwa yoga kutenga syringes.

Kazhinji, varwere vanoshandisa zvinodhaka "NovoRapid" tikafunga refu jekiseni, iyo inobatsira kuramba zvakajairika ropa shuga yomuropa yose zuva. Zvinobatsira tikarega ropa shuga yomuropa pashure kudya, izvo hwezvekukurukurirana zvikuru upenyu chirwere cheshuga zhinji uye anobvumira kudya pashure maawa. Vamwe vanhu vari zano panguva kutanga pavaipfuura chirwere chete kushandisa kemikari ichi.

Kune vanhu vanoti kuti mushonga - kana raitongwa vana vaduku - kunokonzera kare unopinza ndatsamwa muropa shuga, zvichiguma vana unonetsekerei. Kuti izvi zvisaitike, vabereki vakawanda vanoda "NovoRapid" refu jekiseni.

varwere More dzinoti kuti zvakarurama vachiwirirana dose kazhinji chinokurwadzai yomuropa uye kunokanganisa utano. Kuti tidzivise vakadaro Migumisiro havasi kuzvidzora medicate, uye kutsvaka kubatsirwa navanachiremba.