"Nimid" (Mahwendefa): Mirayiridzo kushandiswa uye zvaunofunga

Vanhu kutambura nezvirwere mapfupa, mapfundo tsandanyama somunhu symptomatic kurapwa Vanachiremba kazhinji mishonga "Nimid" (Mahwendefa). Mirayiridzo dzokushandisa rine ruzivo kuti zvinodhaka kwete chete kunobvisa marwadzo, asi anewo Anti-anogumbura chiito. Ngatiedzei kuongorora chokupika chigadzirwa muudzame uye kuziva umo nguva anokwanisa kubatsira.

Drug chimiro uye sezvamunoita

Panyaya marudzi zvinodhaka, ipapo nhasi Pharmacies vanogona kutenga piritsi, mumwe kuturika, granules uye gel. Huru achishingaira pazvokudya pavo nimesulide. Hwendefa Pfungwa zvinodhaka yakabudiswa muna 10 zvidimbu Maronda akasiyana. Rimwe hwendefa rine 100 MG pamusoro nimesulide, uye ebetsero zvinoriumba vaishandisa vemishonga microcrystalline cellulose, yavaibvisa stearate, croscarmellose yavaibvisa uye Aerosil 200. Izvi rine mashoko akadaro Dhavhidhi angave akanyorerei "Nimid" gadziriro (Mahwendefa) mirayiridzo kushandiswa.

The upfu abereka dose sachets. Ichi chimiro zvinodhaka anobatsira kuti kurapwa vana. Zvechokwadi, muna murwiyo, kunze nimesulide, povidone K-30, tabletozy 80 uye Aerosil 200 rine Excipients akadai yavaibvisa saccharin, cucumber acid, uye flavorings. Chishoma kufara kunwa inonaka akabika vabereki vake kuchirapa "coctail".

Muna 1 ml kuturika, uye 1 g gel rine 100 MG kuti nimesulide. Webetsero pakuderedza mu izvi kaviri kushandiswa propylene glycol, yavaibvisa gidroskid, carbomer 940, disodium edelat, aromotizator, mvura Yakanatswa uye methylparaben.

The pharmacological zviito zvinodhaka

Nimesulide, rinova basa wemafuta ari medicament ndohwaJehovha boka nonsteroidal Anti-sulfonanilides. Kamwe ari mumuviri womunhu, izvozvo zvokusarudza kuchititadzisa Cox-2 uye kunoita kuti kurwadziwa kuve kwetunhu prostaglandins mune anogumbura locus. Unonyaradza marwadzo, antipyretic uye Anti-anogumbura mugumisiro kunoitwa pashure "Nimid" Mahwendefa imwe. Mirayiridzo dzokushandisa ine mamwe mashoko chokuita chipimo chemushonga mishonga.

Kuwedzera pane zviri pamusoro apa, mashoko mushonga anokwanisa tunodzivisa kusunungurwa okisijeni vakasununguka radicals uye tunodzivisa kusunungurwa myeloperoxidase, asina kubatsira chemotaxis uye phagocytosis kwendangariro.

Kana Anti-anogumbura zviito chinodhaka, izvozvo zvinoitwa nimesulide kukwanisa tunodzivisa anogumbura nevamiririri uye kuderedza bundu necrosis zvinhu. By zvichivhiringidza kubatana kwetunhu interleukin-6 uye urokinase kugadzirira "Nimid" (mirayiridzo Chinyorwa inosimbisa chokwadi ichi) chinonditadzisa kudzikisirana pamusoro proteoglycans uye collagen shwashwa. Uyezve, nimesulide vakabata yomunhu nociceptive marwadzo mafungiro hurongwa.

Kana tikafunga mashandiro kuti marwadzo chiito, inobatanidzwa chinovhiringidza pamusoro histamine kwebhuku basa rechikepe masero akawanda uye zvinoitwa basa remubatanidzwa paavhareji glucocorticosteroid receptors.

Kana chiremba wako ushandiswe "Nimid" (Mahwendefa), kuti mirayiridzo kushandiswa inofanira nokungwarira kufungwa tisati achitora mushonga. Pashure pezvose, gwaro iri rine mazano kuti zvinofanira kufungwa paaiita mishonga.

Pharmacokinetics

Pashure pokugamuchira yakarumbidza dose zvinodhaka ari kushingaira woga kubva nemudumbu. Uye pashure pemaawa 1.5-2.5 akaratidza kunonyanyisa Kuwanda basa pazvokudya muropa plasma. A maitiro chinoratidza kugadzirira yakakwirira kukwanisa kutaura mapuroteni, uyewo kupinda neropa uropi mechidziro gematoplatsentarny. At dzakakwirira kuwanda nimesulide kunotemwa panguva locus pamusoro kuzvimba, uye mune synovial mvura.

mushonga muviri kunoitika muna chiropa, etc., kazhinji kacho ari kuchinja chimiro vanoshingaira metabolites, panobviswa vachishandisa itsvo (mu weti), panguva - the faeces. The hafu-upenyu yezviri fuma kunokwanisika kuburikidza maawa 3.5-5. Rine zvakawanda chaiwo pharmacokinetic Data "Nimid" gadziriro mirayiridzo kushandiswa.

umboo

Zvinobudirira medicament nokuti fivha kuti anobuda zvirwere kufema turakiti repamusoro uye yokumusoro kufema turakiti. Kazhinji varayire mushonga kuti vanhu vanotambura dzinonzi rheumatoid arthritis, myalgia, osteoarthritis, bursitis, tendonitis, uye dzimwe tsandanyama zvinetso, mapfupa uye vadyi, achiperekedzwa marwadzo syndrome. Negore mazino uye gynecological tsika nokuda postoperative marwadzo uye postrevmaticheskih vaishandisawo "Nimid" medicament. Mirayiridzo zvokushandisa Muzviitiko zvakadaro zvinokurudzirwa kutenga piritsi, upfu kana granules.

Panyaya mushonga mu gel chimiro, kuti Mwari akaronga kuti kukamura uchishandisa kushandiswa mune zvomoto zvinyama (nyoro) izvo zvinokonzerwa traumas siyana. Zvinobudirira zvinoreva muna anogumbura pezvakaitwa uye chinopedza zvirwere zviri zvetsandanyama nemapfupa ezvinhu, osteoarthritis, ankylosing spondylitis , uye nevamwe. Rine rakawedzerwa mazita zvairatidza kuti kushandisa mari "Nimid" mirayiridzo kushandiswa kubva mugadziri.

Kugamuchirwa mamiriro uye dosing hurongwa

Panyaya kushandisa zvinodhaka muchimiro mapiritsi, suspensions, zvakakodzera kurishandisa chete pashure zvokudya. Zviri chinodiwa kuti vakapfuura kwemaminitsi 20 pashure ingestion, zvimwe pharmacokinetic mugumisiro nimesulide DZEMUNHU DZINODZORA. Panyaya zvokurarama dosing uye nguva kurapwa, kuti mibvunzo iyi inofanira kupindura zvakananga kupinda chiremba kufungisisa nomumwe zvechadenga murwere uye mwero chirwere nekuomarara. Naizvozvo, isu funga chete zvayo vanorumbidza, rine mashoko pamusoro mushonga "Nimid" mirayiridzo Chinyorwa.

Mahwendefa vanotumirwa vakuru kazhinji kaviri pazuva pa 100 MG. In chakakomba siyana chirwere dose nezuva anogona kaviri. Kuyaruka 12 kusvika 18 makore yakarumbidza kuverenga dose zvinodhaka mwero 1,5 MG pa 1 kg muviri uremu. Kana marapirwo kunodiwa ne mwana ari pasi pemakore gumi, uye ayo uremu kwazvo makirogiramu 40, zvinonzi ushandiswe 100 MG zvinodhaka pazuva nokuda kugovera mwero pa mumatanho maviri. Pane dzimwe nguva, chiremba anogona kuwedzera inokurudzirwa dose.

Zvinoreva muchimiro granules anoshandiswa vana makore 12 uye vakuru: 1 sachet mangwanani uye manheru. Zviri zvehombodo rakasanganiswa muna 100 ml mvura inodziya nokunwa pashure kudya.

With Panyaya gel "Nimid", izvozvo - haasi anopfuura 4 kanomwe pazuva - nhete rukoko (pasina vachidzipukuta) pamusoro muviri mugove pamwe zvikuru kurwadziwa. Mushure kushandisa mishonga, kugeza maoko ako nesipo pasi pemvura.

mushonga uyu contraindicated?

Regai mishonga kuvanhu peptic urikanwi chirwere, yakanyanya kutyorwa chiropa uye itsvo, uyewo hepatotoxic siyana pavakanzwa nimesulide nhoroondo. Zvakasimba contraindicated mushonga panguva dzakasiyana kuita kuti ropa, cardiac insufficiency uye hypersensitivity mumwe kana kupfuura zvinoumba ari medicament "Nimid Forte". Mirayiridzo dzokushandisa uye rine mashoko kurambidza kushandiswa mari akabatana zvinogona hepatotoxic mishonga nefivha, dzihwa-kufanana inoti uye vanofungidzirwa chakasimba kuvhiya zvokurwara.

Kana mari iri muchimiro gel, hazvina haungopiwi varwere pasi pamakore 12 okukura uye vanhu vari anongoti neutachiona. Kuwedzera chirwere panguva pokushandisa medicament zvive dermatitis, ganda kukuvara uye zvirwere, uyewo Árbol asima, izvo zviri kukonzerwa Asa. Zvinonzi saka haungopiwi rinoreva "Nimid" iri pamusoro pathologies. Mirayiridzo zvokushandisa mahwendefa Pakadaro, zvakare, haisi inokurudzirwa.

Ndinogona kutora mishonga panguva yepamuviri?

Masayendisiti akawana kuti nisumelid kukwanisa kuva nezvahunoita chokubereka. Uyezve, kunoita kuti kurwadziwa kuve kwetunhu prostaglandins, izvo zvinozivikanwa kuti chikonzero oligohydramnios, pulmonary neBP, oliguria uye kukurumidza aienda Batalova mutsinga dzinofamba nemukaka. Kungawedzera ngozi kwakaderera basa, zviri peripheral edema uye ropa kana kushandisa zvinodhaka "Nimid". Mirayiridzo kushandiswa, mahwendefa nezvimwe mishonga iri zvachose hazvitenderwi zvose panguva yepamuviri uye panguva lactation. Pashure pezvose, zvinoshingaira chete nechityu mukaka anogona kupinda muviri wemwana uye kuvhiringidza kushanda kwayo hurongwa zvinokosha. Muzviitiko apo hazvibviri kuita pasina mishonga, uye kubatsirwawo amai kudarika ngozi kukuvadza mwana, kuti chipimo chemushonga uye yawapiwa pakutsvaga chiremba.

nemishonga

Uyewo yakanaka vakawanda pharmacological maitiro, kugadzirira anewo anoyevedza mazita nemishonga. Saka ngationei kuti maitiro adzo kungazoguma kana iwe kushandisa "Nimid". Mahwendefa (murayiridzo Russian inoita data available) anogona kukonzera kuvaviwa, mikoko, siyana ganda mapundu, angioedema, uye mune zvimwe zviitiko Stevens-Johnson chirwere uye epidermal necrolysis. GI anogona, uyewo, kupindura mushonga kubva kupatira, manyoka, dzimwe nguva varwere kuzwa kurwadziwa mudumbu, kuda kurutsa. Very kashoma mapiritsi anogona kukonzera perforation pamusoro urikanwi uye peptic urikanwi uye 12 duodenal urikanwi.

Sezvo basa muviri ari chiropa, naicho chirwere pairi. Saka, shandisa-refu kurapwa mune zvimwe zviitiko, anogona kukonzera kuchinja transaminases, cholestasis, jaundice uye kunyange rikwanise chiropa. Dzakadai hadzina kufambiswa zvakanaka vari chiropa havasi chete mapiritsi uye granules uye upfu, asi "Nimid".

Note zvakananga rinotsanangura zvinoita maitiro urogenital wemuTesitamende zvinodhaka kutarisira. Zvinogona kuva edema, dysuria, Urinary chengetedzo, uye oliguria, chenjera renal kukundikana, interstitial nephritis. The kufema Hurongwa angava dyspnea uye bronchospasm, mazhinji kushandiswa anogona kukonzera kukura asima.

Kuwedzera kune migumisiro izvi, murwere anogona kuva tachycardia, BP, hypothermia, kurukutika uye nezvimwe zvirwere. Munenge zvose nenjodzi inokurudzirwa kudzima mushonga uye kutsvaka kurapwa nokukurumidza. Kuti murege kuva mumamiriro ezvinhu aya, unofanira ukanyatsoongorora zvose zvinogoneka mashoko ari pamusoro zvinodhaka uye ndapfeka "Nimid Forte" (Mahwendefa). Mirayiridzo kushandiswa, riri rimwe pasuru mishonga inogona kubatsira.

Ovhadhozi zvinodhaka uye rwekutanga algorithm

Kana iwe netsaona kusapfuudza zvinobvumidzwa dose, hwobva kuenda kuchipatara. Handiti, mugumisiro kukanganisa kwakadaro kunogona kuva hope, kuda kurutsa, kurutsa, marwadzo muna espigastrii, lethargy, vakawedzera BP. Ichi mazita chete chiedza wanda kuti yepamusoro dose zvinodhaka "Nimid". Mahwendefa - Chinyorwa chinonyevera pamusoro ichi - wabatwa imwe mari zvidimbu 2-3 kupfuura kubvumirwa zvazvingava, anogona kukonzera womukati ropa uye kungaita kuti itsvo kutadza. In okurapa, kunyange wakaiswa zvisingawanzoitiki zviitiko anaphylactoid siyana, kufema mwoyo uye chaanoziva nokuda ovhadhozi zvinodhaka ichi.

Kana tiri bvumidzwa dose ari kupfuura, tinomirira zvekuchipatara kuratidzwa havasi zviripo. Unofanira pakarepo kugeza kunze dumbu, utore osmotic laxative uye chelators. Kudiwa pashure pamusoro apa matanho kuenda kuchipatara, apo vanachiremba vacharamba symptomatic kurapwa. Zvinofanira kucherechedzwa kuti kufambidzana hapana chaicho mushonga.

Ko vanofunga pamusoro mushonga varwere?

Zvechokwadi, mune hosha pamwe kurwadziwa zvinenge varwere vose vanobvuma zvakanaka vaiona mishonga. Vanoona kuti migumisiro kushandiswa kwezvinodhaka kunoitika zvakanaka nokukurumidza, usingagoni asi kufara. Quite mamwe mashoko anogona kunzwika kana murwere akumbirwa refu nzira mishonga yokurapa, "Nimid". Mahwendefa (Chinyorwa anokurudzira kuti ngwariro chaiyo ichi pharmacological enzvimbo zvinodhaka) nokukurumidza kuderedza marwadzo, asi kwapera mazuva mashomanana kugamuchirwa nokuzvinatsa anozivikanwa nemishonga. Wokutanga anotanga sei nimesulide nemudumbu, tsinga Papera (ichi kunoratidzwa kushatirwa, chinja kwemanzwiro uye tsika kusakendenga).

Chokwadi, categorically vanoti mushonga unoita zvakawanda kukuvadza pane zvakanaka, hazvibviri. Pashure pezvose, zvechokwadi zvinobatsira. Asi pano pane kutora pasina uchapupu uye rwendo nyanzvi haisi inokurudzirwa.

Kana mashoko ari pamusoro apa yakaramba mubvunzo kana kwete kutenga "Nimid" (Mahwendefa), mirayiridzo, ongororo, uye zano varwere chiremba anogona kubatsira kusarudza zvakanaka.