Ngozi Yakavanzwa - chirwere Huntington

Medical mabhuku anopa chaizvo kunzwisisa tsanangudzo chirwere, unonzi chirwere Huntington. Kuti tinzwisise kwakatangira uye zvinoratidza ichi chirwere chakaipisisa, zvakakodzera kutanga kunzwisisa neimwe izwi rinoshandiswa mune tsanangudzo yacho.

The chirwere anoonekwa kuti nhaka, autosomal kuzivikanwa. Izvi zvinoreva kuti chirwere chacho chichigarwa nhaka, uye nhaka kubva kana mubereki, ndine kanenge mumwe mutated Gene. Kuitika pavakomana nevasikana zvakafanana.

Huntington chirwere - chirwere chisingaperi mberi. Hazvina kurapwa, zvinoita zvishoma nezvishoma, nguva dzose kuwedzera zviratidzo, dzimwe nguva kufamba rikwanise danho. The chirwere anogara achiperekedzwa chirwere chepfungwa, extrapyramidal chirwere (kufamba zvirwere).

The pathogenesis ichi kwave akadzidza chaizvo havaratidzi. Zvisinei, zvinozivikanwa kuti varwere hwevanhu kazhinji kuperevedza neGhebha (aminobutyric acid, ndoupiko unonyanya kukosha inhibitory neurotransmitter) muuropi mumasero. Zvichakadaro, mune mumasero substantia nigra kazhinji anowedzera uwandu simbi, pane yakapinza nepfungwa yacho dopamine muviri. Dzimwe nyanzvi dzinodavira kuti chirwere chirwere Huntington kunokonzerwa nezvishoma kumaketeni amino acids. Naizvozvo synthesized "zvakaipa" mapuroteni kukanganisa nokukanganisika pezvakaitwa muuropi.

Zvinonyatsozivikanwa yakasimbiswa kuti mukana wokuva mwana pamwe chirwere munhau mhuri zvakakuvadza jini 1: 1 zvisinei zvepabonde mwana.

Zviratidzo Huntington chorea

chirwere Huntington yemanyorero inova kuoneka makore 30 (dzimwe nguva gare gare). Chokutanga, pane vane njere chirwere: a aienda pamusoro pfungwa, "jamhu" rimwe pfungwa. Vanhu vanorasikirwa kukwanisa kuongorora mamiriro ezvinhu uye vafunga.

Zvishoma nezvishoma zvinetso izvi zvinokura advanced dementia. Murwere nokukurumidza kwezvinoshandiswa pfungwa, pfungwa inoderedza haarambi ruzivo. Zvishoma nezvishoma dzakagadzira unhu murwere.

In zvakafanana, dzichiri hyperkinetic zvirwere. Varwere chirwere kuti "Huntington chirwere" involuntarily kutanga kuita zvakawanda kufamba duku, nokudaro kurasikirwa vachikwanisa kubereka zviito nyore. Somuenzaniso, achifamba pamwe grimacing, t maoko uye m. P.

chirwere Huntington haisi chete. Dzimwe nguva, kunyanya mukutanga mumatanho, varwere vanogona kutsunga kudzvinyirira kunyange simba hyperkinesis, uye mune zvimwe zviitiko izvozvo kungaratidzwa chaizvo havaratidzi. Dementia chirwere anogara achiperekedzwa, asi ukuru aro nekuomarara angava akasiyana. Dzimwe nguva varwere, pasinei tisanzwa kudzikisirana, varambe makirisito kuzvida, uye dzimwe nguva nahwo nokukurumidza. Chii chinoita kuti izvozvo features, mushonga haisati kusimbiswa.

chirwere Huntington. Kuongorora chirwere uye kurapwa

Nokuti chirwere, varwere vanofanira kumbotambudzika eeg, MRI. Kazhinji Zvidzidzo izvi zviri pamutemo atrophy pakati cerebral cortex uye kuchinja zvayo magetsi basa, pane anonzi indentation uye thalamus.

Nokuti mashoko nechirwere, vanachiremba uyewo akaongorora cerebrospinal fluid kudzidza nhoroondo hosha mumhuri. Nhasi vakawanda vakagovera nzira preclinical chirwere mhuri vari boka pangozi. It iri aikanganiswa pamusoro lymphocytes kudzidza X-ray. Vana vanoberekwa mumhuri kunodiwa mutakuri chirwere, zvinofanira kuva zvokurapa zvinyorwa.

chirwere Huntington harirapiki. Kuti aivabatsira murwere nemamiriro anogona kupiwa zvivako zviri triftazine, reserpine nezvimwe dopamine mhandu uye mapiritsi.