Mirayiridzo kushandiswa, inofambiswa uye analoginen "Ketanova"

Sei kugadza imwe analoginen "Ketanova" uye vakati mushonga pachayo? Izvi uchadzidza kubva zvinhu yacho. Nesuwo tanga iwe kuti mirayiridzo kushandiswa mishonga, kupa ruzivo pamusoro kusunungurwa chimiro, nenjodzi, akafanana, contraindications, mutengo uye zvichingodaro.

Zvinoumba, kavha, kusunungurwa chimiro

Analogue "Ketanova" uye dzaimiririrwa chishandiso pachayo vangava zvakasiyana zvachose mhando kusunungurwa. The basa zvinobva yezvakaita marwadzo, nzvimbo nenzvimbo yavo uye ezvinhu omurwere.

Pari, mushonga "Ketanov" inowanika zviviri zvakasiyana siyana. We funga nechimwe izvi zvizere.

• Film-zvemapuranga pamahwendefa. The kushingaira pakuderedza zvinodhaka ndiko ketorolac tromethamine. Kana ebetsero zvinoriumba, ipapo zvinosanganisira chibage starch, magnesium stearate, microcrystalline cellulose uye colloidal nesilicon dioxide. The Zvinoumba firimu unhani unotora hydroxypropylmethylcellulose mapiritsi, mvura Yakanatswa, polyethylene glycol, titanium yakasviba uye talc ndokunatsawo. Zvinofanira kucherechedzwa kuti analoginen kwakadaro "Ketanova" se "Ketorolac" rine chete rinoita fuma. Tikaritora gadziriro kutengeswa muna aruminiyamu Maronda akasiyana, izvo inoiswa murwi makadhibhokisi. Mumwe pasuru zvingava gumi zana Mahwendefa.

• Jekiseni "Ketanov". Majekiseni, analogues zvakatuswa pasi apa, uyewo ane ichi kushingaira wemafuta sezvo ketorolac tromethamine. Mukuwedzera, mushonga zvinosanganisira wayo sezvamunoita uye ebetsero zvinoriumba muchimiro yavaibvisa chloride, mvura jekiseni, disodium edetate, panyaya iyi uye yavaibvisa hydroxide. Mishonga iri kutengeswa mune ndiro imwe milliliter. Atorwa kungava shanu kana gumi ndiro.

The pharmacodynamic ehupfumi ane marwadzo

Chii pharmacodynamic ehupfumi vanoonekwa mushonga yayo nerokuti? "Ketanov" (Mahwendefa uye majekiseni) ane anzi unonyaradza marwadzo kushanda. The mushonga ane mwero antipyretic uye Anti-anogumbura ehupfumi.

Maererano nenyanzvi, nheyo zviito zvinodhaka chokuita chinovhiringidza (non-kusarudza) basa enzayemu Cox-2 uye Cox-1. Izvi kunoitika muna peripheral munyama. ekisiposha kwakadaro kunokonzera chinovhiringidza pamusoro PG biosynthesis, kureva modulators thermoregulation, marwadzo nehanya uye kuzvimba.

Application Mahwendefa "Ketanov" kana intramuscular kwokubatsira mushonga unokurudzira paumbwe imwe racemic musanganiswa [-] S- uye [+] R-enantiomers. Sezvineiwo, mashoko unonyaradza marwadzo mugumisiro zvinodhaka ichiwanika chete [-] S-chimiro.

Zvinofanira kuva kunyanya kuzivikanwa kuti yezviri medicament asingadi inoodza mwoyo afemeruke, haana zvainoita opioid receptors, hazvina nhaka anxiolytic uye kunyaradza kushanda uye haakonzeri kuyanzva.

Zvaunofanira kuziva asati kutora chigadzirwa ichi kana kwayo nerokuti? "Ketanov" (mapiritsi uye majekiseni) pamusoro simba rayo unonyaradza marwadzo kushanda akafanana chete kuti morphine. Maererano nenyanzvi, ichi chinomirira yekudyidzana kupfuura zvose zvimwe zvinodhaka dzisiri steroidal.

Pashure nemukanwa kana intramuscular Kutarisirwa unonyaradza marwadzo kushanda ari kuchengetwa neawa nehafu, ukuwo. The kunonyanyisa mugumisiro zvinodhaka kunokwanisika kuburikidza maminitsi 60-120.

pharmacokinetic ehupfumi

The mushonga yepakutanga, uyewo chero analogue "Ketanova" pashure ingestion asi zvakanaka kunakidzwa nemudumbu. The soro wevasungwa zvinodhaka muropa zvasvika pashure anenge makumi mana maminitsi pashure ingestion kutsanya mahwendefa (10 MG). Zvinofanira kucherechedzwa kuti kudyiwa jikichira uye zvokudya zvisingavaki muviri zvinogona kuderedza kufadza wevasungwa zvinodhaka muropa uye kuchengeta kwake budiriro pane matanhatu kwemaminitsi.

About 99 muzana mari anosungwa kuti mapuroteni eplasma. Kana nhamba rusununguko hypoalbuminemia zvinhu muropa inowedzerawo. Maererano bioavailability zvinodhaka, zviri pamusoro 80-100%.

Kana intramuscular Kutarisirwa yava uye zvachose wefodya unopinda muropa zvinodhaka "Ketanov". Analogs (Ukraine yave kugadzira chete "Ketorolac") sezvo kunyura zvakanaka.

Pashure intramuscular jekiseni 30 MG zvinodhaka ndiko ayo soro wevasungwa 1,75-3,2 micrograms / Rine mamiririta uye kushandisa 60 MG - 3,25-5,75 g / Rine mamiririta. The kunonyanyisa wevasungwa zvinodhaka muropa riri kuchengetwa 15-20 uye 35-65 maminitsi, ukuwo.

Kana mushonga chinopinda kupinda mukaka? Uye kudhura, uye zvakachipa analogue "Ketanova", uye akaona mushonga rinokwanisa kusvika nyore kupinda zamu mukaka. Izvi kunoitika pakarepo mushure dose wokutanga medicament ari chitsama 10 milligrams. The soro wevasungwa zvinodhaka ari mukaka panguva chipimo chemushonga zvasvika pashure vanenge 120 maminitsi uye 7,3 kumar / l.

About 50% of raitongwa dose zvinodhaka rinoita mune chiropa. Somugumisiro, basa metabolites vari aumba. Chief pakati pavo weruwa gidroksiketorolak uye glucuronides. Kazhinji itsvo (vanenge 91%) uye ura (anenge 6%).

The hafu upenyu mushonga pavarwere kwomuzvarirwo renal basa iri maawa anenge 5.4. ukoshi iyi chaizvo nokuwedzerwa vakwegura uye vaduku kunodzikira.

chiropa hakuna zvainoita hafu-upenyu zvinodhaka. Zvinofanira kucherechedzwa kuti mushonga hariwaniki nedanho dialysis.

zvairatidza

Chii chinorehwa zvinodhaka "Ketanov"? Analogues zvinodhaka uye zvakakodzera chaizvo kwenguva pfupi ruyamuro kurwadziwa-siyana mavambo.

Nokudaro, vaiona medicament nachiremba:

• postoperative marwadzo (kusanganisira mushure vachibatsira, gynecological uye abdominal kuvhiyiwa);
• ndichinzwa zino (kusanganisira pashure pokuvhiyiwa mu dentistry);
• marwadzo syndromes mushure mokugamuchira nokutyora, dislocation, uye munyoro tishu zvinokuvadza;
• postpartum marwadzo;
• marwadzo syndromes zvichiitika chemajoini;
• marwadzo syndromes kuti anokonzera kenza;
• Sciatica.

vanhu vashoma vanoziva, asi kushandisa mapiritsi "Ketanov" uye injectable mhinduro asina kuratidzwa mune chirwere marwadzo syndromes. mishonga yakadaro zvinokosha chete kuti zvibviswe pfupi-rokuti kusanzwa. Kutora mushonga pamusoro yakareba nguva hakubvumidzwi.

Contraindications

Sezvo vamwe vasiri steroidal mishonga kugadzirira "Ketanov" rakashandiswa marwadzo ane contraindications akasiyana siyana. Ndokusaka usati kuishandisa unofanira bvunza chiremba wako uye kuverenga mirayiridzo. Rinoti zvinotevera contraindications:

• erosive uye maronda maronda ari nemudumbu, kunyanya mune rikwanise danho, hypocoagulation (kusanganisira hemophilia) uye peptic urikanwi;
• Inosimudzira aikanganiswa murwere ketorolac nezvimwe NSAIDs, bronchospasm, kupera muviri, angioedema, asipurini asima, hypovolemia (zvisinei mhosva parinowanika);
• chiropa kana chirwere cheitsvo (ari kukundikana), kunyanya yeplasma creatinine pa 50 MG / L;
• Hemorrhagic Kurohwa (vanofungidzirwa kana yasimbiswa), Hemorrhagic diathesis, vakawedzera mukana dzokororo kana ropa (kusanganisira pashure pokuvhiyiwa), kushandisa concomitant nemamwe NSAIDs, havachanyatsogoni hematopoiesis;
• zera pasi pemakore 16;
• Panguva pamuviri, kuberekwa muitiro uye panguva lactation;
• Treatment echirwere marwadzo syndromes unhu;
• yokutindivadza asati avhiyiwa uye panguva kwavari (nokuti yakawedzera mukana ropa).

Hatigoni kutaura kuti yezviri medicament iri ushandiswe nokungwaririra pavarwere vane cholecystitis, Árbol asima, chirwere chemwoyo, renal kuvhiyiwa (plasma creatinine asingasviki 50 MG / l), BP, kushingaira chiropa, cholestasis, sepsis, chinonzi systemic lupus lupus, uyewo vakwegura (makore anopfuura 65) uye vane polyps vari lining pamusoro nasopharynx uye mhuno.

Drug "Ketanov": mirayiridzo kushandiswa

Analogs zvakafanana achishandisa nzira chikumbiro uye uwandu husingakuvadzi. Asi kuti kudzivisa wakawandisa vasati kushandiswa inokurudzirwa kuona chiremba.

Ndingatarira kunwa mapiritsi "Ketanov"? Ichi chimiro zvinodhaka zvakakodzera kutora chimwe dzaiita (10 MG). Kana zvakakodzera (semuenzaniso, ane simba marwadzo chirwere) medicament dose inogona kaviri. Zvisinei, zvinofanira kucherechedzwa kuti zuva chipimo chemushonga zvinodhaka haafaniri kupfuudza 40 MG.

Kana ingestion zvinodhaka kosi nguva mazuva mashanu (kwete zvimwe).

Kana mumwe chikonzero kana mumwe murwere havagoni kutora waiita chimiro zvinodhaka (semuenzaniso, pamberi erosive kana maronda maronda mudumbu, bowel), zvino ari basa mhinduro jekiseni. chimiro kwakadaro chinotarisirwa intramuscularly.

Pakutanga zvinodhaka mishonga rinoshandiswa shoma inobudirira dosages kuti vakasarudzwa maererano kusimba marwadzo syndromes uye achipindura murwere. Kana zvakakodzera, murwere ushandiswe uye mamwe opioid analgesics.

A chete chipimo chemushonga Pfungwa imwe chete intramuscular jekiseni:

• vanhu pasi pemakore 65 okuberekwa - vanenge 10-30 MG (zvichienderana kusimba marwadzo);
• vanhu makore 65, uyewo varwere havachanyatsogoni itsvo basa - 10-15 MG.

Chipimo chemushonga pashure akadzokorora intramuscular Kutarisirwa:

• vanhu 65 - anenge 10-30 MG, uye ipapo zvakaenzana ose mana nomwe maawa;
• vanhu vakura kupfuura makore 65 uye vari varwere havachanyatsogoni itsvo basa - 10-15 MG ose maawa 4-7.

The daily chipimo chemushonga zvinodhaka kana raitongwa intramuscularly kune vakuru havafaniri kupfuudza 90 MG. Varwere vakwegura uye vaya havachanyatsogoni itsvo basa zvakafanira kuderedza uwandu anosvika 60 MG. Ya kurapwa hakufaniri mazuva anopfuura mashanu.

Munguva kuchinja kubva intramuscular yaitonga zvinodhaka riri mishonga munzvimbo zvachose zuva nezuva chipimo chemushonga vose siyana havafaniri kupfuudza 90 MG kuti vakuru uye 60 MG varwere vakwegura kana varwere havachanyatsogoni itsvo chaitika.

Zviratidzo ovhadhozi

At dzakakwirira mishonga ine akati medicament murwere anogona kuonekwa kurutsa, abdominal marwadzo, renal kuvhiyiwa, metabolic acidosis, kuda kurutsa, erosive gastritis uye peptic urikanwi.

Sezvo mabatiro ezvinhu akadaro kushandisa gastric lavage uye okusuma adsorbents siyana. Uyewo symptomatic kurapa (kureva kutsigira anokosha muviri).

zvinodhaka kwavatori

Apo vagari pokushandisa zvinodhaka pasi kukurukurwa nevamwe NSAIDs, murwere anogona kuva divi zvinokonzerwa Uyezve, uye anticoagulants (kusanganisira "heparin" mune mishonga diki uye ne "Pentoxifylline") - ropa.

Kana concomitant kushandiswa kwezvinodhaka vanotungamira ACE FIs, pangava hadzina kufambiswa zvakanaka zviri itsvo.

Zvinofanira kucherechedzwa kuti kushandisa zvinodhaka pasi review, ne "Probenecid" Anowedzera hafu-upenyu ketorolac wayo yevasungwa mu plasma.

Kana mushonga uyu pamwe lithium, zvinokwanisika kutapudzwa renal Clearance kuti lithium uye kuwedzera ayo yevasungwa ari plasma, asi ne "Furosemide" - richikwidibira ayo diuretic kushanda.

Munguva pokushandisa "Ketorolac" hapana chikonzero kutora opioid analgesics.

The yakanakisisa analogue

"Ketanov" - iri simba chaizvo uye inoshanda unonyaradza marwadzo mushonga, chakatengeswa mune zvinenge zvose drugstores. Achitaura analogs yayo, zvakaoma zita mushonga inonyatsobudirira. Naizvozvo, nokuti kukurumidza ruyamuro kurwadziwa chirwere vanachiremba varayire avo varwere ndiyo chinodhaka. Asi kana vamwe chikonzero zvinodhaka riri contraindicated kwamuri, tinoratidza kuti iwe kuritsiva ne "Ketorolac". Zvichienderana nyika-mugadziri mutengo chokushandisa ichi angava akasiyana. Mari kurongedza mahwendefa Russian inotanga pa 20 rubles, Ukrainian - 35, uye Indian - 45.

Chiizve anonzi mushonga zvinogona kutsiviwa? Ane mamwe analogue? "Ketanov" pasina mushonga, unogona nguva dzose kutenga mu chemishonga. In anawo nzira unogona kutenga nhau dzakafanana akadai "Adolor", "Torolak", "Akyular zvinodhaka", "Toradol", "Dolak", "Ketofril", "Dolomin", "Ketorolac tromethamine-Farmaplant", "Ketadrop "" Ketorolac tromethamine, "" Ketalgin "," Ketorolac-Eskom "," Ketokam "," Ketorolac-Verte "," Ketolak "," Ketorolac-OBL "," Ketorolac Rompharm "," Ketorol "uye vamwe.

Mari zvinodhaka izvi zvinogona kuva yepamusoro chokutanga uye pasi. Yeuka kuti zvinodhaka "Ketanov" (Mahwendefa 10) inogona kutengwa nokuda 50-70 rubles. Zvinofanira akati kuti haisi varumbidzwa kutora panguva yavo kungwara.

Izvo chishandiso kushandisa kuti vemo kurwadziwa? Pane imwe runoenzanirana chimiro "Ketanov" chinodhaka? Mafuta (analogs ose akati nevasori muna mahwendefa zvave akapa pamusoro) pamwe chete vachishingaira nenhumbi zvakaoma kuwana. Zvisinei, pachine mushonga kuti anogona kushandiswa topically. Ichi 2% mishonga inonzi "Ketorol" (yakaitwa India). nzira kwakadaro rinowanika 30-giremu sepombi uye nokukurumidza inobvisa chero marwadzo syndromes (kana rikashandiswa topically).

Reviews pamusoro inonyaradza marwadzo omusoro

Zvino munoziva kuti ndiyo mushonga "Ketanov", nokuti iro Mwari akaronga. Zvinofanira kucherechedzwa kuti anongoda zvose varwere Reviews ari medicament akanaka. Vanhu avo nguva nenguva kushandisa mapiritsi kana mhinduro kuti jekiseni "Ketanov" hurumende kuti yakadaro mushonga nokukurumidza zvikuru anobvisa chero marwadzo syndromes.

Sezvinoratidzwa okurapa, kubata rufimbi rinovapo kwemaawa 12-15 (dzimwe nguva yakareba). Shure kwenguva ino, mapiritsi rinofanira kudzokororwa (kana marwadzo haina akapfuura).

Zvisinei, zvakaoma tisingatauri chokwadi kuti chinodhaka ichi, kufanana nezvimwe NSAIDs, pane zvakawanda nemishonga. Maererano mhinduro wevarwere, dzimwe nguva mishonga iri zvinokonzera svoto uye abdominal kurwadziwa. Muchiitiko chino, nyanzvi dzinokurudzira kuti kutsiva dzaiita zvokutaurwa chimiro zvinodhaka jekiseni. Pashure pezvose, nokuti munhu asina chakavanzika NSAIDs kunogona kukonzera zvinetso zvakakomba pamwe mudumbu (semuenzaniso, inobatsira kuti chitarisiko nemaronda kana erosions).

Zvinofanira kucherechedzwa kuti varwere vakawanda vari kunyanya zvakafadza mutengo nhau Ezvemutauro. Tichifunga kuti zvinokosha kuti kutora chimwe-nguva, uye pamusoro mumwe pfupi, mumwe mhoni pamwe mapiritsi angava zvakakwana kwenguva refu. Izvi zvinoshandawo kune injectable chimiro zvinodhaka.