Lipid peroxidation (LPO) hunokosha kubatana mune metabolic exchange. The chikuru basa ndiko dzifambirane ari lipids foni membranes.
In hwakanaka munhu lipid peroxidation nemauto inonzi antioxidant hurongwa iyo anoita nokukurumidza uye phosphorylation basa nokusunga wakatsamwiswa zvinhu kana neutralize zvakakwana kwazvo peroxides kutadzisa imwe overabundance yokuguma zvibereko muviri. Amplification oxidation kwacho kungava kutanga pfungwa iri pathophysiological pezvakaitwa inokosha mari zvirwere. Izvi zvinosanganisira kuva danho enzymatic uye zvisiri enzymatic autoxidation.
mhando
Yokugadziridza phospholipid bilayer muchitokisi Kamudzira kunosvika enzymatic oxidation. Uyezve, rinobatanidzwa paumbwe pakugadzira vanoshingaira zvinhu, detoxification, metabolic siyana. Non-enzymatic oxidation anoita hworatidza pacharo somunhu rinoparadza chinhu muupenyu sero. Nokuda kuti paumbwe yakawanda vakasununguka radicals uye peroxides kuwanda antioxidant hurongwa basa kunodzikira uye mugumisiro, pane kuparadzwa muviri masero.
PAUL kutenderera
Kutanga lipid peroxidation zvakakodzera pamberi okisijeni vakasununguka radicals, ane simba pamwero panguva yokunyanyisa imwe unpaired Erekitironi. Pashure kupora reokisijeni mamorekuru yakabereka superoxide izvo zvaanoita pamwe rehydrogen maatomu, akatendeuka kupinda rehydrogen peroxide. Nokuti kudzora uwandu superoxide mukati masero kuripo superoxide dismutase, achiumba rehydrogen peroxide uye catalase, peroxidase neutralize kuti mvura. Kana muviri mupenyu hwakafumurwa kuti ionizing nemwaranzi, nhamba vakasununguka hydroxyl radicals kuchawedzera zvinoshamisa. Uyezve hydroxide okisijeni wayo nevamwe vanoshingaira siyana vanogona atange startup muitiro lipid peroxidation.
Products ose lipid peroxidation kana muviri kuraswa, kana akashandiswa kwetunhu prostaglandins (zvinhu zvinobatanidzwa kuzvimba siyana), thromboxanes (raisanganisira thrombogenic Pazvinoitika wanda), adrenal mahormone.
kudzora maitiro
Zvichienderana muchitokisi Kamudzira mamiriro nechigadziko nokukurumidza, uye uwandu basa zvichizoita oxidation zvigadzirwa dzingasiyana. Somuenzaniso, basa lipids peroxidation pamusoro apo chikamu sero rusvingo akatonga unsaturated mafuta acids, uye nomumugwagwa kwaitora nguva, kana hwaro COP ndiyo remafuta akawandisa. Uyezve, chinhu kudzora mari uye mwero inotungamirwa vakasununguka okisijeni radicals, uyewo Utilisation pamusoro peroxides, muri metabolic makemikari. Kunyange zvakaitwa lipids peroxidation pokuita zvinhu kukanganisa sero Kamudzira lipid sezvamunoita uye zvemasanga shanduko maererano nezvaidiwa nhengo. Izvi zvinosanganisira vhitamini E uye K, thyroxine (thyroid kemikari), hydrocortisone, cortisone uye aldosterone (pamusoro dzinovaka). Kuzungunutsa Sero rusvingo simbi ions, mavhitaminzi C uye D.
kutyora muitiro
Metabolic zvibereko lipid peroxidation anogona -wedzera munyama uye muviri zvinwiwa kana antioxidant hurongwa hakuiti kurasa navo zvakakodzera velocity. Naizvozvo kwakakanganiswa senga pakati ions mhiri sero Kamudzira izvo zvisina kunanga angatema Ionic Kuronga emura chikamu ropa,, mwero polarization uye depolarization pamusoro tsandanyama sero Kamudzira (kuvhuna conduction tsinga nomunhu, avo contractility, nguva refu ari refractory nguva), aivabatsira panopindwa mvura munzvimbo extracellular nzvimbo (edema, clots ropa, electrolyte kusaenzana). Mukuwedzera, chikuru zvibereko lipid peroxidation, pashure akatevedzana nokukanganisika siyana, vari kutendeukira aldehydes, ketones, acids nezvakadaro. Ava zvinhu vane hunokachidza zvainoita muviri, izvo kunooneka pacharo ari rutapudzo mwero DNA usage, kuwedzera rirambe richibvira permeability, wedzera oncotic kumanikidzwa, sezvo naizvozvo, sludge-syndrome.
Kuratidzwa pakiriniki
Sezvo kuwedzera reokisijeni vakasununguka radicals ane kukuvadza pamusoro muchitokisi parusvingo, uye metabolic zvigadzirwa kukanganisa muviri uye kwetunhu nucleic acids uye muchetura muviri, vari pathophysiologic chinokonzera kukura zvinoverengeka yokuora ezvinhu. Basa lipid peroxidation mu chiropa kunokosha chirwere majoini, parasitic zvirwere, hemodynamic zvirwere, oncological zvirwere, traumas uye kutsva. POL mumwe zvinokonzera kuti atherosclerosis. Free radicals oxidize remafuta akawandisa uye ayo pasi samolecular uremu chakapatsanurwa kuumba zvigadzirwa kuti kukuvadza vascular rusvingo. Izvi rinotanga kupindana pathological siyana kwese kugadzirisa kukuvadza. Izvi chinokurwadzai clots ropa, kuunganidza ropa clots vari lumen rwengarava zviduku kana kutyira kwemasvingo avo. Somugumisiro kufamba ropa munharaunda iyi DZEMUNHU DZINODZORA, sezvo atova mudziyo lumen. Izvi zvinobatsira kuti uwane kuunganidza ropa. Zvikuru kubatwa kuchinja kwakadaro coronary arteries, yeropa, richiratidzwa pakiriniki zviratidzo zviri coronary chirwere mwoyo.
matanho
Practitioners vanofanira kuyeuka kuti mufambiro chirwere uye dzokurapwa pachishandiswa vanogona Activate kuti mashandiro ose lipid peroxidation. Izvi zvinofanira kuyambira murwere. By afunge zvinhu zvinosanganisira nemwaranzi kurapa (nokuti kenza), ultraviolet chiedza (pamwe kusimba, anogumbura zvirwere sinuses, antibacterial kurapwa makamuri), rinobva minda (MRI, CT, panyama kurapa) purogiramu ari hyperbaric kamuri (mu poliomyelitis, kukwira kurwara).
Madzivirirwe Therapy
Vashandi vanoshanda rentgenkabinetom, orderlies uye vanamukoti, vanachiremba vari physiotherapy, makomo, vanhu vane yokufutisa unofanira kudya zvokudya zvine zvakasikwa antioxidants: hove, sunflower kana mafuta omuorivhi, miriwo, mazai, girini tii. Kuwedzera kuchinja zvokudya, mishonga inogona kushandiswa kuti sunga kune mamwe mapoka kana vakasununguka radicals vanobatanidza pamwe simbi pakati shanduka valency. Saka vakamira musisina vanoshingaira okisijeni mamorekuru, zvomutadzisa kubva tichisunga kusvikira lipid peroxidation amplifiers.
Diagnostics
Panguva kuitika padariro kukura pakutsvakurudza rabhoritari tinokwanisa kuona peroxide ari Zvinoumba zvipenyu zvinwiwa dzemuviri. Kuti aite izvi, ubudise fluorescence microscopy. Zvichitaurwa zviri nyore, kuti kuziva lipid peroxidation. Kukosha chirwere muedzo uyu haadi tsananguro. Zvechokwadi, mune chirwere chinokosha mari kunobva kunyanya basa lipid peroxidation. Kuonekwa wehurumende ichi anosarudza kurapwa.
Kubva nemaonero chakaipa physiology pakati lipid peroxidation kunodikanwa kuti paumbwe steroid mahormone, anogumbura nevamiririri, cytokines uye thromboxanes. Asi kana uwandu nemakemikari Data mukutsinhana zvigadzirwa akapfuudza zvinobvumidzwa kukosha uye kukuvara peroxide sero organelles, DNA uye kuvhiringidza kubatana kwetunhu mapuroteni, chaizvoizvo anopinda antioxidant hurongwa kuti kunoderedza uwandu vakasununguka okisijeni radicals uye ions chainge chakagadzirwa nesimbi chete shanduka valency. Uyezve, inowedzera kwetunhu catalase uye peroxidase nokuda Kuraswa zvakawandisa peroxides uye zvibereko zvimwe kwavo muviri.