Inorwisa mabhakitiriya "Maxipime": mirayiridzo kushandiswa, analogs uye wongororo

Kuwanikwa rokutanga asingaurayiwi (kuti penicillin zvose anozivikanwa nhasi) pakati remakore rechimakumi maviri aiva budiriro mune zvokurapa. MuHondo Yenyika II, mushonga uyu kwakaponesa zviuru kutsigira zviri Motherland.

Kubvira ipapo, nemakemikari omuviri uye mishonga indasitiri yava kutanga uye anopa vatengi dzakawanda inorwisa mabhakitiriya. Mumwe zvemberi uye zvinowanzoshandiswa muminda siyana mishonga iri "Maxipime" izvo akaongororazve chengetedza chokushandisa ichi sezvo kwazvo, chaizvo nokuti siyana zvinokonzerwa noutachiona.

Mamiriro uye Kuronga

The chikuru vanoshingaira wemafuta kwezvinodhaka uyu tsefepimadigidrohlorida monohydrate. Thomas Mukudhinda - yellowish upfu whitish Hue kuti agadzirise hwakazotevera intramuscular kana intravenous yaitonga. In dosages wandei mugadziri anopa vatengi chigadzirwa dzavo "Maxipime." Mushonga unorwisa mabhakitiriya anogona kutengwa muhombodo dose 500 MG uye 1 g

The akagadzirira sezvamunoita kuti atarisire inogona kuchengetwa ari mukamuri tembiricha kuti zuva rimwe. Pasi ezvinhu mufiriji pasherefu upenyu akagadzirira mhinduro yakawedzera kusvika 1 vhiki. In upfu chimiro uye stoppered chinu gadziriro anogona inochengeterwa 3 years. Prerequisites - tembiricha kuti + 30 ° C uye kudzivirirwa chiedza. Kuchinja ruvara chemhinduro asingadi kukanganisa basa zvinodhaka.

Pharmacological simba

"Maxipime 'mirayiridzo unoshandiswa akaiswa sechinhu antibacterial mumiririri rwevharanda 4th chizvarwa cephalosporins boka. Zvingakubatsira migumisiro ndiko kuparadzwa muchitokisi masvingo mabhakitiriya utachiona. The mushonga ane chakarondedzera simba pachinhu zvakawanda giremu-akanaka uye giremu negative tupukanana tusingaoneki, vanoonekwa ne kurwisa kwavo aminoglycosides uye antibaktrialnym kunoreva yechitatu-chizvarwa cephalosporin boka.

Nokuti "Maksipima" chinoratidza kuramba Beta-lactamases uye kushingaira pamusoro vakawanda giremu-akanaka uye giremu negative Kurovedza (ndandanda - mumirayiridzo kushandiswa). Asi mishonga haisi kushingaira pamusoro metitsillinoustoychivym staphylococci, pneumococci penitsillinoustoychivye.

Pashure okusuma asingaurayiwi "Maxipime" (mirayiridzo Chinyorwa zvinosanganisira mashoko akadaro) vari raisangoita zvachose. Therapeutically akakodzera kuwanda huru vanoshingaira zvinoriumba aonekwa ari weti, bile, Árbol secretions, kweprostate gland uye peritoneal mvura.

The hafu-Upenyu anenge maviri maawa. Enzanisa tinogona kutaura kuti, Somuenzaniso, varwere mukuru uyo 9 mazuva kubudikidza intravenous vakawana 2 g mushonga ane nguva penguva pakati kurapwa kwemaawa dzinenge 8 cefepime kuunganidza mumuviri haisi kuwanikwa. Huwandu chikuru yabudiswa muna weti (kuchengetwa kusvika 85% of pakutanga vakagamuchira murwere dosages sezvo kuchinja cefepime).

zvairatidza

Antibacterial "Maxipime" mirayiridzo kushandiswa vanokurudzirwa sarudza panguva dzakasiyana-siyana zvokurwara nezvirwere uye anogumbura hunhu. Migumisiro yakanaka vari vakawana pakurapa nechepazasi kufema turakiti zvirwere (nemabayo uye bronchitis kusanganisira) uye Urinary ducts (zvose kwete yakaoma, uye zvakaoma kunzwisisa kusanganisira pyelonephritis). Positive emuchina ari kuchengetwa pakurapa siyana zvinotapukira intra-abdominal maronda (kwete dzakakudzingai biliary turakiti noutachiona uye peritonitis).

Uyewo, "Maxipime" zvinowanzodavirwa anoshandiswa utano nyanzvi pakurapa gynecological zvirwere, utachiona ganda uye akapfava zvinyama maronda, septicemia (sepsis). Mukurapa varwere febrile neutropenia, "Maxipime" Chinyorwa ndaizoitwa empirical kurapa.

Imwe nzvimbo simba zvinodhaka - kwemabhakitiriya yomumuzongoza vana. Pano, mushonga uyu chiri zvakanaka nekusimba.

Kuzvidzivirira nechiyero zvinodhaka inoshandiswa kudzivisa zvirwere mukufamba abdominal kuvhiyiwa.

Vakawanda tinogona kutaura kuti "Maxipime" bvumidzwa kushandiswa pasi zvose zvinotapuriranwa, kukura iro wakatsamwisa kubatwa utachiona uye utachiona. Kuti kuziva causative Muviri kuona kwayo (kana ravo) aikanganiswa mushonga uyu vari kuita miedzo. Zvisinei, "Maxipime" kunokanganisa zvakawanda kwemabhakitiriya utachiona uye kuti somunhu monotherapy anogona kutorwa kunyange vasati kuziva nayo utachiona. Kana paine njodzi zvakavhenganiswa chirwere (Kurovedza-anaerobic), zvino kune bvunzo Kukosheswa pathogenic mabhakitiriya anogona kutanga kurapwa "Maksipimom" iri tandem pamwe zvinodhaka kukanganisa anaerobes.

Dosing uye dosing regimens

The chipimo chemushonga uye Kutarisirwa chimiro (w / W kana w / o) akatsunga zvichienderana aikanganiswa kwemabhakitiriya, kwokuomerwa hosha mamiriro murwere uye neitsvo. Uye ini / O nzira iri vaiwanzosarudza muzviitiko apo utachiona kwakaoma uye vanotyisidzira upenyu murwere.

Vanhu vane neitsvo utano uye yairema anodarika 40 makirogiramu majekiseni zvakaitwa zvikamu maawa 12 ari dose chairayirwa nachiremba wako. Zvirwere zviri Urinary turakiti nyoro kune mwero zvakaoma kwazvo, dzimwe zvirwere kuitika panguva imwe zvikuru, vari kurapwa dosages pamusoro 0.5-1 g, dzakabatwa nomutsinga kana intramuscularly (sezvinoita chiremba akasarudza). Kurwisa zvirwere zvakakomba kwaiitwa nomutsinga raitongwa pana 2 d fuma (periodicity ndiro - maawa 12). For rinorema kwazvo uye kutakura kukanganisa hupenyu murwere utachiona uye inodiwa chipimo chemushonga iri 2 g, asi periodicity - ose 8 maawa.

Inorwisa mabhakitiriya "Maxipime" rinoshandiswa yokuSpain chete idzodzo zviitiko pakarovererwawo kwemabhakitiriya zvakabatana muna aibuda akabatwa chirwere.

Nokufamba zvomusejari remapazi (nokuti 1 awa pamberi) prophylactically nomutsinga anopfuura 2 awa kutungamirira ge Maksipima "ipapo akadurura mamwe 500 MG ose metronidazole. Panguva imwe chete achiita vaviri zvinhu havafanire.

Avhareji Vhoriyamu mushonga varwere vane uremu muviri asina asvika makirogiramu 40, pakurapa Urinary turakiti zvirwere (yakaoma uye nyore), nyoro zvinyama uye ganda (kwete yakaoma), mabayo uye empirical vabatwe neutropenic fivha ndiyo 50 MG chete kilogram kurema muviri. Majekiseni zvakaitwa zvikamu maawa 12. In kwemabhakitiriya yomumuzongoza uye neutropenic fivha chete 50 MG / makirogiramu raitongwa vanokurudzira zvikamu pakati mishonga, akaenzana maawa 8.

For varwere vanenge abnormalities mu itsvo inoshanda, kunodiwa kugadzirisa kwerunyararo dose. Inorwisa mabhakitiriya "Maxipime" tsanangudzo zvinodhaka (chipimo chemushonga zvichienderana norudzi utachiona hwakakura uye kwokuomerwa utachiona zvichaparadzwa anhonga kubudikidza kupinda chiremba) rinokurudzira kuti kwokutanga Vhoriyamu zvinodhaka kutora kwakafanana kuti vanhu vane neitsvo utano, apo kutsigira chipimo chemushonga kugadziridzwa zvichienderana netsika creatine Clearance.

varwere vaya "Maxipime" uye achirapwa hemodialysis, inokurudzirwa pakupera nzira kuzodzosera kupinda mutsva dose pakati asingaurayiwi akaenzana chepakutanga. Izvi zvakakodzera, kureva. K. For 3 paawa dialysis vachabviswa muviri 68% of yaipedzerwa zvinodhaka "Maxipime" (User rine ruzivo urwu).

Contraindications "Meksipima"

Pasinei zvikuru zvakawanda antibacterial zvinokonzerwa zvinodhaka ichi, hapana ane refu mazita contraindications. "Maxipime" mirayiridzo Chinyorwa unorambidza vanhu vane nomumwe hypersensitivity kuti cefepime uye L-arginine. Uyewo, zviri zvisingagamuchirwi rakapiwa varwere zvinoitwa pakarepo hypersensitivity kune penicillins, vamwe Beta-lactam nevasori, mishonga yakadai cephalosporin.

Vakanyatsoteerera mamiriro ake utano panguva kurapwa "Maksipimom" anofanira kubata vakadzi vane pamuviri navanoyamwisa moms, vanhu vachitambura nezvirwere ari zvomudumbu turakiti, kunyanya mu zvirwere zvakadai maronda kana asingaurayiwi-akabatanidza colitis, remunharaunda enteritis.

Kana matambudziko pamusoro dzokubereka basa, zvinofanira kutaurwa kuti mumiedzo zvekuchipatara mhuka havana nemigumisiro pamusoro amai uye mudumbu zvave kuzivikanwa. Zvisinei, zvakanaka raitungamirirwa zvidzidzo zviri sei muviri mumwe mukadzi akanga akatakurwa kunze. Saka, vakadzi vane pamuviri vane zvinogamuchirika "Maxipime" chete pasi zvokurapa achitarisirwa. In zamu kwevanhu mukaka zvinodhaka ukasunungurwa vashomashoma zvakawanda, asi kwete kufira ngozi. Panguva lactation vanofanira kutora mishonga nokungwarira.

Uyezve, asingaurayiwi "Maxipime" Chinyorwa anokurudzira kushandisa zvakanaka zvikuru vaya vanotambura zvikuru chirwere renal kukundikana. Ongororo dzakaratidza kuti varwere chisingaperi renal kukundikana yakawedzera hafu-upenyu fuma kubva mumuviri. Panguva iyoyowo, vanhu vane chiropa chirwere, kana cystic fibrosis haisi vainzwa upi pharmacokinetic kuchinja nokuda Absorção de Água uye excretion kuti cefepime.

Marwadzo, zvakawandisa of bvumidzwa dose

Vakawanda tinogona kutaura kuti "Maxipime" zvakanaka akashivirira, uye kuitika rwakashata zviitiko haisi kumusoro. Zvose akaudza nyaya kunyanya zvakanga pamusoro kushanda zvomudumbu turakiti zvinetso (dyspepsia, manyoka, kupatira, kuda kurutsa, kurutsa), uye hypersensitivity siyana (mapundu, kuvaviwa, fivhiri).

Uyezve, mashoko pa zvinodhaka ichi sechinhu "Maxipime" asingaurayiwi - rondedzero rekugadzirira, mirayiridzo kushandiswa kwayo, - uchapupu mukana maitiro pamusoro chikamu kumwoyo muchimiro tachycardia (mwoyo palpitations) uye muchipfuva marwadzo. kufema Hurongwa angataura pacharo ihosha huro, kupfupika mweya uye chikosoro. The ungangotarisa Achipindura kubva CNS achava kushaya hope, zvinobvira nomusoro, dzungu, kufunganya, kuvhiringidzika, paresthesia. Zvimwewo kuratidzwa tinogona kutaura kuneta, vaginitis, vangadikitira, marwadzo, musana marwadzo, peripheral edema. Uyewo, sezvo kurutivi Migumisiro vanachiremba kutaura nezvenyaya zvinobvira kuchinja murabhoritari parameters.

Kana impermissibly kugamuchira mishonga yacho mushonga "Maxipime" mirayiridzo Chinyorwa anoudza pamusoro kubudirira hemodialysis muzviitiko izvozvo.

Zvaunofanira kuteerera?

Kurema akasiyana zvinoshamisa mamiriro ezvinhu zvingamuka munguva apo ushandiswe nemishonga inorwisa mabhakitiriya "Maxipime." How kuzvishandisa muupenyu iyi? Kana pakanyorwa "Maksipima" kwakatanga pseudomembranous colitis pamwe kwenguva refu manyoka, kurega kutora zvachose uye chinotarisirwa vancomycin kana metronidazole.

Kana murwere anotambura kwazvo kubatanidzwa chiropa uye itsvo kukundikana, navanachiremba vanofanira kuitisa kuramba richiona zvinodhaka wevasungwa munguva plasma uye, zvichienderana parameters, kuchinja chipimo chemushonga.

Kana mushonga rave richiwanika kwenguva refu kwenguva, zvakakosha kugara kuongorora Zvinoumba peripheral ropa uye dzichipfekeka zviratidzi kuti itsvo uye chiropa.

Muzviitiko apo murwere kubva kure kutapuriranwa chikuru vakachengeta meningeal kufambiswa (kuparadzirwa utachiona, zvose mukati pachoto, uye yose muviri), pane fungidziro kuti yomumuzongoza kana chirwere watopiwa yakaiswa, zvinokosha kuramba kurapwa "Maksipimom" uye achiita kakoe- kana nzira antibacterial mumiririri pamwe nekusimba efficacy nokuda nechirwere.

Pane mukana kuziva zvakanaka pavakanzwa Coombs 'bvunzo, nhema-akanaka - pamberi shuga iri weti.

"Maxipime" pakati chikosoro uye kuchitonhora (i.e. mu kutapukirwa noutachiona) haangavi inobudirira.

Kudyidzana nevamwe zvinhu

Kana murwere basa kugamuchira "Maxipime" yakafanana kushanda nezvimwe zvinodhaka vanofanira kuva pasi zvokurapa achitarisirwa. mushonga uyu haasi pharmaceutically kunoenderana nezvimwe mishonga inorwisa utachiona uye heparin.

Tubular Secretion cefepime bude substantially wakaderedzwa kana pamwe diuretics, aminoglycosides uye polymyxin B. The chete kuwedzera tandem PM wevasungwa "Maksiprima" muropa serum kuchawedzera kusvikira kukura nephrotoxicity nefronekroza. Kuwedzera, mukanyanyisa hafu-upenyu.

Kusanganisa "Maksiprima" pamwe NSAIDs (non-steroidal Anti-anogumbura zvinodhaka) kunetesa excretion pakati cephalosporins muviri uye unogona kukonzera ropa.

Kushandiswa akabatana nevamwe bactericidal mishonga (aminoglycosides) kuchaguma kuratidzwa Mubatanidzwa, pamwe bacteriostatic - daka.

Medicines analogues

Medicaments analogs vanosarudzwa inobva dzakawanda nonproprietary zita (INN), pano ne huru basa chirungiso (nokuti "Maksipima" cefepime akadaro). Chinonyanya dzakakurumbira dzomuzana antibacterial mumiririri "Maxipime" netsinhiro penyanzvi anotaurwa mishonga yakadai se "Cefepime-Alpes", "Cefepime", "Movizar", "maxicef" "Cefepime chena."

Iyi haisi ndandanda, uye sezvo zita "Cefepime", pano, kuwedzera kune apa, kuchine "Cefepime-chinu", "Cefepime-Agio" "Cefepime-Dzhodas" "Cefepime-Alkema," "Cefepime Hydrochloride ".

Uyewo mune rakasiyana-siyana zvinokonzerwa noutachiona rinobatsirwa varayire zvinodhaka kugamuchira "Ladef", "Efipim", "Kefsepim", "Tsefomaks", "chainsWe".

Panyaya mishonga vezera, varege nguva dzose kuva vanobudirira kufanana marezenisi zvinodhaka.

Opinion wevarwere nevashandi vezveutano

Sezvo mushonga une zvakawanda mafomu nenzira dzakasiyana-siyana microbial zvirwere, ipapo mafungiro "Maksipime" pane zvakanaka zvokuita, uye kunaka. Vanhu Vazhinji kutora mishonga, vakaguta nemigumisiro. Kuvandudzwa utano, kunyange kwazvo siyana zvinokonzerwa noutachiona yakaitika mazuva 2-3 kubva pakutanga mishonga. Maererano vashandi utano, mushonga uyewo vaudzewo pachake zvakasiyana yokuora ezvinhu. Uye mari mushonga haisi yakakwirira chaizvo (pane mishonga isingadhuri, asi panguva imwe chete, pane zvakawanda yekudyidzana anodhura pane "Maxipime").

Zvisinei, pane kudaro nechivimbo mafungiro pamusoro zvinodhaka. Mostly mashoko asina kunaka ari avo varwere vanenge pachavo wakaratidzwa yawapiwa nemishonga. Mukuwedzera, akaipa pfungwa wakaratidzwa siyanei boka revanhu vanotora mishonga "Maxipime" kuti chikosoro. Kunyange munyika ino kana mugumisiro iri, sezvo vaitarisirwa. Chero kutonhora chinhu nemavhairasi hunhu, uye "Maxipime" - mumwe germicide, nheyo iyo inobva kwechirwere kuparadzwa sero Kamudzira kwemabhakitiriya.

Buy mushonga unogona chete kuva mushonga kubva chiremba. Unomirirei: chiremba pamwe kushandiswa ruzivo uye ruzivo, saka sarudza inorwisa utachiona uye overenga shoma abudirire dose, kuti zvose ngozi nemishonga kushoma uye kunobatsira muviri zvichabviswa maximized.