Epinephrine hydrochloride: mirayiridzo kushandiswa, rondedzero rekugadzirira

A unopinza kuderera BP somugumisiro Kurwara, mishonga wakawandisa kana zvimwe zvikonzero zvingaita kuti kusingarapiki yakaipa mumuviri uye kunyange rufu. Pari, tsika mushonga kubvisa murwere wehurumende ichi rinoshandiswa adrenaline hydrochloride. It, zvichienderana kunzwisisa mamiriro ezvinhu, varwere vari dzakabatwa subcutaneously, intramuscularly kana nomutsinga, uye zvikuru kwazvo kacho - intracardiac.

Pharmacological migumisiro

The chikuru mugumisiro zvinodhaka kwakabatana zvakananga matambudziko pamusoro a- uye b-adrenergic receptors, uye munzira dzakawanda zviri zvakafanana tsinga internet excitation migumisiro. Kana raitongwa kuti epinephrine hydrochloride kunoita vasoconstriction zvose abdominal nhengo uye ubatanidzwewo skeletal tsandanyama. Nokuda rutapudzo rwakadaro lumen ropa migero rinowanikwa nokuwedzera BP.

Zvisinei, zvinofanira kucherechedzwa kuti kubata Vanamei kuchinja muviri, nokuda nezvainoita b-adrenergic receptors, zvishoma kugara ichienzaniswa noradrenaline. Unhu rokuchinja mwoyo basa zvikuru kunzwisisa. Pashure kweiyi adrenergic receptors kunobatsira kuti kakawanda uye kwakawedzera kwemwoyo, uye panguva imwecheteyo, kana BP rinobuda, musimboti rinofarira vagus tsinga, izvo kuchititadzisa mashandiro mwoyo. Ndokusaka panguva hypoxia vachiita mushonga kunogona kukonzera arrhythmia.

Mukuwedzera, mushonga hunokonzera mboni dilation, kutandara pakati tsandanyama pamusoro ura uye principales. Zvinonzi kwakaratidza kuti varwere vari nokukurumidza zvinyama muviri uye shuga rinobuda muropa pashure chete dose mumwe chishandiso akadai epinephrine hydrochloride. Mirayiridzo dzokushandisa uye rine mashoko pamusoro kurapwa yaizodzorera dzichipfekeka mano skeletal tsandanyama rinenge kusanganisira kuneta.

Panyaya nechepakati tsinga, kuti mishonga dose zvinodhaka, sezvinoita mutemo, havana raidudzwa mugumisiro pairi.

Kuratidza zvinodhaka?

Kushandisa epinephrine hydrochloride unopinza kuderera BP (dzokurapa ezvinhu omurwere yakadaro inonzi akoromoke). Simukai pakadaro kunogona kuguma ovhadhozi kwevanhu mishonga, zvipembenene ikaruma uye rikwanise neutachiona.

Chimwe chiratidzo nokuti mushonga - yomuropa, kunoitika apo ane ovhadhozi insulin yakakodzera. In mamiriro ichi, murwere yava anodonha BP kwete chete waivako, asiwo chechetere yomuropa.

In ophthalmology mushonga waakaudzwa varwere vane yakawedzera intraocular kumanikidzwa (yemaziso). In pfava tsika rinoshandiswa senzira vasoconstrictor.

Kuwedzera kune zviratidzo izvi, epinephrine hydrochloride chinotarisirwa kuti varwere ventricular fibrillation.

dosing maitiro uye nzira kushandiswa

Zvichienderana chirwere chacho kwokuomerwa zvinodhaka murwere kungaratidzwa subcutaneously, intramuscularly uye nomutsinga. Saka kushandisa 0.1% mhinduro kubva 0,2 / 0,3 / 0,5 kana 1 Rine mamiririta. Varwere chenjera cardiac kusungwa raitongwa 1 ml rekugadzirira, ndiye dose rinoshandiswa, uye ventricular fibrillation. Zvinofanira kucherechedzwa kuti pakupa redunhu anosarudza chete chiremba nerimwe nyaya.

In ophthalmology kuzadzisa yomunharaunda vasoconstrictive mugumisiro epinephrine hydrochloride rinoshandisirwa mucous membranes pakati ziso.

Árbol asima yakasvikawo zvinodhaka Kutarisirwa subcutaneously pa 0.3 - 0.5 - 0,7 Rine mamiririta. Asi sezvo kuchirapa mishonga kuti epinephrine negadziriso parenteral kushandiswa, Saka, somunhu mutemo, vari akagadzira varwere vakuru 0.3 - 0.5 - 0.75 Rine mamiririta. Babe, kana zvakakodzera kushandisa medicament ichi maererano nezera vari kutarisirwa 0.1-0.5 Rine mamiririta.

The Kuronga zvinodhaka

Epinephrine hydrochloride wakachena chimiro ari zvishoma Pink kana chichena crystalline upfu. Achifuridzirwa okisijeni uye chiedza anokwanisa kuzvishandura. Zvisinei, chimiro chakadaro, kugadzirira haisi nechikoro kuti mutengi. Tisati rinogona kushandiswa okurapa mune aseptic ezvinhu ari mishonga mafekitari nayo rakasanganiswa kugadzirisa zviri hydrochloric acid. In kushandiswa vemishonga sezvo preservatives yavaibvisa metabisulphite uye chlorobutanol.

pashure chete kuti Pharmacies, varwere vanogona kuwana epinephrine hydrochloride mhinduro, zvakazara vakagadzirira kushandisa.

Release chimiro zvinodhaka

Kusvika panguva mushonga inowanikwa chete mutengi ari muchimiro 0.1% mhinduro iyo inowanika ndiro uye ampoules. Volume Chekutanga Rine mamiririta 30, asi wechipiri - chete 1 Rine mamiririta. Ampoules 6 bv. mumapepa ari atorwa bhokisi.

In chitarisiko afanane mhinduro iri zvachose läpinäkyvä mvura, hapana precipitate uye nerastvoronnyh zvakasiyana okunze.

mushonga uyu contraindicated?

Kana tikafunga kuti huru chiratidzo kuti kushandisa zvinodhaka - kuwedzera BP nokuda aienda midziyo ropa, zvinonzwisisika kuti zvachose hazvigoni kushandiswa varwere vane chirwere cheBP. Uyewo kunoreva zvaisambobvumirwa panguva atherosclerosis, hyperthyroidism uye chirwere cheshuga, nokuti pharmacological mugumisiro zvinodhaka haagoni chete achiipa panguva yekunwa zvirwere, asi kutungamirira nemigumisiro ngozi chaizvo. Somuenzaniso, myocardial infarction, sitiroko uye nevamwe.

Not kushanda epinephrine hydrochloride uye panguva zvomusejari kushandiswa, cyclopropane kana halothane yokutindivadza.

Zvinofanira kucherechedzwa kuti mushonga wacho zvachose hakubvumidzwi panguva yepamuviri uye lactation. Uye pavanoparidza zvinodhaka "Oxytocin" mushonga kunotungamirira vawedzere toxicity.

nemishonga

Pasinei chokwadi kuti mune dzakawanda zvirwere mushonga anogona kuponesa upenyu murwere, kungofanana zvichida, uye kunogona kukuvadza kana musingadi kufunga nomumwe zvatariswa murwere kana kusapfuudza zvinobvumidzwa dose.

Saka, kunyange kana ikashandiswa zvakanaka, mishonga munhu anogona kunzwa dzungu, kufunganya, chakamira pakunodengenyeka zvine, kufunganya uye mukuru muutera. Uyezve, mumwe murwere mushure kwokubatsira mushonga inogona kuchengetwa pallor (nokuda vasoconstriction), vangadikitira uye zvinopfuura kuwedzera BP. Zvisinei, mudzivisi zviratidzo, nokuti ayo pfupi nguva, hakurevi yokurapa kururamiswa kana abolition zvinodhaka zvakakwana.

Avo varatidza adrenaline hydrochloride, murayiridzo Chinyorwa chinonyevera pamusoro zvaibvira pave cardiac arrhythmias, tachycardia, rakapinza kuwedzera BP. In varwere coronary tsinga chirwere vanoshandisa zvinodhaka zvinowedzera mukana angina kurwiswa.

ovhadhozi

Munhu wose anoziva kuti mushonga mishonga kutarisirwa kushandiswa zvinonyatsochengeta chipimo chemushonga uye chete mushonga. Zvikasadaro, utano murwere ari pangozi. Uye epinephrine hydrochloride hakusi kurwadziwa.

Kana runopfuura bvumidzwa chipimo chemushonga mhinduro (kunyange kana raitongwa subcutaneously) murwere pakarepo anovandudza nokukurumidza mydriasis uye kwakawedzera BP. Uyezve, yekudyidzana unoraramisa mwoyo mwero, izvo dzimwe nguva mberi kuti ventricular fibrillation. Uye kana murwere kuwedzera zvakasimba kuti hydrostatic kumanikidzwa iri duku tsinga uye permeability pamusoro pulmonary rirambe richibvira rusvingo, anogona kuva pulmonary edema munyama.

Sei adzikatidza akaipa zvinokonzerwa zvinodhaka?

Kutambura nhamba kumuvengi zviito Vanamei antagonistically kuita Via α- uye β-blockers. Izvi zvinosanganisira mishonga "Inderal" "Tropafen", "Phentolamine" uye vamwe. Kakawanda vanachiremba kubvisa migumisiro adrenaline nokutsanya kushandiswa nitrites. Zvisinei, kushandiswa pamusoro mapoka mishonga iri chete inoshanda kana chiedza anoumba dzakatevedzana nemishonga nzira dzakadai adrenaline hydrochloride (payakavakirwa ndiko: 1-1- (3,4-dihydroxyphenyl) -2-methylaminoethanol hydrochloride).

Kana murwere kana uchishandisa mushonga uyu kuchengetwa zvikuru nemamwe matambudziko akadai ventricular fibrillation kana yakakura pulmonary edema, mukuru-kukurumidza kushandiswa nitrite uye zvakakwana blockers siyana. Nokuti ruponeso varwere vari muzviitiko izvi, vanachiremba vava kunzwisisa kurapa, izvo zvingasanganisira kunyange zvemagetsi defibrillation mwoyo.

Zvemupiro nerubatsiro zvinodhaka

Zviri chete musoro kuti mushonga uri mushonga kwakavakirwa adrenaline unorambidza akasununguka kutengesa kusvika pakuguma user. Pashure nokuzvidzora zvinoreva mashoko anogona kukonzera zvakaipa uremu kunyange pakuomerera zvaidiwa dosing hurongwa. Uyezve, vamwe varwere pakatanga shoma ane adrenaline hydrochloride (mashoko anopupurira ichi) zvakakomba sema maitiro zvingaitika.

Saka usati kuenda chemishonga kuti zvinodhaka izvi, unofanira kubvunza chiremba uyo achanyora mushonga. Hazvina gwaro iri, iro rine mashoko pamusoro nhamba uye chipimo chemushonga zvinodhaka, asi mishonga anofanira kupiwa kana kutenga mishonga.

zvinodhaka kwavatori

chiremba wose anoziva kuti kushandiswa adrenaline nedzimwe symptomatology iri zvachose wairambidza. Pashure pezvose, zvakadai mubatanidzwa ane chirungiso zvazviri uye rinoendesa kudhaka.

Usashandisa mishonga iyi pakurapa varwere tora akarara mapiritsi uye marwadzo analgesics. Uyezve, nezvimwe zvinhu, izvo zvakanyatsorongwa kushandiswa antihistamines, chero chiremba, zvakare, anoramba kunyora mushonga. Adrenaline hydrochloride hazvisi kwete chete youtano - kungava kuurayisa.

Hazvibvumirwi mubatanidzwa zvinodhaka pamwe inhalation rufimbi, sezvo izvi zvingaita kuti pave kunzwisisa cardiac chirwere mune murwere.

analogues mushonga

Nokuti kuti masayendisiti Havamboregi pamusoro kubudirira zvabuda uye kuramba kushanda pakusikwa nemishonga vatsva zvokurarama epinephrine hydrochloride kuti nhasi anotova anoyevedza mazita analogues. Zvisinei, pakusarudza zvinodhaka, zvakafanana chiito pamwe adrenaline, rinoitwa chete nokuda kupinda chiremba. Panyaya iyi, nyanzvi runotungamirirwa kwete chete muchimiro nekuomarara murwere chirwere, asiwo inorangarira maitiro avo nomumwe.

Tsiva epinephrine hydrochloride chiremba angabvuma zvinodhaka akadai "Epinifrin", "Tonogen", "Glaukozan" "Crank hydrochloride" "Suprarenalin" "Epinephrine hydrochloride," "Levorenin", "Eppie", "Renostiptitsin", "Suprarenin" "glauconite", "Epirenan", "Adrenamin", "Gipernefrin", "Stiptirenal", "Paranefrin", "Glaukonin" and said.

Pasinei chaizvo pamazita dzomuzana, mumwe haafaniri kufunga kuti vanogona kuva norusununguko kutenga panguva chemishonga. Nokutenga adrenaline hydrochloride, mushonga muchiLatin kunodiwa kuratidza mishonga. Zvakafanana kunodiwa kana uchida kutenga chero pamusoro mishonga.