"Clofranil": mirayiridzo yekushandura, kubvunzurudza, mapikicha, mifananidzo, migumisiro

kuora mwoyo kurapwa kwacho hakusi kwakakwana pasina kushandisa antidepressants, izvo zvinosanganisira mishonga "Klofranil". Manual rinokurudzira kushandiswa kwayo nokuda kubviswa phobias siyana, marwadzo syndromes.

Description mishonga

The rinoita zvinoriumba zvinodhaka ndiko clomipramine hydrochloride. Neve Indian kambani "Sun Pharmaceutical Industries" muchimiro rebhuruu rwakapoteredza mahwendefa ane mumuhara unhani.

Chipimo chemushonga uwandu clomipramine hydrochloride 0,025 g.

mashandiro pamusoro Action

Medicine "Klofranil" mirayiridzo kushandiswa rinoreva tricyclic antidepressants pamwe chivako. With ake kutaurawo timoanalepticheskaya amakavaitira zvinovhiringidza pfungwa basa, anxiolytic, Alpha adrenotormozyaschim uye inoita kuti zvinhu zvidzikame. Zvapedzisira pfuma zvinogoneka nokuda ukama ne H ₁ histamine receptors.

Siyana unonyaradza marwadzo, uye gistaminoblokiruyuschim antiserotoninovym simba. Anobvisa vaingoerekana leakage kuti weti usiku anovanza chido kudya.

Exhibits anticholinergic mugumisiro peripheral uye nechepakati hunhu zvakakonzera chaizvo holinzavisimym Kanotokonya idzodzo.

Drug "Klofranil" rinoreva antiarrhythmic mishonga yakadai quinidine, ichivharira yavaibvisa migero. Kuchirapa mishonga kuti clomipramine kuti tunodzivisa conduction mwoyo ventricles.

Antidepressant basa iri kukonzerwa kuwedzera noradrenaline nhanho zviri Tutsinga tunofambisa mashoko utwu zviri kubatana pfungwa uye zviri kweserotonin munyika tsinga. neurotransmitters aya vaunganidza nokuti kuti membranes ose presynaptic Tutsinga tunofambisa mashoko utwu ichipererwa vakatakura reuptake.

Refu kunokanganisa zvinoderedza iri dzichipfekeka basa kweserotonin Kanotokonya idzodzo ari mhando uye Beta-adrenozavisimyh iri muuropi, zvinobatsira kuti normalize zviri adrenergic uye serotonergic transference, anoitisa kudzorerwa pachiyero munyika, iyo akatsamwiswawo mwoyo zviratidzo. Mahwendefa "Klofranil" akubatsire psychomotor retardation mhando, akaora mwoyo, mwoyo kunzwa.

Unonyaradza marwadzo basa kwakaratidzwa kana kuchinja monoamine kwevari epfungwa.

Anxiolytic zvazviri kunoitika pamwe kwakaderedza excitation pamusoro nuclei muuropi hunde, izvo nokudzorwa Kanotokonya mashandiro beta- Alpha 2-adrenergic mhando uye noradrenaline redunhu.

The antidepressant basa Zvakacherechedzwa mazuva 7 pashure kutanga kurapwa.
In clomipramine zvichienzaniswa imipramine kufurira kushanda ipfupi, uye kana uchienzaniswa amitriptyline, ari kunyaradza basa zviri zvishoma kuoneka.

Sei tora

Medicament "Klofranil" mirayiridzo kushandiswa vari pachii zvakanaka mwoyo yakasiyana kukura dzinoratidzwa zvimwe zviratidzo.

The mushonga ushandiswe zvokuora mwoyo chirwere hunhu uyo anobuda schizophrenic zviratidzo, marwadzo kwenguva refu, urwere mumuviri uye kusawirirana. Vanobatana presenile uye penga nokuda kokuchembera mhando pezvakaitwa uye avo kuratidzwa muuduku.

Zvinodhaka "Klofranil" mirayiridzo kushandiswa, iyo inopiwa pazasi mufananidzo chinoratidza kushandiswa nyanyisa-muropa chirwere chokuita phobias, kutya zvavanotya panguva nenguva dzirikure inorwadza nezvekufadza mu oncology, migraine, rheumatic chirwere.

Zvinobatsira ne post-herpetic maronda zviri tsinga iri arikunze, uye post-zvinorwadza peripheral neuropathy, pokungorara-rara, catalepsy. The mushonga ari kutora kudzivirira marwadzo mumusoro uye migraine.

How kushandisa

Muchimiro mahwendefa mumiririri "Klofranil" mirayiridzo Chinyorwa anokurudzira kushandisa kana unoparadza zvokudya kana pashure zvokudya kuderedza kutsamwa kuti mucous membranes mudumbu rusvingo.

Nokuti kurapa uchishandisa chipimo chemushonga duku, mitemo iyi inoshanda kuvanhu vakwegura uye kuyaruka.

Depression, nyanyisa-muropa nyonganyonga uye phobias kubata chipimo chemushonga siyana muna 0,025 g 3 mishonga pazuva. Muvhiki rekutanga, nezuva dose rwuchiwanzwa, rimwe zuva unogona kutorwa 0,100 kusvika 0,150 d Kana zvakakodzera, kushandisa yakakwirira mishonga. Kana mamiriro yokuchinja sokuti kutsigira kurapwa, kuti kubva 0,050 kusvika 0,100 g chezvinodhaka.

Kungorara-rara ne kudhakwa catalepsy kubvisa mahwendefa ane zuva dose inobva 0,025 kusvika 0,075 d clomipramine. Marwadzo ikarapwa daily chipimo chemushonga inobva 0,100 kusvika 0,150 d iyo unobatanidzwa pamwe concomitant analgesics, last nhamba chinogona zvishoma nezvishoma kuderedzwa.

Kubvisa vhunduka kutanga kushandiswa zuva nezuva 0,010 magiramu zvinodhaka, iyo inogona pamwe benzodiazepines. Kana mishonga zvakanaka akashivirira, mari yakawanda kuti chimiro zvakanaka kuchinja. Zvadaro shandisa zvishoma nezvishoma abolition kuti benzodiazepine nevamiririri. Treatment ne "Klofranil" Chinyorwa rinokurudzira kudzima paya chete nehafu gore uye kwete pamberi. Panguva ino nguva zvakakodzera kuti aite zvishoma nezvishoma zvinoderedza rutsigiro dosing.

Pakukwegura kurapa ushandiswe daily dose pamusoro 0,010 kusvika ipapo kwemazuva 10 kuwedzera uwandu medicament kune optimum vanochiva izvo anoda kubva 0,030 kusvika 0,050 d dose iri kushandiswa munyika mushonga.

sequela pasingadiwi

Sezvazviri antidepressants zvose zvinogona kukonzera mishonga "Klofranil" nemishonga. Anticholinergic zvazviri kunoratidza damerau kuona basa accommodative paresis, mydriasis, kukwidza kumanikidza mukati ziso, kuwedzera kwemwoyo, yakaoma nemumuromo mhango, matted chikonzero, delirium, kupatira, akafa mitezo dumbu nonconduction hunhu makadzivisa akabuda weti, ziya diki mupanda.

Kuchinja tsinga vaine hope, asthenic muitiro anokonzera nekuvhiri- ngika, kufunganya, nokusagadzikana, kupinduka pinduka, nemanic kana hypomanic kuchinja. Uyewo, nemishonga vanoonekwa ne utsinye, ndangariro dzakaipa, depersonalization, murombo nzeve, kushaya hope, kurota zvinotyisa, asthenia.

Nenjodzi mwoyo uye tsinga zvinozarurwa sinus vachisimudza kana kuchinja cardiac mutinhimira, richaparara orthostatic species conduction kukundikana ventricular nevezera variability.

Rinoreva "Klofranil" mirayiridzo yokushandisa anorondedzera kuchinja zvomudumbu ino, varehwa mune vanonzwa mamiriro chiropa jaundice, chirungurira, kurwadziwa nomudumbu, vakawedzera kana ungaderedza chido kudya, stomatitis, matambudziko mazino, kuchinja zvakabikwa zvaunofarira, ari blackening rurimi.

Hormone nepfungwa inozivikanwa edema testicular ikure thoracal mumasero mune varume uye vakadzi kuwedzera, kunyanya chipimo chemushonga pamusoro prolactin, galactorrhea, mukuru kana vakaderera chido chokurara, kudzikira potency, hyper- kana yomuropa, hyponatremia, kukodzera kusunungurwa antidiuretic kemikari.

Changing basa Anoumba nhengo chokuita rutapudzo pamusoro leukocyte uye masero platelet ropa, purpura, vakawedzera vazhinji eosinophils.

Sema zvinogona kuitika muchimiro ganda rashes yokufunuka, vanotya ultraviolet, angioneurotic edema.

Side migumisiro chokuita kuderera bvudzi mumusoro, petechiae, kunzwa kupisa kana kutonhora mamiriro, kunonoka kana kuita weti kakawanda, pamwe zvinoderedza ropa wevasungwa pakati mapuroteni ne febrile chirwere uye yakakwirira tembiricha.

Somugumisiro nokukundwa Kudzimwa zvinodhaka kungaita kuda kurutsa, kurutsa, nomudumbu, marwadzo, nomusoro, zvakawanda zvive, kushaya hope, zviroto. A zvishoma nezvishoma zvinoderedza dose mishonga inogona kuita kuti munhu kutsamwa uye kuti mamiriro motokari wokusagadzikana.

vana

Nyanyisa-muropa chirwere hunhu ikarapwa mune kutanga dosing pakati 0,0125 14 mazuva vanopedza zvishoma nezvishoma kuwedzera wevasungwa, tichifunga portability yacho medicament. The dose daily pamusoro 2 weeks 0,100 d yakaenzana kana dzaona kubva uremu mwana, nokuti mumwe 1 kg kurema apo nezvokuvandudzika 0,003 g vanoshingaira fuma. Zvichitevera mazuva 14 anoteverwa zvishoma nezvishoma kuwedzera zvinodhaka wevasungwa kusvika 0,200 d kana kuti recalculation uremu.

Kugadzwa rinoreva "Klofranil" vana vanokodzera nyaya dzinovaka hunhu mishonga usiku enuresis. Initial kurapwa chinotarisirwa zuva dose munguva mari 0,020-0,030 d kuti makore 5 kusvika 8 makore nokuti kuyaruka kubvira 9 kusvika 12 makore anoshandiswa 0,025-0,050 d; pashure pemakore 12: 0.025-0.075 d

Kuwedzera chipimo chemushonga kutakura varwere vasiri akabatsira mushonga pashure pemazuva 7 yokurapa. The yose daily dose kurapwa ushandiswe kunwa chimwe chikumbiro manheru pashure kudya. Kana involuntary weti usiku hope, hafu yacho chipimo chemushonga waakaudzwa kunwa kusvika maawa 17. Kamwe kubudirira zvinozoita zvinodhaka regai kupa mumwe mazuva 90, panguva iyo akaita zvishoma nezvishoma zvinoderedza mishonga mumatunhu.

Medicine "Klofranil" dzomuzana

Pane mishonga yakawanda pahwaro clomipramine hydrochloride, vanoonekwa kuchinjaniswa.

Chimwe chishandiso ndehwevakadai Italian chinodhaka "Anafranil", iro zvinoberekwa "Novartis Pharma". Kunogona kusanganisirawo antidepressants tricyclic dzakatevedzana. Maererano psychotropic zvinodhaka zvokuora mwoyo pezvakaitwa uye zvirwere zvepfungwa. Zvinodhaka "Klofranil" uye "Anafranil" marongerwo vane basa kuchatibatsira clomipramine hydrochloride munyu.

Yakabudiswa medicament ari muchimiro kwakajairika mahwendefa uye kuramba kusunungurwa. Simple chipimo chemushonga aro 0,025 g, uye 0,075 d kutadzisa unotora zvinoshingaira chirungiso. Kwakajairika mahwendefa muri chiedza tsvuku shuga zvemapuranga. Refu mushonga chimiro rine roruvara rwakatsvukuruka unhani.

Pane mvura mhando mishonga, iyo inomiririrwa mhinduro intravenous Kutarisirwa vnurtimyshechnogo uye 2 Rine mamiririta. Chipimo chemushonga "Anafranil" jekiseni kugadzirira 0,025 g clomipramine hydrochloride, icho zvazvichanyungudutswa mvura chena uye glycerin.

Mumwe nzira yakadaro zvinodhaka "Clomipramine", iro rinowanika piritsi muchimiro nokuda nomumukanwa yaitonga. Kudzivirira, ivo zvemapuranga ari zvomudumbu hurongwa mucosa. The chipimo chemushonga iri 0,025 d clomipramine hydrochloride. Mabhuku eBraille "25" kureva naro mumwe tablet. Zvazvakaita zvinodhaka nechinangwa rokurwisa depression. In mushonga rikunde psychostimulants, timolepticheskoe uye kunyaradza basa. Zvapedzisira basa iri chokuita neizvi ichivharira neuronal uptake kweserotonin mamorekuru kuti kuvandudza murwere kumunetsawo.

Zvinonzi rakashandiswa pakurapa kuora urongwa, izvo zvinokonzerwa nezvikonzero zvakasiyana-siyana. The mushonga aiitirwa zvakanaka psihopatiiyu, schizophrenia, phobias, kutya chirwere, nyanyisa-muropa hunhu, cataplexy, pokungorara-rara. Children pashure 5 makore akagadzwa kuti kubvisa usiku incontinence.

Muna mushonga "Klofranil" analogues ingasanganisira zvinoshingaira chirungiso vamwe pane clomipramine hydrochloride. Somuenzaniso, mushonga "SONEX" iri kwayo sezvamunoita ndiro rinoita chirungiso zopiclone, iyo iri imwe chete dose kuti medicament ndiyo 0,0075 kutanga kurara, kuratidza chinozorodza, anticonvulsant uye tsandanyama relaxant nemigumisiro. Zvinonyatsorehwa risanyatsobuda "Klofranil" uye "SONEX" ndizvo ehupfumi zvavo kunyaradza.

Available Belarusian mishonga kambani "Rubicon" muchimiro pamahwandefa kumativi, lenticular, ane chena mumuhara chifukidzo uye ngozi vachigoverana hafu. Rinoshandiswa kubata zvikuru kurara zvirwere nenzira ezvinhu uye duku kushaya hope.

"Truksal" mushonga

Zvinonzi vakatenda akafanana inobva analoginen chlorprothixene hydrochloride riri tioksantenoviy rinobva. Zvinonzi neve Danish kambani JSC "Lundbeck". Kugadzirira chokuita neuroleptic vamiririri, vane antipsychotic, kunyaradza uye munyoro antidepressant basa.

Pane ina dzakasiyana dosages zvinodhaka: 0,005, 0,015, 0,025 uye 0,050 magiramu. nhatu mishonga vokutanga anowanika muchimiro shava tableted dzakabatana uye biconvex kumativi chimiro ane mumuhara unhani. The soro dose waimiririra chimwe denderedzwa Hwendefa biconvex hukawanika.

Antipsychotic basa iri kuitwa zvichivhiringidza dopamine Kanotokonya idzodzo. Kana blockade nzvimbo idzi pane antiemetic uye marwadzo nokuitika chezvinodhaka. Drug kuchititadzisa 5-HT2 Kanotokonya kushamwaridzana, α1-adrenergic uye H1-receptors gistaminozavisimye chinokonzera adrenoblokiruyuschee, antihistaminic basa.

The medicament iri semunhu neuroleptic zvinodhaka Anyarara simba, iyo rinotarisirwa kubata pfungwa, schizophrenic uye kupenga nokurwisa.

Rinoshandiswa kubvisa pauduku kuipa maitiro, chinangwa yokukunda hangover kushaya chirwere apo doro uye kushandisa zvinodhaka, kurwisa wokusagadzikana, kutsamwa muitiro, kuvhiringidzika pakukwegura.

The mushonga unoshanda mu mwoyo inoshanduka Besson nevroznom mamiriro.

Pamwe chete marwadzo mishonga mushonga "Truksal" anobvisa chirwere pezvakaitwa.

Enzanisa Ezvemutauro "Klofranil" pamwe dzomuzana

The pedyo mu sezvamunoita uye zviito medicament ndiye "Anafranil" muchimiro mapiritsi pamwe zvavo kusunungurwa. Chipimo chemushonga siyana kutadzisa munhu chipimo chemushonga pamusoro 0,075 magiramu uye mhinduro intramuscular uye intravenous kushandiswa haagoni kuenzaniswa Indian antidepressant, sezvo hazvisi kuwanikwa chimiro ichi.

Varwere vakawanda vanonetseka mubvunzo: sei "Klofranil" kubva "Anafranil"? Chokutanga, pane musiyano pakati Zvinoumba vakaneta ingredients. Kuvapo ari Indian kugadzirira penya yebhuruu, yavaibvisa carboxymethyl starch, hypromellose 2910, macrogol 6000, hamusi mishonga wokuItaly, anoti pamusoro musiyano pakati vezera maviri. zvinhu izvi pamahwandefa "Anafranil" ne stearic acid, glycerol 85%, hydroxypropylmethyl cellulose, copolymer kuti vinylpyrrolidone uye raive nebutiro acetate, crystalline sucrose, polyvinylpyrrolidone K30, yellow simbi oxide 5%, titanium dioxide, macrogol 8000.

Kuvapo zvose zvinodhaka mukaka shuga runogonesa kuti bioavailability yezviri fuma. Zvisinei, kuvapo lactose anovaita kukodzera kuti vanhu vane kusashivirirana kuti chikamu ichi.

Other ebetsero zvinhu zviri analogues maviri anoshandura kupinda simba, kubvisa, rova uye clomipramine hydrochloride excretion kubva mumuviri. Vanodawo basa kukura zvose zvinogoneka nemishonga.
Kusiyana "Anafranil" kubva "Klofranila" nokuda kwomutengo. Italian mushonga kunodyira zvishoma kupfuura Indian ishamwari.

Kana tikaenzanisa chii chakasimba: "Truksal" kana "Klofranil", zvinofungidzirwa kuti wokutanga zvinodhaka ane kunyaradza simba, chinozorodza uye inhibitory zvazviri, izvo anobvumira kuti kukunda siyana pfungwa zvirwere.

Nenzira yekuita simba, neuroleptics yakasiyana zvikuru nemishonga inorwisa zvinodhaka. Chiito chechirwere ichi "Truksan" chinangwa chekudzivisa chirwere chepfungwa chepfungwa, kuderedza basa reurostrmmitter zvinhu. Nekubatsira kwechirwere "Clofranil" basa ravo rinosimbiswa uye rinokurudzirwa.

Dopamine excretion inodzingwa neuroleptics, uye zvinokonzerwa nehutachiona hwepfungwa zvinowedzera nekugadzirwa kwezvinhu izvi.

Mwoyo wevarwere

Nezvemishonga "Clofranil" kuongororwa kunogona kunzwika zvakasiyana. Varwere vakawanda vane mwoyo yakaora mwoyo, chigadzirwa ichi chakabatsira kubvisa pfungwa dzakaipa uye dzakaipa, pane mufaro mukati mehupenyu.

Vamwe vanhu vanorayira mushonga wekudhakwa nekudhakwa kwakanyanya. Mushure mokutora mishonga, murwere akauya munharaunda yakakwana, yakadzikama, yakagadzikana, utsinye hunoparadzana.

Pamusoro pezvinodhaka "Clofranil" mirayiridzo yekushandura kushandiswa ine zvinhu zvakanaka uye zvisina kunaka. Izvi zvinokonzerwa nekuti chikamu "Kusarudzwa Kwakaipisisa" kune rondedzero yakawanda yemigumisiro isina kunaka inogona kuitika munguva yekurapa. Mukuita, vanachiremba vakawanda vanonyorera kubvumira kunobatsira kwechirwere ichi, chinhu chikuru ndechokuti sarudzo yakarurama yakanyatsorongeka uye kururamisa iyo panguva kana zvichidikanwa.

Zvakanaka kuti mushonga we "Clofranil" kuongororwa kunobatanidza nekuratidzwa kwekubudirira kwahwo panguva yakakodzera, iyo inonzi nemuiti wezvinodhaka. Uyezve, kuwanika kwayo muurongwa hwemari kunofadza. Mishonga inotanga kushanda vhiki imwe mushure mokutanga kushandiswa, izvo zvakakosha kuti kubviswa kwekurwa kwakanyanya kwechirwere.

Izvo zvinotadza ndezvokuti mishonga haigone kubuda pakarepo, asi kuderedzwa zvishoma nezvishoma mu dosing kunodiwa.

Varwere vane chinetso chekutyisa muzvikamu zvekutanga zverapi vakawedzera kuzvidya mwoyo. Izvi zvinongoratidzika zvinoratidza pazuva rekutanga, uye zvino zvinoderera mushure memavhiki maviri.