Chimiro cheRPP muhupenyu hwekuongorora ropa

C-reactive protein (CRP kana CRP kubva muChirungu C-reactive protein) inoreva plasma mapuroteni mapuroteni. CRP mukuongorora kwehupenyu hwehupenyu ndiyo inonyanya kunzwisisika, iyo inopindirana nekuwedzera muhutano hwekufungidzira muchikamu chakaoma chekuvhiringidza kunoitika mumuviri.

Izvi zvinoita basa rinodzivirira. Nechinangwa chekuongororwa, kuongorora kweRPP yakafanana neyakayera ye ESR inoshandiswa sechiratidzo chekuvhiringidza.

C-reactive protein - chii ichocho

Puroteni yakagamuchira zita rayo nekuda kwekukwanisa kwayo kupera (kubva muchiLatini izwi praecipitatio, kureva kuti rinoreva kuwira pasi, kureva kusunga uye kunaya). Iyo inosungiririra ku-C-polysaccharides yepneumococci uye zvino inodzivirira muviri kubva kune utachiona.

CRP inokurudzira kugadzirwa kwe leukocytes, iyo inodzivirirawo kubhakitiriya nezvimwe zvirwere. Uyewo, chirongwa ichi chinowedzera kushanda kweT-lymphocytes, iyo inokanganisa phagocytosis, agglutination uye kugadzirisa kwekuitika kunoitika mumuviri.

Basa reRPP mumuviri

Ndeipi basa reprotini iyi mumuviri? CRP inobvisa kubva mumuviri mafuta acids uye bioactive lysophospholipid, iyo inoumbwa semugumisiro wekuvhiringidza kwemukati membrane mune chero chekuvhiringidza kana tissue necrosis.

Phosphatidylcholine ndiro chinhu chikuru cheese membranes. Kazhinji, inowanikwa mukati memukati memakumbo uye haigoni kuonekwa pamusoro pavo. Nechinhu chipi nechipi chokuputika, masero, uye nekudaro zvidimbu zvavo, zvakakuvara. Phosphatidylcholine inowanikwa pane kunze kweropa membrane. Ivo vanogadziriswa ne phosphatidylserine uye phosphadidylethanolamine. Izvo phospholipid inoshandisa hydrolysis uye inoshandurwa kuva mutevedzeri akasimba ekugadzirwa kwezvinhu zvipenyu mumuviri.

Nokudaro, vanosimudzira hemolysis (kuparadzwa) kweaerythrocytes uye vanoita zvinoparadza pamakumbo emakamuri pachavo. Izvi zvinokonzera kuumbwa kwezvirwere uye mamwe maantijeni anobudisa pachena pamusoro penhare uye inova nzvimbo yekusunga kweRPP uye yakakonzerwa nekamu membrane. Uyezve, macrophage inoshandiswa, iyo inobva yawana zvakasara zvekamuri rakakanganisika.

Nokudaro, CRP mu biochemical blood analysis ndiyo chiratidzo chekuvhiringidza kwechigunzva mune chero chekuvhiringidza, tsvina uye necrosis.

Zvikonzero zvekuwedzera DRR

CRP inobudiswa nemasero eropa uye glycoprotein. CRP kuongorora - chii ichocho? Pasi pesimba revamiririri vehupenyu (ivo vakambokurukurwa pamusoro), iyo iyo inotungamirirwa ne hydrolysis ye phospholipid, kugadzirwa kweRPP kunosimudzirwa. Zvarinotaura zvinotanga kumuka mushure maawa mashoma. Uye rimwe zuva mushure mekutanga kwekuvhiringidza kana imwe nzira yehutachiona, chirongwa cheRPP mukudzidza ropa rinonzi biochemistry chinogona kuva makumi emakore akakwirira kudarika chinowanzoitika. Izvi zvinonyanya kuzivikanwa muzvirwere zvebhakitiriya.

CRP yakasimudzwa uye ine necrotic inoshandiswa mumatumbu anowanikwa muzvishoma, kurohwa uye kuora kwemakumbo. Migumisiro yeongororo yezvechirwere ichangobva kuve yakaratidza kuti kuwedzera kwepuroteni iyi mu serumisi inoratidzika kune atherosclerosis yemidziyo yeropa. Izvo zvakawanikwa kuti ne-atherosclerotic inoshandiswa mumubhedha wemakumbo, chirwere chinononoka chokuputika kwemasvingo emidziyo yeropa chinoitika. Zvimwe zvinokonzera kuchinja kwechirwere ichi ndezvekuti:

• Kusvuta,
• Kuneta,
• Diabetes mellitus.

Migumisiro yeRPP pamarapirwo epfungwa

Kunyange kuwedzera kwechidiki muRPP muhupenyu hwekuongorora ropa kunogona kuratidza kuvapo kwekudzikira kwepfupi mumasvingo emidziyo uye nokudaro kuva chiratidzo chekuchinja kweatrosclerotic.

Zvinonyatsozivikanwa kuti kuwedzera kwehutachiona hwepasi pasi (lipodrotein) (LDL) kunokanganisa kuumbwa kwe atherosclerotic plaques mumuchenje wemitsipa yeropa. Asi zviongorori zvitsva zvakaratidza kuti kune varwere vane makwidziro akakwirira eCRP muropa uye nharaunda yakakwana yeLDL, mungozi yekudzivirira hutano hwemwoyo yakawanda kwazvo kupfuura kune avo vane CRP inoramba iri yakasviba, uye nhamba yeLDL inomuka.

Mune varwere vane chirwere chemwoyo (CHD), uyewo kune vanhu vane chirwere chepfungwa, chirwere chemwoyo kana vakawana nzira yekupfuura mu stenosis ye coronary arteries, kuongororwa kweRPP positive (pamusoro pezvakagadziriswa) chiratidzo chehurombo husina kunaka. Izvi zvinogona kuratidza kuti zvinogona kuitika kudzokorora kana kurwadziwa kwemoyo, nezvimwewo.

Biochemistry: CRP yakakwirira pane yakasikwa. Nezvarinotaura

Kuongorora kweRRR - chii ichi uye chii chingawedzerwa ichi kuwedzera? Kutanga, zvinofanira kuonekwa kuti chimiro chechiratidzo ichi muropa chinobva pane 0 kusvika 0.5 mg / l. Kuwedzera huwandu hwayo muropa kunogona kukanganisa zvose zvinoratidzira maitiro, uye muviri. Ngatimbokurukurai nezvehutano hunotaura kuti kukosha kweRPP kunogona kuwedzera.

Zviratidzo zvechipatara zvinowedzera huwandu hweRPP

Saka, kukosha uku kuri kuwedzera mumatambudziko anotevera:

• Mushure mokunge zvirwere zvinotapukira zvakanyanya, kunyanya dai dzaiva zvechigadzirwa chebhakitiriya.
• Pakuwedzeredza zvirwere zvinoputika kana zvirwere zvinotapukira, zvinosanganisira atherosclerotic kuchinja mumasvingo emiropa.
• Chekupi kwekukuvadza kwehutachiona hwehutachiona (kukuvadzwa kwemoyo, kuvhiyiwa, kushungurudzika, chishuvhuni, kupisa, nezvimwewo).
• Nekuparadzaniswa kwemakumbo mumamiriro ezvinhu ehutano uye pamwe nekuonekwa kwemasitasvi matsva.
• Pakudzvinyirirwa kweropa.
• Ne endocrine pathologies (kuneta, chirwere cheshuga, kuwedzerwa kana kusasha kwehomoni dzepabonde, nezvimwewo).
• Mumamiriro ezvinhu ekuputsa mapuroteni metabolism.
• Nokuchinja kwe-atherosclerotic mumidziyo.
• Vanhu vanoshatisa kusvuta.

Mamiriro ezvinhu anokonzerwa neRPP

Pamusoro pemamiriro ezvinhu aya, zvimwe zvezvematongerwo enyika zvinogona kukanganisa kushandiswa kwemagariro eCropical. Saka, huwandu hwahwo hunogona kuwedzera nekuwanda kwekuita muviri, semuenzaniso:

• Vatambi panguva yemakwikwi kana kusimbisa dzidzo.
• Mumadzimai panguva yekuzvitakura, kunyanya kana pane chexicon.
• Paunotora mishonga yekudzivirira mahomoni kana mamwe mahomoni.
• Kushandisa doro kana kudya kwemazuva masikati ekupa ropa kuti uongorore.
• Kuvapo kwekuputika kana kuisa mukati momuviri.

Muzviitiko zvipi iyo CRP iri pasi pemaitiro

Mukuwedzera, kuongororwa kweRPP muhupenyu hwekuongorora ropa kunogona kunge kwakadzika uye kuve pasi pezvakanaka pamusana pokutora mamwe mishonga, kunyanya kana murwere achivatora kwenguva yakareba. Iyi mishonga inosanganisira:

• Glucocorticoid hormone.
• Kwete-steroidal anti-inflammatory drugs.
• Beta-blockers.

CRP: kazhinji

Ongororo yeDRR inoratidza zviratidzo zvikuru. Kuongorora kweRPP kunogona kuitwa nenzira dzakasiyana-siyana. Uchapupu hwake hunogona kusiyana zvishoma zvichienderana nekunzwa kwezvakasiyana siyana zvekare. Nokudaro, mune rimwe laboratori inobereka kukwidziridzwa kweRPP, chimiro chinoratidzwa kana chibereko chacho chikapiwa.

Nokudaro, rimwe laboratories rinoratidza chimiro che 0 kusvika ku 0.5 mg / l. Uye vamwe, vachishandisa nzira dzakasiyana-siyana, nhamba muzvakabudiswa zvikamu zvekudzidza kuti CRP iyo yakasarudzika inobva 0 kusvika 0.3 mg / l. Nokudaro, kana uchiverenga chigumisiro, iwe unofanirwa kuteerera nguva dzose.

Mukuwedzera, migumisiro yenyaya iyi yakarondedzerwa zvishoma munguva ichangopfuura. Pamberi pekare, nzira yekare yakashandiswa, iyo yakapa migumisiro yakaenzana. Iko kuwanda kwekutaura kwenyaya iyi kwakapiwa mumitambo. Saka, chigumisiro chacho chaifungidzirwa se "chakaipa" (-). Kana chiitiko chakanaka chikawanikwa, chakabudiswa nenzira yemhinduro yakadaro - "zvakanaka" (+). Mune mabheji, nhamba yemigwagwa kubva kune imwe kusvika kune ina yakanyorwa.

Kuongorora kurapa kweRPP

Mukuwedzera kune dzimwe zviratidzo uye nzira dzokuongorora, CRP inokoshawo. Saka, puroteni iyi inotanga kupinda kunopindira kwehutachiwana mumuviri kana kuti kukura kweimwe hutachiona. Mushure memaawa mashomanana mushure mekugadzirwa kwemyocardial infarction, chiyero chechiratidzo ichi muropa chinotanga kukura. Uye muzuva rimwe chete inogona kuwedzera muma makumi makumi maviri.

Kudzidza kwechiratidzo ichi mumasimba kunobatsira chiremba kutonga kubudirira kwemasarudzo ekurapa maitiro. Nokudaro, sezvo simba rerheumatic process kana imwe chirwere chinoderera, rutivi rweRPP muropa runoitawo kuderera.

Kuongorora uku kwakave kwakanyatsodzidzisa, uye kunyange kukurudzirwa kwekutsvaga kutsvaga kwekutsvakurudza hakugone kuidzikisa.

Nzira yekupedza muedzo weC-proactive protein

Kuti upe kupfupiswa kwakadaro, kurovedzwa kwakakosha hazvidiwi. Asi inofanira kutarirwa mupfungwa kuti kuongorora kweropa kunotorwa mambakwedza musimba risina chinhu. Pakati pezuva, zvimwe zviratidzo zvingasiyana zvishoma, somuenzaniso, glucose kana leukocyte. Kuongororwa ropa kunowanzotarisirwa mumatambudziko. Izvi zvingave zvirwere zvemukoko, dzinosanganisira kudzidza kweRPP, kana chirwere chekuongorora ropa, iyo inoongorora ESR. Zvose zvavo, pamwe chete nekuongorora uye kuunganidzwa kweamamnesis, zvakakosha pakuzivikanwa kwakakodzera.

Ropa paRPP inotorwa kubva mumhino muimba yekurapa ye polyclinic kana imwe nzvimbo yezvechiremba.

Usati wopa ropa pachidzidzo ichi kuti uwane mhinduro yakavimbika, zvinokosha kuchengeta mitemo yakawanda iri nyore:

1. Kudya manheru kunofanira kunge kusina kunonoka uye kuwanda.
2. Nenguva isati yatanga kupa ropa haina kukurudzirwa kutora chero zvokudya uye zvinokurudzirwa kusvuta. Kubvumira kunwa mvura.
3. Zuva risati rasvika iwe unofanirwa kurega kutora chero doro, doro rakasimba uye kofi.
4. Maawa mashomanana usati waedzwa, hazvikurudzirwi kuti uwedzere kana kuti, zvakasiyana, kudarika. Mune mamwe mazwi, haukwanisi kuenda kuropa sampling mushure mekunge sauna, kushamba, gungwa kana solarium, kana kushambira mumugodhi wechando.
5. Pamberi pehofisi, zvinokurudzirwa kugara uye kuzorora kwemaminitsi mashomanana.

Pane zvirwere zvipi kune kuwedzera kweRPP

Kana kuongororwa kweropa kweRPP kwapera, zvinowanzoita kusvika ku 0.5 mg / l. Kana uwandu hwechiratidzo ichi hwakakwirira, zvino maererano nezvimwe zviratidzo, murwere anokwanisa kufungidzirwa nezvezvirwere zvinotevera:

• Rheumatic system pathologies (rheumatoid arthritis, systemic lupus erythematosus, nezvimwewo).
• Acute bacterial infections.
• Fungal zvirwere.
• Zvirwere zvemuviri wepamuviri (ulcerative gastritis, mudumbu ulcer kana duodenal ulcer, ulcerative colitis, nezvimwewo).
• Kuparadzaniswa kwechirwere chakaipa kana metastasis panguva yezvirongwa.
• Multiple myeloma.
• Myocardial infarction (yavapo pazuva repiri mushure mekurwa kweRPP inokura uye inonyangarika chete pamagumo emavhiki matatu, panyaya ye angina ino index inoramba iri yakakwana).
• Endocarditis.
• Secondary amyloidosis.
• Tuberculosis.
• Meningitis.
• Neutropenia.
• Sepsis yevana vachangoberekwa.
• Matambudziko mushure mekuvhiyiwa, somuenzaniso, peritonitis kana kubuda mushure.
• Mumamiriro ekugadzirisa, kuwedzera muRPP kunogona kuratidza kukanganisa kupindura.

Saka, takawana zvose pamusoro pechidzidzo chakadai seRPP nekuongorora - chii ichocho uye pasi pemamiriro api iyo inogona kuwedzera. Kudzidza kweRPP mumagetsi ehutano hwemwoyo kunoshumira semhando yemararamiro uye inobvumira kufanotaura kuti zvinogona kuitika. Izvi zvinoita kuti zvikwanise kuwana nguva nekudzivirira kuora kwemamiriro ekurwara, kudzivirira zvinetso.

Nzira yekubata nayo CRP yakakwirira

Inofanira kunzwisiswa kuti kuwedzera kwehuwandu hweRPP chiratidzo chete, kwete chirwere. Kune chimwe chezvinhu zvinogona kuitika zviratidzo izvi zvinoratidza, chiremba anosarudza. Kuti aite izvi, anofanirwa kunyatsoongorora zvese zvakawanikwa zveongororo, chengorora murwere uye kunyatsounganidza anamnesis. Mushure meizvozvo, chete kuongororwa kuchave kwakagadziridzwa. Mishonga haigoni chiratidzo chakasiyana, asi hutachiona sehuwandu.