Chii chinobatsira "Nize" (mapiritsi)? Mirayiridzo yekushandisa, zvakafanana

Unoziva here zvinobatsira "Nize" (mapiritsi)? Kana iwe usine ruzivo rwakadaro, tichaupa mune zvinyorwa zvenyaya ino.

Packaging yekugadzirira nekugadzirwa kwayo

Pamusoro pezvinobatsira "Nize" (mapiritsi), tichataura pasi apa. Izvo zvinoshanda zvechirwere ichi ndeslide. Uyewo muhutano hwayo hunosanganisira zvikamu zvakadai se microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, starch yegorosi, magnesium stearate, sodium carboxymethyl starch, pineapple flavor uye talc.

Nokutengesa, mushonga uri mubvunzo unouya mumabhalters emapiritsi gumi, akaiswa mumapakiti emakadhibhodi.

Nheyo yekuita kwechiremba

Usati wapindura mubvunzo wezvinobatsira "Nize" (mahwendefa), iwe unofanira kutitaurira kuti mushonga uyu unoshanda sei.

Maererano nemirayiridzo, iyi ndiyo NSAID inonyatsodzivisa COX-2, kureva, enzyme inobatanidzwa mukushandiswa kwe prostaglandin, vanyori vekutambudzika, kuputika, uye edema. Mukuwedzera kune-anti-inflammatory properties, mushonga uri mubvunzo unoratidza antipyretic uye analgesic effect.

Inofanirawo kutaurwa kuti mushonga uyu unodzivisa (reversibly) kuumbwa kwe prostaglandin E2 mumakwara ekukwira kwee nociceptive system uye kuratidza kuvhiringidza, uyewo munzira dzenzira (zvinorwadza) mumutsipa wepelinha.

Kugadzirira "Naise", iyo yakafanana iyo yakanyorwa pasi apa, inoderedza kukanda kwe prostaglandin H2 (nguva pfupi), iyo, pasi pesimba re prostaglandin isomerase, prostaglandin E2 inooneka. Kupera kwemafuro ekupedzisira kunounza kuderera kwehuwandu hwekushandiswa kwe EP-type receptors (prostanoid), iyo inoratidzirwa mukurwisa-kupisa uye kuenzanisa zvinokonzera.

Inofanirawo kucherechedza kuti, kune chiremba chisingaenzaniswi, mushonga uri mubvunzo unobata COX-1. Pasi pemamiriro ezvinhu emuviri, inenge isingaiti kudzivirira kuitika kwe prostaglandin E2 kubva kuArachidonic acid. Izvi zvinoderedza nhamba yemigumisiro yemishonga.

Nzvimbo huru dzechirwere (NSAIDs)

Mushonga we "Naise" unokwanisa kubvisa kukanganiswa kweplatelets. Izvi zvinoitika nekudzivisa kubatana kwe thromboxane A2 uye endoperoxides. Mukuwedzera, iyo inoderedza kusunungurwa kwe histamine, uye inoderedzawo chirwere che bronchospasm, icho chakakonzerwa nemigumisiro yeacetaldehyde uye histamine.

Nyanzvi dzakaratidza kuti nimesulide inhibisa kupatsanurwa kweurokinase uye interleukin-6, kudzivirira kuparadzwa kwemakumbo emakumbo. Mukuwedzera, inhibits the synthesis of metalloproteases, kudzivirira kuparadzwa kwegorgen uye proteoglycans.

Maererano nemirayiridzo, kuburikidza nekuderedza basa remyeloperoxidase, mishonga iri mumubvunzo inoratidzira antioxidant properties uye inopedza kugadzirwa kwezvinhu zve (kuora) O ₂ kuora. Iyo inobatanidza ne glucocorticoid receptors uye inoita kuti iite, iyo inobatsira pakusimudzira chiito chinopesana nekuputika.

Kinetics wezvinodhaka

Mushure mekupedza, inesthetic "Naise" inobviswa kubva mumukumbo. Kudya kunoderedza kuwandisa kwekugadzirisa kwechirwere, asi hachikanganisa dhigirii.

Iyo nhamba yepamusoro ye-nimesulide muropa inosvika mushure memaawa 2.6. Kubatana kwayo nemapuroteni kusvika kusvika 95%.

Ichi chinodhaka chinopinda mumatumbu ose emadzimai echikadzi. Mukuwedzera, inowanika mumamiriro e-acidic ekutsvaira kwechirwere uye synovial fluid.

Metabolism ye nimesulide inoitwa muchiropa. Hupenyu hwayo hupenyu hwemaawa mashanu. Iyo yakanyanyisa kunyanya neitsvo, uye pamwe chete ne bile.

Zviratidzo zvekutora mapiritsi

Chii chinobatsira "Nize" (mapiritsi)? Nzira dzinofungidzirwa dzinogadzwa pa:

• Radiculitis, rheumatoid arthritis, sciatica;
• Lumbago, osteoarthritis, articular syndrome ne rheumatic fever uye kuwedzerwa kwegout;
• Psoriatic arthritis, arthralgia, ankylosing spondylitis;
• Arthritis yakabva zvakasiyana-siyana, osteochondrosis uye radicular syndrome;
• Kusuruvara kwemigumisiro, myalgia yeusingaiti rheumatic uye rheumatic genesis, bursitis, kuputika kwetendon;

• Syndrome syndrome yemarudzi akasiyana-siyana (kusanganisira kushungurudzika, postoperative period, dinoti, algodismenorrhea, misoro);
• Kuvhiringidzika kwemishuloskeletal system, pamwe chete nemaviri mashoma.

Uyezve zvinofanira kuonekwa kuti "Nyz" inobatsira kutonhora zvakanaka. Ichi chinodhaka chinoshandiswa kwefivha yezvakasiyana-siyana, kusanganisira zvirwere zvinoputika uye zvinopararira.

Contraindications NSAIDs

Mushonga we "Naise" panguva yekuzvitakura inorambidzwa. Uyewo haifaniri kushandiswa apo:

• I "aspirin triad";
• Zvirwere zvinokonzera uye zvinokonzera chironda chemuviri wepamuviri (pamwe nekuwedzera);
• Breastfeeding;
• Kubvambura kubva pamakumbo emimba;
• Kushushikana kwechiropa basa;
• Muhuduku kusvika kumakore maviri;
• Kuora kwemasimba kunotsanangurwa;
• Hypersensitivity.

Nekunyanya kukodzera iyi mishonga inorayirirwa kurudzi rwechipiri chirwere cheshuga, arterial hypertension uye kusagadzikana kwepfungwa.

Nzira yekugamuchira "Nize" sei?

Mishonga iri mubvunzo nenzira yemapiritsi inongoratidzwa chete nemuromo. Varwere vakura vanokurudzirwa kutora 100 mg kaviri pazuva. Izvo zvakanyanya kuwedzerwa kwemishonga pazuva ndeye 400 mg.

Kana iri mahwendefa asingabviriki, usati watora mishonga iyi, inofanira kunge yakapera yakapera mu 5 ml yemvura yakasara (mu 1 dessert spoon). Shandisa iri mishonga pakuguma kwekudya kana mushure mekudya.

Vana havasi kupa mishonga iyi mumapiritsi. Kwavari, pane imwe nzira yemishonga - kusimiswa. Inokurudzirwa kutora iyo pazera remakore maviri.

Dzimwe nguva zviitiko

Chirwere ichi "Naise", chiyero chayo chakataurwa pamusoro, chinogona kukonzera kusapindira kwakashata kwakadai se:

• Kushungurudza, kuora hepatitis, nausea, thrombocytopenia, kurutsa;
• Agranulocytosis, kurwadziwa mukati mudumbu, anemia, diarrhea, leukopenia;
• Zvirwere zvinokonzera uye zvinouraya zvegumbo rekudya, misoro, kuwedzerwa kwechiropa transaminases;
• Anaphylactic shock, uzuzi, kupisa kweganda;
• Kuwedzerwa kwenguva yeropa, bronchospasm, hematuria, kuchengetedza mvura.

Mhosva yekudarika

Ndezvipi zviratidzo paunotora mapepa akawanda eNize? Muyero wemishonga iyi inofanira kutsanangurwa nechiremba anoenda. Kana mushonga wacho uchinge wakanganisa (muhuwandu hwakawanda), murwere anogona kukura zviratidzo zvinotevera: kusuruvara, kuwedzerwa kweropa, kushungurudzwa kwemuviri wepamuviri, kusagadzikana kwekuita basa, kushaya simba kwepfungwa uye kuora mwoyo.

Kuti abvise mamiriro ezvinhu akadaro, murwere anoshambidzwa nemudumbu, anorayirwa kushandiswa marara uye anoita chirwere chechiratidzo.

Kubatana Kwemishonga

Nekutaurirana kwemazwi pamwe chete kweNaise ne diuretics, digoxin, phenytoin, antihypertensive agents uye lithium, pamwe chete nedzimwe NSAIDs, cyclosporine, anticoagulants, methotrexate, mishonga ye hypoglycemic (muromo), murwere angava nekubatana kwezvinodhaka Nokukwikwidzana nemishonga iyi yekusunga mapuroteni).

"Naise": kufanana nekuongorora

Iwe unogona kugadzirisa mushonga pamwe nemishonga yakadai seNimulide, Aponil, Arkoksia, Mesulid, Meloksikam, Nimesil, Movalis, Nimesulid, Denebol, Nimika.

Nyaya yevashandi mhinduro pamusoro pemishonga iri mubvunzo inofadza. Maererano nemaonero avo, "Nize" inokurumidza kununurwa pamarwadzo, uye mishonga inoshandiswawo seyakagadzirisa zvakanyanya anti - inflammatory drug. Kunyange zvazvo vamwe varwere vachiti mishonga iyi ine chimwe chinhu chakakosha. Iyo inowanzokonzera kushushikana kwakashata kwakadai sechezzinesi, kushaya simba uye nezvinetso zvine chirwere chekudya. Muchiitiko ichi, vanachiremba vanokurudzira kuti iwe ushandise mushonga wacho nemishonga yakafanana.