Benzathine benzylpenicillin: tsananguro, zvivako uye chikumbiro, analogs

Benzathine Benzylpenicillin ane mushonga uye ndezvaiye penicillin boka. Anoshandiswa kurapa marudzi ose zvirwere zvinokonzerwa nemabhakitiriya kubatwa kwayo chiito. Munyaya ino tichashandisa yakataurwa muudzame mirayiridzo kushandiswa, zviratidzo uye contraindications kuti mushonga, uyewo pasi zvishoma vezera.

Benzathine benzylpenicillin: rondedzero zvinodhaka

mushonga uyu ndiwo mumwe boka kuti penicillin inorwisa mabhakitiriya okutanga. Pasinei refu chaizvo chikumbiro rokuti, hakuna akarasika kushanda kwayo nokuda siyana nezviito uye anokwanisa kuuraya-siyana pathogenic mabhakitiriya. The mushonga Somuenzaniso, unogona kukurira hwechigwadara, meningococci, njovhera uye muzvizhinji kuti streptococci uye staphylococci. Akanga jekiseni sezvo ari zvomudumbu turakiti haina kunyura benzathine benzylpenicillin.

Recipe muchiLatin runowanzotaurwa ushandiswe navanachiremba, uye ipapo murwere zvakaoma kunzwisisa zvaakanga wakapiwa. Kudzivisa kuvhiringidzika ichi, iwe chete kuziva zita mushonga mumutauro ichi - Benzathine benzylpenicillinum.

Kazhinji, mushonga chinotarisirwa nomutsinga kana intramuscularly. Asi zvinokwanisika uye zvinodhaka hurukuro mumuviri pachishandiswa musana canal, subcutaneously kana kuburikidza njodzi yacho.

Benzylpenicillin - mushonga rakanyorwa kubva chete rinoita fuma. Asi anopinda mushonga dziri munyu. Saka fuma inogona kuchengetwa kwenguva refu pasina rokukoromorwa pasi. Uye pashure pakatanga kuti penicillin G wobudiswa mumuviri munyu uye anotanga ayo antibacterial chiito.

Zvichienderana hurongwa umo munyu une fuma, muri mhando dzakawanda kurapwa. Pasinei neizvi, vose vane nehasha zvimwechetezvo, uye modes siyana chourongwa uye ya kushanda.

umboo

Benzathine benzylpenicillin ari nachiremba zvinotevera zvirwere:

• Zvirwere ari kufema nadzo (pleurisy, mabayo, bronchitis, empyema , uye zvichingodaro.).
• Zvirwere genitourinary ino (njovhera, mwandabvu, urethritis, cystitis, adnexitis, salpingitis).
• Zvirwere yokumusoro kufema turakiti (rutsvuku fivha, tonsillitis, sinusitis, otitis nhau, sinusitis, laryngitis, etc.).
• Purulent Zvirwere of ziso nadzo, mapfupa uye ganda, mucous membranes (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, muchikuvadza utachiona, uye zvichingodaro.).
• Brain pute.
• Purulent yomumuzongoza.
• Septicemia, sepsis.
• Arthritis.
• Peritonitis.
• Zvirwere zvinokonzerwa spirochetes (yaws, hwechigwadara, etc.).
• Fever anokonzerwa gonzo nokuruma.
• Zvirwere zvinokonzerwa Listeria, Clostridium, Pasteurella.

Uyezve, mushonga chinotarisirwa mu prophylactically postoperative yematambudziko uye zvakaoma kunzwisisa pamwe streptococcal chirwere (endocarditis, rheumatic nefivha, glomerulonephritis uye zvichingodaro.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) pakarepo pashure Kutarisirwa anotanga dziparare, achisunungura zvinoshingaira fuma. Panguva iyoyowo zvinodhaka anoramba muropa chinotevera 3 mavhiki pashure jekiseni. The mvura fuma chinopinda nani zvikuru pane ari tishu. Zvinofanira kurangarirwa kuti benzyl kuti penicillin anokwanisa kukunda placental mechidziro kuoneka mumukaka ekukurerai. Yabudiswa kuburikidza itsvo dziri kuchinja chimiro. Mumakore 8 Mazuva okutanga akabudiswa vanenge 33% of raitongwa dose.

Pamuviri uye uchiyamwisa

Sezvataurwa pamusoro apa, mushonga anokwanisa zvinopfuura placenta uye kupinda zamu mukaka. Saka, achiyamwa anofanira dzakavharwa kana vachiita zvinodhaka.

Panguva pamuviri, kugadzwa zvinodhaka zvinoita chete kana kubatsira vakadzi mukuru ngozi nokuda mwana. Chisarudzo chinofanira kuitwa nachiremba, vachinyevera mai ramangwana pamusoro zvose pezvingazoitika.

Contraindications

Benzathine benzylpenicillin (yokubika anogona mishonga chiremba) ane nhamba contraindications. Hazvifaniri ushandiswe kuvanhu zvinotevera zvirwere:

• Kurambidzwa kuenda kuti penicillin kana cephalosporin, imwe sema maitiro kwavari.
• Yakakwirira pamwero potassium muropa (hyperkalaemia).
• Arrhythmia.
• Hay Fivha.
• Árbol asima.
• Renal insufficiency.
• Pseudomembranous colitis.

Matanho medicament raitongwa vana kusvika mwedzi mitanhatu uye nguva isati yakwana.

nemishonga

Benzathine benzylpenicillin zvingasafadza kunaka zvinokonzerwa, wozvinyora pazasi.

Various neutachiona:

• fivhiri;
• mikoko;
• okusafunga pamusoro mucous membranes uye ganda;
• kurwadza kwemajoini;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• exfoliative dermatitis;
• anaphylactic kuvhunduka.

Nenjodzi zviri kumwoyo:

• thrombocytopenia;
• kupererwa neropa;
• coagulation zvirwere;
• leukopenia.

Mukuwedzera:

• stomatitis;
• nomusoro;
• glossitis;
• marwadzo munharaunda chourongwa;
• abscesses;
• infiltrates;
• nejedhi peripheral;
• fistulas.

With kushandiswa kwenguva yakareba inokuvadza notumwe uye Micro-zvinenge anogona kusaurayiwa, ipapo mushonga acharasikirwa kubudirira kwayo.

Benzathine benzylpenicillin: mirayiridzo kushandiswa

Varwere vakuru nemakore 12, ari mushonga kuzvidzivirira mwero uye kurapwa kwezvirwere zvinotapuriranwa chinotarisirwa kamwe pavhiki panguva chipimo chemushonga kuti 300 600 zviuru. Zviumbu kana kaviri pamwedzi mamiriyoni 1,2 dzakabatana.

Sezvo matanho kuti rheumatism anobaya mushonga 6 kwemavhiki, kamwe pavhiki 600 zviuru dzakabatana. Panguva iyoyowo taurira asipurini kana zvimwe NSAIDs.

Varwere vaduku nemakore 12, mushonga chinotarisirwa kamwe pavhiki panguva mwero 5-10 zviuru. Vezvikwata muzana 1 kg.

Between majekiseni vanofanira kutora nzvimbo dzinenge 8 mazuva. Avhareji chipimo chemushonga mamiriyoni 2,3 dzakabatana.

Asati kushandiswa, mushonga akanga zvazvichanyungudutswa sesaline, mvura jekiseni kuna hoc kana novocaine (2,5% kana 5%).

Patange mushonga vangava nenzira dzinotevera:

• intramuscular;
• intravenous;
• subcutaneous;
• Lumbar (nomukombiyuta musana Canal);
• pleural (kuburikidza pulmonary pleura);
• subconjunctival (nomukombiyuta ocular munyama);
• kuchadonha kubudikidza nzeve;
• kuchadonha kubudikidza mhino;
• zvakananga njodzi nhengo tishu.

Pamwe nemamwe zvinodhaka

Benzathine benzylpenicillin (murayiridzo zvakananga sezvakaratidzwa) anogona kushamwaridzana nevamwe zvinodhaka. Saka benzylpenicillin ave zvinotevera matanho: munhu synergistic, anopikisana uye bacteriostatic.

Mukuwedzera, zvinodhaka zvinowedzera kubudirira zvinodhaka, kuva zvisina kunanga anticoagulants. Uye anoderedza kubudirira ethinyl estradiol uye siyana kunanzvana pamuviri.

Shandisa pamwe NSAIDs, allopurinol, diuretics kunoguma ipfupi tubular secretion uye vakawedzera kuwanda vanoshingaira chirungiso. Uyezve, allopurinol rinowedzerawo zvikuru mukana neutachiona.

matanho okudzivirira

Hazvo kutangira jekiseni zvaanofanira aspirate. Kana mushonga netsaona anopinda nenhumbi ropa, zvinogona kukonzera ischemia kana embolism. Uyezve, pangava kunzwa kuzvidya mwoyo, kupfuura madzerere.

Muzviitiko apo zvaunofanira kuita majekiseni maviri panguva, mushonga chinotarisirwa dzakasiyana maoko kana magaro.

Apo kuratidzwa sema kurapa wokutanga anofanira kwaizombomiswa pakarepo. Maererano ezvinhu chiremba anogona mishonga chisimbwa mishonga.

Kazhinji benzylpenicillin kugadza "Levorinum" kana "Nystatin", sezvo paine mukana fungal zvirwere. Saka ndiwo mushonga kwenguva refu zvinodhaka zvingaitika chinovhiringidza pamusoro intestinal microflora iyo zvinowanisa mavhitaminzi B. Panyaya iyi, unogona kupiwa kune intramuscular kwokubatsira mavhitaminzi izvi.

Zvokungwarira

Benzathine benzylpenicillin basa pamwe kungwarira varwere vakaona zvakasiyana-siyana itsvo basa, pane kubatwa kune sema kuratidzwa, dzakakwirira aikanganiswa yezviri chirungiso. Chisarudzo chokupedzisira nguva dzose kunobva kuna chiremba, uyo anofanira kuziva nhoroondo murwere wake.

Not yakarumbidza mushonga nokuda pakurapa neurosyphilis, sezvo chirwere ichi hakungagoni kukwanisika zvinodiwa wevasungwa kuti vanoshingaira fuma muropa romurwere.

analogs

Pane zvimwe zvinodhaka kuti vane zvimwechetezvo sezvo benzathine benzylpenicillin. Analogs Chokwadi, uyewo ndezvaJehovha penicillin boka. We nyora kupfuura akakurumbira uye inobudirira:

• "Gramoks-D" - anogadzirwa muchimiro upfu aiendeswa ruminant uye kunanzvana yaitonga.
• "Amosin" - anogadzirwa capsules, mapiritsi uye upfu kuti kunanzvana yaitonga.
• "Chibhokisi" - unoitwa muchimiro manyuchi.
• "Hikontsil" - rinowanika muchimiro upfu uye capsules kuti kunanzvana yaitonga.
• Azlocillin yavaibvisa munyu - weupfu fuma iyo kuti mhinduro intravenous jekiseni.
• "Ampicillin" - inowanika pamahwendefa, capsules, granules, ichangoburwa kuita slurry, uye rakundwa nomuromo.
• "Ekobol" - yakabereka Mahwendefa.
• "Ospamoks" - unoitwa muchimiro mapiritsi, capsules uye upfu kuti kunanzvana yaitonga.
• "Phenoxymethylpenicillin" - inowanika pamahwendefa, dragees, granules uye Nezvakakuyiwa.
• "Star-Pen" - unoitwa muchimiro granules, izvo rakasanganiswa uye vatora nomuromo.
• "Oxacillin" - unoitwa muchimiro mapiritsi, capsules, upfu, umo, mhinduro jekiseni.
• "Standatsillin" - rinowanika capsules.
• Carbenicillin disodium munyu - anogadzirwa upfu muchimiro nokuda kwezvifananidzo zvaAtemisi jekiseni mhinduro.

Saka, pasinei kushandisa zvinodhaka pane mushonga nekaupenyu refu-refu, iye achiri inoramba rimwe inonyatsobudirira yomuchipatara pamusoro dzakasiyana-siyana zvirwere.