Bacteriophages: mhando uye chinangwa

Phage lysis - chirongwa kuparadzwa utachiona kubudikidza phages, kazhinji rikaitika sei nhengo panguva vaingoerekana kupora. Kana kuzvicheka-kuporesa kumboitika, muviri vangabatsirwa kudzidzisa runoenzanirana bacteriophage, zvichiguma mishonga kambani. Akadana bacteriophages Mavhairasi utachiona kuti pinda uye kukonzera nemukuparadzwa yavo (lysis) pamusangano naye kubatwa masero microbial.

MuchiGiriki bacteriophage rinoreva "inodya mabhakitiriya." Zvakasikwa, zvinenge aya akasiyana chaizvo uye tiri huru kupfuura parizvino anozivikanwa nemavhairasi mapoka. Phages muri nemavhairasi vakasiyana zvinomera, mhuka uye mamiriro kwevanhu, zvakawanda zvakaoma. Ivo inowanikwa kwemvura, mhepo, ivhu, zvokudya, pamusoro nyaya ganda, mhuka shinda, muna pfupi, kwose kune utachiona.

Mumakore achangopfuura, kufarira bacteriophages anoshandiswa serimwe rinogona kutsiva nemishonga. Izvi hazvishamisi, uye avo uye zvimwe zvinodhaka anokanganisa zvakananga utachiona. Zvisinei, mishonga vanozivikanwa tigume kwete chete pane pathogenic kasvisto, asiwo utility. Bacteriophages, mhando zvacho zvakasiyana, kuita zvokusarudza, chete utachiona "avo", vachisiya ngwanda kwake. Chaizvoizvo, saka masayendisiti uye havana wekuvamba mazita, zviri nyore zvikuru kuti avaidze azvaitwa kwemabhakitiriya yavari pachena.

Bacteriophages: Types

Revai streptococcal, coliform mubonda, klebsiellezny, anonzi Staphylococcus, Pseudomonas, Salmonella, nemanyoka, fivha bacteriophage uyewo "Intestifag" uye "Piobakteriofag".

Active gadziriro kunotemwa avo mwero dilution panguva iyo lysis tisanzwe tsika. Saka, titer 10 yechipiri dhigirii zvinoreva kuti Exhibits lytic bacteriophage vanoshingaira ehupfumi ari dilution 1 000 000 nguva. Pamusangano tembiricha kuti 4-6 C zvinodhaka vane ehupfumi dzavo kusvikira makore 12.

Zvichienderana kusunungurwa siyana yakasiyana basa bacteriophages. Mhando zvinodhaka anogona kukanganisa zvose munhu utachiona, uye kakawanda pakarepo. Monophages kukanganisa utachiona inoverengeka zvakafanana kwemabhakitiriya. K kunzwisisa gadziriro (polyvalent) zvinosanganisira bacteriophage "Sekstafag" rinokwanisa panguva tunodzivisa nezvebasa staphylococci, streptococci, kusanganisira enterococci, Pseudomonas uye Escherichia coli coli, Proteus, Klebsiella. Uyezve, pane "Intestifag" aiendeswa pakurapa intestinal zvirwere, izvozvo unotora munhu Salmonella, fivha, manyoka, proteus, coli uye streptococcal (kudzvanyirira enterococci) phages.

Drugs akashandiswa dysbacteriosis, intestinal zvirwere, inflammations ari urogenital maitiro uye broncho-pulmonary midziyo chokubata septic urongwa, uyewo zvirwere nomumukanwa mhango uye sinuses. Vari akashandiswa mukati, kusanganisira muchimiro enemas, uye kwaunogara - kurigeza, kugeza maronda, douching. Somuenzaniso, "The Bacteriophage Klebsiella polyvalent akanatsa" nokuda kurapwa ozeny, rinoskleromy, zvirwere zvinokonzerwa ne utachiona Klebsiella nemabayo, anoshandiswa inhalation panguva maronda trachea, dokeriro uye pharynx, dzakabatwa turunda zvakakangwa mu mvura, otitis, kushandiswa Kusuka mu sinusitis. Kana cystitis, enterocolitis, urethritis, mabayo zvinodhaka chinobviswa nomuromo.

Bacteriophages vane vakawanda zvakanakira pamusoro nemishonga. Havana nemishonga, vari basa kunyange vacheche uye vakadzi pamuviri, havana muropa. Vanogona kuva pamwe chero zvinodhaka, uyewo kushandiswa nokuda kudzivirira zvirwere. Mugadzire izvi zvine simba pamusoro pokumuka kutapata kunobatsira, regai vasaziva dzinongoitika kasvisto uye zvazvinoita zvinooneka mukati maawa 2-4 mushure ingestion. Havazivi kusaurayiwa utachiona.

Mumwe drawback muri bacteriophages. Mhando inoshandiswa mukurapa nhasi, asi vashoma, iyo ichikutadzisa kushandisa kwavo zvirwere zvakawanda.

Outlook chikumbiro

Kuti abudirire kushandisa utachiona zvigadzirwa, zvinokosha kuziva aikanganiswa utachiona kwavari. Zvisinei, masayendisiti akacherechedza muenzaniso kunakidza: ari aikanganiswa zvigare phages haina akaderedzwa, asi kunowedzera, nokuda vapfume mishonga pamwe netsika itsva. Kusvika panguva bacteriophage staphylococcal akabudirira lyse 90% kuti utachiona zvose kwemabhakitiriya akasunungura panguva septic maronda.

Vazhinji zvirwere nyanzvi dzinodavira kuti phage kurapa achakurumidza revolutionize pakurwisa zvirwere. Immunologists ona tariro kushandiswa mari idzi apo Immunopreparat simba. Maererano Analytical zvidzidzo zviri mashomanana akatevera, mumwe ndiyo nzvimbo pharmacology achava kugadzirwa phages.