ALT yakavandudzwa. Chii chandinofanira kuita?

Iyo enzyme alanine aminotransferase (ALAT), iri muropa, inoshandiswa sechiratidzo kuti ione kutyorwa kwemabasa ayo. Chii chinoratidza kuti kana ALT yakavandudzwa here?

Pakati pemakemikari akawanda ari zviratidzo zvehepatocellular disorders, inonyanya kukosha uye inokosha ndeye alanine aminotransferase (ALT) uye aspartate aminotransferase (ACAT). Pamusana pavo, kuchinja kwekuita ku gamma-boka re ketoglutarate yemagma-maqembu e alanine ne aspartate inowedzera. Somugumisiro weizvi, pyruvic uye oxalic-acetic acids inoumbwa.

Zvose ALT neAASAT zviri masero enzymes emakemikisi, chiropa, mwoyo. Asi alanine aminotransferase inonyanya muropa uye inofungidzirwa kuti ndiyo inonyanya kukosha, uye aspartate aminotransferase inoumbwa nedzimwe nhengo dzakawanda uye masukisi, kusanganisira masaga, maronda, nezvimwewo, kuwedzera kune zvataurwa pamusoro apa. Ndokusaka enzyme inokosha ye ACAT isingazivikanwi Sechiratidzo chechiropa chinoshanda, uye chinotora chikamu pakuchinjana kweamino acid.

Kana masero echiropa, mwoyo, itsvo dzikaparadzwa, alanine aminotransferase (ALAT) inopinda muropa. Kuwedzera kweyero enzyme iri muropa inopupurira nezvezvirwere zvakavanzwa. Kana kuongororwa kwakaitwa kunoratidza kuti kune yakakwirira yeAlat muropa, zvinokwanisika kukura zvirwere zvakakomba zvakadai se:

- cirrhosis,

- viral hepatitis,

- myocarditis,

- kenza yeropa,

- kushaya mwoyo,

- chirwere chemwoyo.

Kubuda muApartate aminotransferase muropa kunogona kutungamirira pakutanga

- kubvisa,

- kenza yeropa,

- muscular dystrophy ,

- pancreatitis,

- paroxysmal myoglobinuria,

- hepatitis,

- dermatomyositis,

- kushaya mwoyo.

Kana nharaunda yose ye ASAT neAlt ichiwedzerwa, zvinotevera zvinobvira:

- yakazara hepatic necrosis,

- Toxinogenic chiropa kukuvara,

- chirwere chakanyanya hepatitis,

- kuparara kwevascular refu.

Zvimwe kune zvirwere zvevanhu, kuongororwa kweropa kunoratidza kuti chiratidzo chezvose ASAT neAlt chiri kuwedzerwa, kureva, chiyero chezvinyorwa zvevamwe mapurojekiti mumatambudziko aya zvinenge zvakafanana uye zvinoratidza kuvapo kwehutachiona. Asi kune rumwe rutivi rwakasiyana. Kana ALT yakasimudzirwa kune imwe nzvimbo yakawanda kupfuura aspartate aminotransferase, izvi zvinoratidza nguva yekudzivirirwa kwekuvandudzwa kwehutachiona hwehutachiona. Kana iyo ASAT iri muropa yakawanda, inowanzova dambudziko remoyo.

Mune munhu ane utano, zviri mumaseremia aya emawere anofanirwa kunge ari pamatanho e:

- nokuda kwevarume kusvika kumakiti 41 pamatare (U / L);

- kuvakadzi kusvika kumakiti 31 pamatare (U / L).

Kuti uone hutano hwemakemikari aya eprotheni metabolism, chirwere chekuongorora ropa chinotorwa . Chimiro cheAlt mairi chichava 28-190 nmol / (sec) kana 0.1-, 68 μmol / (ml h), uye AcAt - 28-25 nmol / (sec) kana 0.1-, 45 μmol / (Ml h). Izvi zvinowanzoitirwa nzira yeReitman-Frenkel (nzira yekuratidzwa kwemavara).

Kazhinji, kuongororwa ropa kwealanine aminotransferase kunoitwa kuti udzidze nezvehupenyu hwechiropa, uye pane aspartate aminotransferase - kuona hupenyu hwemyocardium (musimba wemwoyo). Kana kuongororwa kunoratidza hukuru hwavo muropa, saka mune nhengo idzi pane nzira dzekuparadzwa nekufa kwemasero. Saka, kana ASAT ichinge yanyanya kudarika ropa rayo nema2-20, zvino zvinoita kuti ukure myocardial infarction. Kana ALT yakasimudzirwa, pane chirwere chechirwere muropa.

Neine ropa rezasi realanine aminotransferase uye aspartate aminotransferase, nyanzvi dzinoziva kuti kune urombo hwe pyridoxine (vitamini B6) mumuviri. Kazhinji izvi zvinoitika panguva yekudzivirira, uye kazhinji hemodialysis uye kushaya kwepso.

Zvinosuruvarisa, iyo inobva maune enzyme inotorwa muropa remuviri wemunhu ane hutano, iyo isingazivikanwi, saka iyo nzira yekugonesa kwayo (muyero wekubvisa plasma, zvimwe zviputi uye masukisi kubva kune chero zvinhu zvinokonzerwa nekugadziriswa kwavo, biotransformation, kubviswa kubva mumuviri) zvinonzwisisika.