Prostaglandin - nayo ... Prostaglandins (zvinodhaka): zita mutengo

Vazhinji kwemasayendisiti mumuviri hunotsigirwa prostaglandins, izvo anobudiswa neZvapupu zvinenge nyama yose. Vanowanzoororwa seva mahormone, zvisinei, havasi. Ivo vanoita preferentially panguva nzvimbo kwetunhu uye ipapo pasi kuparadzwa. The mahormone zvakare nesimba simba ravo kure uye vari musiyano chete kwemakemikari anobudiswa omumuviri uye nyama havasi vakawanda.

kubatana kwetunhu prostaglandins

Ngatimboonai paumbwe fuma ichi pamuviri. Prostaglandin - a fuma yakaumbwa panguva muviri pamusoro arachidonic acid, ivo Eicosanoids. Mafuta acids tiri chikamu phospholipids, izvo zvinowanika nyama yose. Pasi zvinoitwa phospholipase A2 decays arachidonic acid, pashure unomutswa uri cyclooxygenase kana lipoxygenase anotenderera. Prostaglandins ndiwo chigadzirwa rokutanga.

Chii muchinangwa muviri?

Eicosanoids vanoita zvakasiyana-siyana mabasa. Prostaglandin - imwe pfuma kuti ari kushingaira munyaya dzakawanda kwemasayendisiti kuitika mumuviri wedu. Somuenzaniso, prostaglandin E ane depressor zvazviri, i.e. kunoderedza BP ne bata vascular matauriro. Uyezve, prostaglandins (zvinodhaka uye zvakasikwa) kuti Activate kuti contractile kushanda myometrium, wakakodzera vari kushandiswa izvo kuti induction zvebasa. Izvi zvinhu kuwedzera kwetunhu madzihwa kuti zvinoberekwa wakanwa masero ari mudumbu. Madzihwa anoita unodzivirira basa, kudzivisa kuitwa hasha zvikonzero pamusoro mucosa. Uyezve, nokuda zvinhu izvi zviri woutsinye paumbwe pepsin uye hydrochloric acid, iro zvinobudirira kushandiswa pakurapa gastric zvirwere chokuita rakawedzera secretion izvi zvinhu. Ivo kukanganisa rheological ehupfumi ropa, zvichivhiringidza platelet aggregation. Prostaglandin E sei kumeso tsandanyama masero ari trachea uye principales, kunosimudzirawo kutandara zvavo, uye nokudaro, rokuwedzera Airways. Nezvebasa rinokosha prostaglandins ari kuzvimba uye kurwadziwa. Izvi zvinhu kwete chete chokuita etsinga harinzwi uye fibers, asi zvinobatanidzwa kuonekwa nevamwe zviratidzo kuzvimba. Zvakachinja vascular inzwi pasi zvinoitwa prostaglandins zvichitungamirira kuzara, uye kuwedzera permeability porusvingo - mhaka paumbwe edema. Prostaglandins, kuwedzera kune angangodaro kukanganisa kune vagus etsinga, zvichikonzera svoto uye kurutsa. Yakadaro divi maturo kazhinji yaisangana varwere. Prostaglandins - zvinodhaka (mazita pazasi) kushandisa chete pasi oma zvairatidza.

Kusakarongeka pakati prostaglandins uye zvinodhaka Anti-anogumbura

Prostaglandin - iri zvakananga ubatanidzwe kushoma. The chiito pamusoro NSAIDs inobva rutapudzo kuti kwetunhu (cyclooxygenase enzayemu kukurukurirana kwacho). Kushandisa NSAIDs refu kunoita kuti kushayikwa prostaglandins, zvichizoita vasingadzoreki chipingamupinyi kushanda mudumbu - vasanyanye secretion pakati madzihwa. Uyu chikuru divi mugumisiro zvinodhaka izvi.

Prostaglandins - gadziriro: zita

zvinodhaka izvi zviri kureva zvirwere mudumbu uye duodenum urikanwi, erosive zvisikwa. Mukuwedzera, vari dzakabatwa kuti vabatsire marwadzo ari myometrium uye kuvandudza ropa rheology.

"Misoprostol"

Prostaglandins (zvinodhaka) vari rinoparadzirwa pakurapa gastric uye duodenal maronda nokuda Anti-secretory kwayakaita. Chiito ichi Rinobatanidzwa ne ine zvainoita prostaglandin receptors, izvo dziri mune gastric parietal masero. Saka, "Misoprostol" mabasa somunhu dzinongoitika prostaglandin. Kweiyi madzihwa Kugadzirwa kunobatsira kudzivirira mucous Kamudzira uye kunodzivisa kuumbwa nemaronda itsva. izvi zvose zvinoita zvakanaka mamiriro kuporeswa nemaronda uye erosions.

"Alprostadil"

The mushonga ndiye prostaglandin chinodhaka E. Kazhinji chinotarisirwa muzviitiko apo runodiwa yakawedzera rutapudzo of myometrium - induction zvebasa. Uyewo, kuti mushonga inoshandiswa kuvandudza ropa wokufambisa - chinovhiringidza kuti platelet aggregation uye vasodilation (atherosclerosis). Inowanika ndiro nokuda intravenous yaitonga.

Contraindications

Vose mushonga hauna chinotarisirwa, kana pane hypersensitivity kuti prostaglandins uye analogs ayo. Pakati contraindications - zera 18, nepamuviri uye achiyamwa. Uyewo tora Yambiro yavo varwere renal uye hepatic insufficiency, pathologies ari kwemakemikari anobudiswa ezvinhu, enterocolitis, kupererwa neropa.

Self-kwokubatsira prostaglandin zvinodhaka pasina kubvunza nyanzvi haabvumirwi. Chete chiremba anogona kuwana zvakanaka chipimo chemushonga uye kugadziridza kurapwa plan, kufungisisa nomumwe zvechadenga murwere. Zvichienderana Nzvimbo yako ichachinja mutengo. Prostaglandin inowanika dzakasiyana siyana uye pasi siyana muchiso mazita, uyewo rinokanganisa mutengo.

nemishonga

Kakawanda, apo kushandisa zvinodhaka kungaita kuti abnormalities of zvomudumbu ino - kuda kurutsa, kurutsa, manyoka uye dyspeptic zvirwere. Kana iwe uri sema, kwakaratidzwa pruritus, mapundu, akatsvuka uye kuzvimba, uye pazvinobvira anaphylactic siyana. Administration zvinodhaka anogona nechokuita paunowana kumwedzi, dysmenorrhea. Achidzikisa myometrium chinowanzoonekwa inozivikanwa uchirwadziwa mudumbu. Pakati mhiri kukanganiswa - dzungu, nomusoro, muviri uremu nokufamba.

The mwero ngozi nemishonga iri nomumwe nomumwe murwere. Kana kucherechedza dzakadaro mananara taurai chiremba wako uye kushandura kurapwa urongwa.

Prostaglandin - imwe pfuma inodiwa pakurapa peptic urikanwi chirwere uye dzimwe pathologies. Dzinowanzotanga kubatanidzwa nemamwe zvinodhaka kuti vabudirire zvinozoita. The kusarudza mishonga kwayo chipimo chemushonga kuvimba kunotoda mhosva uye munhu murefu maitiro.