Bundu zvechinguvana HE4: inopangidza. Zviratidzo ovarian kenza vakadzi

Gore negore, kenza varwere vari kuwedzera. Kurwisa Izvi hazvirevi nyasha munhu. Masayendisiti uye vanachiremba vachiri kuedza kukurira panowanikwa nekenza chinokonzera uye kuwana nzira dzinoshanda kurapwa. Zvinosuruvarisa, mukutanga nzendo chirwere chiri asymptomatic. Varwere vakawanda vauye chiremba pamwe zvichemo, vanoona kuti vane yokunyanyisa mwero dambudziko nako kurwa nokunonoka. Saka, rufu mwero nokuda kenza zvakakwirira. Asi masayendisiti akakwanisa kutaura dambudziko. Mhando dzakawanda kenza anogona kuonekwa panguva tanga, panguva chaiyo kushanyira vanachiremba uye kupa ropa kuti miedzo. Special rabhoritari nzira achitirega kure kwevanhu ropa "zvikwangwani" -onkomarkery, chinetso kwakaitika. Izvi zvinobvumira iwe kuziva chirwere chichiri kutanga, izvo achawanda kakawanda mikana nokupora.

To musi, kumwe kutya hadzi kenza - ovarian kenza. Rufu kubva ndicho chikuru pakati dzimwe malignancies hadzi sikarudzi. Musavhunduka. Pashure pezvose, kuona kutanga hosha uve tanga ayo kukura uye kuderedza ngozi njodzi. Special kudzidza ropa kuvapo bundu zvechinguvana HE4 kunze pangozi.

The zvinokonzera ovarian kenza

Ipai chaiyo zvikonzero ovarian yamamota vakadzi, hazvibviri. Pane zvinhu zvinoverengeka kuti kutsamwisa kukura anomera:

• Zvakachinja hormone background. Kakawanda, hormone kusaenzana kunoitika vakadzi panguva kubereka. Panguva iyi, kuwedzera mukadzi kurara mahormone mumuviri. Somugumisiro, izvozvo zvinoita kuti chidzoke kenza namamota, kusanganisira ovarian. Hormone RINOFAMBIRA zvingaitikawo, uye vasikana nevakadzi vaduku. Saka, vanhu paunowana kumwedzi zvinogara vanofanira kubhadhara ngwariro chaiyo utano.
• Bad tsika. Ose vakadzikama munhu anoziva kuti kusvuta, doro, hakuvaki zvokudya - vabatsiri zvirwere zvakasiyana-siyana. No kunze, uye ovarian kenza. Somuenzaniso, vakadzi vanoshungurudza zvigadzirwa ane mhiri mafuta, carcinogens, madhayi nezvimwe zvinokuvadza yokuvirisa vakachengeta pangozi onkovracha.
• Permanent chinja pabonde, pamuviri. Kana vanhu kuchinja magiravhusi, kwete hanya utano hwavo, ipapo abate zvirwere, nezvirwere zvepabonde, nyore. Munguva yemberi iri kuchaderedza vemo masoja emuviri uye, naizvozvo, panowanikwa malignancy. Abate pamuviri pasingadiwi kunogona kuva mugumisiro unzenza. Vakadzi vazhinji, vasingaoni imwe nzira yokubuda pamuviri. Izvi kuvhiya kupindira - munhu mupfungwa yakakura nokuda munhukadzi muviri, izvo anochinja hormone nomwero. Mugumisiro - kushaya mbereko, kenza.
• Operations ari ovaries, izvo zvinosimudzira paumbwe atypical epithelial masero ari nhengo.
• Dzinza rako. Masayendisiti zvakaratidza zviitiko apo kuvapo majini zvakananga ari DNA cheni inosimudzira chitarisiko nyanyisa anomera muvanhu.
• Bundu pakati ovary vakadzi dzimwe nguva vanova se migumisiro nezvimwe zvirwere oncological.

Zviratidzo zviri chirwere

Mukutanga zvokukura ovarian kenza kuona zvisingaiti. Zviratidzo kuonekwa kana hosha akatema muviri rakadzika. The chikuru Zviratidzo ovarian kenza vakadzi:

• kumwedzi zvirwere;
• kuita weti kakawanda;
• kudzvanya manzwiro ari dzakaderera mudumbu;
• vachirwadziwa kurwadziwa ovary;
• nezvinetso defecation;
• kusanzwa, marwadzo panguva zvepabonde.

kuratidzwa izvi zviri chirwere haagoni kunzi chaicho ovarian kenza. Saka, kudzivisa njodzi, zvinokosha kushanya ane gayinakorojisiti.

Diagnostics

Zvatinosiita rokuongorora uri gynecological cheya achasarudza kuchinja ovarian marongerwo. Kuzosimbisa kwokutanga zvokuongorora murwere anorayirwa kuti vanoverengeka paku zveBhaibheri:

• Ultrasound kuongorora nhengo dzokubereka nadzo;
• zvinyama biopsies kuona kenza mamiriro;
• MRI - nzira naro localization uye miganhu yamamota kuona zvizere;
• Maekisirei uye musiyano mhinduro kuchaitawo kuzobvumira kuona nzvimbo bundu.

Uyewo, nokuti chirwere ose ovarian kenza varwere akadana bvunzo ropa, iro aiona kuvapo bundu zvezvinangwa. In kwavo wevasungwa kutonga pamberi chirwere. Kuona ovarian kenza ropa kuyambuka hwokuziva vaviri bundu zvezvinangwa - CA125 uye HE4. Yokupedzisira mhando zvechinguvana achangobva atanga kutsanangura, asi chinonyanya zvakarurama rinoratidza kuchiita chirwere.

Chii HE4?

Bundu - chairo fuma, iyo inotanga ichibudisa muviri pamwe maronda chero nhengo yomuviri bundu. Uyewo zvezvinangwa inogona zvakapararira munyika dzose utano munhu, asi kuwedzera wevasungwa kenza nyanzvi vanoona uye kunoirinda ndokuyerera.

HE4 - bundu zvechinguvana kuti ovarian kenza vakadzi, anogadzirwa duku kwazvo pamuviri kuramba utano vasiri ushande. Kana njodzi epithelium pamusoro ovarian kenza, chaiyo mapuroteni wevasungwa rinobuda.

Kare, kusimbisa chirwere, "ovarian kenza" anoshandiswa CA-125 zvechinguvana, iyo pakutsvaga imwe bvunzo ropa. Asi nzira iyi haana kushanda, nokuti wevasungwa pamusoro zvechinguvana ichi aigona kuwedzera uye vasiri neoplastic zvirwere kana mapundu dzimwe nhengo. Inosimudzira serum kwevari CA-125 vangava pamusoro 3rd kana 4th pavaipfuura chirwere. In kwokutanga nzendo chirwere yokuziva achishandisa zvechinguvana ichi kutonetsa. Kakawanda, pachiyero "bhikoni" kunowedzerwa kana kuratidza zvekuchipatara zviratidzo ovarian kenza vakadzi.

HE4 ane yepamusoro specificity (95%) uye wanda (76%) zvichienzaniswa CA-125. Pane zvidzidzo vakaratidza kuti vakadzi vane yakakwirira Kuwanda HE4 zvechinguvana CA-125 ropa anoramba muupenyu. Naizvozvo, nokuti kutsunga ovarian kenza achiri Danho zviri nani kushandisa, izvo anosarudza kuti nzira HE4.

Kuti migumisiro kuva mukuru chikamu zvakarurama, nyanzvi kutsanangura maviri chete bundu zvechinguvana (CA-125 HE4). Zvadaro shandisa rinokosha kwemasvomhu algorithm kuti kazhinji kubvumira kuti kutaura pamusoro pokumuka oncological pezvakaitwa vari ovaries. Specificity uye aikanganiswa kuti nzira iyi kunowedzera mu kakawanda (kusvika 96%).

Bundu zvechinguvana HE4: kwomuzvarirwo vakadzi

Rokuongorora, kufunga chete pamusoro pamusana pachisara iyo anosarudza kuti HE4 nezvisingabvumwi. For chirwere pevara chete misoro nzira vaongo- maturusi uye nzira nokuda kuona muedzo kuti bundu zvezvinangwa. Munguva pachisara kutsunga chiratidzo nokuda ovarian kenza anofanira yakaratidza, kwakaitika vakadzi mukuguma ura kana kwete, sezvo Range netsika dziri vakadzi kubereka kumusoro.

In vakadzi risati mukuguma ura HE4 indekisi kunofanira asingasviki 70 pmoles / Rine mamiririta.

Mukadzi wakaitwa kubereka, HE4 pamwero romuzvarirwo kana akaratidza kuti 140 pmol / Rine mamiririta.

Bundu zvechinguvana HE4: inopangidza

Ngatimbotaurei zvazviri. Kana bundu zvechinguvana HE4 rakakwirira, inoratidza panowanikwa epithelial ovarian kenza. Just cherechedza kuti mune dzimwe mhando kenza yacho ovaries (semuenzaniso, mucinous) uwandu serum HE4 haina ichiwedzerwa.

Yakakwirira Kuwanda HE4 haisi anoratidza ovarian kenza nguva dzose. Dzimwe padanho zvechinguvana ichi kwakasimudzirwa muna renal kukundikana, kenza yemapapu, endometrial, itsvo fibrosis.

gadziriro zvakakodzera kuongorora zvakare zvarinoita ufanane zvechinguvana muropa.

Kugadzirira ongororo

Kuti usarudze bundu zvechinguvana HE4 ropa wakatorwa kubva tsinga kuti akatsanya. Saka, usati ruoko pamusoro pachisara maawa 12 pamberi nzira havagoni kudya mafuta zvokudya, doro, zvihwitsi, nyama, haugoni kuputa. Pazuva ongororo anogona kunwa chete mvura iri shoma.

mhedziso

Kuisa yakarurama zvokuongorora kunogona chete kuva chiremba, kuvimba mashoko kubva marudzi vanoverengeka Diagnostics. Kudzivisa zvinetso zvoutano, kuwana tsika kuti kamwe pagore kunoonekwa nachiremba. Pashure pezvose, kuziva chii akanaka - inokosha.